Search

The global pandemic of SARS-CoV-2, or severe acute respiratory syndrome coronavirus, in 2020 claimed millions of lives globally. The clinical manifestation of this virus is called COVID-19, and it can cause everything from flu-like symptoms to severe clinical consequences and even death. The global health organization (WHO) created awareness campaigns to reduce infection rates and slow the virus's rapid spread because there was no proven medication that could treat this infection or lessen its problems with little to no negative effects on the health of the patients. Despite the fact that vaccinations have been created as preventative measures, people still prefer to use conventional herbal drugs because it offers exceptional health benefits and, with comparatively minor side effects, can either prevent a viral infection or restrict the development of serious symptoms through various mechanistic pathways. This thorough analysis offers empirical data clarifying the protective effect of various plants against SARS-CoV-2, opening the door for additional research to reevaluate plant-based extracts—rich in bioactive compounds—in more sophisticated clinical evaluations to determine their effect on COVID-19 patients. [ABSTRACT FROM AUTHOR]

Polycystic ovarian syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age, characterized by hyperandrogenism and chronic oligo/ anovulation. PCOS is a complex illness that is impacted and complicated by a variety of genetic and environmental factors. The disruption of reproductive hormones such as LH, FSH, oestrogen, and testosterone disrupts the normal menstrual cycle and can result in oligomenorrhoea and amenorrhea-like abnormalities. Although there are significant variations between people, PCOS is characterized by hyperandrogenism, irregular menstruation, and different sized ovarian cysts. Polycystic ovarian syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age, characterized by hyperandrogenism and chronic oligo/ anovulation. PCOS is a complex illness that is impacted and complicated by a variety of genetic and environmental factors. Additionally, these women most likely have a higher risk of ovarian cancer, venous thromboembolism, cardiovascular and cerebrovascular events, and other illnesses. In addition to its enormous economic burden (an annual health-care expenditure of $5.39 billion in the United States in 2019), PCOS has a negative impact on the long-term health of affected women. The most prevalent endocrine condition, known as polycystic ovary syndrome (PCOS), affects 6%–8% of women globally who are of reproductive age. The first studies to ascertain prevalence in a medically unselected (unbiased) population were started by Azziz and colleagues, who reported PCOS prevalence’s ranging from 4% to 6.6% among unselected reproductive-age women living in the Southeast of the United States using the NIH 1990 criteria. The demand for herbal medications has developed as a result of high economic costs and a large number of unfavourable side effects linked with the use of allopathic drugs. Herbal plants have been a key source of therapeutic remedies since ancient times. Exceptionally, despite the huge transformation in the pharmaceutical area, the use of herbal treatments is expanding day by day in underdeveloped countries. [ABSTRACT FROM AUTHOR]

Background: Commiphoracaudatais a traditional medicinal plant which having various medicinal activities but the present research work was focussed on the wound healing activity. The leaves were extracted using continuous hot percolation method. Based on the phytochemical studies, the ethanolic extract was selected for the preparation of herbal tablet. Direct compression was done by making eight batches [F1-F8] of herbal tablets. The pre and post compression studies were investigated for the developed formulation to select optimized one. Aim and objective: The current investigation of the present research is to formulate and develop the herbal tablet from the ethanolic leaf extract of medicinal plant Commiphoracaudata(Wight &Arn.) Engl.and to evaluate the in vitro wound healing studies. Materials and methods: Petroleum ether, Chloroform, Acetone, Ethanol, HPMC, Carbopol, Starch, Lactose monohydrate, Crospovidone, Mannitol, Magnesium stearate, Disodium hydrogen phosphate, Potassium dihydrogen phosphate phosphate which are used for the extraction process and formulation and evaluation of the herbal tablet to analyse the wound healing studies. Result: From this formulation F7 shows the better results than the rest of other formulations and it was subjected for the fibroblast cell line studies(3T3-CCL92) resulted in a significant increase in the percentage from 34.7-53.29% and the dose-response curve produced to be linear which conform the wound healing activity. Then the formulation F7 were carried out for short term accelerated stability studies for 3 months which shows negligible changes. Conclusion: the herbal tablet used for the treatment of wound healing activity as a traditional system of medicine. [ABSTRACT FROM AUTHOR]