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Your search keyword '"Kirschner J"' showing total 1,270 results
Start Over Author "Kirschner J" Publication Type Academic Journals
1,270 results on '"Kirschner J"'

1. STUDY PROTOCOL OF A MULTI-STAGE RANDOMISED CONTROLLED STUDY FOR THE ASSESSMENT OF POSTOPERATIVE THERAPEUTIC PROCEDURES AFTER TOTAL KNEE ARTHROPLASTY

Author

Prill R, Kirschner J, Michel S, Schulz R, and Hommel H

Subjects
Total Joint Replacement, knee, arthroplasty, Patient related outcomes, functional outcomes, trial, Medicine (General), R5-920
Abstract

Background: There continues to be a lack of evidence to support physiotherapeutic rehabilitation measures after total knee arthroplasty (TKA), especially in the area of functional test procedures, which are indispensable for assessing perioperative physiotherapeutic interventions, including their efficacy. Objective: A multi-stage randomized controlled study design is concerned with the establishment of an evidence-based perioperative physiotherapeutic treatment programme to evaluate physical functional test procedures with regard to their predictive value and the efficacy of physiotherapeutic interventions. Setting: The RCT will be realized in a medical clinic in the department of orthopaedics, sports medicine and rehabilitation.Participants: A first stage will include young, healthy subjects (Group A) and subjects who are due to undergo TKA and are then to be treated with a standard rehabilitation programme (Group B). Design: Selected promising physical functional test procedures will be tested for their reliability. Inter-tester reliability will be determined in Group A. The test-retest reliability at different perioperative timepoints will be determined in Group B. Measurements: The following test procedures will be investigated for reliability: 10-m walk test, timed up and go, three times sit to stand, the isometric maximal force of knee extension, stair climbing and the cumulative leg circumference. In addition, these test procedures will be correlated with each other and with the WOMAC and KSS for selected aspects of validity. In a second stage, the reliable test procedures will be applied to investigate selected promising physiotherapeutic interventions. Conclusions: The investigation could change perioperative assessments and physiotherapeutic treatment in patients who have undergone TKA.

Published
2018
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2. Fine-tuning of canted magnetization in stepped Fe films through thickness variation, Au capping, and quantum confinement

Author

Daobrowski, M, Cinal, M, Schmid, AK, Kirschner, J, and Przybylski, M

Abstract

We present a joint experimental and theoretical study that demonstrates how to efficiently control a canted state of magnetization in Fe films grown on Ag(001) vicinal surface and precisely characterize it with the magneto-optical Kerr effect. It is shown that by employing different mechanisms to tune the magnetization tilting angle, any magnetization orientation within the plane perpendicular to the step edges can be achieved. In particular, increasing the Fe film thickness leads to continuous rotation of the magnetization easy axis toward the film surface and the sense of this rotation in uncovered films is opposite to that in films covered with Au. Another tuning mechanism is provided by oscillatory changes of the tilting angle at low temperatures due to formation of quantum well states in Fe films. The observed canting of magnetization is explained within a phenomenological model by an interplay of the shape anisotropy and two magnetocrystalline anisotropy terms, perpendicular and step-induced anisotropies, which results in an effective uniaxial magnetic anisotropy. The fitted thickness dependencies of the anisotropy constants accurately reproduce experimental variations of the tilting angle with both Fe and Au thicknesses as well as transient changes of the magnetization orientation in ultrathin Fe films upon submonolayer Au coverage, observed with spin-polarized low-energy electron microscopy.

Published
2019

3. Fine-tuning of canted magnetization in stepped Fe films through thickness variation, Au capping, and quantum confinement

Author

Dąbrowski, M, Cinal, M, Schmid, AK, Kirschner, J, and Przybylski, M

Subjects
Physical Sciences, Chemical Sciences, Engineering, Fluids & Plasmas
Abstract

We present a joint experimental and theoretical study that demonstrates how to efficiently control a canted state of magnetization in Fe films grown on Ag(001) vicinal surface and precisely characterize it with the magneto-optical Kerr effect. It is shown that by employing different mechanisms to tune the magnetization tilting angle, any magnetization orientation within the plane perpendicular to the step edges can be achieved. In particular, increasing the Fe film thickness leads to continuous rotation of the magnetization easy axis toward the film surface and the sense of this rotation in uncovered films is opposite to that in films covered with Au. Another tuning mechanism is provided by oscillatory changes of the tilting angle at low temperatures due to formation of quantum well states in Fe films. The observed canting of magnetization is explained within a phenomenological model by an interplay of the shape anisotropy and two magnetocrystalline anisotropy terms, perpendicular and step-induced anisotropies, which results in an effective uniaxial magnetic anisotropy. The fitted thickness dependencies of the anisotropy constants accurately reproduce experimental variations of the tilting angle with both Fe and Au thicknesses as well as transient changes of the magnetization orientation in ultrathin Fe films upon submonolayer Au coverage, observed with spin-polarized low-energy electron microscopy.

