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BackgroundHome-based intervention occupies a prominent place in the treatment of autism spectrum disorder （ASD） in children， whereas previous studies on the effect of home-based early intensive behavioral intervention on verbal ability of children with ASD are somewhat inadequate.ObjectiveTo study the effects of intensive family behavioral of intervention based on Verbal Behavior Milestones Assessment and Placement Program （VB-MAPP） on the language ability of children with ASD， so as to provide references for the development of family intervention strategies for children with ASD.MethodsChildren aged 2 to 3 years old who attended the Children's Rehabilitation Department of the Second Affiliated Hospital of Shantou University Medical College from September 2020 to December 2021 and met the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） diagnostic criteria for ASD were selected as the study objects. A non-randomized concurrent control trial was conducted to compare a study group （n=24） receiving home-based early intensive behavioral intervention using VB-MAPP with a control group （n=14） receiving training from other special institutions or early childhood education institutions. The intervention lasted for 6 months in both groups. Before and after the intervention， the VB-MAPP milestone assessment was performed in the two groups， and the VB-MAPP milestone score， mand， trac and listener responds were selected as the study indicators. Then the intervention effect was compared between two groups， and the multiple linear regression was performed to screen the related influencing factors.ResultsAfter intervention， the total milestone assessment score， mand， tact and listener responds scores of study group were higher than those of control group， with statistical difference （Z=-4.339~-2.195， P

Uranium content measurement is very important to nuclear material accounting and product quality control in nuclear bulk facilities. It needs high accuracy and precision. In this work, 3 different measurement steps from 2 analytical standards GB 11841—1989 and ASTM C1267-17, which were uranium content test methods by iron(Ⅱ) reduction followed by chromium(Ⅵ) titration, were discussed by simulated experiments and following uncertainty evaluation. The results show that, the total uncertainties of the 3 steps are all lower than 0.1%, which is the international target value of uranium content measurement by redox potential titration method. The step for 2.3 g sample of GB 11841—1989 is more suitable to sign value measurement in reference material production, because of its lowest uncertainty. In routine testing works, the step for 0.20-0.25 g sample of GB 11841—1989 is better in sample weighting, the step of ASTM C1267-17 is better in titration and potassium dichromate solution preparation.

Background: To explore the association of polymorphisms of apoptosis-linked genes caspase3 (CASP3), integrin a subunit 1 (ITGA1), glutathione sulfur transferase M1 (GSTM1) with susceptibility to gastric cardia carcinoma (GCC). Methods: From February 2016 to March 2018, selection of 113 GCC patients was as the gastric cancer (GC), and selection of 75 patients without gastric disease was as the control. Detection of CASP3, ITGA1 and GSTM1 gene polymorphisms in patients' peripheral blood was to analyze their association with GC. Division of the GC was into the good prognosis and the unpleasing prognosis in the light of the survival of patients after surgery of 3 years, and the predictable value of gene polymorphisms of CASP3, ITGA1 and GSTM1 in GCC patients was analyzed. Results: CASP3 gene rs12108497 locus, ITGA1 gene rs1862610 locus and GSTM1 genotype of the GC and the control were in accord with Hardy-Weinberg equilibrium (P > 0.05); The detection rate of CASP3 gene rs12108497 locus TC/CC type, ITGA1's gene rs1862610 locus AC/AA type and GSTM1 blank type in the GC was elevated vs. the control (P < 0.05); Logistic regression analysis manifested smoking, anxiety, helicobacter pylori infection, family history of gastrointestinal tumor, combination with chronic gastric disease, CASP3 gene and GSTM1 gene polymorphism were risk factors for GC (P < 0.05); Stratification was in the light of individual smoking status, discovering that the detection rates of CASP3 gene rs12108497 locus TC/CC type, ITGA1 gene RS1862610 locus AC/AA type and GSTM1 blank type in the smoking were crucially augmented vs. the smoking (P < 0.05); The detection rates of CASP3 gene rs12108497 locus TC/CC type, ITGA1 gene rs1862610 locus AC/AA type and GSTM1 blank type in the death were augmented vs. the survival (P < 0.05); Combined detection of CASP3, ITGA1 and GSTM1 gene polymorphisms was provided with predictive value for GCC's prognosis (P < 0.05). Conclusions: CASP3 and GSTM1 genes are susceptibility genes for GCC, which might be associated with the occurrence of GCC in smoking patients, and the joint detection of multiple genes is provided with predictive value for patients' prognosis.

