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Your search keyword '"Kiyonari, Hiroshi"' showing total 615 results
Start Over Author "Kiyonari, Hiroshi" Publication Type Academic Journals
615 results on '"Kiyonari, Hiroshi"'

1. Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism

Author

Nomura, Kazuhiro, Kinoshita, Shinichi, Mizusaki, Nao, Senga, Yoko, Sasaki, Tsutomu, Kitamura, Tadahiro, Sakaue, Hiroshi, Emi, Aki, Hosooka, Tetsuya, Matsuo, Masahiro, Okamura, Hitoshi, Amo, Taku, Wolf, Alexander M., Kamimura, Naomi, Ohta, Shigeo, Itoh, Tomoo, Hayashi, Yoshitake, Kiyonari, Hiroshi, Krook, Anna, Zierath, Juleen R., Kasuga, Masato, and Ogawa, Wataru

Published
2024
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6. Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER

Author

Inoue, Ryota, Tsuno, Takahiro, Togashi, Yu, Okuyama, Tomoko, Sato, Aoi, Nishiyama, Kuniyuki, Kyohara, Mayu, Li, Jinghe, Fukushima, Setsuko, Kin, Tatsuya, Miyashita, Daisuke, Shiba, Yusuke, Atobe, Yoshitoshi, Kiyonari, Hiroshi, Bando, Kana, Shapiro, A.M. James, Funakoshi, Kengo, Kulkarni, Rohit N., Terauchi, Yasuo, and Shirakawa, Jun

Published
2022
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8. Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction

Author

Sasaki, Lena, Hamada, Yuki, Yarimizu, Daisuke, Suzuki, Tomo, Nakamura, Hiroki, Shimada, Aya, Pham, Khanh Tien Nguyen, Shao, Xinyan, Yamamura, Koki, Inatomi, Tsutomu, Morinaga, Hironobu, Nishimura, Emi K., Kudo, Fujimi, Manabe, Ichiro, Haraguchi, Shogo, Sugiura, Yuki, Suematsu, Makoto, Kinoshita, Shigeru, Machida, Mamiko, Nakajima, Takeshi, Kiyonari, Hiroshi, Okamura, Hitoshi, Yamaguchi, Yoshiaki, Miyake, Takahito, and Doi, Masao

Published
2022
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13. A unique mode of keratinocyte death requires intracellular acidification

Author

Matsui, Takeshi, Kadono-Maekubo, Nanako, Suzuki, Yoshiro, Furuichi, Yuki, Shiraga, Keiichiro, Sasaki, Hiroyuki, Ishida, Azusa, Takahashi, Sonoko, Okada, Takaharu, Toyooka, Kiminori, Sharif, Jafar, Abe, Takaya, Kiyonari, Hiroshi, Tominaga, Makoto, Miyawaki, Atsushi, and Amagai, Masayuki

Published
2021

14. A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach

Author

Douchi, Daisuke, Yamamura, Akihiro, Matsuo, Junichi, Lee, Jung-Won, Nuttonmanit, Napat, Melissa Lim, Yi Hui, Suda, Kazuto, Shimura, Mitsuhiro, Chen, Sabirah, Pang, ShuChin, Kohu, Kazuyoshi, Kaneko, Mari, Kiyonari, Hiroshi, Kaneda, Atsushi, Yoshida, Hideyuki, Taniuchi, Ichiro, Osato, Motomi, Yang, Henry, Unno, Michiaki, Bok-Yan So, Jimmy, Yeoh, Khay Guan, Chuang, Linda Shyue Huey, Bae, Suk-Chul, and Ito, Yoshiaki

Published
2022
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17. Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis

Author

Negishi, Hideo, Endo, Nobuyasu, Nakajima, Yuki, Nishiyama, Tatsuaki, Tabunoki, Yuichiro, Nishio, Junko, Koshiba, Ryuji, Matsuda, Atsushi, Matsuki, Kosuke, Okamura, Tomohisa, Negishi-Koga, Takako, Ichinohe, Takeshi, Takemura, Shunji, Ishiwata, Hiroyuki, Iemura, Shun-ichiro, Natsume, Tohru, Abe, Takaya, Kiyonari, Hiroshi, Doi, Takeshi, Hangai, Sho, Yanai, Hideyuki, Fujio, Keishi, Yamamoto, Kazuhiko, and Taniguchi, Tadatsugu

Published
2019

19. Tracing the origin of hair follicle stem cells

Author

Morita, Ritsuko, Sanzen, Noriko, Sasaki, Hiroko, Hayashi, Tetsutaro, Umeda, Mana, Yoshimura, Mika, Yamamoto, Takaki, Shibata, Tatsuo, Abe, Takaya, Kiyonari, Hiroshi, Furuta, Yasuhide, Nikaido, Itoshi, and Fujiwara, Hironobu

