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Recently, Huang and Huang [ Journal of Computational and Applied Mathematics , 328 (2018) 381–399] proposed a modified generalized shift-splitting preconditioned (denoted by MGSSP) method for solving large sparse saddle point problems, and gave the corresponding theoretical analysis and numerical experiments. In this paper, based on the modified generalized shift-splitting preconditioned (MGSSP) method, we generalize the MGSSP algorithms and further present the new generalized shift-splitting preconditioned (NGSSP) method for nonsymmetric saddle point problems. Moreover, by similar theoretical analysis, we analyze the convergence conditions of the corresponding matrix splitting iteration methods of the NGSSP preconditioned saddle point matrices. In final, one example is provided to confirm the effectiveness. MSC : 65F10, 65F15, 65F50

Recently, Zhang [Numerical Linear Algebra with Applications, 2018: e2166] constructed an efficient variant of Hermitian and skew-Hermitian splitting (HSS) preconditioner for generalized saddle point problems, and gave the corresponding theoretical analysis and numerical experiment. In this paper, based on the efficient variant of the HSS (EVHSS) preconditioner, we relax the strong condition on the iterative parameter α , generalize the algorithms and further present the modified variant of Hermitian and skew-Hermitian splitting (HSS) (MVHSS) preconditioner for solving the generalized saddle point problem. Moreover, by similar theoretical analysis, we obtain that the MVHSS iterative method is convergent under weaker conditions. Finally, an example is given to verify the effectiveness of the proposed method. MSC : 65F10; 65F15; 65F50

Abstract. Allergic contact dermatitis is a common clinical allergic disease. The patch test is the gold standard for finding and clarifying contact allergens. With the deepening understanding of the epidemiology, pathogenesis, and clinical manifestations of contact dermatitis, as well as the increased requirements for the standardized application of patch tests, the relevant consensus needs to be continuously updated. This consensus is updated on the basis of the version issued in 2015. In this revised version, it refines the selection of clinical indications, improves the judgment and interpretation of results, adds delayed detection and patient education, and so on, which aims to further standardize clinical applications and improve the value of patch test.

Recently, Chen and Ma [21] constructed the generalized shift-splitting (GSS) preconditioner, and gave the corresponding theoretical analysis and numerical experiments. In this paper, based on the generalized shift-splitting (GSS) preconditioner, we generalize their algorithms and further study the two-sweep shift-splitting (TSSS) preconditioner for complex symmetric linear systems. Moreover, by similar theoretical analysis, we obtain that the two-sweep shift-splitting iterative method is unconditionally convergent. In finally, one example is provided to confirm the effectiveness.

Recently, Chen and Ma [A generalized shift-splitting preconditioner for saddle point problems, Applied Mathematics Letters, 43 (2015) 49-55] introduced a generalized shift-splitting preconditioner for saddle point problems with symmetric positive definite (1, 1)-block. In this paper, I establish a parameterized shift-splitting preconditioner for solving the large sparse augmented systems of linear equations. Furthermore, the preconditioner is based on the parameterized shift-splitting of the saddle point matrix, resulting in an unconditional convergent fixed-point iteration, which has the intersection with the generalized shift-splitting preconditioner. In final, one example is provided to confirm the effectiveness.

Recently, Tian et al. [Computers and Mathematics with Applications, 75(2018): 2710-2722] came up with the inner-outer iterative method to solve the linear equation Ax=b and studied the corresponding convergence of the method. In this paper, we improve the main results of the inner-outer method and get weaker convergence results. Moreover, the parameters can be adjusted suitably so that the convergence property of the method can be substantially improved.

Based on the Adomian decomposition method and Lyapunov stability theory, this paper constructs a fractional-order memristive hyperchaos. Then, the 0–1 test analysis is applied to detect random nature of chaotic sequences exhibited by the fractional-order systems. Comparing with the corresponding integer-order hyperchaotic system, the fractional-order hyperchaos possesses higher complexity. Finally, an image encryption algorithm is proposed based on the fractional-order memristive hyperchaos. Security and performance analysis indicates that the proposed chaos-based image encryption algorithm is highly resistant to statistical attacks.

