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14. Avances en nutrición de precisión y enfermedades cardiometabólicas

Author

Martínez-González, Miguel A., Planes, Francisco J., Ruiz-Canela, Miguel, Toledo, Estefanía, Estruch, Ramón, Salas-Salvadó, Jordi, Valdés-Más, Rafael, Mena, Pedro, Castañer, Olga, Fitó, Montse, Clish, Clary, Landberg, Rikard, Wittenbecher, Clemens, Liang, Liming, Guasch-Ferré, Marta, Lamuela-Raventós, Rosa M., Wang, Dong D., Forouhi, Nita, Razquin, Cristina, and Hu, Frank B.

Published
2024
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15. Recent advances in precision nutrition and cardiometabolic diseases

Author

Martínez-González, Miguel A., Planes, Francisco J., Ruiz-Canela, Miguel, Toledo, Estefanía, Estruch, Ramón, Salas-Salvadó, Jordi, Valdés-Más, Rafael, Mena, Pedro, Castañer, Olga, Fitó, Montse, Clish, Clary, Landberg, Rikard, Wittenbecher, Clemens, Liang, Liming, Guasch-Ferré, Marta, Lamuela-Raventós, Rosa M., Wang, Dong D., Forouhi, Nita, Razquin, Cristina, and Hu, Frank B.

Published
2024
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25. Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications

Author

de Roos, Baukje, Aura, Anna-Marja, Bronze, Maria, Cassidy, Aedin, Conesa, María-Teresa Garcia, Gibney, Eileen R, Greyling, Arno, Kaput, Jim, Kerem, Zohar, Knežević, Nada, Kroon, Paul, Landberg, Rikard, Manach, Claudine, Milenkovic, Dragan, Rodriguez-Mateos, Ana, Tomás-Barberán, Francisco A, van de Wiele, Tom, and Morand, Christine

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Obesity, Nutrition, Prevention, 3.3 Nutrition and chemoprevention, Prevention of disease and conditions, and promotion of well-being, Cancer, Metabolic and endocrine, Oral and gastrointestinal, Cardiovascular, Cardiovascular Diseases, Diet, Vegetarian, Health Promotion, Humans, Metabolic Diseases, Phytochemicals, Healthy diet, Cardiometabolic diseases, Inter-individual variability in responses, Stakeholders, Food industry, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract

BackgroundA healthy diet and optimal lifestyle choices are amongst the most important actions for the prevention of cardiometabolic diseases. Despite this, it appears difficult to convince consumers to select more nutritious foods. Furthermore, the development and production of healthier foods do not always lead to economic profits for the agro-food sector. Most dietary recommendations for the general population represent a "one-size-fits-all approach" which does not necessarily ensure that everyone has adequate exposure to health-promoting constituents of foods. Indeed, we now know that individuals show a high variability in responses when exposed to specific nutrients, foods, or diets.PurposeThis review aims to highlight our current understanding of inter-individual variability in response to dietary bioactives, based on the integration of findings of the COST Action POSITIVe. We also evaluate opportunities for translation of scientific knowledge on inter-individual variability in response to dietary bioactives, once it becomes available, into practical applications for stakeholders, such as the agro-food industry. The potential impact from such applications will form an important impetus for the food industry to develop and market new high quality and healthy foods for specific groups of consumers in the future. This may contribute to a decrease in the burden of diet-related chronic diseases.

Published
2019

34. Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction

Author

Manach, Claudine, Milenkovic, Dragan, Wiele, Tom, Rodriguez‐Mateos, Ana, Roos, Baukje, Garcia‐Conesa, Maria Teresa, Landberg, Rikard, Gibney, Eileen R, Heinonen, Marina, Tomás‐Barberán, Francisco, and Morand, Christine

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Nutrition, Obesity, Prevention, 3.3 Nutrition and chemoprevention, Prevention of disease and conditions, and promotion of well-being, Oral and gastrointestinal, Stroke, Metabolic and endocrine, Cardiovascular, Good Health and Well Being, Cardiovascular Diseases, Diet, Diet, Healthy, Health Behavior, Healthy Aging, Humans, Metabolic Diseases, Phytochemicals, Plants, Edible, Randomized Controlled Trials as Topic, Risk Factors, Risk Reduction Behavior, Bioavailability and metabolism, Biological responsiveness, Cardiometabolic health, Inter-individual variation, Plant food bioactives, Food Sciences, Public Health and Health Services, Food Science, Nutrition & Dietetics, Food sciences, Nutrition and dietetics
Abstract

Bioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability.

