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Your search keyword '"Li, Lu"' showing total 13,422 results
Start Over Author "Li, Lu" Publication Type Academic Journals
13,422 results on '"Li, Lu"'

1. Speech-Processing Network Formation of Cochlear-Implanted Toddlers with Early Hearing Experiences

Author

Meiyun Wu, Haotian Liu, Xue Zhao, Li Lu, Yuyang Wang, Chaogang Wei, Yuhe Liu, and Yu-Xuan Zhang

Abstract

To reveal the formation process of speech processing with early hearing experiences, we tracked the development of functional connectivity in the auditory and language-related cortical areas of 84 (36 female) congenitally deafened toddlers using repeated functional near-infrared spectroscopy for up to 36 months post cochlear implantation (CI). Upon hearing restoration, the CI children lacked the modular organization of the mature speech-processing network and demonstrated a higher degree of immaturity in temporo-parietal than temporo-frontal connections. The speech-processing network appeared to form rapidly with early CI experiences, with two-thirds of the developing connections following nonlinear trajectories reflecting possibly more than one synaptogenesis-pruning cycle. A few key features of the mature speech-processing network emerged within the first year of CI hearing, including left-hemispheric advantage, differentiation of the dorsal and ventral processing streams, and functional state (speech listening vs. resting) specific patterns of connectivity development. The developmental changes were predictable of future auditory and verbal communication skills of the CI children, with prominent contribution from temporo-parietal connections in the dorsal stream, suggesting a mediating role of speech-processing network formation with early hearing experiences in speech acquisition.

Published
2025
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2. Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans.

Author

Karwatowska-Prokopczuk, Ewa, Lesogor, Anastasia, Yan, Jing-He, Hoenlinger, Angelika, Margolskee, Alison, Li, Lu, and Tsimikas, Sotirios

Subjects
Antisense oligonucleotide, ApoC-III, Cardiovascular disease, Ethnicity, Pancreatitis, Triglycerides, Adult, Female, Humans, Male, Middle Aged, Young Adult, Apolipoprotein C-III, Asian, Double-Blind Method, Oligonucleotides, Oligonucleotides, Antisense, Triglycerides, Japan, United States
Abstract

BACKGROUND: Olezarsen is a GalNAc3-conjugated, hepatic-targeted antisense oligonucleotide that lowers apolipoprotein C-III (apoC-III) and triglyceride levels. The efficacy and safety of olezarsen has not previously been studied in ethnically diverse American populations. The aim of this study is to assess the effect of olezarsen in healthy Japanese Americans. METHODS: A randomized, placebo-controlled, double-blind phase 1 study was performed in 28 healthy Japanese American participants treated with olezarsen in single-ascending doses (SAD; 30, 60, 90 mg) or multiple doses (MD; 60 mg every 4 weeks for 4 doses). The primary, secondary, and exploratory objectives were safety and tolerability, pharmacokinetics, and effects of olezarsen on fasting serum triglycerides and apoC-III, respectively. RESULTS: There were 20 participants (16 active:4 placebo) in the SAD part of the study, and 8 participants (6 active:2 placebo) in the MD part of the study. For the primary endpoint, no serious adverse events or clinically relevant laboratory abnormalities were reported. The majority of olezarsen plasma exposure occurred within 24 h post-dose. In the SAD cohorts at Day 15 the percentage reduction in apoC-III/TG was - 39.4%/ - 17.8%, - 60.8%/ - 52.7%, and - 68.1%/ - 39.2% in the 30, 60 and 90 mg doses, respectively, vs 2.3%/44.5% increases in placebo. In the MD cohort, at Day 92 the percentage reduction in apoC-III/TG was - 81.6/ - 73.8% vs - 17.2/ - 40.8% reduction in placebo. Favorable changes were also present in VLDL-C, apoB and HDL-C. CONCLUSIONS: Single- and multiple-dose administration of olezarsen was safe, was well tolerated, and significantly reduced apoC-III and triglyceride levels in healthy Japanese Americans.

Published
2024

39. A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study

Author

Wang, Zhen, Yao, Jundong, Jing, Xiang, Li, Kaiyan, Lu, ShiChun, Yang, Hong, Ding, Hong, Li, Kai, Cheng, Wen, He, Guangzhi, Jiang, Tianan, Liu, Fangyi, Yu, Jie, Han, Zhiyu, Cheng, Zhigang, Tan, Shuilian, Wang, Zhen, Qi, Erpeng, Wang, Shuo, Zhang, YiQiong, Li, Lu, Dong, Xiaocong, Liang, Ping, and Yu, Xiaoling

Published
2024
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44. Observation and mechanism of non-uniform distribution of tin nuclei in preparing vapor diffusion coated Nb3Sn thin film for SRF applications: Observation and mechanism of non-uniform distribution...

Author

Wu, Shuai, Ye, Yang, Yang, Zi-Qin, He, Yuan, Li, Jian-Peng, Jiang, Guang-Ze, Li, Lu, Huang, Shi-Chun, Wu, An-Dong, Li, Hang-Xu, Lu, Shao-Hua, Liu, Tao, Qiu, Feng, Wang, Cang-Long, Duan, Ji-Zheng, Tan, Teng, Wang, Zhi-Jun, Zhang, Sheng-Hu, Zhao, Hong-Wei, and Zhan, Wen-Long

Published
2025
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48. Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells

Author

Li, Lu, Jiang, Wenhao, Wei, Wenjun, Krishnamoorthy, Gnana P., Hu, Pingping, Chen, Mengni, Tiedje, Vera, Acuña-Ruiz, Adrián, Wang, He, Wang, Zhihong, Wang, Jianbiao, Liu, Hanqing, Chen, Wanyuan, Guan, Haixia, Chen, Chuang, Zhang, Hao, Wang, Yu, Fagin, James A., Guo, Tiannan, Zhu, Yi, Wang, Yingrui, Gao, Jianqing, and Sun, Yaoting

Published
2024
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