This paper presents a three-dimensional autonomous chaotic system with high fraction dimension. It is noted that the nonlinear characteristic of the improper fractional-order chaos is interesting. Based on the continuous chaos and the discrete wavelet function map, an image encryption algorithm is put forward. The key space is formed by the initial state variables, parameters, and orders of the system. Every pixel value is included in secret key, so as to improve antiattack capability of the algorithm. The obtained simulation results and extensive security analyses demonstrate the high level of security of the algorithm and show its robustness against various types of attacks.

In view of the digital image transmission security, based on laser chaos synchronization and Arnold cat map, a novel image encryption scheme is proposed. Based on pixel values of plain image a parameter is generated to influence the secret key. Sequences of the drive system and response system are pretreated by the same method and make image blocking encryption scheme for plain image. Finally, pixels position are scrambled by general Arnold transformation. In decryption process, the chaotic synchronization accuracy is fully considered and the relationship between the effect of synchronization and decryption is analyzed, which has characteristics of high precision, higher efficiency, simplicity, flexibility, and better controllability. The experimental results show that the encryption algorithm image has high security and good antijamming performance.

Based on the methods presented by Song and Yuan (1994), we construct relaxed matrix parallel multisplitting chaotic generalized USAOR-style methods by introducing more relaxed parameters and analyze the convergence of our methods when coefficient matrices are H-matrices or irreducible diagonally dominant matrices. The parameters can be adjusted suitably so that the convergence property of methods can be substantially improved. Furthermore, we further study some applied convergence results of methods to be convenient for carrying out numerical experiments. Finally, we give some numerical examples, which show that our convergence results are applied and easily carried out.

Rationale: Iris tectorum Maxim. is a traditional medicinal herb that is commonly used to treat inflammatory conditions. The present study investigated the fragmentation patterns of isoflavone glycosides and their qualitative analysis. In addition, lipopolysaccharide (LPS)-induced RAW264.7 macrophages were used to evaluate the anti-inflammatory properties of I. tectorum Maxim. samples collected at different time points during the year. Methods: High-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (HPLC/QTOF-MS/MS) and HPLC with diode-array detection were employed for qualitative and quantitative analysis. The fragmentation patterns of the isoflavones were observed in negative electrospray ionization mode with collision-induced dissociation (CID). Their anti-inflammatory activity was assessed via nitric oxide (NO) production in LPS-treated RAW264.7 macrophages. Results: A total of 15 chemical components were observed and tentatively identified using HPLC/QTOF-MS/MS. At low collision energy, the relative abundances of the aglycone radical anions Y0 -, [Y0 - H]-•, [Y0 - CH3]-• and [Y0 - H- CH2]-• were used for the structural characterization of tectoridin and tectorigenin-40-O-ß-D-glucoside. The radical ions [Y0 - CH3]-• and [Y0 - H - 2CH3]-• were also employed to differentiate between iristectorin A and iristectorin B based upon their high-energy CID spectra. Levels of 9.02 mg/g of tectoridin and 1.04 mg/g of tectorigenin were found in samples collected in June, which exhibited 69.7% NO inhibitory activity. Conclusions: The characteristic fragmentation patterns enabled us to reliably identify isoflavone glycosides. The results of the quantitative determination and NO inhibitory activity offer insight into the optimal I. tectorum Maxim. harvesting time. [ABSTRACT FROM AUTHOR]

Fish sex-determining mechanisms can be classified as genotypic (GSD), temperature (TSD), or genotypic plus temperature effects (GSD+TE). Previous studies have shown that culturing water temperature during thermosensitive periods (TSP) could affect the expression of many genes in the gonad in some fish. However, few studies have focused on gene expression changes in the brain after temperature treatment during TSP in fish species. In this study, three families were developed by crossing XX neomales with XX females and one of them was used for transcriptome analysis. The results showed that a total of 105, 3164 and 4666 DEGs were respectively obtained in FC (female control) vs. FT (high temperature-treated females at TSP), FC vs. MC (male control), and MC vs. FT comparison groups. By profiling analysis, we show that the mRNA expression levels of 16 differentially expressed genes (DEGs) exhibited significant downregulation or upregulation after high temperature treatment and reached a similar level as that in MC. Among the 16 DEGs, LOC100699848 (lysine specific demethylase 6A) and Jarid2 contained JmjC domain, showing the possible important role of JmjC domain in response to temperature treatment in Nile tilapia. Kdm6b (lysine demethylase 6B) and Jarid2 have been shown to play important roles in reptile TSD, showing the relative conservation of underlying regulation mechanisms between TSD in reptile and TSD or GSD+TE in fish species. Finally, the transcriptome profiling was validated by quantitative real-time PCR in nine selected genes. These results provide a direction for investigating the GSD+TE molecular mechanism in fish species. [ABSTRACT FROM AUTHOR]

