27 results on '"Kim, Myeong Seon"'
Search Results
2. Impact of community health interventions on maternal and child health indicators in the upper east region of Ghana
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Sakeah, Evelyn, Bawah, Ayaga A., Asuming, Patrick O., Debpuur, Cornelius, Welaga, Paul, Awine, Timothy, Anyorikeya, Maria, Kuwolamo, Irene, Oh, Juhwan, Lee, Hoon Sang, Lee, Hwa-Young, Lee, Inseok, Kim, Myeong Seon, Hong, Seoyeon, Awoonor-Williams, John Koku, Phillips, James F., Aboagye, Patrick, and Oduro, Abraham R.
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- 2023
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3. Promoting homogeneous lithiation of silicon anodes via the application of bifunctional PEDOT:PSS/PEG composite binders
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Kong, Nyung Joo, Kim, Myeong Seon, Park, Jae Hyun, Kim, Jongbok, Jin, Jungho, Lee, Hyun-Wook, and Kang, Seok Ju
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- 2024
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4. Unveiling the role of electrode-level heterogeneity alleviated in a silicon-graphite electrode under operando microscopy
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Kim, Juyoung, Kim, Min-Ho, Kim, Youngmin, Kim, Myeong Seon, Choi, Ahreum, Jeong, Kyeong-Min, and Lee, Hyun-Wook
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- 2023
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5. Clinical outcome of pulmonary lymphangitic carcinomatosis in gynecologic malignancy: A single-institution experience
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Kim, Myeong-Seon, Jeong, Soo Young, Lee, Yoo-Young, Choi, Chel Hun, Kim, Tae-Joong, Kim, Byoung-Gie, Bae, Duk-Soo, and Lee, Jeong-Won
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- 2022
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6. In Vivo Comparison of MONOFIX, A Novel Barbed Suture with a Triangular Stopper, with Pre-existing Products in a Porcine Model
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Kim, Jihye, Eom, Hye Jin, Shin, Hyeongchan, Jeong, Soo Young, Kim, Myeong Seon, Yoon, Hye Sung, In, Chang Hoon, Kim, Byoung-Gie, Bae, Duk-Soo, and Lee, Jeong-Won
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- 2020
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7. The prevention of postoperative port-site adhesion following single-port access (SPA) laparoscopic surgeries
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Noh, Joseph J., Kim, Myeong-Seon, Jeong, Soo-Young, Kang, Jun-Hyeok, Park, Byung-Kwan, and Kim, Tae-Joong
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- 2021
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8. Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers
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Sa, Jason K., Hwang, Jae Ryoung, Cho, Young-Jae, Ryu, Ji-Yoon, Choi, Jung-Joo, Jeong, Soo Young, Kim, Jihye, Kim, Myeong Seon, Paik, E. Sun, Lee, Yoo-Young, Choi, Chel Hun, Kim, Tae-Joong, Kim, Byoung-Gie, Bae, Duk-Soo, Lee, Yeri, Her, Nam-Gu, Shin, Yong Jae, Cho, Hee Jin, Kim, Ja Yeon, Seo, Yun Jee, Koo, Harim, Oh, Jeong-Woo, Lee, Taebum, Kim, Hyun-Soo, Song, Sang Yong, Bae, Joon Seol, Park, Woong-Yang, Han, Hee Dong, Ahn, Hyung Jun, Sood, Anil K., Rabadan, Raul, Lee, Jin-Ku, Nam, Do-Hyun, and Lee, Jeong-Won
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- 2019
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9. Near zero-strain silicon oxycarbide interphases for stable Li-ion batteries.
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Yeom, Su Jeong, Wi, Tae-Ung, Jung, Soon-Jae, Kim, Myeong Seon, Jeon, Sang-Chae, and Lee, Hyun-Wook
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LITHIUM-ion batteries ,ELECTROCHEMICAL analysis ,SILICON ,NANOTUBES ,ANODES - Abstract
We investigate silicon oxycarbide nanotubes that incorporate Si, SiC, and silicon oxycarbide phases, which exhibit near zero-strain volume expansion, leading to reduced electrolyte decomposition. The composite effectively accommodates the formation of c-Li
15 Si4 , as validated by in situ TEM analyses and electrochemical tests, thereby proposing a promising solution for Li-ion battery anodes. [ABSTRACT FROM AUTHOR]- Published
- 2023
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10. Design Principles for Fluorinated Interphase Evolution via Conversion-Type Alloying Processes for Anticorrosive Lithium Metal Anodes.