Accurate location of the fault section in distribution networks is essential in ensuring power supply reliability and self-healing. Based on the extraction and analysis of fault feature information of automatic monitoring devices， this paper constructs the switching function and fitness function suitable for multi-state and different distributed power sources. It introduces additional fault criteria to improve the traditional fitness function. Moreover， it proposes an improved whale optimization algorithm based on multiple strategies. It uses the Sobol sequence to obtain a uniformly distributed initial population and uses differential variation perturbation factor and adaptive weight to improve the optimization accuracy and convergence speed. The simulation on an example shows that the improved whale optimization algorithm used in fault location is characterized by its strong fault tolerance， high fault identification rate， and optimization stability； Moreover， the algorithm can enhance the solution efficiency of fault location.

Block collapse or sliding is one of the main failure modes of rock slope engineering. Namely, block stability analysis plays a key role in rock slope engineering. Taking the Shenxianju rock slope in Xianju County, Zhejiang Province as the research background, this paper mainly conducts the stability analysis and visualization of rock blocks. A new method for fitting structural planes and free faces is proposed based on the linear regression method and the non-uniform rational B-spline method. Then, based on the coordinate projection method, the method for calculating the stability coefficients of the single sliding surface and double sliding surface blocks is proposed. Finally, the unmanned aerial vehicle (UAV) measurement technology combined with the coordinate projection method is used to develop a CPG program using MATLAB, which can be adopted in the stability analysis of planar polyhedron blocks and curved blocks in rock slope engineering. This program enables the spatial representation and visualization of structural planes, free faces and unstable blocks. Engineering practice shows that the new proposed method is effectively applicable to engineering geological disasters, such as rockfall and collapse. The results of the program calculation are basically consistent with those of the coordinate projection block theory, demonstrating that this method is reliable and the developed CPG program is feasible. This method is of vital significance in practical engineering since it can greatly improve the efficiency of block stability analysis.

Bio-inspired self-repairing hardware is a reconfigurable system characterized by high fault-tolerant ability. To further increase the placement performance and reduce the fault-tolerant cost, a dynamical evolution approach to multi-objective dynamic placement is developed. A primary challenge for our study is computational complexity. Based on group theory, the computing task was divided on the dimensions of time and space to increase the utilization of online computing resources. By introducing the multi-step placement transformation, a discrete dynamical system model was built and the multi-objective dynamic placement was converted into a stability problem of constrained systems. In order to satisfy the dynamical requirements, an artificial particle system model was built and its evolution laws were verified by dynamic analysis. By simulating the evolution laws, a dynamical evolution algorithm was proposed, which could avoid large-scale iterative calculation used in the conventional optimization search algorithms. Experiments have shown that the dynamical evolution method could offer high placement performance with low fault-tolerant cost. Besides, it also has the advantage of high design flexibility since there is no initial placement constraint.

The finite element model of a pair of straight bevel gears is established,and the simulation is carried out by using the ANSYS/LS-DYNA software to verify the accuracy of the simulation method. Based on this,a pair of zero spiral bevel gears are created for comparative analysis. According to the simulation results,the gear contact force,tooth surface contact stress,tooth root bending stress and vibration of large gear are compared and analyzed. It is found that the transmission characteristics of the straight bevel gear and the zero spiral bevel gear are obvious difference at the same load and speed. This provides a reference for the selection and application of these two types of bevel gears in the aeronautical field.

The strength of the new filling cementing material which is mixed by fly ash, lime, desulfurization gypsum and a small amount of cement is tested in order to apply to backfill mining in Xinyang coal mine.The optimum ratio of cement, lime, desulfurization gypsum and fly ash in coal mine is determined by orthogonal test method.Hydration mechanism of new filling materials is studied by the XRD and electron microscope scanning(SEM).The types of hydration products and the micro development form of cementitious materials at different ages are revealed.Finally a new type of backfilling cementing material is invented by mixing cementitious materials, coal and water and it's characteristics is compared with previous version.The results show that the best ratio of new cementing material for coal mine is Cement:Lime:Desulfurization gypsum:Fly ash=10%:1.8%:9%:79.2%;The main presence of hydration products is needle, linked through flocculent filamentous product when the curing age of the new cementing material is 3 days;The main forms of the hydration products are clusters, blocks or patches, and hydration products were closely bonded when the curing period reached 28 days;It was found that the new filling material can greatly reduce the cost of the cementitious material and apply to the requirement of filling mining in the Xinyang coal mine despite the intensity and bleeding rate and other indicators decreased slightly through comparing new type of backfilling cementing material with the high concentration of cemented filling materials at the same concentration.