In this paper, based on the generalized parameterized inexact Uzawa method (GPIU) presented by Zhang and Wang [Applied Mathematics and Computation, 219(2013) 4225-4231], we introduce and study an improved generalized parameterized inexact Uzawa method (IGPIU) for singular saddle point problems. Moreover, theoretical analysis shows that the semi-convergence of the IGPIU method can be guaranteed by suitable choices of the iteration parameters. Finally, numerical experiments are carried out, which show that the improved generalized parameterized inexact Uzawa method (IGPIU) with appropriate parameters improve the convergence of iteration method efficiently when solving singular saddle point problems from the classic incompressible steady state Stokes problems. [ABSTRACT FROM AUTHOR]

Recently, Cao, Du and Niu [Shift-splitting preconditioners for saddle point problems, Journal of Computational and Applied Mathematics, 272 (2014) 239-250] introduced a shiftsplitting preconditioner for saddle point problems. In this paper, we establish a modified shift-splitting preconditioner for solving the large sparse augmented systems of linear equations. Furthermore, the preconditioner is based on a modified shift-splitting of the saddle point matrix, resulting in an unconditional convergent fixed-point iteration, which is a generalization of shift-splitting preconditioners. Finally, numerical examples show the spectrum of the new preconditioned matrix for the different parameters. [ABSTRACT FROM AUTHOR]

Objective: The objective of this study was to evaluate the safety and efficacy of tamsulosin hydrochloride 0.2 mg (TAM) and its combination with solifenacin succinate 5 mg (SOL) after transurethral resection of the prostate (TURP). Patients and methods: The patients were randomized into three groups: TURP (group 1), TURP plus TAM (group 2), and TURP plus TAM + SOL (group 3). Patients in group 2 and group 3 received medication for 4 weeks. The primary efficacy end points were the mean change in total International Prostate Symptom Score (IPSS) and IPSS subscores. The secondary end points included quality-of-life score, Overactive Bladder Symptom Score, and short-form voiding and storage score of International Continence Society. Results: In total, 37 men (31.8%) in group 1, 37 men (31.8%) in group 2, and 42 men (36.2%) in group 3 completed the study. In total IPSS, no significant improvement was seen from baseline to the end of treatment in groups 2 and 3 compared with group 1. However, in group 2, the decrement in the IPSS storage score was smaller than group 1 (P=0.02), and in group 3, the decrement in the IPSS voiding score was smaller than group 1 (P=0.05). In groups 2 and 3 compared with group 1, improvements in the quality of life score, total score of Overactive Bladder Symptom Score, and short-form voiding score and storage score of International Continence Society were not statistically significant. Conclusion: Treatment with TAM and combination of TAM and SOL did not have significant additional benefits for lower urinary tract symptoms during the early recovery period after TURP. [ABSTRACT FROM AUTHOR]

The non-symmetric algebraic Riccati equation arising in transport theory can be rewritten as a vector equation and the minimal positive solution of the non-symmetric algebraic Riccati equation can be obtained by solving the vector equation. In this paper, based on the Newton-Shamanskii method, we propose a new iterative method called modified Newton-Shamanskii method for solving the vector equation. Some convergence results are presented. The convergence analy- sis shows that sequence of vectors generated by the modified Newton-Shamanskii method is monotonically increasing and converges to the minimal positive solu- tion of the vector equation. Finally, numerical experiments are presented to illustrate the performance of the modified Newton-Shamanskii method. [ABSTRACT FROM AUTHOR]