Published
2017

35. Effects of a Phytoestrogen Intervention and Estrogen Receptor β Genotype on Prostate Cancer Proliferation and PSA Concentrations—A Randomized Controlled Trial.

Author

Ahlin, Rebecca, Josefsson, Andreas, Nybacka, Sanna, Landberg, Rikard, Stranne, Johan, Steineck, Gunnar, and Hedelin, Maria

Subjects
PROSTATE-specific antigen, RESEARCH funding, SURGERY, PATIENTS, CELL proliferation, STATISTICAL sampling, RADICAL prostatectomy, PROSTATE tumors, PHYTOESTROGENS, TUMOR markers, TREATMENT effectiveness, PREOPERATIVE care, RANDOMIZED controlled trials, DESCRIPTIVE statistics, SOYBEAN, ESTROGEN receptors, GENETIC polymorphisms, ETIOLOGIC fraction, FLAXSEED, CONFIDENCE intervals, DATA analysis software, GENETICS, BIOMARKERS, GENOTYPES
Abstract

A phytoestrogen-rich diet has been suggested to reduce tumor proliferation among men with prostate cancer, and the effect may differ between men with different polymorphisms of the estrogen receptor‐beta gene (ERβ). Patients with low- or intermediate-risk prostate cancer scheduled for radical prostatectomy were randomized to an intervention group (n = 71) provided with soybeans and flaxseeds (∼200 mg phytoestrogens/day) to eat until surgery (approximately 6 wk) or to a control group (n = 69). Tumor proliferation was assessed using Ki-67 indexes, prostate-specific antigen (PSA) concentrations were analyzed in blood, and ERβ polymorphism was genotyped in all subjects. The intervention group had a 13% unit lower risk [95% confidence interval (CI): −28%, 1.8%] of a higher Ki-67 index compared to controls, but the effect was most pronounced among TT carriers of ERβ [risk difference (RD) −19%, 95% CI: −45%, 6.8%]. Subjects with genotype TC/CC had a lower risk (RD −29%, 95% CI: −46%, −1.2%) and TT genotype a higher risk (RD 25%, 95% CI: 8.7%, 42%) of increased PSA concentration, comparing the intervention group to controls. In conclusion, a phytoestrogen-rich diet may cause lower tumor proliferation and concentration of PSA in men with prostate cancer with a specific genetic upset of ERβ. [ABSTRACT FROM AUTHOR]

Published
2025
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38. LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Author

