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Mixtures of OXONE® and hydrobromic acid or hydrochloric acid afford solutions of bromine or chlorine, respectively. α-Bromo- or α-chloro-α,β-unsaturated carbonyl compounds were prepared by addition of hydrobromic acid or hydrochloric acid to the mixture of α,β-unsaturated carbonyl compounds and OXONE® in CH2Cl2 followed by treatment of Et3N in moderate to good yields. [ABSTRACT FROM AUTHOR]

A newly synthesized experimental compound, EK-2612 is one of the class of cyclohexane-l,3diones which are commonly known to be grasskillers. A greenhouse study was conducted to evaluate the herbicidal performances of EK-2612 on several grass species in comparison with tralkoxydim, a commercialized cyclohexanedione derivative. Like tralkoxydim, the compound EK-2612 showed excellent control efficacy on most grass weeds tested through foliar application rates between 250 and 63 g AI ha- 1. Unlike tralkoxydim, however, EK-2612 showed a good rice safety, and there was no rice damage observed at the level below 125 g AIha-1, while rice injury developed at the same application rates of traikoxydim. With this rice safety, EK-2612 controlled barnyardgrass effectively up to the two-leaf stage under both submerged and dried paddy conditions. An in vitro ACCase assay indicated that EK-2612 is a strong ACCase inhibitor; however, the dose-response was not substantially different in rice and barnyardgrass, showing I50 values of 0.1 and 0.12µM, respectively. These results suggest that the compound EK- 2612 is targeting plant ACCase, but the whole-plant rice safety is not attributable to a different inhibition of the target site in rice from that in barnyardgrass. [ABSTRACT FROM AUTHOR]