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Firn from an ice cave in the highest mountain of Greece, Mount Olympus, was sampled and analyzed to determine the tritium content in order to estimate rates of accumulation and to date the ice plug. The presence of a sharp raise of tritium content indicating the nuclear testing era was expected to be preserved into ice beds. Tritium concentrations were found to vary from 0.9 to 11 TU. This peak did not appear in the analyzed samples, providing an upper age limit of less than 50 years for the oldest sampled layer. It is suggested that the rate of melting is responsible for the absence of older firn layers.

Background: In the absence of breast-feeding and its immunomodulatory factors, supplementation of starter infant formula (IF) with probiotics is currently used to support immune functions and gut development., Aim: To assess whether immune-related beneficial effects of regular dose (10(7) CFU/g of powder) of the probiotic Bifidobacterium lactis CNCM I-3446 (hereafter named B. lactis) in starter IF supplementation can be maintained with starter IF containing a low dose (10(4) CFU/g of powder) of B. lactis., Method: This trial was designed as a pilot, prospective, double-blind, randomized, single-center clinical trial of two parallel groups (n = 77 infants/group) of C-section delivered infants receiving a starter IF containing either low dose or regular dose of the probiotic B. lactis from birth to six months of age. In addition, a reference group of infants breast-fed for a minimum of four months (n = 44 infants), also born by C-section, were included. All groups were then provided follow-up formula without B. lactis up to 12 months of age. Occurrence of diarrhea, immune and gut maturation, responses to vaccinations, and growth were assessed from birth to 12 months. The effect of low-dose B. lactis formula was compared to regular-dose B. lactis formula, considered as reference for IF with probiotics, and both were further compared to breast-feeding as a physiological reference., Results: Data showed that feeding low-dose B. lactis IF provides similar effects as feeding regular-dose B. lactis IF or breast milk. No consistent statistical differences regarding early life protection against gastrointestinal infections, immune and gut maturation, microbiota establishment, and growth were observed between randomized formula-fed groups as well as with the breast-fed reference group., Conclusion: This pilot study suggests that supplementing C-section born neonates with low-dose B. lactis-containing starter formula may impact immune as well as gut maturation similarly to regular-dose B. lactis, close to the breast-feeding reference.

Background: Hepatitis B virus infection is an important public health problem worldwide and eliminating mother-to-infant transmission is important to decrease the prevalence of chronic HBV-infection. Although, immunoprophylaxis given at birth largely prevents mother-to-infant transmission, perinatal HBV viremia has been reported in HBsAg(-) newborns born mainly to HBeAg(+) women in endemic areas., Objectives: To examine the incidence of perinatal HBV viremia in newborns of HBsAg(+) predominantly HBeAg(-) mothers., Study Design: Peripheral blood was obtained at birth from 109 HBsAg(+) mothers and their newborns before the administration of active-passive immunoprophylaxis. Infants were prospectively followed and appropriately vaccinated., Results: Although most (92.7%) of the HBsAg(+) mothers were HBeAg(-), 73.4% had detectable HBV viremia. Neonatal viremia was detected in 3/8 (37.5%) and 24/101 (23.8%) newborns of HBeAg(+) and HBeAg(-) mothers, respectively (p=0.386). However, HBV-DNA levels were significantly higher in newborns of HBeAg(+) mothers (p=0.025). No child developed chronic HBV infection, but one child had evidence of subclinical hepatitis., Conclusions: Although the clinical significance of low viremia levels in almost one in four newborns of HBsAg(+) mothers in a low endemicity area is unclear, it may enhance our understanding of HBV mother-to-infant transmission., (Copyright © 2010 Elsevier B.V. All rights reserved.)

The aim of this two-part treatment series is on the one hand to emphasize the difficulties a clinician is confronted with when planning complex cases, and on the other hand to reveal the rationale supporting the final treatment plan selection. Among the challenging cases to be considered are periodontal compromised rest dentitions requiring prosthodontic rehabilitation. For these patients the decision-making process deals with the indications and limitations of both the fields of fixed and removable prosthodontics. The first part of this article deals with the various prosthodontic treatment options, together with the advantages and disadvantages related to each one. This second part of the article presents the final treatment plan, the decision-making process, and the sequence of the treatment steps.

Objective: This study evaluated the fracture resistance of different zirconia three-unit posterior all-ceramic fixed partial dentures before and after fatigue loading., Material and Methods: Forty-eight zirconia three-unit posterior all-ceramic fixed partial dentures were fabricated using different manufacturing systems and conventionally cemented on human teeth. The restorations were divided according to the system used for manufacturing the frameworks into 3 groups of 16 specimens each (DCS, Procera and Vita CerecInlab). Half of each group was artificially aged through dynamic loading and thermal cycling, whereas the other half was left with no artificial aging. Afterwards, all specimens were tested for fracture resistance using compressive load on the occlusal surface. Non-parametric ANOVA using the Kruskal-Wallis and Wilcoxon rank tests was performed to test for differences in fracture resistance values with a global significance level of 0.05., Results: All artificially aged specimens survived with no failures. The median fracture resistance values (before; after artificial aging) were: DCS (1683 N; 1618 N), Procera (1522 N; 1256 N), and Vita CerecInlab (1702 N; 1556 N). No significant differences were found for comparisons between different groups before artificial aging. Artificial aging did not significantly influence the fracture resistance of different groups. After artificial aging, group Procera showed significantly lower fracture resistance than the Vita CerecInlab (p=0.015) and DCS (p=0.038) groups., Conclusions: All tested restorations have the potential to withstand occlusal forces applied in the posterior region and can therefore represent interesting alternatives for replacing porcelain-fused-to-metal restorations. Further assessment is needed before recommending such restorations in daily practice.