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The formation of supramolecular host-guest complexes is a very useful and widely employed tool in chemistry. However, supramolecular chemistry in non-conventional solvents such as supercritical carbon dioxide (scCO2), one of the most promising sustainable solvents, is still in its infancy. In this work, we explored a successful route to the development of green processes in supercritical CO2 by combining a theoretical approach with experiments. We were able to synthesize and characterize an inclusion complex between a polar aromatic molecule (benzoic acid) and peracetylated-β-cyclodextrin, which is soluble in the supercritical medium. This finding opens the way to wide, environmental friendly, applications of scCO2 in many areas of chemistry, including supramolecular synthesis, reactivity and catalysis, micro and nano-particle formation, molecular recognition, as well as enhanced extraction processes with increased selectivity. [ABSTRACT FROM AUTHOR]

Supercritical carbon dioxide, an environmentally friendly medium, is promising as an alternative to traditional organic solvents. However, polar molecules and high molar mass compounds are often poorly soluble in supercritical carbon dioxide. The first host–guest complex obtained in such a solvent is discussed herein, together with an analysis of the driving forces for the formation of supramolecular structures and suggestions for possible applications to fix solubility issues. More information can be found in the Full Paper by F. Ingrosso, A. Marsura, M. F. Ruiz‐López et al. on page 2972 ff. [ABSTRACT FROM AUTHOR]

The formation of supramolecular host-guest complexes is a very useful and widely employed tool in chemistry. However, supramolecular chemistry in non-conventional solvents such as supercritical carbon dioxide (scCO2 ), one of the most promising sustainable solvents, is still in its infancy. In this work, we explored a successful route to the development of green processes in supercritical CO2 by combining a theoretical approach with experiments. We were able to synthesize and characterize an inclusion complex between a polar aromatic molecule (benzoic acid) and peracetylated-β-cyclodextrin, which is soluble in the supercritical medium. This finding opens the way to wide, environmental friendly, applications of scCO2 in many areas of chemistry, including supramolecular synthesis, reactivity and catalysis, micro and nano-particle formation, molecular recognition, as well as enhanced extraction processes with increased selectivity., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)