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Objectives. This study aimed to analyze the effectiveness, benefits and safety of water aerobic exercise in improving the quality of life of pregnant women from a psychological and physical perspective. Materials and methods. The present study is defined as a type of systematic review research using searches from journal databases such as MEDLINE-PubMed, Web of Science, Scopus and Science Direct. The inclusion criteria for this study were articles published in the last 5 years and articles discussing pregnancy, aquatic aerobic exercise and quality of life in pregnancy. A total of 53 articles from the Science Direct, PubMed, and Web of Science databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) assessment. Results. The findings of this systematic review indicate that participating in aquatic aerobic exercises has been found toreduce pain during labour, reduce the use of epidural analgesics during labour, reduce depression during pregnancy, reduce the risk of fetal distress, stabilize blood pressure, reduce back pain, and improve the psychological condition of pregnant women. Conclusions. The regular practice of water aerobic exercise carried out from the 2nd trimester of pregnancy contributes to having a positive impact on improving the quality of life of pregnant women.

BACKGROUND: A recent phase III trial (NCT01372774) comparing use of stereotactic radiosurgery [SRS] versus whole-brain radiation therapy [WBRT] after surgical resection of a single brain metastasis revealed that declines in cognitive function were more common with WBRT than with SRS. A secondary endpoint in that trial, and the primary objective in this secondary analysis, was to identify baseline biomarkers associated with cognitive impairment after either form of radiotherapy for brain metastasis. Here we report our findings on APOE genotype and serum levels of associated proteins and their association with radiation-induced neurocognitive decline. METHODS: In this retrospective analysis of prospectively collected samples from a completed randomized clinical trial, patients provided blood samples every 3 months that were tested by genotyping and enzyme-linked immunosorbent assay, and results were analyzed in association with cognitive impairment. RESULTS: The APOE genotype was not associated with neurocognitive impairment at 3 months. However, low serum levels of ApoJ, ApoE, or ApoA protein (all P < .01) and higher amyloid beta (Aβ 1-42) levels (P = .048) at baseline indicated a greater likelihood of neurocognitive decline at 3 months after SRS, whereas lower ApoJ levels were associated with decline after WBRT (P = .014). CONCLUSIONS: Patients with these pretreatment serum markers should be counseled about radiation-related neurocognitive decline.

Abstract Hyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan degradation for fetal membrane rupture at parturition remains unknown. Here, we reveal that versican (VCAN) is the major hyalectan in the amnion, where its cleavage increases at parturition with spontaneous rupture of membrane. We further reveal that ADAMTS4 is a crucial proteolytic enzyme for VCAN cleavage in the amnion. Inflammatory factors may enhance VCAN cleavage by inducing ADAMTS4 expression and inhibiting ADAMTS4 endocytosis in amnion fibroblasts. In turn, versikine, the VCAN cleavage product, induces inflammatory factors in amnion fibroblasts, thereby forming a feedforward loop between inflammation and VCAN degradation. Mouse studies show that intra-amniotic injection of ADAMTS4 induces preterm birth along with increased VCAN degradation and proinflammatory factors abundance in the fetal membranes. Conclusively, there is enhanced VCAN cleavage by ADAMTS4 in the amnion at parturition, which can be reenforced by inflammation.

Study purpose. This study aims to analyze and highlight the potential of Sea Cucumber in reducing oxidative stress and inflammation caused by exercise. Materials and methods. The study is a type of systematic review research using searches from various journal databases such as Science Direct, Pubmed and Web of Science. The inclusion criteria in this study were journals published in the last 5 years which discussed sea cucumber, oxidative stress, inflammation and exercise. Furthermore, the exclusion criteria in this research are journals that are not reputable or are not indexed by Scopus and Web of Science. A total of 1038 articles from the Science Direct, Pubmed and Web of Science databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) assessment. Results. The results of this systematic review research report that the strong phenolic content found in Sea Cucumber has anti-oxidant properties which may reduce oxidative stress. Furthermore, the anti-inflammatory properties of sea cucumbers have the potential to reduce uncontrolled inflammation caused by intense exercise. Conclusions. The phenolic content in sea cucumbers has strong anti-oxidant properties in reducing oxidative stress. In addition, the anti-inflammatory properties of sea cucumbers may reduce uncontrolled inflammation caused by exercise. In this case, sea cucumbers have an anti-inflammatory effect by suppressing the secretion of pro-inflammatory cytokines. Through this systematic review, we recommend that future studies should perform clinical trials on the potential effects of sea cucumber on oxidative stress biomarkers and inflammatory biomarkers after exercise.