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Kim, Min-Ho, Wi, Tae-Ung, Seo, Jeongwoo, Choi, Ahreum, Ko, Sangho, Kim, Juyoung, Jung, Ukhyun, Kim, Myeong Seon, Park, Changhyun, Jin, Sunghwan, and Lee, Hyun-Wook
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- 2023
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11. Comparison of Surgical Outcomes of Hysterectomy by Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus Single-Port Access (SPA) Surgery.
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Noh, Joseph J., Kim, Myeong-Seon, Kang, Jun-Hyeok, Jung, Ji-Hee, Chang, Chi-Son, Jeon, Jungeun, and Kim, Tae-Joong
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VAGINAL hysterectomy , *ENDOSCOPIC surgery , *SURGICAL robots , *LAPAROSCOPIC surgery , *RHINORRHEA , *MINIMALLY invasive procedures , *PATIENT selection - Abstract
Single-port access (SPA) laparoscopic surgery and vaginal natural orifice transluminal endoscopic surgery (vNOTES) have many advantages. The objective of the present study is to compare patient characteristics, operative details, and postoperative outcomes between the two surgical methods. Patients who were planned to undergo vNOTES or SPA laparoscopic surgery between April 2020 and June 2021 were prospectively enrolled. The surgical method was determined by a single surgeon after imaging results evaluation and a physical exam. Those who had favorable pelvic conditions without any evidence of adhesion were scheduled for vNOTES. A total of 33 patients underwent a vNOTES hysterectomy while 40 patients received a SPA laparoscopic hysterectomy. All surgeries were performed by one surgeon. The proportion of the patients who had a history of vaginal delivery was significantly higher in the vNOTES group. The operative time for port installation was significantly longer in the vNOTES group, but the total operative time was shorter compared to the SPA group. The postoperative pain scores 12 h after the operations were also significantly lower in the vNOTES group. Other surgical outcomes were comparable between the two groups. The present study demonstrated that the early operative outcomes of vNOTES hysterectomy were comparable to those of SPA hysterectomy. It also highlights the importance of adequate patient selection when determining surgical methods based on imaging results and physical examinations. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Perceptions about family planning and contraceptive practice in a marital dyad
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Lee, Taewha, Lee, Hyeonkyeong, Ahn, Hyun Mi, Jang, Younkyoung, Shin, Hyejeong, and Kim, Myeong Seon
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- 2014
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13. Establishing a nurse‐managed health center for the urban poor in Dhaka, Bangladesh.
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Lee, Tae Wha, Lee, Su Jeong, Kim, Myeong Seon, and Choi, Yoona
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ANALYSIS of variance ,CHI-squared test ,COMMUNITY health services ,HEALTH risk assessment ,INTERVIEWING ,RESEARCH methodology ,METROPOLITAN areas ,NURSE administrators ,PHYSICAL diagnosis ,POVERTY ,RESEARCH ,RESEARCH funding ,T-test (Statistics) ,OUTPATIENT medical care management ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Objectives: Despite the rise in community health problems in populations living in urban slums, activities of community health nurses are limited in Bangladesh. This study aimed to describe how a nurse‐managed health center (NMHC) was developed in Dhaka, Bangladesh. Design: An exploratory‐descriptive research design was used. Sample and Measurements: The commitment phase was conducted to establish partnerships in the community. Involvement of community leaders and members and partnerships with various organizations were established successfully in the commitment phase. The assessment phase was completed by implementing personal interviews, community site visits, and household surveys of 172 households in the community. Action plans were developed and strategies were followed to change the community during the planning phase. Results: Household survey results showed that community people suffered from non‐communicable diseases, risk behaviors, and inadequate housing conditions. The high‐priority community needs included nutrition and chronic management services, behavior change programs, and a clean environment. Action plans for health programs based on community needs and strategies such as securing manpower and equipment were developed. Conclusions: The systematic process of creating a NMHC, and the necessity of the community health nurse's role in responding to health needs of the urban poor in Dhaka, Bangladesh was confirmed. [ABSTRACT FROM AUTHOR]
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- 2020
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14. Hardening Properties of Cheeses by Latilactobacillus curvatus PD1 Isolated from Hardened Cheese- Dd ukbokki Rice Cake.
