4,438 results on '"Jing, FENG"'
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2. N-doped NiS2 nanosheets array on carbon fiber as an efficient hydrogen evolution reaction electrocatalyst
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Jing, Feng, Du, Shibo, Ding, Zhiheng, Chen, Xuepeng, Liu, Zhen, and Mei, Hongying
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- 2024
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3. Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis
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Xu, Min, Wang, Hai-Xia, Zu, Ping, Jiang, Nan, Bian, Jing-Feng, Xu, Ji-Rong, Luo, Wei, and Zhu, Peng
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- 2024
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4. Application of ambient noise tomography to coastal granite islands: A case study of Wuzhizhou Island in Hainan, China
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Huang, Cheng, Liu, Sheng, Long, Jun-Qiao, Zhang, Chang-Rong, Xiao, Bo, Wang, Da-Cheng, Wei, Cheng-Long, Wang, Rui, Yan, Li, Hu, Xuan, Xin, Zhuo, Meng, Xiu-Ji, and Xing, Jing-Feng
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- 2024
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5. Unsupervised exceptional human action detection from repetition of human assembling tasks using entropy signal clustering
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Yang, Chao-Lung, Hsu, Shang-Che, Kang, Yu-Chung, Nian, Jing-Feng, and Cakravastia, Andi
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- 2024
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6. Fighting Against Risks and Uncertainties: Chinese University Students' Decision-Making About Study Abroad Under COVID-19
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Wenqin Shen, Yilin Chai, Feifei Gu, Kun Zhang, Jing Feng, Xueting Liu, and Ziyou Mo
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Building on a theoretical model of decision-making under risk and uncertainty, this paper examines how Chinese college students made decisions about international moblity or immobility during the COVID-19 pandemic. The paper finds that among the 118 interviewees, most continued to choose to study abroad, whilst some gave up after getting offers from prestigious Western universities. We further analysed the divergent patterns of two choices which can be explained by resilience to risks and uncertainties and lack of thereof. For those who have given up studying abroad, the symbolic capital and labor market advantages brought by degrees (especially master degrees) from Western universities have become uncertain and offset by the risk of the epidemic. These findings suggest that, in addition to safety, college students will prefer certainty more than before when choosing whether to go abroad and the study abroad landscape may change based on this mindset.
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- 2023
7. Do STEM Students Vote?
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D'Wayne Bell, Jing Feng, John B. Holbein, and Jonathan Smith
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Pundits, politicians, and academics have long worried about potentially low rates of civic participation among STEM-oriented students. Does studying STEM actually decrease the odds that young people will be actively involved in democracy? To answer this question, we created a dataset of over 23 million students in the United States, matched to national validated voting records. This novel dataset is the largest known individual-level dataset in the United States, connecting high school and college students to voting outcomes. It also contains a rich set of demographic and academic variables, to account for many of the common issues related to students' selection into STEM coursework. We consider two measures of STEM participation: Advanced Placement (AP) exam taking in high school and college major. Using both measures, we find that, across model specifications, the estimated relationships between STEM and voting are small in magnitude--about the same effect size as a single get-out-the-vote mailer. Our analyses demonstrate that, on average, marginally more STEM coursework in high school and college does not contribute noticeably to the low voting rates among young people in the United States.
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- 2024
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8. Exceptional figure of merit achieved in boron-dispersed GeTe-based thermoelectric composites
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Yilin Jiang, Bin Su, Jincheng Yu, Zhanran Han, Haihua Hu, Hua-Lu Zhuang, Hezhang Li, Jinfeng Dong, Jing-Wei Li, Chao Wang, Zhen-Hua Ge, Jing Feng, Fu-Hua Sun, and Jing-Feng Li
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Science - Abstract
Abstract GeTe is a promising p-type material with increasingly enhanced thermoelectric properties reported in recent years, demonstrating its superiority for mid-temperature applications. In this work, the thermoelectric performance of GeTe is improved by a facile composite approach. We find that incorporating a small amount of boron particles into the Bi-doped GeTe leads to significant enhancement in power factor and simultaneous reduction in thermal conductivity, through which the synergistic modulation of electrical and thermal transport properties is realized. The thermal mismatch between the boron particles and the matrix induces high-density dislocations that effectively scatter the mid-frequency phonons, accounting for a minimum lattice thermal conductivity of 0.43 Wm−1K−1 at 613 K. Furthermore, the presence of boron/GeTe interfaces modifies the interfacial potential barriers, resulting in increased Seebeck coefficient and hence enhanced power factor (25.4 μWcm−1K−2 at 300 K). Consequently, we obtain a maximum figure of merit Z max of 4.0 × 10−3 K−1 at 613 K in the GeTe-based composites, which is the record-high value in GeTe-based thermoelectric materials and also superior to most of thermoelectric systems for mid-temperature applications. This work provides an effective way to further enhance the performance of GeTe-based thermoelectrics.
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- 2024
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9. Remnant cholesterol and risk of incident hypertension: a population-based prospective cohort study
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Guo, Da-Chuan, Gao, Jing-Wei, Wang, Xiang, Chen, Zhi-Teng, Gao, Qing-Yuan, Chen, Yang-Xin, Wang, Jing-Feng, Liu, Pin-Ming, and Zhang, Hai-Feng
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- 2024
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10. Highly stabilized and efficient thermoelectric copper selenide
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Hu, Haihua, Ju, Yiwei, Yu, Jincheng, Wang, Zechao, Pei, Jun, Thong, Hao-Cheng, Li, Jing-Wei, Cai, Bowen, Liu, Fengming, Han, Zhanran, Su, Bin, Zhuang, Hua-Lu, Jiang, Yilin, Li, Hezhang, Li, Qian, Zhao, Huijuan, Zhang, Bo-Ping, Zhu, Jing, and Li, Jing-Feng
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- 2024
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11. Complete monotonicity of the remainder in an asymptotic series related to the psi function
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Yang, Zhen-Hang and Tian, Jing-Feng
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- 2024
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12. AHA Life’s Essential 8 and new-onset CKD: a prospective cohort study from the UK Biobank
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Ruan, Yong-Xiang, Wu, Mao-Xiong, Gao, Jing-Wei, Guo, Da-Chuan, Cai, Yang-Wei, Huang, Ze-Gui, He, Wan-Bing, Chen, Yang-Xin, Wang, Jing-Feng, and Zhang, Hai-Feng
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- 2024
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13. Effect of rare earth on primary carbides in H13 die steel and their addition method: a review
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Wang, Jing-feng, Wang, Lin-zhu, Chen, Chao-yi, Wang, Xiang, and Zhao, Fei
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- 2024
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14. Relative peripheral refraction in school children with different refractive errors using a novel multispectral refraction topographer
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Hui-Ling Hu, Serena Zhe-Chuang Li, Ai-Ying Feng, Hao-Xi Zhong, Jing-Feng Mu, and Mei-Zhou Liu
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relative peripheral refraction ,myopia ,school children ,multispectral refraction topography ,Ophthalmology ,RE1-994 - Abstract
AIM: To compare relative peripheral refraction (RPR) in Chinese school children with different refractive errors using multispectral refraction topography (MRT). METHODS: A total of 713 eyes of primary school children [172 emmetropia (E), 429 low myopia (LM), 80 moderate myopia (MM), and 32 low hypermetropia (LH)] aged 10 to 13y were analyzed. RPRs were measured using MRT without mydriasis. MRT results showed RPR at 0-15° (RPR 0-15), 15°-30° (RPR 15-30), and 30°-45° (RPR 30-45) annular in the inferior (RPR-I), superior (RPR-S), nasal (RPR-N), and temporal (RPR-T) quadrants. Spherical equivalent (SE) was detected and calculated using an autorefractor. RESULTS: There were significant differences of RPR 15-30 between groups MM [0.02 (-0.12; 0.18)] and LH [-0.13 (-0.36; 0.12)] (P