Published
2019

5. Canted stripe phase evolution due to a spin reorientation transition in Fe films grown on Ag(001) vicinal surface

Author

Dabrowski, M, Cinal, M, Przybylski, M, Chen, G, N'Diaye, AT, Schmid, AK, and Kirschner, J

Abstract

The evolution of the domain structure with the thickness of bcc Fe films deposited on the Ag(116) vicinal surface is studied by spin-polarized low-energy electron microscopy. We show that a spin reorientation transition proceeds via two mechanisms: continuous rotation of magnetization within the vertical plane perpendicular to the steps and discontinuous reorientation of the in-plane component of magnetization, leading to splitting of the domains. In contrast to previously investigated systems with stripe domains, we reveal that in the case of a vicinal ferromagnetic surface, the domain width increases while changing the orientation of the magnetization from a canted out-of-plane state into an in-plane state. A theoretical model developed in this work successfully describes the domain structure behavior observed in our experiments and can be equally applied to other ferromagnetic films grown on vicinal surfaces.

Published
2016

6. The Multiple Sclerosis Inventory of Cognition for Adolescents (MUSICADO): A brief screening instrument to assess cognitive dysfunction, fatigue and loss of health-related quality of life in pediatric-onset multiple sclerosis

Author

Kraus, V., Dornfeld, E., Elpers, C., Lohmann, H., Weddige, A., Hagspiel, S., Kirschner, J., Brehm, M., Blank, C., Schubert, J., Schimmel, M., Pacheè, S., Mohrbach, M., Karenfort, M., Kamp, G., Lücke, T., Neumann, H., Lutz, S., Gierse, A., Sievers, S., Schiffmann, H., de Soye, I., Trollmann, R., Candova, A., Rosner, M., Neu, A., Romer, G., Seidel, U., John, R., Hofmann, C., Schulz, Kinder, S., Bertolatus, A., Scheidtmann, K., Lasogga, R., Leiz, S., Alber, M., Kranz, J., Bajer-Kornek, B., Seidl, R., Novak, A., Storm van's Gravesande, K., Calabrese, P., Blaschek, A., Rostásy, K., Huppke, P., Rothe, L., Mall, V., Kessler, J., and Kalbe, E.

Published
2019
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10. A randomized placebo-controlled phase 3 trial of an antisense oligonucleotide, drisapersen, in Duchenne muscular dystrophy

Author

Araujo, A., Bertini, E., Born, P., Cances, C., Chabrol, B., Chae, J.-H., Colomer Oferil, J., Comi, G.P., Cuisset, J.-M., D'Anjou, G., Desguerre, I., Erazo Torricelli, R., Escobar, R., Feder, D., Ferlini, A., Giugliani, R., Henricson, E., Herczegfalvi, A., Jong, Y.-J., Kimura, S., Kirschner, J.-B., Kleinsteuber, K., Kostera-Pruszczyk, A., Kudr, M., Mueller-Felber, W., Niks, E.H., Ogata, K., Palermo, C., Pane, M., Pascual, I., Pereon, Y., Raskin, S., Rasmussen, M., Reed, U., Schara, U., Selby, K., Sobreira, C., Takeshima, Y., Vilchez Padilla, J.J., Vita, G., Vondracek, P., Wiegand, G., Wilichowski, E., Goemans, Nathalie, Mercuri, Eugenio, Belousova, Elena, Komaki, Hirofumi, Dubrovsky, Alberto, McDonald, Craig M., Kraus, John E., Lourbakos, Afrodite, Lin, Zhengning, Campion, Giles, Wang, Susanne X., and Campbell, Craig

Published
2018
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11. Characterization of pulmonary function in 10–18 year old patients with Duchenne muscular dystrophy

Author

Bernert, G., Knipp, F., Buyse, G.M., Goemans, N., Van den Hauwe, M., Voit, T., Doppler, V., Gidaro, T., Cuisset, J.-M., Coopman, S., Schara, U., Lutz, S., Kirschner, J., Borell, S., Will, M., D'Angelo, M.G., Brighina, E., Gandossini, S., Gorni, K., Falcier, E., Politano, L., D'Ambrosio, P., Taglia, A., Verschuuren, J.J.G.M., Straathof, C.S.M., Vílchez Padilla, J.J., Muelas Gómez, N., Sejersen, T., Hovmöller, M., Jeannet, P.-Y., Bloetzer, C., Iannaccone, S., Castro, D., Tennekoon, G., Finkel, R., Bönnemann, C., McDonald, C., Henricson, E., Joyce, N., Apkon, S., Richardson, R.C., Meier, Thomas, Rummey, Christian, Leinonen, Mika, Spagnolo, Paolo, Mayer, Oscar H., and Buyse, Gunnar M.