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Kim, Jeong-A., Kim, Geun-Su, Choi, Se-Mi, Kim, Myeong-Seon, Kwon, Do-Young, Kim, Sang-Gu, Lee, Sang-Yun, Lee, Kang-Wook, Succi, Mariantonietta, and Sorrentino, Elena
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CHEESE ,CAKE ,LACTIC acid bacteria ,LACTOBACILLUS casei ,LEUCONOSTOC mesenteroides ,CHEESECAKE ,RICE - Abstract
Hardening of cheese is one of major issues that degrade the quality of Home Meal Replacement (HMR) foods containing cheese such as Cheese-ddukbokki rice cake (CD, stir-fried rice cakes with shredded cheese). The quality of cheese, such as pH, proteolytic, and flavor properties, depends on various lactic acid bacteria (LAB) used in cheese fermentation. The hardening of cheese is also caused by LAB. In this study, various LAB strains were isolated from CD samples that showed rapid hardening. The correlation of LAB with the hardening of cheese was investigated. Seven of the CD samples with different manufacturing dates were collected and tested for hardening properties of cheese. Among them, strong-hardening of cheese was confirmed for two samples and weak-hardening was confirmed for one sample. All LAB in two strong-hardening samples and 40% of LAB in one weak-hardening sample were identified as Latilactobacilluscurvatus. On the other hand, most LAB in normal cheese samples were identified as Leuconostoc mesenteroides and Lactobacillus casei. We prepared cheese samples in which L. curvatus (LC-CD) and L. mesenteroides (LM-CD) were most dominant, respectively. Each CD made of the prepared cheese was subjected to quality test for 50 days at 10 °C. Hardening of cheese with LC-CD dominant appeared at 30 days. However, hardening of cheese with LM-CD dominant did not appear until 50 days. The pH of the LC-CD was 5.18 ± 0.04 at 30 days, lower than that of LM-CD. The proteolytic activity of LC-CD sample was 2993.67 ± 246.17 units/g, higher than that of LM-CD sample (1421.67 ± 174.5 units/g). These results indicate that high acid production and high protease activity of L. curvatus might have caused hardening of cheese. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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15. Anti-Cancer Activity of As4O6 and its Efficacy in a Series of Patient-Derived Xenografts for Human Cervical Cancer.
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Noh, Joseph J., Kim, Myeong-Seon, Cho, Young-Jae, Jeong, Soo-Young, Lee, Yoo-Young, Ryu, Ji-Yoon, Choi, Jung-Joo, Bae, Illju, Wu, Zhaoyan, Kim, Byoung-Gie, Hwang, Jae Ryoung, and Lee, Jeong-Won
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VASCULAR endothelial growth factor receptors , *CERVICAL cancer , *ENZYME-linked immunosorbent assay , *PEPTIDASE - Abstract
Purpose: To investigate the anti-cancer effects of tetraarsenic hexoxide (TAO, As4O6) in cervical cancer cell lines and in a series of patient-derived xenograft (PDX) mouse models. Methods: Human cervical cancer cell lines, including HeLa, SiHa and CaSki, and human umbilical vein endothelial cells (HUVECs), were used to evaluate the anti-cancer activity of TAO. Cellular proliferation, apoptosis, and enzyme-linked immunosorbent assay (ELISA) for matrix metallopeptidase 2 (MMP-2) and 9 (MMP-9) were assessed. The tumor weights of the PDXs that were given TAO were measured. The PDXs included primary squamous cell carcinoma, primary adenocarcinoma, recurrent squamous cell carcinoma, and recurrent adenocarcinoma. Results: TAO significantly decreased cellular proliferation and increased apoptosis in cervical cancer cell lines and HUVEC. The functional studies on the cytotoxicity of TAO revealed that it inhibited the activation of Akt and vascular endothelial growth factor receptor 2 (VEGFR2). It also decreased the concentrations of MMP-2 in both cervical cancer cell lines and HUVECs. Active caspase-3 and p62 were both increased by the treatment of TAO, indicating increased rates of apoptosis and decreased rates of autophagy, respectively. In vivo studies with PDXs revealed that TAO significantly decreased tumor weight for both primary squamous cell carcinoma and adenocarcinoma of the cervix. However, this anti-cancer effect was not seen in PDXs with recurrent cancers. Nevertheless, the combination of TAO with cisplatin significantly decreased tumor weight in PDX models for both primary and recurrent cancers. Conclusions: TAO exerted inhibitory effects on angiogenesis, cellular migration, and autophagy, and it showed stimulatory effects on apoptosis. Overall, it demonstrated anti-cancer effects in animal models for human cervical cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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16. Impact of adjuvant treatment on survival in patients with 2023 FIGO stage IIC endometrial cancer: a retrospective analysis from two tertiary centers in Korea and Taiwan.