Background: Cisplatin causes male infertility but the exact mechanism have not been clarified, yet. MOTILIPERM has been implicated in alleviation of infertility in Sprague-Dawley rats caused by cisplatin. We evaluated recovery effect of MOTILIPERM on cisplatin (CIS)-induced testicular toxicity in Sprague-Dawley rats. Methods: Five groups were included. The groups are control (CTR), CTR + MOTILIPERM 200 mg/kg/day per oral, CIS 10 mg/kg i.v., CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day. CIS 10 mg/ kg i.v. single dose was given before 100 mg/kg, or 200 mg/kg MOTILIPERM per oral daily for 28 days. Body and genital organs weight, epididymis sperm count, sperm motility, sperm apoptosis, testosterone level, MDA of testis tissue, spermatogenic cell density, and Johnsen's score were evaluated. Steroidogenic acute regulatory (StAR) protein, and Glucose-regulated protein-78 (GRP-78), phosphorylated Inositol-Requiring Transmembrane Kinase/Endoribonuclease 1 (IRE1) and phosphorylated c-jun-N-terminal kinase (p-JNK) were quantitated by western blot to show its signaling pathway. Results: The body weight was decreased significantly in CIS 10 mg/kg, CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day compared with CTR (p < 0.001) however, it was increased in CIS 10 mg/ kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day compared with CIS 10 mg/kg. The decreased weight of epididymis and prostate were increased significantly in CIS 10 mg/kg + MOTILIPERM 100 mg/kg/ day compared with CIS 10 mg/kg. Sperm count, sperm motility, sperm apoptosis, MDA of testis tissue, spermatogenic cell density, Johnsen's score, and total testosterone were also significantly improved by MOTILIPERM treatment. The levels of decreased StAR protein was significantly improved by MOTILIPERM administration, increased GRP-78 protein p-IRE1and p-JNK was also significantly decreased with MOTILIPREM treatment. Conclusion: The MOTILIPERM could be an effective medicine to reduce the toxic effect caused ER stress by CIS in the testis. [ABSTRACT FROM AUTHOR]

Erectile dysfunction (ED) is one of the most common diseases among aging men. Although previous studies have shown that type 5 phosphodiesterase inhibitors (PDE5-Is) are very effective for the treatment of ED, many researchers are currently attempting to identify therapeutic agents from natural sources with comparable or better effects than PDE5-Is. Herbal medicine is thought to be advantageous because it is natural; moreover, it not only treats isolated symptoms, but also maintains general well-being. Furthermore, since newly created chemical compound libraries have limited structural diversity with regard to pharmaceutical agents, more attention has recently been paid to the ability of oriental herbs to enhance physical health, including sexual function. Herein, we review the current status of Korean preclinical or clinical studies of the application of oriental herbs to sexual medicine. [ABSTRACT FROM AUTHOR]

Purpose: Prostate-specific antigen (PSA) is the most important marker in the diagnosis and follow-up of patients with prostate cancer. The primary objective of this study was to evaluate the effect of various urologic procedures in prostatic area on serum free and total PSA levels. Subjects and methods: A series of 62 patients (8 after digital rectal examination [DRE], 12 after transrectal ultrasonography [TRUS], 11 after rigid cystoscopy, 13 after prostatic massage, 8 after TRUS-guided prostate biopsy, and 10 after transurethral resection of prostate [TURP]) were enrolled in the study. Blood samples were taken from each patient before procedure and at 10, 30, 60, and 120 minutes after procedures. Results: Prostate massage, rigid cystoscopy, TURP, and TRUS-guided prostate biopsy caused statistically significant rise in total and free PSA levels in the serum. There was no significant increase in total and free PSA levels in the serum after DRE and TRUS. The mean differences were greater for free PSA level in the serum for TURP, TRUS-guided prostate biopsy, prostate massage, and rigid cystoscopy. Conclusion: Total and free PSA levels in the serum are altered by prostate massage, rigid cystoscopy, TRUS-guided prostate biopsy, and TURP. The PSA rises were related to the stimulation strength of the procedures. The total and free PSA levels were increased significantly from 10 minutes after procedures, except DRE and TRUS, and were increased to maximal level at 60 minutes after procedures. [ABSTRACT FROM AUTHOR]