Ronkainen, Justiina, Nedelec, Rozenn, Atehortua, Angelica, Balkhiyarova, Zhanna, Cascarano, Anna, Ngoc Dang, Vien, Elhakeem, Ahmed, van Enckevort, Esther, Goncalves Soares, Ana, Haakma, Sido, Halonen, Miia, Heil, Katharina F., Heiskala, Anni, Hyde, Eleanor, Jacquemin, Bénédicte, Keikkala, Elina, Kerckhoffs, Jules, Klåvus, Anton, Kopinska, Joanna A., Lepeule, Johanna, Marazzi, Francesca, Motoc, Irina, Näätänen, Mari, Ribbenstedt, Anton, Rundblad, Amanda, Savolainen, Otto, Simonetti, Valentina, de Toro Eadie, Nina, Tzala, Evangelia, Ulrich, Anna, Wright, Thomas, Zarei, Iman, d’Amico, Enrico, Belotti, Federico, Brunius, Carl, Castleton, Christopher, Charles, Marie-Aline, Gaillard, Romy, Hanhineva, Kati, Hoek, Gerard, Holven, Kirsten B., Jaddoe, Vincent W. V., Kaakinen, Marika A., Kajantie, Eero, Kavousi, Maryam, Lakka, Timo, Matthews, Jason, Piano Mortari, Andrea, Vääräsmäki, Marja, Voortman, Trudy, Webster, Claire, Zins, Marie, Atella, Vincenzo, Bulgheroni, Maria, Chadeau-Hyam, Marc, Conti, Gabriella, Evans, Jayne, Felix, Janine F., Heude, Barbara, Järvelin, Marjo-Riitta, Kolehmainen, Marjukka, Landberg, Rikard, Lekadir, Karim, Parusso, Stefano, Prokopenko, Inga, de Rooij, Susanne R., Roseboom, Tessa, Swertz, Morris, Timpson, Nicholas, Ulven, Stine M., Vermeulen, Roel, Juola, Teija, Sebert, Sylvain, Sebert, Sylvain, Juola, Teija, Nedelec, Rozenn, Ronkainen, Justiina, Heiskala, Anni, Halonen, Miia, He, Yiyan, Miettunen, Jouko, Karhunen, Ville, Kajantie, Eero, Vääräsmäki, Marja, Keikkala, Elina, Nyberg, Pia, Serpi, Raisa, Felix, Janine, Jaddoe, Vincent, Marques, Irene, Moreira da Silva Santos, Susana, Kavousi, Maryam, Voortman, Trudy, Ginos, Bigina, Chadeau-Hyam, Marc, Järvelin, Marjo-Riitta, Tzala, Evangelia, De Toro, Nina, Wright, Thomas, Bodinier, Barbara, Dagnino, Sonia, Evans, Jayne, Webster, Claire, Kolehmainen, Marjukka, Hanhineva, Kati, Lakka, Timo, Savolainen, Otto, Zarei, Iman, Näätänen, Mari, Klåvus, Anton, Eloranta, Aino-Maija, Väistö, Juuso, Kårlund, Anna, Mikkonen, Santtu, Atalay, Merja, Atalay, Mustafa, Landberg, Rikard, Brunius, Carl, Ribbenstedt, Anton, Swertz, Morris, Hyde, Eleanor, Haakma, Sido, van Enckevort, Esther, Heude, Barbara, Charles, Marie-Aline, Zins, Marie, Lepeule, Johanna, Jacquemin, Bénédicte, Calas, Lucinda, Lequy-Flahault, Emeline, Lun Yuan, Wen, Seyve, Emie, Conti, Gabriella, Vermeulen, Roel, Hoek, Gerard, Kerckhoffs, Jules, Prokopenko, Inga, Kaakinen, Marika, Balkhiyarova, Zhanna, Ulrich, Anna, Roseboom, Tessa, De Rooij, Susanne, Motoc, Irina, Marie Ulven, Stine, Holven, Kirsten B., Matthews, Jason, Rundblad, Amanda, Das, Siddhartha, Timpson, Nicholas, Elhakeem, Ahmed, Luiza Goncalves Soares, Ana, Lekadir, Karim, Maria Cascarano, Anna, Maria Atehortua Labrador, Angélica, Ngoc Dang, Vien, Heil, Katharina F., Gallin, Catherine, Díaz, Oliver, Bulgheroni, Maria, Simonetti, Valentina, D’Amico, Enrico, Giani, Laura, Manzino, Fabrizio, Parusso, Stefano, Castleton, Christopher, Moimas, Diego, Atella, Vincenzo, Piano Mortari, Andrea, Kopinska, Joanna, Marazzi, Francesca, Giaccherini, Matilde, and Belotti, Federico

Published
2022
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39. Dietary biomarkers—an update on their validity and applicability in epidemiological studies.