This paper researches the Chang-Zhu-Tan urban agglomerations, uses the gravitational model and the field strength model, based on the gross production of the city, the urban population, economic distance and commuting time four aspects index system, calculates the gravitational and field strength values of the core city of Changsha to the Chang-Zhu-Tan urban agglomerations, and obtains theoretically spatial extent of the Chang-Zhu-Tan urban agglomerations. The result shows that: the spatial extent of the Chang-Zhu-Tan urban agglomerations the Government establishes is consistent with the spatial extent and theoretical calculations; while the 2.4 calculation result proves that the application of gravity model and field intensity model is feasible to define the spatial extent of urban agglomeration.

ABSTRACT: Numerical modeling of earthquake dynamics and derived insight for seismic hazard relies on credible, reproducible model results. The sequences of earthquakes and aseismic slip (SEAS) initiative has set out to facilitate community code comparisons, and verify and advance the next generation of physics-based earthquake models that reproduce all phases of the seismic cycle. With the goal of advancing SEAS models to robustly incorporate physical and geometrical complexities, here we present code comparison results from two new benchmark problems: BP1-FD considers full elastodynamic effects, and BP3-QD considers dipping fault geometries. Seven and eight modeling groups participated in BP1-FD and BP3-QD, respectively, allowing us to explore these physical ingredients across multiple codes and better understand associated numerical considerations. With new comparison metrics, we find that numerical resolution and computational domain size are critical parameters to obtain matching results. Codes for BP1-FD implement different criteria for switching between quasi-static and dynamic solvers, which require tuning to obtain matching results. In BP3-QD, proper remote boundary conditions consistent with specified rigid body translation are required to obtain matching surface displacements. With these numerical and mathematical issues resolved, we obtain excellent quantitative agreements among codes in earthquake interevent times, event moments, and coseismic slip, with reasonable agreements made in peak slip rates and rupture arrival time. We find that including full inertial effects generates events with larger slip rates and rupture speeds compared to the quasi-dynamic counterpart. For BP3-QD, both dip angle and sense of motion (thrust versus normal faulting) alter ground motion on the hanging and foot walls, and influence event patterns, with some sequences exhibiting similar-size characteristic earthquakes, and others exhibiting different-size events. These findings underscore the importance of considering full elastodynamics and nonvertical dip angles in SEAS models, as both influence short- and long-term earthquake behavior and are relevant to seismic hazard.

Dynamic modeling of sequences of earthquakes and aseismic slip (SEAS) provides a self-consistent, physics-based framework to connect, interpret, and predict diverse geophysical observations across spatial and temporal scales. Amid growing applications of SEAS models, numerical code verification is essential to ensure reliable simulation results but is often infeasible due to the lack of analytical solutions. Here, we develop two benchmarks for three-dimensional (3D) SEAS problems to compare and verify numerical codes based on boundary-element, finite-element, and finite-difference methods, in a community initiative. Our benchmarks consider a planar vertical strike-slip fault obeying a rate- and state-dependent friction law, in a 3D homogeneous, linear elastic whole-space or half-space, where spontaneous earthquakes and slow slip arise due to tectonic-like loading. We use a suite of quasi-dynamic simulations from 10 modeling groups to assess the agreement during all phases of multiple seismic cycles. We find excellent quantitative agreement among simulated outputs for sufficiently large model domains and small grid spacings. However, discrepancies in rupture fronts of the initial event are influenced by the free surface and various computational factors. The recurrence intervals and nucleation phase of later earthquakes are particularly sensitive to numerical resolution and domain-size-dependent loading. Despite such variability, key properties of individual earthquakes, including rupture style, duration, total slip, peak slip rate, and stress drop, are comparable among even marginally resolved simulations. Our benchmark efforts offer a community-based example to improve numerical simulations and reveal sensitivities of model observables, which are important for advancing SEAS models to better understand earthquake system dynamics.