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- 2024
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15. Sleep traits and breast cancer risk: a two-sample Mendelian randomization study
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Jing Feng, Yixue Wen, Zhen Zhang, and Ye Zhang
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Sleep traits ,Chronotype ,Daytime dozing ,Breast cancer ,Mendelian randomization ,Medicine ,Science - Abstract
Abstract Globally, breast cancer continues to be the leading cause of cancer-related incidence and mortality among females. Research has shown that sleep patterns significantly influence tumor onset and progression. In this research, the association was examined through the application of a two-sample Mendelian randomization (MR) approach. For the analysis of seven sleep patterns, genetic tools were sourced from both the UK Biobank and 23andMe, including morning/evening person (chronotype) n = 177,604, morning person (chronotype) n = 248,094, daytime dozing/sleepiness n = 193,472, getting up in the morning n = 193,717, and sleeplessness n = 193,987; sleep duration n = 192,810; and nap during the day n = 166,853. The Breast Cancer Association Consortium (BCAC) supplied genome-wide association studies (GWAS) data, including 133,384 breast cancer cases and 113,789 controls, alongside subtype-specific data with 106,278 cases and 91,477 controls. We discovered that chronotype encompasses both morning and evening types contributes to the risk of overall breast cancer. While daytime dozing and morning person (chronotype) are linked to a lower risk of breast cancer in general, In subtype-specific analyses, morning person (chronotype) was negatively associated with luminal B, HER2-negative-like, and daytime dozing was negatively correlated with luminal A-like, luminal B-like, and HER2-enriched-like. The study corroborates that chronotype is a danger element for breast cancer, aligning with previous observational findings. The association between being a morning person (chronotype) or having daytime dozing and a decreased risk of breast cancer underscores the significance of sleep patterns in formulating strategies for cancer prevention.
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- 2024
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16. Study on the crystallographic orientation dependent electrochemical corrosion rates of aluminum and its binary alloys
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Haini Jin, Yudong Sui, Xiaohua Yu, Hao Zhou, Jing Feng, and Yehua Jiang
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract This paper provides a study for crystallographic orientation-dependent corrosion rate of aluminum employing an ab initio model with inputs from first-principles calculations. Results showed that the sequence of corrosion rate is in the order of (111)
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- 2024
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17. Advancements in methodologies and techniques for the synthesis of energetic materials: A review
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Wei Du, Lei Yang, Jing Feng, Wei-hua Zhu, Jin-shan Li, Peng-cheng Zhang, and Qing Ma
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Energetic materials ,Advanced synthetic tools and techniques ,Flow chemistry ,Electrochemical synthesis ,Microwave-assisted synthesis ,Chemical technology ,TP1-1185 - Abstract
Recent years have witnessed significant advancements in methodologies and techniques for the synthesis of energetic materials, which are expected to shape future manufacturing and applications. Techniques including continuous flow chemistry, electrochemical synthesis, microwave-assisted synthesis, and biosynthesis have been extensively employed in the pharmaceutical and fine chemical industries and, gratifyingly, have found broader applications. This review comprehensively introduces recent advancements in the utilization of these emerging techniques, aiming to provide a catalyst for the development of novel green methods and techniques for synthesizing energetic materials.
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- 2024
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18. OsAlR3 regulates aluminum tolerance through promoting the secretion of organic acids and the expression of antioxidant genes in rice
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Chang Su, Jingbo Wang, Jing Feng, Sixu Jiang, Fuyuan Man, Linlin Jiang, and Minghui Zhao
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OsAlR3 ,Al tolerance ,Metabolome ,Transcriptome ,Organic acids ,ROS ,Botany ,QK1-989 - Abstract
Abstract In acidic soils, aluminum (Al) toxicity inhibits the growth and development of plant roots and affects nutrient and water absorption, leading to reduced yield and quality. Therefore, it is crucial to investigate and identify candidate genes for Al tolerance and elucidate their physiological and molecular mechanisms under Al stress. In this study, we identified a new gene OsAlR3 regulating Al tolerance, and analyzed its mechanism from physiological, transcriptional and metabolic levels. Compared with the WT, malondialdehyde (MDA) and hydrogen peroxide (H2O2) content were significantly increased, superoxide dismutase (SOD) activity and citric acid (CA) content were significantly decreased in the osalr3 mutant lines when exposed to Al stress. Under Al stress, the osalr3 exhibited decreased expression of antioxidant-related genes and lower organic acid content compared with WT. Integrated transcriptome and metabolome analysis showed the phenylpropanoid biosynthetic pathway plays an important role in OsAlR3-mediated Al tolerance. Exogenous CA and oxalic acid (OA) could increase total root length and enhance the antioxidant capacity in the mutant lines under Al stress. Conclusively, we found a new gene OsAlR3 that positively regulates Al tolerance by promoting the chelation of Al ions through the secretion of organic acids, and increasing the expression of antioxidant genes.
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- 2024
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19. A fast and high‐accurate commutation failure identification method for LCC‐HVDC system
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Jing Feng, Zhijie Liu, Kejun Li, Bingkun Li, Jiachen Li, and Liangzi Li
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Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Electricity ,QC501-721 - Abstract
Abstract Commutation failure (CF) is one of the most common issues in line‐commuted converter‐based high voltage direct current systems (LCC‐HVDC), leading to critical power system security and stability problems. Accurate and rapid identification of CF is crucial to prevent subsequent CF in HVDC systems. However, the existing CF identification methods are lack of the required accuracy and speed. The relationship between bridge arm current, commutation voltage, and trigger pulse based on the commutation progress mechanism after the AC fault is analysed in this paper. A novel CF identification method is presented, which utilises the CF identification factor, enabling fast and high‐accurate identification without relying on the value of the extinction angle. The proposed method offers a simpler and more efficient implementation in engineering practice. Finally, the effectiveness of the proposed method is verified in both the standard International Council on Large Electric systems HVDC model and the Hardware in Loop test using practical project parameters. The results demonstrate that the proposed method can accurately and fast identify CF.
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- 2024
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20. Single-crystalline hole-transporting layers for efficient and stable organic light-emitting devices
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Gao-Da Ye, Ran Ding, Su-Heng Li, Lei Ni, Shu-Ting Dai, Nian-Ke Chen, Yue-Feng Liu, Runda Guo, Lei Wang, Xian-Bin Li, Bin Xu, and Jing Feng
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Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
Abstract Efficient charge-carrier injection and transport in organic light-emitting devices (OLEDs) are essential to simultaneously achieving their high efficiency and long-term stability. However, the charge-transporting layers (CTLs) deposited by various vapor or solution processes are usually in amorphous forms, and their low charge-carrier mobilities, defect-induced high trap densities and inhomogeneous thickness with rough surface morphologies have been obstacles towards high-performance devices. Here, organic single-crystalline (SC) films were employed as the hole-transporting layers (HTLs) instead of the conventional amorphous films to fabricate highly efficient and stable OLEDs. The high-mobility and ultrasmooth morphology of the SC-HTLs facilitate superior interfacial characteristics of both HTL/electrode and HTL/emissive layer interfaces, resulting in a high Haacke’s figure of merit (FoM) of the ultrathin top electrode and low series-resistance joule-heat loss ratio of the SC-OLEDs. Moreover, the thick and compact SC-HTL can function as a barrier layer against moisture and oxygen permeation. As a result, the SC-OLEDs show much improved efficiency and stability compared to the OLEDs based on amorphous or polycrystalline HTLs, suggesting a new strategy to developing advanced OLEDs with high efficiency and high stability.