Study purpose. This study aims to analyze and highlight the potential of rosella flowers in reducing oxidative stress and inflammation after physical activity. Materials and methods. The study used a systematic review method by searching various journal databases such as Scopus, Web of Science, Pubmed and Embase. The inclusion criteria in this study were articles published in the last 5 years and articles discussing Rosella Flowers, Oxidative Stress, Free Radicals, Inflammation, and Exercise. The exclusion criteria in this research were articles published in disreputable journals. A total of 357 articles from the Scopus, Web of Science Pubmed and Embase databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) assessment. Results. The results of this systematic review research report that the flavonoid content found in rosella flowers has anti-oxidant and anti-inflammatory properties which have the potential to reduce oxidative stress and uncontrolled inflammation caused by physical activity and intense exercise. Conclusions. Rosella flowers show their ability as an anti-oxidative by donating hydrogen atoms to free radicals through phenolic compounds, thus breaking the cycle of ROS formation. The natural active ingredients in rosella flowers are able to reduce MDA and increase GSH which contributes to reducing oxidative stress and decreasing TNF-α which provides an anti-inflammatory effect in athletes after exercise.

Graves’ disease (GD) is an autoimmune disorder disease, and its prevalence continues to increase worldwide. Pyrroloquinoline quinone (PQQ) is a naturally antioxidant compound in milk, vegetables, and meat. We aim to identify the treatment efficacy of PQQ on GD and its regulatory effect on intestinal microbiota. The GD mice model was built by an adenovirus expressing autoantigen thyroid-stimulating hormone receptor (Ad-TSHR289). Fecal samples were collected for 16S rDNA sequencing after PQQ pretreatments (20, 40, or 60 mg/kg BW/day) for 4 weeks. Thyroid and intestine functions were measured. The levels of serum TSHR and T4 were significantly raised, and the thyroid gland size was typically enlarged in the GD group than in controls, reversed by PQQ therapy. After PQQ replenishment, IL6 and TNFα levels in small intestine tissues were lower than those in the GD group, with Nrf2 and HO1 levels improved. Also, the PQQ supplement could maintain the mucosal epithelial barrier impaired by GD. In microbial analyses, PQQ treatment could prompt the diversity recovery of gut microbiota and reconstruct the microbiota composition injured by GD. Lactobacillus served as the most abundant genus in all groups, and the abundance of Lactobacillus was increased in the GD group than in control and PQQ groups. Besides, Lactobacillus was highly correlative with all samples and the top 50 genera. PQQ supplementation regulates thyroid function and relieves intestine injury. PQQ changes the primary composition and abundance of GD’s intestine microbiota by moderating Lactobacillus, which may exert in the pathogenesis and progression of GD.

It has been suggested that grip strength can predict physical fitness in children and adults. The overall plan of this study will validate this conclusion. The study analysed the correlation between hand grip strength and sit-and-reach in 70 children aged 6-7 years with the aim of gaining insight into the correlation between grip strength and sit-and-reach. Descriptive statistics were used in the study to find out the mean scores and differences in these exercises. The correlation between hand grip strength and sit-and-reach flexibility was also explored using Pearson's correlation coefficient. The results showed the correlation coefficient between hand grip strength (mean±sd=5.46±3.75) and sit-and-reach flexibility (mean±sd=8.25±5.28) was 0.078, indicating a weak positive correlation (p 0.05). The results of the study suggest that grip strength is not a valid predictor of physical dexterity in seated forward bends in 6-7 years old children age group. As suggested in the previous studies, grip strength can predict physical fitness in children, such as a strong correlation between grip strength and physical flexibility, lung function, muscular endurance, and physical stability. However, from the results, grip strength is not a reliable predictor of physical flexibility. We need to further validate the predictive role of grip strength for other physical fitness indicators. This is a very important validation for us to develop children's physical fitness assessment programs more efficiently in the future.

BackgroundSame-day surgery cancellation results in decreased operating room (OR) utilization, reduced productivity, and inconvenience for patients. We aim to assess the cancellation rates of elective surgeries, identify common causes, and evaluate changes due to the COVID pandemic.MethodsA retrospective cohort study was conducted identifying all same-day surgery cancellations at a tertiary pediatric academic hospital from 1/1/2015 to 12/31/2017 (pre-COVID) and from 4/1/2020 to 3/31/2021 (post-COVID). Statistical analysis was performed using generalized regression with cancellation as the dependent variable. Period, age, ethnicity, gender, preferred language, and insurance were independent variables.ResultsThere were 55465 scheduled cases (41670 before and 13795 after COVID), with 1508 cancellations (2.7%). Of those, 1247 (3.0%) were before COVID and 261 (1.9%) after COVID (p