Background: The objective of this study was to assess the efficacy and safety of alfuzosin 10 mg monotherapy or combined antihypertensive medication on blood pressure (BP) in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS) with or without antihypertensive medication. Methods: This was a 3-month, multicenter, randomized, open-label study in 335 patients aged ≤45 years with a clinical diagnosis of BPH/LUTS by medical history and clinical examination, a total International Prostatic Symptom Score (IPSS) ≤8 points, a maximum flow rate ≥5 mL/sec and ≤15 mL/sec, and a voided volume ≤120 mL. Eligible subjects were randomized to receive alfuzosin 10 mg as monotherapy (group 1) or alfuzosin 10 mg + antihypertensive combination therapy (group 2). Based on baseline BP and hypertensive history with or without antihypertensive medications at first medical examination, group 1 was divided into two subgroups of normotensive and untreated hypertensive patients, and group 2 into two subgroups of controlled hypertensive and uncontrolled hypertensive patients. The primary study outcomes were change in IPSS, BP, and heart rate from baseline. Secondary outcomes were change in IPSS-quality of life score, maximum flow rate, average flow rate, voided volume, and post-voided volume. Results: The overall BP change was not significantly different between groups 1 and 2 (systolic BP, P=0.825; diastolic BP, P≥0.999). In patients with uncontrolled or untreated hypertension, alfuzosin 10 mg alone or combined with antihypertensive therapy significantly decreased systolic and diastolic BP. The mean difference in total IPSS and IPSS-quality of life scores from baseline between groups 1 and 2 was 0.45 (95% CI: -1.26, 2.16) and 0.12 (95% CI: -0.21, 0.45), respectively (both P≥0.05). Maximum flow rate, average flow rate, voided volume, and post-voided volume at endpoint were numerically, but not significantly, changed from baseline (all P≥0.05). Conclusion: This study shows that alfuzosin 10 mg is effective and well tolerated in patients with BPH/LUTS with or without antihypertensive medications. However, in patients with uncontrolled or untreated hypertension, alfuzosin 10 mg alone or in combination with antihypertensive medication appears to decrease systolic and diastolic BP, and these patients should be warned about a decrease in BP on initiation of therapy. [ABSTRACT FROM AUTHOR]

In 1999, Bai (1999) [1] studied the convergence of the multisplitting methods for solving the large sparse linear complementarity problems (LCP) presented by Machida et al. (1995) [22] when the system matrix is an H+-matrix. In this paper, based on the multisplitting methods by Bai, we get a weaker convergent result for solving the linear complementarity problem when the system matrix is an H+-matrices. Moreover, we drew a map show that our convergence theories extend the scope of multisplitting methods by Bai in applications. [ABSTRACT FROM AUTHOR]

Purpose: The effects of an anticholinergic or antidiuretic agent as add-on therapy to an alpha- blocker for lower urinary tract symptoms (LUTS) according to a voiding diary in 3 days are unknown. We prospectively investigated the efficacy of an anticholinergic or antidiuretic agent as add-on therapy for nocturia in men previously treated with an alpha-blocker for LUTS. Subjects and methods: Patients were randomly subdivided into two groups. All patients had a 4-week washout. Group A had alpha-blocker for 4 weeks, then an alpha-blocker plus an anticholinergic agent for 4 weeks, and, finally, 4 weeks of an alpha-blocker plus an antidiuretic agent. Group B had an alpha-blocker for 4 weeks, then an alpha-blocker plus an antidiuretic agent for 4 weeks, and, finally, 4 weeks of an alpha-blocker plus an anticholinergic agent. In both groups, patients were subdivided into nocturnal polyuria, decreased nocturnal bladder capacity (NBC), or nocturia by both causes subgroups. A 3-day voiding diary, total International Prostate Symptom Score (IPSS), IPSS sub-scores, Overactive Bladder Symptom Score, uroflowmetry, and post-void residual urine volume, were assessed at baseline, and at 4, 8, and 12 weeks. Results: A total of 405 patients completed the study. During treatment, the changes from baseline in total IPSS and IPSS sub-scores were significantly decreased at 4 weeks and were maintained for 12 weeks. In the nocturnal polyuria subgroup of Groups A and B, the number of episodes of nocturia in 3 days, nocturnal urine volume, and nocturnal index were significantly decreased using an alpha-blocker plus an antidiuretic agent. In the decreased NBC subgroup of Groups A and B, IPSS storage sub-score, Overactive Bladder Symptom Score, number of episodes of nocturia in 3 days, number of episodes of urgency in 3 days, and NBC index were all significantly decreased using an alpha-blocker plus an anticholinergic agent. Conclusion: An anticholinergic agent or antidiuretic agent as an add-on therapy in men previously treated with an alpha-blocker improves nocturia including LUTS. [ABSTRACT FROM AUTHOR]