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- 2024
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21. New insights for composition design: A novel synergistic corrosion-resistant effect of Fe–Mn–Al–Cr–Si–Mo–C lightweight steel in 3.5 wt% NaCl solution
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Yuxiang Liu, Hongjiang Pan, Yanping Zhao, Lichu Zhou, Jing Feng, and Yehua Jiang
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Lightweight steel ,Chromium alloyed steels ,Corrosion resistance ,Electrochemical test ,Immersion test ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Nowadays, a good corrosion resistance of lightweight steel is demanded for its application. However, due to the high contents of Mn and C, which are always corrosion-susceptible elements in steels, the conventional lightweight steel is not desirable for this mission. Although Cr is widely believed to be a common alloying element to improve the corrosion resistance of most steels, it is considered to be ineligible using in the lightweight steel due to the relatively high content of C. This is because the trade-off between corrosion resistance and mechanical properties by alloying Cr. In recent years, the rapid developments of additive and coating manufacturing have provided new possibilities for both the Cr alloying and microstructural modulation to improve corrosion resistance of lightweight steel. In this case, to design a certain chemical composition using in additive and coating manufacturing, it is interesting to clarify the effects of Cr alloying on the corrosion resistance of lightweight steel. To reveal it, in the present work, the Fe–Mn–Al–Cr–Si–Mo–C lightweight steel alloyed with Cr contents of 4 wt%, 8 wt% and 12 wt% are prepared. The corrosion resistances and mechanisms of Cr-alloyed lightweight steels in 3.5 wt% NaCl solution are investigated by electrochemical and immersion tests. The present work may provide new insights for the composition design of lightweight steel, especially for the directions of additive and coating manufacturing.
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- 2024
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22. Colchicine Inhibits NETs and Alleviates Cardiac Remodeling after Acute Myocardial Infarction
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Li, Yue-wei, Chen, Si-xu, Yang, Ying, Zhang, Zeng-hui, Zhou, Wei-bin, Huang, Yu-na, Huang, Zhao-qi, He, Jia-qi, Chen, Ting-feng, Wang, Jing-feng, Liu, Zhao-yu, and Chen, Yang-xin
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- 2024
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23. Comparative studies on the physicochemical properties of in-situ hydrophobic silica aerogels by ambient pressure drying method
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Wang, Shengyuan, Zhu, Zhixiang, Zhong, Ya, Gao, Jun, Jing, Feng, Cui, Sheng, and Shen, Xiaodong
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- 2023
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24. Highly enhanced thermoelectric and mechanical performance of copper sulfides via natural mineral in-situ phase separation
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Xi Yan, Hongjiang Pan, Yixin Zhang, Tianyu Yang, Yangwei Wang, Kun Huang, Chongyu Wang, Jing Feng, and Zhenhua Ge
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in situ precipitates ,jamesonite ,natural mineral ,thermoelectric ,copper sulfides ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
In situ phase separation precipitates play an important role in enhancing the thermoelectric properties of copper sulfides by suppressing phonon transmission. In this study, Cu1.8S composites were fabricated by melting reactions and spark plasma sintering. The complex structures, namely, micron-PbS, Sb2S3, nano-FeS, and multiscale pores, originate from the introduction of FePb4Sb6S14 into the Cu1.8S matrix. Using effective element (Fe) doping and multiscale precipitates, the Cu1.8S+0.5 wt% FePb4Sb6S14 bulk composite reached a high dimensionless figure of merit (ZT) value of 1.1 at 773 K. Furthermore, the modulus obtained for this sample was approximately 40.27 GPa, which was higher than that of the pristine sample. This study provides a novel strategy for realizing heterovalent doping while forming various precipitates via in situ phase separation by natural minerals, which has been proven to be effective in improving the thermoelectric and mechanical performance of copper sulfides and is worth promoting in other thermoelectric systems.
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- 2024
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25. Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma
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Xiangyi Ma, Xinyu Li, Qi Sun, Fuxiao Luan, and Jing Feng
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retinoblastoma ,molecular biological ,RB1 ,epigenetics ,Biology (General) ,QH301-705.5 - Abstract
Retinoblastoma (RB) is the most common intraocular malignant tumor in children, primarily attributed to the bi-allelic loss of the RB1 gene in the developing retina. Despite significant progress in understanding the basic pathogenesis of RB, comprehensively unravelling the intricate network of genetics and epigenetics underlying RB tumorigenesis remains a major challenge. Conventional clinical treatment options are limited, and despite the continuous identification of genetic loci associated with cancer pathogenesis, the development of targeted therapies lags behind. This review focuses on the reported genomic and epigenomic alterations in retinoblastoma, summarizing potential therapeutic targets for RB and providing insights for research into targeted therapies.
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- 2024
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26. Enhanced quantum coherence of plasmonic resonances with a chiral exceptional points
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Yu-Wei Lu, Jing-Feng Liu, Renming Liu, and Hao-Xiang Jiang
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Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Abstract While strategies to enhance the quantum coherence of plasmonic resonances have attracted a lot of attention in the past, the advent of non-Hermitian optics carries promising possibilities in this direction, mostly of which are still unexplored. In this work, we show that the quantum coherence of plasmonic resonances can be enhanced by integrating a plasmonic antenna in a photonic cavity operated at a chiral exceptional point (CEP), where the phase of light offers an additional degree of freedom for flexibly manipulating the quantum dynamics. The few-mode quantization theory is employed to demonstrate the advantages and related quantum-optics applications of the proposed hybrid cavity in both off- and on-resonance plasmon-photon coupling. For the former case, the local density of states evolves into sub-Lorentzian lineshape, resulting in reduced dissipation of polaritonic states. On resonance, we identify two mechanisms improving the quantum yield by two orders of magnitude at room temperature: the reduction of plasmonic absorption through Fano interference and the enhancement of cavity radiation through superscattering. Our results establish CEP-engineered plasmonic resonances as a promising platform for controlling quantum states and building high-performance quantum devices.
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- 2024
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27. Deterministic positioning and alignment of a single-molecule exciton in plasmonic nanodimer for strong coupling
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Renming Liu, Ming Geng, Jindong Ai, Xinyi Fan, Zhixiang Liu, Yu-Wei Lu, Yanmin Kuang, Jing-Feng Liu, Lijun Guo, and Lin Wu
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Science - Abstract
Abstract Experimental realization of strong coupling between a single exciton and plasmons remains challenging as it requires deterministic positioning of the single exciton and alignment of its dipole moment with the plasmonic fields. This study aims to combine the host–guest chemistry approach with the cucurbit[7]uril-mediated active self-assembly to precisely integrate a single methylene blue molecule in an Au nanodimer at the deterministic position (gap center of the nanodimer) with the maximum electric field (EFmax) and perfectly align its transition dipole moment with the EFmax, yielding a large spectral Rabi splitting of 116 meV for a single-molecule exciton—matching the analytical model and numerical simulations. Statistical analysis of vibrational spectroscopy and dark-field scattering spectra confirm the realization of the single exciton strong coupling at room temperature. Our work may suggest an approach for achieving the strong coupling between a deterministic single exciton and plasmons, contributing to the development of room-temperature single-qubit quantum devices.