Subjects
Stem cells -- Origin, Hair follicles -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Tissue stem cells are generated from a population of embryonic progenitors through organ-specific morphogenetic events.sup.1,2. Although tissue stem cells are central to organ homeostasis and regeneration, it remains unclear how they are induced during development, mainly because of the lack of markers that exclusively label prospective stem cells. Here we combine marker-independent long-term 3D live imaging and single-cell transcriptomics to capture a dynamic lineage progression and transcriptome changes in the entire epithelium of the mouse hair follicle as it develops. We found that the precursors of different epithelial lineages were aligned in a 2D concentric manner in the basal layer of the hair placode. Each concentric ring acquired unique transcriptomes and extended to form longitudinally aligned, 3D cylindrical compartments. Prospective bulge stem cells were derived from the peripheral ring of the placode basal layer, but not from suprabasal cells (as was previously suggested.sup.3). The fate of placode cells is determined by the cell position, rather than by the orientation of cell division. We also identified 13 gene clusters: the ensemble expression dynamics of these clusters drew the entire transcriptional landscape of epithelial lineage diversification, consistent with cell lineage data. Combining these findings with previous work on the development of appendages in insects.sup.4,5, we describe the 'telescope model', a generalized model for the development of ectodermal organs in which 2D concentric zones in the placode telescope out to form 3D longitudinally aligned cylindrical compartments. Live imaging and single-cell transcriptomics of mouse hair follicles reveal their development from 2D concentric zones in the placode to 3D longitudinal compartments, one of which is a stem cell compartment., Author(s): Ritsuko Morita [sup.1] , Noriko Sanzen [sup.1] , Hiroko Sasaki [sup.1] , Tetsutaro Hayashi [sup.2] , Mana Umeda [sup.2] , Mika Yoshimura [sup.2] , Takaki Yamamoto [sup.3] [sup.4] , [...]

Published
2021
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20. Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.

Author

Kon, Kazuhiro, Ode, Koji L., Mano, Tomoyuki, Fujishima, Hiroshi, Takahashi, Riina R., Tone, Daisuke, Shimizu, Chika, Shiono, Shinnosuke, Yada, Saori, Matsuzawa, Kyoko, Yoshida, Shota Y., Yoshida Garçon, Junko, Kaneko, Mari, Shinohara, Yuta, Yamada, Rikuhiro G., Shi, Shoi, Miyamichi, Kazunari, Sumiyama, Kenta, Kiyonari, Hiroshi, and Susaki, Etsuo A.

Subjects
SLEEP, NEURONS, PROTEIN kinases, SLOW wave sleep, NEURAL inhibition, NON-REM sleep, INTERNEURONS, WAKEFULNESS
Abstract

The homeostatic regulation of sleep is characterized by rebound sleep after prolonged wakefulness, but the molecular and cellular mechanisms underlying this regulation are still unknown. In this study, we show that Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent activity control of parvalbumin (PV)-expressing cortical neurons is involved in homeostatic regulation of sleep in male mice. Prolonged wakefulness enhances cortical PV-neuron activity. Chemogenetic suppression or activation of cortical PV neurons inhibits or induces rebound sleep, implying that rebound sleep is dependent on increased activity of cortical PV neurons. Furthermore, we discovered that CaMKII kinase activity boosts the activity of cortical PV neurons, and that kinase activity is important for homeostatic sleep rebound. Here, we propose that CaMKII-dependent PV-neuron activity represents negative feedback inhibition of cortical neural excitability, which serves as the distributive cortical circuits for sleep homeostatic regulation. The role of cortical PV neurons in the regulation of sleep architecture and homeostatic sleep rebound is not fully understood. Here, the authors show that CaMKII-mediated control of cortical parvalbumin-neuron activity regulates the homeostatic sleep rebound in mice. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs

Author

Sato, Ko, Matsumoto, Ikumi, Suzuki, Koya, Tamura, Atsushi, Shiraishi, Aki, Kiyonari, Hiroshi, Kasamatsu, Jun, Yamamoto, Hideki, Miyasaka, Tomomitsu, Tanno, Daiki, Miyahara, Anna, Zong, Tong, Kagesawa, Takafumi, Oniyama, Akiho, Kawamura, Kotone, Kitai, Yuki, Umeki, Aya, Kanno, Emi, Tanno, Hiromasa, Ishii, Keiko, Tsukita, Sachiko, and Kawakami, Kazuyoshi

Published
2021
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28. Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles

Author

Arimoto, Kei-ichiro, Hishiki, Takayuki, Kiyonari, Hiroshi, Abe, Takaya, Cheng, Chuyi, Yan, Ming, Fan, Jun-Bao, Futakuchi, Mitsuru, Tsuda, Hiroyuki, Murakami, Yoshiki, Suzuki, Hideyuki, Zhang, Dong-Er, and Shimotohno, Kunitada

Subjects
Infectious Diseases, Aetiology, 2.1 Biological and endogenous factors, Infection, Animals, Cell Line, Gene Deletion, Gene Order, Gene Targeting, Genetic Loci, Genetic Vectors, Hypertrophy, Interferons, Lipopolysaccharides, Male, Mice, Mice, Knockout, Seminal Vesicles, Ubiquitin-Activating Enzymes, Ubiquitin-Protein Ligases, Ubiquitins, Vesicular Stomatitis, Vesicular stomatitis Indiana virus, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Immunology
Abstract