Author

Landberg, Rikard, Karra, Prasoona, Hoobler, Rachel, Loftfield, Erikka, Huybrechts, Inge, Rattner, Jodi I, Noerman, Stefania, Claeys, Liesel, Neveu, Vanessa, Vidkjaer, Nanna Hjort, Savolainen, Otto, Playdon, Mary C, and Scalbert, Augustin

Subjects
*FRUIT, *PREDICTIVE tests, *SEAFOOD, *FOOD consumption, *COFFEE, *NUTRITIONAL assessment, *RESEARCH methodology evaluation, *DAIRY products, *GRAIN, *MEAT, *FISHES, *FOOD, *DOSE-response relationship in biochemistry, *TEA, *RESEARCH methodology, *FATS & oils, *VEGETABLES, *WESTERN diet, *ALCOHOLS (Chemical class), *BIOMARKERS, *EPIDEMIOLOGICAL research, *LEGUMES, *RELIABILITY (Personality trait), RESEARCH evaluation
Abstract

The aim of this literature review was to identify and provide a summary update on the validity and applicability of the most promising dietary biomarkers reflecting the intake of important foods in the Western diet for application in epidemiological studies. Many dietary biomarker candidates, reflecting intake of common foods and their specific constituents, have been discovered from intervention and observational studies in humans, but few have been validated. The literature search was targeted for biomarker candidates previously reported to reflect intakes of specific food groups or components that are of major importance in health and disease. Their validity was evaluated according to 8 predefined validation criteria and adapted to epidemiological studies; we summarized the findings and listed the most promising food intake biomarkers based on the evaluation. Biomarker candidates for alcohol, cereals, coffee, dairy, fats and oils, fruits, legumes, meat, seafood, sugar, tea, and vegetables were identified. Top candidates for all categories are specific to certain foods, have defined parent compounds, and their concentrations are unaffected by nonfood determinants. The correlations of candidate dietary biomarkers with habitual food intake were moderate to strong and their reproducibility over time ranged from low to high. For many biomarker candidates, critical information regarding dose response, correlation with habitual food intake, and reproducibility over time is yet unknown. The nutritional epidemiology field will benefit from the development of novel methods to combine single biomarkers to generate biomarker panels in combination with self-reported data. The most promising dietary biomarker candidates that reflect commonly consumed foods and food components for application in epidemiological studies were identified, and research required for their full validation was summarized. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Long-term whole-grain rye and wheat consumption and their associations with selected biomarkers of inflammation, endothelial function, and cardiovascular disease

Author

Mhd Omar, Nor Adila, Wu, Huaxing, Larsson, Anders, Wolk, Alicja, and Landberg, Rikard

Subjects
Wheat -- Health aspects -- Properties, Inflammation -- Diagnosis, Cardiovascular diseases -- Diagnosis, Biological markers -- Analysis, Food/cooking/nutrition, Health
Abstract

Background/objectives Whole-grain (WG) intake has been associated with a lowered risk of developing type 2 diabetes, cardiovascular disease, and some cancers in epidemiological studies. Reduced subclinical inflammation could be one important mechanism behind such associations. This study investigated whether high long-term WG rye and wheat intakes were associated with lower concentrations of biomarkers of inflammation, endothelial function, and protein biomarkers associated with cardiovascular disease. Subjects/methods We assessed WG intake by food frequency questionnaire (FFQ) and by measuring alkylresorcinols (ARs) in plasma and adipose tissue, respectively. Selected biomarkers in free-living 109 women and 149 men were analyzed from two clinical subcohort studies (Swedish Mammography Cohort-Clinical (SMC-C) and Cohort of Swedish Men-Clinical (COSM-C), respectively. Total WG rye and wheat (WGRnW) and the ratio of WG rye to WG rye and wheat (WGR/WGRnW) were estimated from FFQs. ARs were measured in plasma and adipose tissue by gas chromatography-mass spectrometry (GC-MS) and the biomarkers by ELISA. Results We found no consistent associations between WG intake assessed by different methods and the selected biomarkers. However, WGRnW intake was inversely associated with cathepsin S (P-trend < 0.05) and total AR and C17:0/C21:0 in plasma were inversely associated with the endostatin concentration (P-trend < 0.05) adjusted for BMI, age, and sex. Conclusion The results give limited support to the hypothesis that a high WG wheat and rye intake is associated with lower concentrations of common biomarkers of inflammation and CVD that have previously been reported inversely associated with WG intake or an overall healthy lifestyle., Author(s): Nor Adila Mhd Omar [sup.1] , Huaxing Wu [sup.2] , Anders Larsson [sup.3] , Alicja Wolk [sup.1] [sup.4] , Rikard Landberg [sup.2] [sup.5] Author Affiliations: (1) Unit of Cardiovascular [...]