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- 2024
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28. Improve the satisfaction of medical staff on the use of home nursing mobile APP by using a hybrid multi-standard decision model
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Ziwei Ke, Weiyang Qian, Nan Wang, Yen-Ching Chuang, Biying Wei, and Jing Feng
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Home nursing ,Mobile Application (APP) ,Satisfaction ,Decision making and trial evaluation laboratory (DEMATEL) ,Importance-performance analysis (IPA) ,Multi-criteria decision-making (MCDM) ,Nursing ,RT1-120 - Abstract
Abstract Objective To identify critical satisfaction gaps in a home nursing mobile application (APP) using a systematic decision-making model. Methods Initially, the decision-making trial and evaluation laboratory method was used to analyze the relationship structure and corresponding weights among the indicators. The Importance-Performance Analysis (IPA) method was used to identify the categories of all indicators and their corresponding strategic directions. Twenty-six home nursing specialists currently providing home nursing services were recruited for this study. Results The IPA results revealed that “Assurance,” “Reliability,” and “Personal security protection” are critical satisfaction gaps. From the influence network and weight results, “information quality” and “system quality” were the critical quality factors in the home nursing mobile APP. The influence of the network relationship structure and weight demonstrated a 98.12% significance level, indicating good stability. Conclusion Continuous improvement in information and system quality is recommended to optimize the overall quality of the home nursing mobile APP. Additionally, user demands should be considered, and personal safety guarantee functions should be developed and integrated into the system to ensure the safety of home nursing workers.
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- 2024
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29. HMGN1 loss sensitizes lung cancer cells to chemotherapy
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Xianli Wu, Geqi Cai, Jing Feng, and Wenchu Lin
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Medicine ,Science - Abstract
Abstract The high mobility group nucleosome binding (HMGN) family, constitutes a large family of non-histone protein family known to bind the acidic patch of the nucleosomes with various key cellular functions. Several studies have highlighted the pivotal roles of HMGNs in the pathogenic process of various cancer types. However, the roles of HMGN family in lung adenocarcinoma (LUAD) have not been fully elucidated. Herein, integrative analyses of multiple-omics data revealed that HMGNs frequently exhibit dysregulation in LUAD. Subsequent analysis of the clinical relevance of HMGN1 demonstrated its association with poor prognosis in LUAD and its potential as a diagnostic marker to differentiate LUAD from healthy controls. Additionally, functional enrichment analysis suggested that HMGN1 was mainly involved in DNA repair. To corroborate these findings, cellular experiments were conducted, confirming HMGN1’s crucial involvement in homologous recombination repair and its potential to enhance the sensitivity of LUAD cells to standard chemotherapeutic drugs. This study proposes HMGN1 as a novel prognostic biomarker and a promising target for chemotherapy in lung adenocarcinoma.
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- 2024
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30. Exploring the effect of alloying elements on the thermoelasticity and strength of bcc Fe-based alloys by first-principles phonon calculations
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Yang Lin, Wei Yu, Guangchi Wang, Zulai Li, Yehua Jiang, Jing Feng, and Xiaoyu Chong
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Thermodynamics ,Phonon ,Elastic properties ,First-principles calculations ,Thermal stress ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Designing compositions for novel alloys requires a fundamental grasp of the role of each alloying element in its properties. This study delves into the influence of alloying elements in Ultra-High Strength Steels on essential high-temperature properties, including thermoelasticity, thermal stress, and strength, utilizing first-principles phonon calculations. These properties are pivotal for steels used in high-temperature applications. Our investigation quantitatively forecasts the impact of alloying elements on elastic properties, providing valuable insights for advanced alloy design in high-temperature environments. The introduction of alloying elements markedly amplifies the elastic modulus of Fe-based alloys. The Ni, Mo, Cr, and C elements significantly enhance the anisotropy of the alloy. While refining elastic modulus and mechanical properties, alloying elements induce thermal stress, posing a potential risk of high-temperature cracking. The quantitative analysis underscores the robust strengthening potential for C, Ni, Mo, and W elements, with interstitial C emerging as pivotal in enhancing mechanical properties. The findings of this study illuminate the diverse roles played by different alloying elements and offer theoretical guidance for the design of advanced Ultra-High Strength Steels.
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- 2024
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31. Safety and feasibility of transumbilical single-port laparoscopic uterine artery embolization combined with surgical embryo retrieval for the treatment of cesarean scar pregnancy
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Li Mengchun, He Jing, Feng Jun, Zhang Yueming, Hou Wenjie
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cesarean scar pregnancy ,transumbilical single-port laparoscopy ,uterine artery embolization ,accelerated recovery ,Medicine - Abstract
Objective To evaluate the safety and feasibility of transumbilical single-port laparoscopic uterine artery embolization combined with incision and embryo retrieval in the treatment of cesarean scar pregnancy. Methods Eleven patients with cesarean scar pregnancy who underwent transumbilical single-hole laparoscopic uterine artery embolization combined with incision and embryo retrieval were recruited in the study group, and ten patients who underwent multi-hole laparoscopic uterine artery embolization combined with incision and embryo retrieval were assigned into the control group. Baseline data and perioperative clinical data were compared between two groups. Results No significant differences were found in age, number of pregnancies, number of cesarean sections, time interval from last cesarean section, clinical classification, number of days of menopause, and the presence or absence of symptoms of vaginal bleeding between two groups (all P > 0.05). No significant differences were observed in operation time, intraoperative bleeding and postoperative retention time of catheterization between two groups (all P > 0.05). In the study group, postoperative numeric rating scale (NRS) score was significantly lower and the length of hospital stay was significantly shorter compared with those in the control group (both P < 0.05). Conclusions Compared with traditional multi-port laparoscopic uterine artery embolization combined with incision and embryo retrieval, transumbilical single-port laparoscopic uterine artery embolization combined with incision and embryo retrieval is a feasible and safe procedure, which can alleviate postoperative pain, shortern the length of hospital stay and yield better cosmetic results.
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- 2024
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32. Capturing and visualizing the phase transition mediated thermal stress of thermal barrier coating materials via a cross-scale integrated computational approach
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Mengdi Gan, Tianlong Lu, Wei Yu, Jing Feng, and Xiaoyu Chong
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thermodynamics ,first-principles calculations ,thermophysical properties ,thermal stress ,thermal conductivity ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
The generation and evaluation of severely high thermal stress (σ) is known to be responsible for failure of thermal barrier coatings (TBCs) during thermal cycling. It is crucial and challenging to capture fluctuations in σ caused by the phase transition, which has motivated us to develop a high-throughput multiscale evaluation method for σ in TBCs that considers the phase transition of the top ceramic materials by coupling first-principles calculations with finite element simulations. The method quantitatively evaluates and visualizes σ of the real TBC structure under thermal cycling by multifield coupling. Additionally, the thermophysical properties calculated by the first-principles calculations consider the effects of temperature and phase transition, which not only reduces the cost of obtaining data but also has a more physical connotation. In this work, rare earth tantalites (RETaO4) are introduced as ceramic layers, and the results demonstrate that σ undergoes a rapid escalation near the phase transition temperature (Tt), particularly in the TBCs_GdTaO4 system, where it rises from 224 to 435 MPa. This discontinuity in σ may originate from the significant alterations in Young’s modulus (increase by 27%–78%) and thermal conductivity (increase by 53%–146%) near Tt. The TBCs_NdTaO4 and TBCs_SmTaO4 systems exhibit noteworthy temperature drop gradients and minimal σ fluctuations, which are beneficial for extending service lifetime of TBCs. This approach facilitates the prediction of failure mechanisms and provides theoretical guidance for the reverse design of TBC materials to obtain low thermal stress systems.