ISG15 conjugation (ISGylation) to proteins is a multistep process involving interferon (IFN)-inducible UBE1L (E1), UbcH8 (E2), and ISG15 E3 ligases (E3s). Studies performed over the past several years have shown that ISGylation plays a pivotal role in the host antiviral response against certain viruses. Recent in vitro studies revealed that human Herc5 and mouse Herc6 are major ISG15 E3 ligases, respectively. However, the global function of Herc5/6 proteins in vivo still remains unclear. Here, we report generation and initial characterization of Herc6 knockout mice. Substantial reductions of ISGylation were observed in Herc6-deficient cells after polyinosinic-polycytidylic acid double-stranded RNA injection of mice or IFN treatment of cells. On the other hand, Herc6-deficient cells and wild-type (WT) cells had similar responses to IFN stimulation, Sendai virus (Z strain) infection, and vesicular stomatitis virus infection. These results indicate that Herc6 does not play a critical role in antiviral defense of these viral infections in mice. Interestingly, male Herc6-deficient mice showed seminal vesicle hypertrophy. No such problem was detected in WT and ISG15 activating enzyme Ube1L-deficient mice. These results suggest that in addition to promoting protein ISGylation, Herc6 has a novel and protein ISGylation-independent function in the male reproductive system.

Published
2015

33. Loss of Dja2 accompanies pH deviation in lysosomes and lysosome‐related organelles.

Author

Terada, Kazutoyo, Endo, Motoyoshi, Kiyonari, Hiroshi, Takeda, Naoki, and Oike, Yuichi

Subjects
ORGANELLES, ALVEOLAR macrophages, PROTEIN C, LYSOSOMES, MECONIUM aspiration syndrome, GLYCOLIPIDS, AMILORIDE
Abstract

The Dja2 knockout (Dja2−/−) mice had respiratory distress, and >60% died within 2 days after birth. The surviving adult Dja2−/− mice were infertile and the lungs of Dja2−/− mice showed several abnormalities, including the processing defect of prosurfactant protein C in the alveolar epithelial type II cells and the accumulation of glycolipids in enlarged alveolar macrophages. The luminal pH of acidic organelles in Dja2−/− cells was shifted to pH 5.37–5.45. This deviated pH was immediately restored to control levels (pH 4.56–4.65) by the addition of a diuretic, ethyl isopropyl amiloride (EIPA). Although the role of DJA2 in maintaining the pH homeostasis of lysosome‐related organelles is currently obscure, this rapid and remarkable pH resilience is best explained by an EIPA‐sensitive proton efflux machinery that is disorganized and overactivated due to the loss of Dja2. [ABSTRACT FROM AUTHOR]

Published
2024
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43. The adherens junctions control susceptibility to Staphylococcus aureus α-toxin

Author

Popov, Lauren M., Marceau, Caleb D., Starkl, Philipp M., Lumb, Jennifer H., Shah, Jimit, Guerrera, Diego, Cooper, Rachel L., Merakou, Christina, Bouley, Donna M., Meng, Wenxiang, Kiyonari, Hiroshi, Takeichi, Masatoshi, Galli, Stephen J., Bagnoli, Fabio, Citi, Sandra, Carette, Jan E., and Amieva, Manuel R.

Published
2015

48. Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism

Author

Sasako, Takayoshi, Ohsugi, Mitsuru, Kubota, Naoto, Itoh, Shinsuke, Okazaki, Yukiko, Terai, Ai, Kubota, Tetsuya, Yamashita, Satoshi, Nakatsukasa, Kunio, Kamura, Takumi, Iwayama, Kaito, Tokuyama, Kumpei, Kiyonari, Hiroshi, Furuta, Yasuhide, Shibahara, Junji, Fukayama, Masashi, Enooku, Kenichiro, Okushin, Kazuya, Tsutsumi, Takeya, Tateishi, Ryosuke, Tobe, Kazuyuki, Asahara, Hiroshi, Koike, Kazuhiko, Kadowaki, Takashi, and Ueki, Kohjiro

Published
2019
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50. Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells

Author

Nojiri, Takashi, Hosoda, Hiroshi, Tokudome, Takeshi, Miura, Koichi, Ishikane, Shin, Otani, Kentaro, Kishimoto, Ichiro, Shintani, Yasushi, Inoue, Masayoshi, Kimura, Toru, Sawabata, Noriyoshi, Minami, Masato, Nakagiri, Tomoyuki, Funaki, Soichiro, Takeuchi, Yukiyasu, Maeda, Hajime, Kidoya, Hiroyasu, Kiyonari, Hiroshi, Shioi, Go, Arai, Yuji, Hasegawa, Takeshi, Takakura, Nobuyuki, Hori, Megumi, Ohno, Yuko, Miyazato, Mikiya, Mochizuki, Naoki, Okumura, Meinoshin, and Kangawa, Kenji

Published
2015

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