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Lee YY, Lai YL, Kim MS, Chang K, Kim HS, Cheng WF, and Chen YL
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- Humans, Female, Retrospective Studies, Middle Aged, Taiwan epidemiology, Aged, Chemotherapy, Adjuvant, Republic of Korea, Tertiary Care Centers, Radiotherapy, Adjuvant, Neoplasm Recurrence, Local pathology, Adult, Carcinoma, Endometrioid pathology, Carcinoma, Endometrioid mortality, Carcinoma, Endometrioid therapy, Disease-Free Survival, Kaplan-Meier Estimate, Hysterectomy, Endometrial Neoplasms pathology, Endometrial Neoplasms mortality, Endometrial Neoplasms therapy, Neoplasm Staging
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Objective: In early-stage endometrial cancer, aggressive histologic types (grade 3 endometrioid, serous, clear cell, carcinosarcomas, undifferentiated, mixed, and other unusual types) are associated with an increased risk of distant metastases and worse survival. However, the optimal adjuvant treatment for these patients remains controversial. The present study investigated the outcomes of different adjuvant treatments in patients with 2023 FIGO stage IIC endometrial cancer., Methods: We retrospectively identified patients with 2023 FIGO stage IIC endometrial cancer who underwent surgery followed by either adjuvant treatment or observation from 2000 to 2020 at two tertiary centers in Korea and Taiwan. Recurrence-free survival (RFS) and overall survival (OS) were evaluated using Kaplan-Meier estimates and Cox proportional-hazards models. We also analyzed recurrence patterns after different adjuvant treatments., Results: A total of 272 patients were identified; 204 received adjuvant treatment postoperatively, whereas 68 only underwent observation. Adjuvant treatment was not associated with improved RFS or OS. Non-endometrioid histologic types (p=0.003) and presence of lymphovascular space invasion (LVSI, p=0.002) were associated with worse RFS, whereas only non-endometrioid histologic types impacted OS (p=0.004). In subgroup analyses, adjuvant treatment improved OS in patients with LVSI (p=0.020) and in patients with both LVSI and grade 3 endometrioid histologic type (p=0.007). We found no difference in locoregional and distant recurrence between patients undergoing adjuvant treatment or observation., Conclusion: In this study, the addition of adjuvant treatment was associated with an OS benefit for patients with LVSI, especially those with grade 3 endometrioid tumors., Competing Interests: No potential conflict of interest relevant to this article was reported., (© 2024. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology.)
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- 2024
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17. Role of reactive thrombocytosis after primary cytoreductive surgery in advanced ovarian cancer.
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Kim MS, Baek SH, Noh JJ, Shim JI, Kang JH, Jeong SY, Choi CH, Kim TJ, Lee JW, and Lee YY
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We investigated the incidence of reactive thrombocytosis after maximal cytoreductive surgery in advanced epithelial ovarian cancer (EOC) and its role in patient survival. We retrospectively reviewed the electronic medical records of patients who underwent primary cytoreductive surgery for advanced EOC from 1 January 2012 to 31 December 2017. We analyzed the serum platelet counts at various time points from before surgery, during the peri-operative period, and after each cycle of adjuvant chemotherapy. A total of 474 patients were eligible for the analysis. Among them, 401 patients (84.6%) had FIGO stage III disease status. The most common histology type was serous adenocarcinoma (405 patients, 85.4%). Seventy-nine patients (22.6%) received splenectomy, and optimal cytoreduction was achieved in 326 patients (68.8%). A week after surgery, thrombocytosis was observed in 165 patients (34.8%) in the entire cohort. Higher platelet counts were observed in patients with splenectomy compared with patients without splenectomy. In particular, thrombocytosis on the fifth cycle of adjuvant chemotherapy showed the most significant effects on overall survival in multivariate analysis. In a logistic regression model, splenectomy was significantly attributed to thrombocytosis on the fifth cycle of chemotherapy. Reactive thrombocytosis after primary cytoreductive surgery is associated with poor survival in advanced EOC, particularly when thrombocytosis is observed during adjuvant chemotherapy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Kim, Baek, Noh, Shim, Kang, Jeong, Choi, Kim, Lee and Lee.)