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- 2024
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33. Exceptional electrostrain with minimal hysteresis and superior temperature stability under low electric field in KNN-based lead-free piezoceramics
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Huan Liu, Yijin Hao, Ziqi Yang, Tianyi Feng, Bin Su, Xin Zhang, Mengping Xue, Bo-Ping Zhang, and Jing-Feng Li
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lead-free piezoelectric ceramics ,potassium sodium niobate ,electrostrain ,temperature stability ,low hysteresis ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
Over the past two decades, (K0.5Na0.5)NbO3 (KNN)-based lead-free piezoelectric ceramics have made significant progress. However, attaining a high electrostrain with remarkable temperature stability and minimal hysteresis under low electric fields has remained a significant challenge. To address this long-standing issue, we have employed a collaborative approach that combines defect engineering, phase engineering, and relaxation engineering. The LKNNS-6BZH ceramic, when sintered at Tsint = 1170 ℃, demonstrates an impressive electrostrain with a d33∗ value of 0.276% and 1379 pm·V–1 under 20 kV·cm–1, which is comparable to or even surpasses that of other lead-free and Pb(Zr,Ti)O3 ceramics. Importantly, the electrostrain performance of this ceramic remains stable up to a temperature of 125 ℃, with the lowest hysteresis observed at 9.73% under 40 kV·cm–1. These excellent overall performances are attributed to the presence of defect dipoles involving VA′–VO∙∙ and BNb′–VO∙∙, the coexistence of R–O–T multiphase, and the tuning of the trade-off between long-range ordering and local heterogeneity. This work provides a lead-free alternative for piezoelectric actuators and a paradigm for designing piezoelectric materials with outstanding comprehensive performance under low electric fields.
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- 2024
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34. 'Analysis of factors affecting resistance of nitrile rubber to petroleum exploitation medium'
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LI Yuan, HUANG Zi-hua, CAO Zheng, HE Jian, DONG Jing-jing, FENG Wan-sheng, ZHENG Yong
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nitrile rubber,petroleum exploitation medium, bound acrylonitrile content,curing system, reinforcing system, plasticizing system, physical and mechanical property, heat air aging resistance, ,Organic chemistry ,QD241-441 ,Chemical engineering ,TP155-156 ,Chemicals: Manufacture, use, etc. ,TP200-248 - Abstract
The effects of bound acrylonitrile content, curing system, reinforcing system and plastici-zing system on the corrosion resistance of nitrile rubber (NBR) to common chemical media in the field of petroleum exploitation were studied. The results showed that with the increase of bound acrylonitrile content, the physical and mechanical properties and thermal air aging resistance of NBR vulcanizates increased, the resistant to non-polar media such as kerosene and submarine control fluid was better, the resistance to methanol, distilled water and ethylene glycol aqueous solution decreased gradually, and the resistant to acid, alkali and brine had little diffe-rence. The curing system affected mainly the physical and mechanical properties and heat air aging resistance of NBR vulcanizates, and had little effect on the resistance of NBR vulcanizates to various petroleum exploitation media. For the high hardness NBR vulcanizates, the physical and mechanical properties of the vulcanizates were the best when small particle size carbon black was used as reinforcing system, and the effect of different reinforcing system on the heat air aging resistance of NBR vulcanizates was not obvious. However, the vulcanizates had better resistance to methanol and kerosene when large particle size carbon black was used as a reinforcing filler, and inert reinforcing filler should be selected. The physical and mechanical properties of NBR vulca-nizates added with macromolecule ester plasticizer were better than those with small molecule ester plasticizers and liquid NBR plastici-zer, and the heat air aging properties were similar, but the volume change of resistance to various media was larger, and the resistance to methanol, kerosene and 10% sodium hydroxide solution were poor, while the resistance to other petroleum exploitation media were less affected.
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- 2024
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35. 3,7-Dinitroimidazo[1,2-b]pyridazine-6,8-diamine: A promising building block for advanced heat-resistant and low-sensitivity energetic materials
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Jing Feng, Jie Sun, Lei Yang, Zhen-qi Zhang, Yang Liu, Qing Ma, and Li-shuang Hu
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Heat-resistant explosive ,Fused imidazopyridazine ,Thermal stability ,Physical performance ,Synthesis ,Characterization ,Chemical technology ,TP1-1185 - Abstract
Constructing heat-resistant fused heterocyclic compounds is increasingly fascinating in the field of energetic materials due to their excellent energy, high thermal stability, and low sensitivity, as well as high density in general. This study synthesized a novel heat-resistant explosive based on the imidazo [1,2-b]pyridazine fused ring,3,7-dinitroimidazo [1,2-b]pyridazine-6,8-diamine (5),using a three-step facile method. This compound exhibited a high density (1.856 g cm−3) and low mechanical sensitivities (IS = 40 J, FS = 350 N). Meanwhile, it displayed a higher thermal decomposition temperature of 324 °C compared to conventional heat-resistant explosive HNS (Td = 318 °C). In addition, it demonstrated significantly higher detonation performance (D = 8336 m s−1, p = 27.25 GPa) than both TNT (D = 6881 m s−1, p = 19.5 GPa) and HNS (D = 7612 m s−1, p = 24.3 GPa). Theoretical analysis shows that the intramolecular hydrogen bonding interactions of NH2–NO2–NH2 might be the main reason for the heat resistance of energetic materials based on the imidazo [1,2-b]pyridazine fused ring. The results of this study suggest that compound 5 is a promising building block and a candidate for heat-resistant energetic materials.
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- 2024
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36. Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus
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Entezar Berik, Zijia Zhang, Wei Li, Yawen Liu, Sihan Chen, Wenyong Wu, Zhaojun Wang, Xinqin Kong, Wenqiang Pei, Huiqing Dong, Huali Long, Min Lei, Jennifer Yiyang Wang, Liangfeng Liu, Jinjun Hou, Jing Feng, Zhaoxia Li, Wanying Wu, and De-an Guo
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Therapeutics. Pharmacology ,RM1-950 - Published
- 2024
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37. Synergistically optimized electron and phonon transport in high-performance copper sulfides thermoelectric materials via one-pot modulation
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Yi-Xin Zhang, Qin-Yuan Huang, Xi Yan, Chong-Yu Wang, Tian-Yu Yang, Zi-Yuan Wang, Yong-Cai Shi, Quan Shan, Jing Feng, and Zhen-Hua Ge
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Science - Abstract
Abstract Optimizing thermoelectric conversion efficiency requires the compromise of electrical and thermal properties of materials, which are hard to simultaneously improve due to the strong coupling of carrier and phonon transport. Herein, a one-pot approach realizing simultaneous second phase and Cu vacancies modulation is proposed, which is effective in synergistically optimizing thermoelectric performance in copper sulfides. Multiple lattice defects, including nanoprecipitates, dislocations, and nanopores are produced by adding a refined ratio of Sn and Se. Phonon transport is significantly suppressed by multiple mechanisms. An ultralow lattice thermal conductivity is therefore obtained. Furthermore, extra Se is added in the copper sulfide for optimizing electrical transport properties by inducing generating Cu vacancies. Ultimately, an excellent figure of merit of ~1.6 at 873 K is realized in the Cu1.992SSe0.016(Cu2SnSe4)0.004 bulk sample. The simple strategy of inducing compositional and structural modulation for improving thermoelectric parameters promotes low-cost high-performance copper sulfides as alternatives in thermoelectric applications.