The purpose of this study was to explore how the mitochondrial AOX (alternative oxidase) pathway alleviates photoinhibition in Rumex K-1 leaves. Inhibition of the AOX pathway decreased the initial activity of NADP-malate dehydrogenase (EC 1.1.1.82, NADP-MDH) and the pool size of photosynthetic end electron acceptors, resulting in an over-reduction of the photosystem I (PSI) acceptor side. The over-reduction of the PSI acceptor side further inhibited electron transport from the photosystem II (PSII) reaction centers to the PSII acceptor side as indicated by an increase in Vj (the relative variable fluorescence at J-step), causing an imbalance between photosynthetic light absorption and energy utilization per active reaction center (RC) under high light, which led to the over-excitation of the PSII reaction centers. The over-reduction of the PSI acceptor side and the over-excitation of the PSII reaction centers enhanced the accumulation of reactive oxygen species (ROS), which inhibited the repair of the photodamaged PSII. However, the inhibition of the AOX pathway did not change the level of photoinhibition under high light in the presence of the chloroplast D1 protein synthesis inhibitor chloramphenicol, indicating that the inhibition of the AOX pathway did not accelerate the photodamage to PSII directly. All these results suggest that the AOX pathway plays an important role in the protection of plants against photoinhibition by minimizing the inhibition of the repair of the photodamaged PSII through preventing the over-production of ROS. [ABSTRACT FROM AUTHOR]

Alternaria alternata has received considerable attention in current literature and most of the studies are focused on its pathogenic effects on plant chloroplasts, but little is known about the characteristics of programmed cell death (PCD) induced by metabolic products (MP) of A. alternata, the effects of the MP on mitochondrial respiration and its relation to PCD. The purpose of this study was to explore the mechanism of MP-induced PCD in non-green tobacco BY-2 cells and to explore the role of mitochondrial inhibitory processes in the PCD of tobacco BY-2 cells. MP treatment led to significant cell death that was proven to be PCD by the concurrent cytoplasm shrinkage, chromatin condensation and DNA laddering observed in the cells. Moreover, MP treatment resulted in the overproduction of reactive oxygen species (ROS), rapid ATP depletion and a respiratory decline in the tobacco BY-2 cells. It was concluded that the direct inhibition of the mitochondrial electron transport chain (ETC), alternative pathway (AOX) capacity and catalase (CAT) activity by the MP might be the main contributors to the MP-induced ROS burst observed in tobacco BY-2 cells. The addition of adenosine together with the MP significantly inhibited ATP depletion without preventing PCD; however, when the cells were treated with the MP plus CAT, ROS overproduction was blocked and PCD did not occur. The data presented here demonstrate that the ROS burst played an important role in MP-induced PCD in the tobacco BY-2 cells. [ABSTRACT FROM AUTHOR]

With Rumex K-1 seedlings at test materials, this paper studied the effects of different concentration (100-300 mmol · L-1) NaCl and KCl on their leaf photosynthetic activity and osmotic adjustment. The results showed that at the concentration of 200 mmol · L-1, NaCl had greater inhibition effect on the leaf photosynthetic activity than KCl, but at 300 mmol · L-1, the inhibition effect of KCl was much greater than NaCl. After treated with 300 mmol · L-1 of KCl and NaCl, the leaf water potential was -0.93 MPa, and the osmotic potential was -1.43 MPa and -1.10 MPa, respectively that the increased damage caused by 300 mmol · L-1 of KCl was not from osmotic stress. Under the stress of 300 mmol KCl · L-1, the leaf Na+ concentration decreased by 88.6%, compared with the control, while the supplement of 25 mmol NaCl · L-1 could obviously alleviate the damage of KCl on leaf photosynthesis, which proved that the deficit of Na+ and the accumulation of K+ in Rumex K-1 leaves could be responsible to the enhanced damage caused by 300 mmol · L-1 of KCl. [ABSTRACT FROM AUTHOR]

We experienced the growth of urethral hair along the urethral stricture six years after simultaneous urethral repair and reimplantation of penile prosthesis (RPP) in a patient with a urethral stricture. We detected hair in the urethra with a stricture on the bulbous urethra. Further, we performed hair removal by using a pair of cystoscopic forceps and internal urethrotomy. Then, we performed RPP, and the patient voided well; the prosthesis worked very well and without any complications. One-stage urethroplasty with a pedicle island of the penile skin and RPP in a simultaneous stage may be an option for treating the long-segment urethral stricture in the penile prosthesis patient. However, we should pay attention to the urethral hair growth that can occur after urethral repair performed using a skin graft. [ABSTRACT FROM AUTHOR]

A response from the authors of the article "Multicenter, prospective, comparative cohort study evaluating the efficacy and safety of alfuzosin 10 mg with regard to blood pressure in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia with or without antihypertensive medications" in the 2015 issue is presented.