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- 2022
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18. The implementation of enhanced recovery after surgery protocols in ovarian malignancy surgery.
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Noh JJ, Kim MS, and Lee YY
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The enhanced recovery after surgery (ERAS) refers to multimodal interventions to reduce the length of hospital stay and complications at various steps of perioperative care. It was first developed in colorectal surgery and later embraced by other surgical disciplines including gynecologic oncology. The ERAS Society recently published guidelines for gynecologic cancer surgeries to enhance patient recovery. However, limitations exist in the implementation of the guidelines in ovarian cancer patients due to the distinct characteristics of the disease. In the present review, we discuss the results that have been published in the literature to date regarding the ERAS protocols in ovarian cancer patients, and explain why more evidence needs to be specifically assessed in this type of malignancy among other gynecologic cancers., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/gs.2020.04.07). The authors have no conflicts of interest to declare., (2021 Gland Surgery. All rights reserved.)
- Published
- 2021
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19. En bloc pelvic resection of ovarian cancer with rectosigmoid colectomy: a literature review.
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Kim MS, Noh JJ, and Lee YY
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Maximal cytoreductive surgery is an important prognostic factor in advanced epithelial ovarian cancer (EOC). To achieve maximal cytoreductive surgery, en bloc pelvic resection with rectosigmoid colectomy can be an effective surgical strategy. This surgical methodology was first described in 1968 as "radical oophorectomy." Since then, it has been adopted by many medical institutions around the world, and its safety has been shown by many studies. However, research on the surgical method is still lacking due to the limited number of prospective comparative studies. We will review the journals on en bloc pelvic resection with rectosigmoid colectomy published to date and discuss its efficacy, complications, and surgical techniques of the procedures., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/gs-19-540). The series “Ultra-Radical Surgery in Ovarian Cancer: Surgical Techniques for Gynecologic Oncologist” was commissioned by the editorial office without any funding or sponsorship. The authors have no other conflicts of interest to declare., (2021 Gland Surgery. All rights reserved.)
- Published
- 2021
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20. Hysterectomy and Adnexal Procedures by Vaginal Natural Orifice Transluminal Endoscopic Surgery (VNH): Initial Findings From a Korean Surgeon.
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Kim MS, Noh JJ, and Kim TJ
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Objective: To evaluate feasibility and safety of hysterectomy and adnexal procedures by vaginal natural orifice transluminal endoscopic surgery (vNOTES). Study Design: This is a prospective observational study at a tertiary center and teaching University hospital. We enrolled prospectively 34 patients with benign diseases sequentially. Results: We measured baseline characteristics, surgical data, and pain score (VAS) after surgery. We surveyed before/after surgery. The time of port installation and each stage of surgery was measured. The learning curve was assessed through the graph according to the number of operations using linear and logarithmic regression curve estimation. The complications of surgery were investigated. The median age of the patients was 47.5 years (38-73). Median BMI was 22.4 (18.2-30.0). 20 cases of leiomyoma, four cases of adenomyosis, three cases of uterine prolapse, four cases of endometrial hyperplasia, and three cases of CIN were diagnosed. The median uterine weight was 180.0 g. The median port-installation time was 15.0 min (range, 4-35 min) and median total operation time was 85.5 min (range 43.0-132.0). Complications occurred in three patients. Two cases of bladder injury happened during vesicovaginal space dissection before the installation of the Wound Retractor (WR). One patient underwent transumbilical single-port surgery because of late-onset postoperative bleeding on the 13th postoperative day. The mean postoperative VAS scores were 3.36 immediately after surgery and 3.06, 2.79, and 2.45 at 6, 12, and 24 h after surgery, respectively. In continuous variable analysis, we detected a correlation between port-installation time and postoperative VAS ≥4 (pain score as need for medication). Based on a learning curve, port-installation time and total operation time appeared to reach the proficiency level by the 10th case. Conclusions: Although there were three complications, vNOTES offers advantages to patients and surgeons. More surgical techniques will be developed in vNOTES., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Kim, Noh and Kim.)
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- 2021
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21. Comparison of Laparoscopy and Laparotomy for Para-Aortic Lymphadenectomy in Women With Presumed Stage I-II High-Risk Endometrial Cancer.