Published
2021
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44. Perspective: Metabotyping—A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease

Author

Palmnäs, Marie, Brunius, Carl, Shi, Lin, Rostgaard-Hansen, Agneta, Torres, Núria Estanyol, González-Domínguez, Raúl, Zamora-Ros, Raul, Ye, Ye Lingqun, Halkjær, Jytte, Tjønneland, Anne, Riccardi, Gabriele, Giacco, Rosalba, Costabile, Giuseppina, Vetrani, Claudia, Nielsen, Jens, Andres-Lacueva, Cristina, and Landberg, Rikard

Published
2020
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48. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A, Hémon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Förster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra HM, Bueno-de-Mesquita, H Bas, Engeset, Dagrun, Skeie, Guri, Hjartåker, Anette, Menéndez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J, Khaw, Kay-Thee, Wareham, Nicholas J, Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Complementary and Integrative Health, Nutrition, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Cancer, Adult, Aged, Body Mass Index, Coffee, Cross-Sectional Studies, Diet, Europe, Exercise, Female, Flavonoids, Food Analysis, Food Handling, Fruit, Humans, Hydroxybenzoates, Life Style, Male, Mental Recall, Middle Aged, Nutrition Assessment, Polyphenols, Proanthocyanidins, Prospective Studies, Socioeconomic Factors, Tea, Dietary intake, EPIC, Food sources, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract

Background/objectivesPolyphenols are plant secondary metabolites with a large variability in their chemical structure and dietary occurrence that have been associated with some protective effects against several chronic diseases. To date, limited data exist on intake of polyphenols in populations. The current cross-sectional analysis aimed at estimating dietary intakes of all currently known individual polyphenols and total intake per class and subclass, and to identify their main food sources in the European Prospective Investigation into Cancer and Nutrition cohort.MethodsDietary data at baseline were collected using a standardized 24-h dietary recall software administered to 36,037 adult subjects. Dietary data were linked with Phenol-Explorer, a database with data on 502 individual polyphenols in 452 foods and data on polyphenol losses due to cooking and food processing.ResultsMean total polyphenol intake was the highest in Aarhus-Denmark (1786 mg/day in men and 1626 mg/day in women) and the lowest in Greece (744 mg/day in men and 584 mg/day in women). When dividing the subjects into three regions, the highest intake of total polyphenols was observed in the UK health-conscious group, followed by non-Mediterranean (non-MED) and MED countries. The main polyphenol contributors were phenolic acids (52.5-56.9 %), except in men from MED countries and in the UK health-conscious group where they were flavonoids (49.1-61.7 %). Coffee, tea, and fruits were the most important food sources of total polyphenols. A total of 437 different individual polyphenols were consumed, including 94 consumed at a level >1 mg/day. The most abundant ones were the caffeoylquinic acids and the proanthocyanidin oligomers and polymers.ConclusionThis study describes the large number of dietary individual polyphenols consumed and the high variability of their intakes between European populations, particularly between MED and non-MED countries.

Published
2016

49. The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants

Author

Kværner, Ane Sørlie, Birkeland, Einar, Bucher-Johannessen, Cecilie, Vinberg, Elina, Nordby, Jan Inge, Kangas, Harri, Bemanian, Vahid, Ellonen, Pekka, Botteri, Edoardo, Natvig, Erik, Rognes, Torbjørn, Hovig, Eivind, Lyle, Robert, Ambur, Ole Herman, de Vos, Willem M., Bultman, Scott, Hjartåker, Anette, Landberg, Rikard, Song, Mingyang, Blix, Hege Salvesen, Ursin, Giske, Randel, Kristin Ranheim, de Lange, Thomas, Hoff, Geir, Holme, Øyvind, Berstad, Paula, and Rounge, Trine B.

Published
2021
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