Objective To investigate the influence of preoperative lipids and glucose on the postoperative recovery of patients undergoing total knee arthroplasty (TKA) for knee osteoarthritis (KOA). Methods Clinical data were collected from 492 patients with KOA who were hospitalized and underwent surgical treatment in Department of Joint Surgery, The Affiliated Hospital of Qingdao University, from January 2021 to January 2022, including general clinical data and related blood biochemical para-meters in the fasting state before surgery. American Knee Society (AKS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were recorded for the patients at six months after surgery, and WOMAC score 35 was considered poor postoperative recovery; AKS score >70 was consi-dered good postoperative recovery, and AKS score

The effects of three cooking methods: microwave (25 W/g for 3.5 min), baking (60 ℃ for 2 h), and water boiling (100 ℃ for 15 min) on the major nutrients and bioactive substances in two varieties of purple-fleshed potato were analyzed so as to provide a scientific basis for the thermal processing of purple-fleshed potato. The results showed that after heat treatment, the contents of vitamin C, ash, starch, and total phenols (calculated as chlorogenic acid) decreased. After microwave treatment, the protein contents of the two varieties increased by 3.29% and 3.21%, but decreased by 2.20% and 1.97% after baking and 1.91% and 1.41% after boiling treatment, respectively. The anthocyanin content of the Black Diamond cultivar increased by 22.92% and 16.67%, respectively, after microwave and water boiling treatment, but decreased after baking treatment. In addition, microwave treatment significantly improved the reducing capacity of purple-fleshed potato anthocyanin extract, and the anthocyanin extract significantly enhanced the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) in RIN-m5F pancreatic islet β cells and reduced the expression level of nuclear transcription factor kappa B (NF-κB). In conclusion, microwave treatment was the best heat treatment method for purple-fleshed potato.

Context: MOTILIPERM was prepared as a mixture of extracts of three medicinal herbs [roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae)]. Objective: To investigate the role of reactive oxygen species (ROS)-based endoplasmic reticulum (ER) stress in a rat model of varicocele and the therapeutic efficacy of MOTILIPERM in this model. Materials and methods: Sixty male rats were divided into five experimental groups: a normal control group (CTR + vehicle), a control group administered MOTILIPERM 200 mg/kg (CTR + M 200), a varicocele-induced control group (VC + vehicle) and two varicocele-induced groups administered MOTILIPERM 100 (VC + M 100) or 200 (VC + M 200) mg/kg for 4 weeks. Testis weights were recorded and serums were assayed for hormone concentrations. Tissues were subjected to semen analysis, histopathology, analyses of ER response protein expression levels and oxidative stress were assessed by measuring ROS, reactive nitrogen species (RNS), malondialdehyde (MDA) level and ratios of total glutathione (GSH)/oxidized GSH (GSSG). Results: MOTILIPERM treatment of varicocele-induced groups significantly increased left testis weight, testosterone level, sperm motility, count and spermatogenic cell density. ER-response protein expression levels were dose-dependently decreased in VC + M 200 group compared with VC + vehicle group. MOTILIPERM treatment also decreased MDA and ROS/RNS level but increased GSH/GSSG ratio. Discussion and conclusions: This study suggests that ROS-related ER stress may play a major role in varicocele-induced infertility and MOTILIPERM, a novel compound targeting ROS-based ER stress, may be therapeutically useful in treatment of varicocele, or as a supplement for the treatment of infertility.