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Paik ES, Baek SH, Kang JH, Jeong SY, Kim MS, Kim WY, Lee YY, Choi CH, Lee JW, Kim BG, Bae DS, and Kim TJ
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Objective: To compare laparoscopic surgery to laparotomy for harvesting para-aortic lymph nodes in presumed stage I-II, high-risk endometrial cancer patients. Methods: Patients with histologically proven endometrial cancer, presumed stage I-II with high-risk tumor features who had undergone hysterectomy, bilateral salpingoophorectomy, or pelvic and para-aortic lymphadenectomy by either laparoscopy or laparotomy in Samsung Medical Center from 2005 to 2017 were retrospectively investigated. The primary outcome was para-aortic lymph node count. Secondary outcomes were pelvic lymph node count, perioperative events, and postoperative complications. Results: A total of 90 patients was included (35 for laparotomy, 55 for laparoscopy) for analysis. The mean (±SD) para-aortic lymph node count was 10.66 (±7.596) for laparotomy and 10.35 (±5.848) for laparoscopy ( p = 0.827). Mean pelvic node count was 16.8 (±6.310) in the laparotomy group and 16.13 (±7.626) in the laparoscopy group ( p = 0.664). Lower estimated blood loss was shown in the laparoscopy group. There was no difference in perioperative outcome between the groups. Additional multivariate analysis showed that survival outcome was not affected by surgical methods in presumed stage I-II, high-risk endometrial cancer patients. Conclusions: Study results demonstrate comparable para-aortic lymph node count with less blood loss in laparoscopy over laparotomy. In women with presumed stage I-II, high-risk endometrial cancer, laparoscopy is a valid treatment modality., (Copyright © 2020 Paik, Baek, Kang, Jeong, Kim, Kim, Lee, Choi, Lee, Kim, Bae and Kim.)
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- 2020
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22. Pretreatment Lymph Node Metastasis as a Prognostic Significance in Cervical Cancer: Comparison between Disease Status.
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Jeong SY, Park H, Kim MS, Kang JH, Paik ES, Lee YY, Kim TJ, Lee JW, Kim BG, Bae DS, and Choi CH
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- Female, Humans, Middle Aged, Prognosis, Progression-Free Survival, Uterine Cervical Neoplasms mortality, Uterine Cervical Neoplasms pathology, Lymph Node Excision methods, Lymphatic Metastasis pathology, Uterine Cervical Neoplasms complications
- Abstract
Purpose: Lymph node metastasis (LNM) is the most significant prognostic factor in cervical cancer that was recently incorporated into the International Federation of Gynecology and Obstetrics (FIGO) staging system. This study was performed to evaluate whether the prognostic significance of LNM differs according to disease status., Materials and Methods: Patients with FIGO stage IB or higher cervical cancer who had pretreatment computed tomography and/or magnetic resonance imaging studies as well as long-term follow-up were enrolled in this retrospective study. The hazard ratio (HR) of Cox regression was used to determine the prognostic significance of LNM. The HRs were compared between the different tumor groups (based on stage, histology, tumor size, primary treatment, age, parametrium involvement, and lymphovascular space invasion)., Results: A total of 970 patients treated between January 1999 and December 2007 were included. The pretreatment LNM had prognostic significance in patients with stage IB1/IIA (HR for progression-free survival 2.10, p=0.001; HR for overall survival 1.99, p=0.005). However, the significance gradually decreased or disappeared with advancing stages. Similarly, the prognostic significance of the pretreatment LNM decreased with advancing disease status, including old age, parametrial involvement or lymphovascular space involvement. In contrast, the tumor size was associated with the prognostic significance of LNM with advancing status. The significance of the clinical LNM did not reflect the significance of the clinical stage. In contrast, the tumor size, parametrial involvement, and significance of the pathologic LNM reflected the clinical stage., Conclusion: In patients with cervical cancer, pretreatment LNM on imaging has different clinical significance depending on the tumor status.
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- 2020
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23. Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients.