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- 2024
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38. CT-based pancreatic radiomics predicts secondary loss of response to infliximab in biologically naïve patients with Crohn’s disease
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Tian Yang, Jing Feng, Ruchen Yao, Qi Feng, and Jun Shen
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Crohn’s disease ,Pancreas ,Radiomics ,Secondary loss of response ,Computed tomography enterography ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Objectives Predicting secondary loss of response (SLR) to infliximab (IFX) is paramount for tailoring personalized management regimens. Concurrent pancreatic manifestations in patients with Crohn’s disease (CD) may correlate with SLR to anti-tumor necrosis factor treatment. This work aimed to evaluate the potential of pancreatic radiomics to predict SLR to IFX in biologic-naive individuals with CD. Methods Three models were developed by logistic regression analyses to identify high-risk subgroup prone to SLR. The area under the curve (AUC), calibration curve, decision curve analysis (DCA), and integrated discrimination improvement (IDI) were applied for the verification of model performance. A quantitative nomogram was proposed based on the optimal prediction model, and its reliability was substantiated by 10-fold cross-validation. Results In total, 184 CD patients were enrolled in the period January 2016 to February 2022. The clinical model incorporated age of onset, disease duration, disease location, and disease behavior, whereas the radiomics model consisted of five texture features. These clinical parameters and the radiomics score calculated by selected texture features were applied to build the combined model. Compared to other two models, combined model achieved favorable, significantly improved discrimination power (AUCcombined vs clinical 0.851 vs 0.694, p = 0.02; AUCcombined vs radiomics 0.851 vs 0.740, p = 0.04) and superior clinical usefulness, which was further converted into reliable nomogram with an accuracy of 0.860 and AUC of 0.872. Conclusions The first proposed pancreatic-related nomogram represents a credible, noninvasive predictive instrument to assist clinicians in accurately identifying SLR and non-SLR in CD patients. Critical relevance statement This study first built a visual nomogram incorporating pancreatic texture features and clinical factors, which could facilitate clinicians to make personalized treatment decisions and optimize cost-effectiveness ratio for patients with CD. Key points • The first proposed pancreatic-related model predicts secondary loss of response for infliximab in Crohn’s disease. • The model achieved satisfactory predictive accuracy, calibration ability, and clinical value. • The model-based nomogram has the potential to identify long-term failure in advance and tailor personalized management regimens. Graphical Abstract
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- 2024
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39. Efficacy of home phototherapy versus inpatient phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis
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Rui Li, Tingting Li, Xudong Yan, Jing Feng, Zhangbin Yu, and Cheng Chen
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Home phototherapy ,Neonatal hyperbilirubinemia ,Efficacy ,Meta-analysis ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Home phototherapy (HPT) remains a contentious alternative to inpatient phototherapy (IPT) for neonatal hyperbilirubinemia. To guide evidence-based clinical decision-making, we conducted a meta-analysis of randomized clinical trials (RCTs) and cohort studies and assessed the comparative risks and benefits of HPT and IPT. Methods PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure Database, Wanfang Database, Chinese Science and Technique Journals Database, ClinicalTrials.gov, and International Clinical Trial Registry Platform trial were searched from inception until June 2, 2023. We included RCTs and cohort studies and adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Study quality was assessed with the Cochrane Collaboration Risk of Bias tool and the Newcastle–Ottawa scale. The outcome measures were phototherapy duration, daily bilirubin level reduction, exchange transfusion, hospital readmission, parental stress scale, and complications. We used fixed- or random-effects meta-analysis models, assessed heterogeneity (I 2 ), conducted subgroup analyses, evaluated publication bias, and graded evidence quality. Results Nine studies (998 patients) were included (four RCTs, five cohort studies). HPT was associated with longer phototherapy duration (SMD = 0.55, 95% CI: 0.06–1.04, P = 0.03). Cohort study subgroup analysis yielded consistent results (SMD = 0.90; 95% CI: 0.69 to 1.11, P
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- 2024
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40. SETDB2 interacts with BUBR1 to induce accurate chromosome segregation independently of its histone methyltransferase activity
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Yanhong Tu, Haomiao Zhang, Jialin Xia, Yu Zhao, Ruifang Yang, Jing Feng, Xueyun Ma, and Jing Li
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APC/C ,BUBR1 ,CDC20 ,chromosome segregation ,mitosis ,SETDB2 ,Biology (General) ,QH301-705.5 - Abstract
SETDB2 is a H3K9 histone methyltransferase required for accurate chromosome segregation. Its H3K9 histone methyltransferase activity was reported to be associated with chromosomes during metaphase. Here, we confirm that SETDB2 is required for mitosis and accurate chromosome segregation. However, these functions are independent of its histone methyltransferase activity. Further analysis showed that SETDB2 can interact with BUBR1, and is required for CDC20 binding to BUBR1 and APC/C complex and CYCLIN B1 degradation. The ability of SETDB2 to regulate the binding of CDC20 to BUBR1 or APC/C complex, and stabilization of CYCLIN B1 are also independent of its histone methyltransferase activity. These results suggest that SETDB2 interacts with BUBR1 to promote binding of CDC20 to BUBR1 and APC3, then degrades CYCLIN B1 to ensure accurate chromosome segregation and mitosis, independently of its histone methyltransferase activity.
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- 2024
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41. Enhancement of the thermoelectric performance of half-metallic full-Heusler Mn2VAl alloys via antisite defect engineering and Si partial substitution
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Hezhang Li, Kei Hayashi, Zhicheng Huang, Hiroto Takeuchi, Gakuto Kanno, Jing-Feng Li, and Yuzuru Miyazaki
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Half metal ,Full-Heusler alloy ,Thermoelectric properties ,Antisite defect ,Partial substitution ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
A half-metallic full-Heusler Mn2VAl alloy is a potential p-type thermoelectric material that can directly generate electricity from waste heat via the Seebeck effect. For practical use, the Seebeck coefficient S of Mn2VAl should be increased while maintaining a high electrical conductivity σ from its half-metallic character. Herein, we achieved this objective through antisite defect engineering. Theoretically, it was predicted that the S was maximized by regulating partial density of states of majority-spin sp-electrons through the control of the fraction of antisite defect, fAD, between V and Al atoms in Mn2VAl. Experimentally, a significant increase in S and a slight decrease in σ were observed for an Mn2VAl sample with an optimal fAD = 33%, enhancing the thermoelectric power factor PF by 2.7 times from an Mn2VAl sample with fAD = 14%. Furthermore, we combined the antisite defect engineering with a partial substitution method. An Mn2V(Al0.96Si0.04) sample with fAD = 33% exhibited the highest PF = 4.5 × 10−4 W·m−1·K−2 at 767 K among the samples. The maximum dimensionless figure-of-merit zT of the Mn2V(Al0.96Si0.04) sample with fAD = 33% was measured to be 3.4 × 10−2 at 767 K, which is the highest among the p-type half-metallic full-Heusler alloys.
