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Metastasis is a major cause of breast cancer death. MPP7 is a cell polarity controller highly linked to cell migration; however, the function of MPP7 in breast cancer remains unknown. In this study, we reported that MPP7 expression was upregulated in breast cancer tissues and high MPP7 expression predicted poor survival in patients with breast cancer. Ectopic expression of MPP7 markedly enhanced the migration and invasion in breast cancer cells. In contrast, depletion of MPP7 resulted in impaired cell mobility and metastasis. Moreover, we demonstrated that MPP7 exerted its promotional effect via modulation of EMT and activation of the EGFR/AKT cascade. Our study reveals an oncogenic role of MPP7 in breast cancer and suggests that MPP7 may serve as a potential target for exploring novel therapeutic strategies against breast cancer metastasis. [ABSTRACT FROM AUTHOR]

• The impacts of the expansion and spatial patterns of ISA on LST were investigated. • The mean LST and the density of the ISA are the highest in the center of the GBA. • The mean LST in the high density area is about 2.85 °C higher than low density area. • The correlation between nighttime LST and landscape metrics is weaker than daytime. The rapid development of urban megaregions has changed the regional thermal environment by raising the land surface temperature (LST) in a continuous area. The thermal environment problem in urban megaregions has become a research focus. This study aimed to investigate the relationship between the LST and the external expansion and internal spatial patterns of impervious surfaces area (ISA) in Guangdong – Hong Kong – Macao Greater Bay Area (GBA). The Landsat and MODIS data, as well as various geospatial approaches, including buffer-based zoning, impervious surface density gradients and landscape-based metrics statistics, were used to facilitate the analysis. We found that the areas of ISA increased from 1697.293 km2 in 2000 to 9754.936 km2 in 2015 in the GBA, expanding to the east, southeast and south. The mean LST increased by 7.41 °C and 10.23 °C in the daytime and nighttime, respectively. The internal density of ISA had increased significantly in the past 15 years. The highest ISA density and the highest LST appeared in the 15 km buffer zone closest to study area's center. And the LST was decreased by 0.15 °C for each 15 km increased in the distance to the study area's center. There was a significant strong positively correlation between the LST and the density of the ISA. The LST of the very-high-density area of the ISA was about 2.85 °C higher than that of the very-low-density area. The internal landscape pattern of ISA was strongly correlated with the LST. The study highlight that the center of urban megaregion had the larger ISA patches, which were simpler in shape, more aggregated and connected, and less fragmented seemed to exacerbate elevate in the LST in successive regions. In particular, the study found that the nighttime LST were affected by the environmental characteristics of urban megaregion. The correlation between the LST and the ISA was higher at daytime than at nighttime. [ABSTRACT FROM AUTHOR]