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Cho MA, Jeong SY, Sohn I, Kim MS, Kang JH, Paik ES, Lee YY, and Choi CH
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- Carcinoma, Ovarian Epithelial mortality, Female, Humans, Middle Aged, Retrospective Studies, Survival Analysis, Adrenergic beta-Antagonists therapeutic use, Angiotensin Receptor Antagonists therapeutic use, Antihypertensive Agents therapeutic use, Calcium Channel Blockers therapeutic use, Carcinoma, Ovarian Epithelial drug therapy, Sodium Chloride Symporter Inhibitors therapeutic use
- Abstract
Purpose: We investigated the impact of four types of antihypertensive medications, angiotensin receptor blockers (ARBs), beta blockers (BBs; both selective and non-selective), calcium channel blockers (CCBs), and thiazide diuretics (TDs) on survival outcomes in epithelial ovarian cancer (EOC)., Materials and Methods: A single-institutional retrospective chart review of 878 patients with EOC was performed. Survival was compared according to use of the four antihypertensive medications during primary treatment. Propensity score matching (ratio 1:3) was performed to control possible associated covariates, such as age, International Federation of Gynecology and Obstetrics stage, residual status after primary debulking surgery, and co-morbidity., Results: Among 878 patients, 56 patients (6.4%) were ARB users, 62 (7.1%) were BB users, 107 (12.2%) were CCBs users and 32 (3.6%) used TDs. Median progression-free survival (PFS) for ARB, BB, and CCB users was 37.8, 27.2, and 23.6 months compared with 33.6 months for non-users. ARB was associated with 35% decreased risk of disease progression (hazard ratio [HR], 0.65; 95% confidence interval [CI], 0.42 to 0.99; p=0.046) in multivariate analysis. After propensity score matching, median PFS for ARB users was 37.8 months and ARB use remained to be associated with lower recurrence rate in univariate (p=0.035) and multivariate analysis (HR, 0.60; 95% CI, 0.39 to 0.93; p=0.022)., Conclusion: In this study, ARBs use during primary treatment is associated with lower recurrence in EOC patients. However, CCBs, BBs, and TDs did not show beneficial impact.
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- 2020
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24. Uterine artery ligation at its origin following retroperitoneal space development decreases blood loss during single-port total laparoscopic hysterectomy.
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Choi HJ, Kim MS, and Kim TJ
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- Adult, Body Mass Index, Female, Humans, Hysterectomy methods, Laparoscopy methods, Middle Aged, Prospective Studies, Registries, Retroperitoneal Space surgery, Retrospective Studies, Treatment Outcome, Uterine Artery surgery, Blood Loss, Surgical prevention & control, Hemostasis, Surgical methods, Hysterectomy adverse effects, Laparoscopy adverse effects, Ligation methods
- Abstract
Objective: This study aimed to determine risk factors associated with the failure of uterine artery ligation at its origin following development of the retroperitoneal space (UALr) and evaluated its efficacy in decreasing estimated blood loss (EBL) during single-port total laparoscopic hysterectomy (SP-TLH)., Materials and Methods: This study includes patient data collected prospectively from May 1st, 2013 to establish a registry for single-port surgery. Data for the present study were collected retrospectively from May 1st, 2013 to August 30th, 2016. Patients who underwent SP-TLH for a symptomatic benign disease. When bilateral UALr was performed successfully, the case was classified as part of the UALr success group. When only unilateral UALr was completed or UALr failed, the case was classified as part of the failure group. We compared patients' baseline characteristics and surgical outcomes between the two groups., Results: Bilateral UALr was successfully performed in 155 cases and failed in 64 patients. Body Mass Index (BMI) was significantly different between the two groups (24.1 kg/m2 vs. 22.86 kg/m2, p = 0.025). A BMI higher than 23.6 kg/m
2 was a risk factor for UALr failure in a multivariate analysis (odds ratio = 2.42, p = 0.004). EBL was significantly lower in the UALr success group compared to the UALr failure group (100 [100.0-200.0] vs. 200 [100.0-250.0], p < 0.001), and incidence of Hb decrease of more than 2 g/dl was higher in the UALr failure group (36.1% vs. 54.7%, p = 0.017)., Conclusion: We identified higher BMI as a risk factor for UALr failure and demonstrated the safety and efficacy of UALr in reducing blood loss during SP-TLH., Competing Interests: Declaration of Competing Interest The author(s) have no conflicts of interest relevant to this article., (Copyright © 2020. Published by Elsevier B.V.)- Published
- 2020
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25. Prevalence and oncologic outcomes of BRCA1/2 mutation and variant of unknown significance in epithelial ovarian carcinoma patients in Korea.