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- 2024
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42. Compressive and creep behavior of Mg-Gd-Y-Zn-Mn-Nd alloy with different orientations
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Chun-Hua Ran, Miao Ding, Xiao-Feng Li, Li-Chang Fan, Hao Lv, Xiao-Hong Wang, Le Shen, Jing-Feng Wang, and Jun Tan
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Mg-Gd-Y-Zn-Mn-Nd alloy ,Anisotropic characteristic ,High temperature compressive properties ,Compressive creep behaviors ,Mining engineering. Metallurgy ,TN1-997 - Abstract
This paper presents an experimental study on the compressive properties and creep behavior of Mg-Gd-Y-Zn-Mn-Nd alloy. A total of 42 specimens are prepared and tested, including 18 compression tests and 24 creep tests. The investigation aims to evaluate the influence of material orientation, temperature, and initial stress (for creep test only) on the compressive behavior of the Mg-Gd-Y-Zn-Mn-Nd alloy. First, the results of compression tests are analyzed, revealing insights into the anisotropic behavior, failure mode, yield strength, ultimate compressive strength, and failure strain of the Mg-Gd-Y-Zn-Mn-Nd alloy under compressive loading. Then, according to the experimental data from creep tests, where the steady creep rate, stress exponent and activation energy are calibrated. Furthermore, the creep mechanisms of the Mg-Gd-Y-Zn-Mn-Nd alloy under various material orientations are discussed. Additionally, the authors analyze and compare the Electron Backscatter Diffraction (EBSD) data of the Mg-Gd-Y-Zn-Mn-Nd alloy before and after undergoing compressive creep. Finally, based on the test results, a mathematical model is proposed to describe the development of compressive creep strain.
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- 2024
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43. β-Globin Gene Cluster Haplotype Frequencies in Khalkhs and Buryats of Mongolia
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Shimizu, Koji, Tokimasa, Kozue, Takeuchi, Yukiko, Gereksaikhan, Tudevdagva, Tanabe, Yuichi, Omoto, Keiichi, Imanishi, Tadashi, Harihara, Shinji, Hao, Luping, and Jing, Feng
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- 2007
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44. Correction to: AHA Life’s Essential 8 and new‑onset CKD: a prospective cohort study from the UK Biobank
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Ruan, Yong-Xiang, Wu, Mao-Xiong, Gao, Jing-Wei, Guo, Da-Chuan, Cai, Yang-Wei, Huang, Ze-Gui, He, Wan-Bing, Chen, Yang-Xin, Wang, Jing-Feng, and Zhang, Hai-Feng
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- 2024
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45. Effects of semaglutide on gut microbiota, cognitive function and inflammation in obese mice
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Jing Feng, Zhenjie Teng, Yu Yang, Jingzhen Liu, and Shuchun Chen
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Glucagon-like peptide-1 receptor agonist ,Semaglutide ,Gut microbiota ,Obesity ,Cognitive function ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Objective This study aims to investigate the effects of semaglutide on gut microbiota, cognitive function, and inflammation in obese mice. Method Twenty-four C57BL/6J male mice were randomly assigned to three groups: a normal-chow diet group (NCD, n = 8), high-fat diet group (HFD, n = 8), and HFD+semaglutide group (Sema, n = 8). The mice were fed a HFD to establish an animal model of obesity and then administered with semaglutide or saline for 12 weeks. Cognitive function was assessed using the Morris water maze test. Serum pro-inflammatory cytokines were measured. 16S rRNA gene sequencing technology was used to explore gut microbiota characteristics in obese mice. Result Obese mice showed significant cognitive impairment and inflammation. Semaglutide improved cognitive function and attenuated inflammation induced by a HFD diet. The abundance of gut microbiota was significantly changed in the HFD group, including decreased Akkermansia, Muribaculaceae, Coriobacteriaceae_UCG_002, Clostridia_UCG_014 and increased Romboutsia, Dubosiella, Enterorhabdus. Whereas semaglutide could dramatically reverse the relative abundance of these gut microbiota. Correlation analysis suggested that cognitive function was positively correlated with Muribaculaceae and Clostridia_UCG_014, and negatively associated with Romboutsia and Dubosiella. Romboutsia was positively correlated with TNFα, IL-6 and IL-1β. While Clostridia_UCG_014 was negatively related to TNFα, IL-6 and IL-1β. Conclusions For the first time semaglutide displayed different regulatory effects on HFD-induced gut microbiota dysbiosis. Semaglutide could regulate the structure and composition of gut microbiota associated with cognitive function and inflammation. Thus, affecting gut microbiota might be a potential mechanism of semaglutide in attenuating cognitive function and inflammation.
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- 2024
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46. In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia
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Verity J. Ford, Willard N. Applefeld, Jeffrey Wang, Junfeng Sun, Steven B. Solomon, Harvey G. Klein, Jing Feng, Juan Lertora, Parizad Parizi‐Torabi, Robert L. Danner, Michael A. Solomon, Marcus Y. Chen, and Charles Natanson
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catecholamine levels ,microcirculatory perfusion ,septic cardiomyopathy ,stress‐induced cardiomyopathy ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background High levels of catecholamines are cardiotoxic and associated with stress‐induced cardiomyopathies. Using a septic shock model that reproduces the reversible cardiomyopathy seen over 10 days associated with human septic shock, we investigated the effects of catecholamines on microcirculatory perfusion and cardiac dysfunction. Methods and Results Purpose‐bred beagles received intrabronchial Staphylococcus aureus (n=30) or saline (n=6). The septic animals were than randomized to epinephrine (1 μg/kg per minute, n=15) or saline (n=15) infusions from 4 to 44 hours. Serial cardiac magnetic resonance imaging, catecholamine levels, and troponins were collected over 92 hours. Serial adenosine‐stress perfusion cardiac magnetic resonance imaging was performed on septic animals randomized to receive saline (n=8 out of 15) or epinephrine (n=8 out of 15). High‐dose sedation was given to suppress endogenous catecholamine release. Despite catecholamine levels largely remaining within the normal range throughout, by 48 hours, septic animals receiving saline versus nonseptic animals still developed significant worsening of left ventricular ejection fraction, circumferential strain, and ventricular‐aortic coupling. In septic animals that received epinephrine versus saline infusions, plasma epinephrine levels increased 800‐fold, but epinephrine produced no significant further worsening of left ventricular ejection fraction, circumferential strain, or ventricular‐aortic coupling. Septic animals receiving saline had a significant increase in microcirculatory reserve without troponin elevations. Septic animals receiving epinephrine had decreased edema, blunted microcirculatory perfusion, and elevated troponin levels that persisted for hours after the epinephrine infusion stopped. Conclusions Cardiac dysfunction during sepsis is not primarily due to elevated endogenous or exogenous catecholamines nor due to decreased microvascular perfusion‐induced ischemia. However, epinephrine itself has potentially harmful long‐lasting ischemic effects during sepsis including impaired cardiac microvascular perfusion that persists after stopping the infusion.