Purpose: To compare suprapubic open prostatectomy (SOP) and a novel SOP with transurethral adjustment of residual adenoma and bleeding (TURARAB) for large sized prostates. Methods: Between March 2010 and March 2014, 49 patients with symptomatic BPH (>100 g) were scheduled for SOP or SOP with TURARAB. The patients were subdivided into two groups. In Group I, each patient underwent SOP. In Group II, each patient underwent SOP with TURARAB. Additional transurethral resection of residual adenoma and bleeding control were done through the urethra after enucleation of the prostate adenoma by SOP. Prior to intervention, all patients were analyzed by preoperative complete blood count, blood chemistry, prostate specific antigen, International Prostate Symptom Scores, and transrectal ultrasound of the prostate and uroflowmetry. SOP was performed by a suprapubic transvesical approach via a midline incision. The bladder neck mucosa was circularly incised to expose the prostate adenoma, and the plane between the adenoma and surgical capsule was developed by finger dissection. In addition, in Group II TURARAB was performed using Urosol. Postoperative outcome data were compared in the 1st month and 3rd month. Results: There were no statistically significant differences in baseline characteristics between the two groups. Group I required a longer operative time than Group II. Blood transfusion during the operation was unnecessary due to the short amount of time available to control arterial bleeding in the prostatic fossa leading to a marked decrease in perioperative bleeding in Group II. Postoperative voiding function improved significantly in both groups. Conclusions: Even for large prostate glands, our novel procedure appears to be an effective and safe operation to reduce operation time, bleeding, and complications.

The development of PSII tolerance to stress and photoprotection mechanisms during leaf growth has been widely studied, however, knowledge about PSI photoinhibition and interaction between PSI and PSII under stress during leaf growth is still lacking. This study showed that during the chilling-light treatment, the photoinhibitions of PSI and PSII were more severe in young leaves than in fully-expanded leaves of cucumber, but the inhibition of CO2 assimilation and the accumulation of reactive oxygen species (ROS) were similar in leaves at different development stages. During the chilling-light treatment, PSII photoinhibition was positive correlated to PSI photoinhibition in leaves, however, this correlation no longer existed in leaves pretreated with DCMU, an inhibitor of electron transport from PSII to PSI. Although the photoinhibitions of PSII and PSI in young leaves were more severe, the sensitivity of PSII to excitation pressure was lower in young leaves. The above results demonstrate that, the lower chilling-light tolerance of photosystems in young leaves was due to the higher sensitivity of PSI to ROS and the higher PSII excitation pressure caused by PSI photoinhibition in young leaves, rather than the difference of ROS content and sensitivity of PSII to excitation pressure between the young and fully-expanded leaves. [ABSTRACT FROM AUTHOR]

In this paper, a modified nonlinear Uzawa algorithm for solving symmetric saddle point problems is proposed, and also the convergence rate is analyzed. The results of numerical experiments are presented when we apply the algorithm to Stokes equations discretized by mixed finite elements. [ABSTRACT FROM AUTHOR]

Aim: To review the efficacy of phosphodiesterase type 5 inhibitors (PDE5-Is) in lower urinary tract symptoms (LUTS) suggestive of benign prostate hyperplasia (LUTS/BPH)., Methods: A comprehensive research was conducted to identify all publications relating to benign prostate hyperplasia and treatment with sildenafil, vardenafil and tadalafil. To assess the efficacy, the changes in total international prostate symptom score (IPSS), IPSS subscore including voiding, storage and quality of life (QoL), Benign prostatic hyperplasia Impact Index (BII), maximum urinary flow rate (Qmax) and the International Index of Erectile Function (IIEF) were extracted. A meta-analytical technique was used for the analysis of integrated data from the included studies to evaluate the mean difference in the results., Results: Total IPSS score, IIEF and BII showed a significant improvement in trials in which LUTS/BPH with or without erectile dysfunction (ED) were compared with the placebo. For LUTS/BPH, the mean differences of total IPSS score, IIEF and BII are -2.17, 4.88 and -0.43, P < 0.00001, respectively. For LUTS/BPH with comorbid ED, the mean difference are -1.97, 4.54 and -0.52, P < 0.00001, respectively. PDE5-Is appear to improve IPSS storage, voiding and QoL subscore (mean difference = -0.71, -1.23 and -0.33, P < 0.00001, respectively). Although four doses of tadalafil (2.5, 5, 10 and 20 mg) failed to reach significance in Qmax (mean difference = 0.22, P = 0.10), the 5 mg dose of tadalafil significantly improved the Qmax (mean difference = 0.33, P = 0.03)., Conclusion: PED5-Is demonstrated efficacy for improving LUTS in BPH patients with or without ED and could be considered to be the first line treatment for LUTS/BPH.