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Seo JH, Jeong SY, Kim MS, Kang JH, Paik ES, Lee YY, Kim TJ, Lee JW, Kim BG, Bae DS, and Choi CH
- Abstract
Objective: BRCA mutational status is important in the management of ovarian cancer, but there is a lack of evidence supporting genetic testing in Asian populations. This study was performed to investigate the prevalence and prognostic outcomes of BRCA1/2 mutation and variant of unknown significance (VUS) in Korean patients diagnosed with epithelial ovarian cancer (EOC)., Methods: Among patients newly diagnosed with EOC between January 2007 and January 2017, those tested for germline BRCA1/2 mutation were studied, regardless of family history. Overall survival (OS) and progression-free survival (PFS) were compared between the patients with and without BRCA1/2 mutation and VUS., Results: A total of 313 patients underwent BRCA testing: 88 patients had a BRCA1/2 mutation and 48 patients had a BRCA1/2 VUS (28.1% and 15.3%, respectively). There were no significant associations between BRCA1/2 mutation, BRCA1/2 wild-type, or BRCA1/2 VUS with age at diagnosis, histologic distribution, or residual disease status after primary cytoreductive surgery. BRCA1 mutation, including BRCA1 VUS, showed no difference in PFS or OS compared to BRCA1 wild-type. In contrast, BRCA2 mutation showed longer PFS than that of BRCA2 wild-type ( P =0.04) or BRCA2 VUS ( P =0.02). BRCA2 mutation, including BRCA2 VUS, did not show any difference in OS compared to BRCA2 wild-type., Conclusion: BRCA mutation and BRCA VUS had similar clinical characteristics and survival outcomes, except that BRCA2 mutation showed better PFS. The results of this study will help to understand the prognostic significance of BRCA mutation and VUS in Korean patients., Competing Interests: Conflict of interest: No potential conflict of interest relevant to this article was reported., (Copyright © 2019 Korean Society of Obstetrics and Gynecology.)
- Published
- 2019
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26. Comparison between Laparoendoscopic Single-Site and Conventional Laparoscopic Surgery in Mature Cystic Teratoma of the Ovary.
- Author
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Kim MS, Choi CH, Lee JW, Kim BG, Bae DS, and Kim TJ
- Abstract
Objective: The objective of the study is to compare the intra- and post-operative outcomes of laparoendoscopic single-site surgery (LESS) and conventional laparoscopic surgery (CLS) in mature cystic teratoma (MCT) of the ovary., Methods: We reviewed 254 patients who underwent surgery (cystectomy) for ovarian MCT from March 1, 2014, to August 31, 2016. During the study period, 216 patients underwent LESS and 38 patients underwent CLS. The outcome measures included operation time, estimated blood loss, changing hemoglobin (Hb) level, postoperative pain, and complications. Statistical analysis was performed using SPSS 24., Results: There was no statistically significant difference in age, body mass index, sexual experience, cyst size, operative time, adhesiolysis, preoperative Hb, Hb changes, postoperative pain scores (visual analog scale), hospital days, and complications between the two groups. In emergent situation, the frequency of CLS was high as three cases (7.9%) versus one case (0.5%, P = 0.007) with LESS. As the year progressed, the frequency of LESS increased. There were one case of re-operation for bleeding control and transfusion, one case of postoperative peritonitis and transfusion, and one case of postoperative transfusion in LESS. During LESS, additional port(s) was/were created in 13 cases (6.0%, P = 0.249)., Conclusions: LESS is not inferior to CLS in MCT surgery, and LESS is useful for the surgery of MCT. Our study demonstrates that LESS confers feasibility, convenience, and safety regarding cystectomy of MCT., Competing Interests: There are no conflicts of interest., (Copyright: © 2019 Gynecology and Minimally Invasive Therapy.)
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- 2019
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27. Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review.
- Author
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Kim MS, Choi CH, Kim TJ, Lee JW, Lee J, Bae DS, and Kim BG
- Abstract
Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a history of bloody vaginal discharge for 7 months. Gynecological examination showed an exophytic, hard and pigmented cervical mass involving the upper vagina. The patient was diagnosed with cervical melanoma after a punch biopsy and underwent a radical hysterectomy, upper vaginectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy. After surgeries, the patient underwent 2-cycles of adjuvant immunotherapy with pembrolizumab, but died within 8 months. In this report, treatment with pembrolizumab after radical surgery was not effective for this patient who had a primary cervical melanoma that metastasized to bone and lung tissue. We do not know why pembrolizumab was ineffective for this patient, but there are several possible explanations; further research is needed., Competing Interests: Conflict of interest: No potential conflict of interest relevant to this article was reported.
- Published
- 2018
- Full Text
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