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- 2024
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47. Cardiac Magnetic Resonance Studies in a Large Animal Model That Simulates the Cardiac Abnormalities of Human Septic Shock
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Verity J. Ford, Willard N. Applefeld, Jeffrey Wang, Junfeng Sun, Steven B. Solomon, Stanislav Sidenko, Jing Feng, Cynthia Sheffield, Harvey G. Klein, Zu‐Xi Yu, Parizad Torabi‐Parizi, Robert L. Danner, Vandana Sachdev, Michael A. Solomon, Marcus Y. Chen, and Charles Natanson
- Subjects
cardiac dysfunction ,edema ,sepsis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Septic shock is associated with increases in end‐diastolic volume (EDV) and decreases in ejection fraction that reverse within 10 days. Nonsurvivors do not develop EDV increases. The mechanism is unknown. Methods and Results Purpose‐bred beagles (n=33) were randomized to receive intrabronchial Staphylococcus aureus or saline. Over 96 hours, cardiac magnetic resonance imaging and echocardiograms were performed. Tissue was obtained at 66 hours. From 0 to 96 hours after bacterial challenge, septic animals versus controls had significantly increased left ventricular wall edema (6%) and wall thinning with loss of mass (15%). On histology, the major finding was nonocclusive microvascular injury with edema in myocytes, the interstitium, and endothelial cells. Edema was associated with significant worsening of biventricular ejection fractions, ventricular‐arterial coupling, and circumferential strain. Early during sepsis, (0–24 hours), the EDV decreased; significantly more in nonsurvivors (ie, greater diastolic dysfunction). From 24 to 48 hours, septic animals' biventricular chamber sizes increased; in survivors significantly greater than baseline and nonsurvivors, whose EDVs were not different from baseline. Preload, afterload, or heart rate differences did not explain these differential changes. Conclusions The cardiac dysfunction of sepsis is associated with wall edema. In nonsurvivors, at 0 to 24 hours, sepsis induces a more severe diastolic dysfunction, further decreasing chamber size. The loss of left ventricular mass with wall thinning in septic survivors may, in part, explain the EDV increases from 24 to 48 hours because of a potentially reparative process removing damaged wall tissue. Septic cardiomyopathy is most consistent with a nonocclusive microvascular injury resulting in edema causing reversible systolic and diastolic dysfunction with more severe diastolic dysfunction being associated with a decreased EDV and death.
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- 2024
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48. Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis
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Yang Hong, Jing Feng, Zijia Dou, Xiuxiu Sun, Yingying Hu, Zhouxiu Chen, Ling Liu, Henghui Xu, Menghan Du, Pingping Tang, Xin Liu, and Yong Zhang
- Subjects
ACSL4 ,Berberine ,Atherosclerosis ,Endothelial ,Ferroptosis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The discovery of an inhibitor for acyl-CoA synthetase long-chain family member 4 (ACSL4), a protein involved in the process of cell injury through ferroptosis, has the potential to ameliorate cell damage. In this study, we aimed to investigate the potential of berberine (BBR) as an inhibitor of ACSL4 in order to suppress endothelial ferroptosis and provide protection against atherosclerosis. An atherosclerosis model was created in ApoE-/- mice by feeding a high fat diet for 16 weeks. Additionally, a mouse model with endothelium-specific overexpression of ACSL4 was established. BBR was administered orally to assess its potential therapeutic effects on atherosclerosis. Human umbilical vein endothelial cells (HUVECs) were exposed to oxidized low density lipoprotein (ox-LDL) to simulate atherosclerotic endothelial damage in vitro. The interaction between ACSL4 and BBR has been confirmed, with BBR playing a role in inhibiting erastin-induced ferroptosis by regulating ACSL4. Additionally, BBR has been found to inhibit lipid deposition, plaque formation, and collagen deposition in the aorta, thereby delaying the progression of atherosclerosis. It also restored the abnormal expression of ferroptosis-related proteins in atherosclerotic vascular endothelial cells both in vivo and in vitro. In conclusion, BBR, acting as an ACSL4 inhibitor, can improve atherosclerosis by inhibiting ferroptosis in endothelial cells. This highlights the potential of targeted inhibition of vascular endothelial ACSL4 as a strategy for treating atherosclerosis, with BBR being a candidate for this purpose.
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- 2024
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49. A survey on deep learning in medical ultrasound imaging
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Ke Song, Jing Feng, and Duo Chen
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medical ultrasound imaging ,deep learning ,ultrasound beamforming ,medical image analysis ,clinical diagnosis ,Physics ,QC1-999 - Abstract
Ultrasound imaging has a history of several decades. With its non-invasive, low-cost advantages, this technology has been widely used in medicine and there have been many significant breakthroughs in ultrasound imaging. Even so, there are still some drawbacks. Therefore, some novel image reconstruction and image analysis algorithms have been proposed to solve these problems. Although these new solutions have some effects, many of them introduce some other side effects, such as high computational complexity in beamforming. At the same time, the usage requirements of medical ultrasound equipment are relatively high, and it is not very user-friendly for inexperienced beginners. As artificial intelligence technology advances, some researchers have initiated efforts to deploy deep learning to address challenges in ultrasound imaging, such as reducing computational complexity in adaptive beamforming and aiding novices in image acquisition. In this survey, we are about to explore the application of deep learning in medical ultrasound imaging, spanning from image reconstruction to clinical diagnosis.
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- 2024
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50. The clinical characteristics and pathogenic variants of primary pigmented nodular adrenocortical disease in 210 patients: a systematic review
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Julian Sun, Lin Ding, Liping He, Hang Fu, Rui Li, Jing Feng, Jianjun Dong, and Lin Liao
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PRKAR1A ,Cushing’s syndrome ,clinical characteristics ,pathogenic variants ,primary pigmented nodular adrenocortical disease ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
AimsPrimary pigmented nodular adrenocortical disease (PPNAD), as a rare kind of Cushing’s syndrome, is frequently misdiagnosed. To get a better understanding of the disease, we analyzed the clinical characteristics and pathogenic variants of PPNAD.MethodsDatabases were searched, and the pathogenic variants and clinical manifestations of patients were summarized from the relevant articles.ResultsA total of 210 patients in 86 articles were enrolled with a median age of 22 and a female-to-male ratio of 2:1. Sixty-six (31.43%) patients were combined with Carney complex (CNC) and 94.29% were combined with osteoporosis/osteopenia. Among 151 patients who underwent genetic testing, 87.42% (132/151) had pathogenic variants. Six gene mutations (PRKAR1A, PDE11A, PRKACA, CTNNB1, PDE8B, and ARMC5) were detected in the patients. The most common mutation was PKAR1A, accounting for 79.47% (120/151). There was a significant correlation between PRKAR1A pathogenic variant and spotty skin pigmentation in CNC concurrent with PPNAD (p < 0.05). Among pregnant patients with PPNAD, those without surgical treatment and with bilateral adrenalectomy suffered from a high-risk perinatal period. However, patients with unilateral adrenalectomy presented a safe perinatal period.ConclusionsFor young patients with Cushing’s syndrome, especially female patients with spotty skin pigmentation and osteoporosis/osteopenia, PPNAD should be considered. Unilateral adrenal resection may be considered as an option for women with fertility needs. In view of the difficulty of PPNAD diagnosis, genetic testing before surgery might be a reasonable option. Patients with PPNAD with spotty skin pigmentation should consider the PRKAR1A pathogenic variant and pay attention to CNC.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42023416988.
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- 2024
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