Published
2017
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14. Idebenone reduces respiratory complications in patients with Duchenne muscular dystrophy

Author

Bernert, G., Knipp, F., Buyse, G.M., Goemans, N., van den Hauwe, M., Voit, T., Doppler, V., Gidaro, T., Cuisset, J.-M., Coopman, S., Schara, U., Lutz, S., Kirschner, J., Borell, S., Will, M., D'Angelo, M.G., Brighina, E., Gandossini, S., Gorni, K., Falcier, E., Politano, L., D'Ambrosio, P., Taglia, A., Verschuuren, J.J.G.M., Straathof, C.S.M., Vílchez Padilla, J.J., Muelas Gómez, N., Sejersen, T., Hovmöller, M., Jeannet, P.-Y., Bloetzer, C., Iannaccone, S., Castro, D., Tennekoon, G., Finkel, R., Bönnemann, C., McDonald, C., Henricson, E., Joyce, N., Apkon, S., Richardson, R.C., McDonald, Craig M., Meier, Thomas, Voit, Thomas, Schara, Ulrike, Straathof, Chiara S.M., D'Angelo, M. Grazia, Bernert, Günther, Cuisset, Jean-Marie, Finkel, Richard S., Goemans, Nathalie, Rummey, Christian, Leinonen, Mika, Spagnolo, Paolo, and Buyse, Gunnar M.

Published
2016
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15. Real-World Data on the Efficacy of Gene Replacement Therapy for Spinal Muscular Atrophy (SMA).

Author

Weiß, C., Becker, L.-L., Friese, J., Blaschek, A., Hahn, A., Illsinger, S., Schwartz, O., Bernert, G., von der Hagen, M., Husain, R. A., Goldhahn, K., Pechmann, A., Kirschner, J., Flotats-Bastardas, M., Schreiber, G., Schara, U., Plecko, B., Trollmann, R., Horber, V., and Wilichowski, E.

Subjects
SPINAL muscular atrophy, GENE therapy, GROSS motor ability, NEWBORN screening, GENE targeting
Abstract

This article presents long-term data on the efficacy of gene replacement therapy (GRT) for spinal muscular atrophy (SMA) using onasemnogene abeparvovec (OA). The study includes patients who were older, heavier, or more severely affected than those in previous clinical trials, as well as a large cohort of presymptomatic SMA patients identified through newborn screening. The results show that younger patients treated with OA had better motor function outcomes compared to those treated at a later age. The study provides valuable evidence for future treatment decisions, particularly for patients with limited trial data available. [Extracted from the article]

Published
2023
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16. Ocular Myasthenia: It's Worth a Second Look.

Author

Friedrich, S., Gastaldi, M., Eckenweiler, M., Lochmüller, H., Kirschner, J., and Pechmann, A.

Subjects
MUSCLE weakness, MYASTHENIA gravis, TREATMENT effectiveness, DIPLOPIA, ELECTROPHYSIOLOGY, PERIODICAL publishing
Abstract

This article, published in the journal Neuropediatrics, discusses a case of ocular myasthenia, a common presentation of myasthenia gravis (MG) in children. The case presented challenges in diagnosis and treatment, requiring specialized laboratory tests and high doses of pyridostigmine. The patient initially had right-sided ptosis and diplopia, which worsened and showed rapid alteration. Despite negative ACh-receptor antibodies and normal CSF, MRI, and electrophysiology results, the patient was successfully treated with pyridostigmine. The article highlights the importance of live cell-based assays in confirming the diagnosis of ocular MG when other tests are negative, and suggests that higher doses of pyridostigmine may be necessary for successful treatment. [Extracted from the article]

Published
2023
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48. Prospective study on anti-ganglioside antibodies in childhood Guillain-Barre syndrome

Author

Schessl, J., Koga, M., Funakoshi, K., Kirschner, J., Muellges, W., Weishaupt, A., Gold, R., and Korinthenberg, R.

Subjects
Gangliosides -- Research, Anti-antibodies -- Research, Guillain-Barre syndrome -- Development and progression, Children -- Diseases, Children -- Development and progression, Children -- Research
Published
2007

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