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This study examined the relationship between job satisfaction and unethical pro‐organizational behaviours (UPB) by testing a moderated mediation model that focused on how employees' belongingness mediates the relationship between job satisfaction and UPB and how corporate ethical values moderate this mediated relationship. Our investigation included 369 employees from different organizations in Southeast China. The regression analysis revealed that job satisfaction positively influences UPB through belongingness. In addition, a moderated regression analysis indicated that low corporate ethical values strengthen not only the effect of belongingness on UPB but also the indirect effect of job satisfaction on UPB. These findings deepen our understanding of UPB by showing that individuals with a high level of job satisfaction are more likely to engage in UPB through belongingness when corporate ethical values are low. Finally, the theoretical and managerial implications of these results are discussed. [ABSTRACT FROM AUTHOR]

Abundant evidence has demonstrated an association between parental psychological control and adolescent aggressive behavior. However, the mediating and moderating mechanisms underlying this relation are still under-investigated. Grounded in the social development model and stress-buffering model, this study investigated whether deviant peer affiliation mediates the relation between parental psychological control and adolescent aggressive behavior, and whether this indirect link is moderated by school connectedness. A total of 4265 adolescents (Mean age = 13.66 years, SD = 2.74, 48.63% male) from southern China completed questionnaires regarding parental psychological control, deviant peer affiliation, school connectedness, and aggressive behavior. Structural equation models revealed that the relation between parental psychological control and aggressive behavior is partially mediated by deviant peer affiliation. Moreover, this indirect link was stronger for adolescents with low levels of school connectedness than for those with high levels of school connectedness. This study thus identifies the potential underlying mechanism by which parental psychological control is associated with adolescent aggressive behaviors, which has important implications for theory and prevention. [ABSTRACT FROM AUTHOR]

A small-molecule amino-functionalized organoplatinum(ii) complex Pt–N has been developed. The unique properties of Pt–N, including a well-defined chemical structure, an excellent solubility in environmentally friendly polar solvents and good electron extraction to high work-function metals, make it a promising candidate for cathode interfacial modification of solution processed multilayer polymer solar cells (PSCs). The resultant PSCs with an ITO/PEDOT:PSS/PTB7:PC71BM/interlayer/Al device configuration exhibited significantly improved efficiencies from 3.62% for an unmodified device to 8.89% by using a Pt–N cathode interlayer, benefiting from the dramatic enhancement in the open circuit voltage (0.53 V for bare Al PSCs to 0.75 V for Pt–N/Al PSCs), the fill factor (43.58% for bare Al PSC to 72.49% for Pt–N/Al PSC), and a slight increase in short-circuit current density. These results indicate that Pt–N is a new promising candidate as the cathode interlayer for highly efficient PSCs. [ABSTRACT FROM AUTHOR]

In this work, first-principle calculations at different levels of theory have been carried out to investigate a series of complexes formed between iodo-perfluorobenzene and several heteroatomic rings. Such model systems are selected to mimic halogen bonding interactions experimentally found within supramolecular architectures. In all cases, the predicted intermolecular distances are significantly shorter than the sums of van der Waals radii of I and N (O or S) atoms and the interactions appear to be highly directional. Halogen bonding energies, calculated at the MP2/lan12dz level, are substantial, ranging from −2.50 to −7.53 kcal/mol. Given the strength as well as the directionality comparable to hydrogen bonds, these synthons should be of general use in many fields of chemistry. Finally, to gain more insights into the nature of such interactions, we have used the natural bond orbital and atoms in molecules analyses on the studied systems, which show a considerable magnitude of charge transfer, significant orbital interaction, and distinct bond critical points between the two interacting atoms. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011 [ABSTRACT FROM AUTHOR]

Abstract: In this work, a systematic theoretical investigation on a series of dimeric complexes formed between MH2 and HX has been carried out by employing correlated ab initio methods. It was shown that besides dihydrogen bonds, there also exists novel noncovalent X⋯H interactions between the two molecules, which have similar characteristics to traditional halogen bonds. Upon complexation, the Hend to elongate in all cases, concomitant with red-shifts of the Hing frequencies. X⋯H interaction energies, calculated at the MP2/aug-cc-pvtz level, range from −2.11 to −11.78kJ/mol; the interactions are much weaker than corresponding dihydrogen bonds. The major stabilization source of dihydrogen and halogen bonds arises from the electrostatic force, while charge-transfer force plays a minor role in the formation of the complexes. AIM analyses further confirm the presence of X⋯H interactions in the systems, and the electron density at bond critical points correlates fairly well with the interaction energy. [Copyright &y& Elsevier]

Background: The underlying molecular mechanisms of the excitatory/inhibitory (E/I) imbalance induced by sevoflurane exposure to neonates remain poorly understood. This study aimed to investigate the long-term effects of prolonged sevoflurane exposure to neonatal rats during the peak period of synaptogenesis on the changes of trans-synaptic neurexin-neuroligin interactions, synaptic ultrastructure in the hippocampus and cognition.Methods: A total of 30 rat pups at postnatal day (P) 7 was randomly divided into two groups: the control group (exposed to 30 % oxygen balanced with nitrogen) and the sevoflurane group (exposed to 2.5 % sevoflurane plus 30 % oxygen balanced with nitrogen) for 6 h. Neurocognitive behaviors were assessed with the Open field test at P23-25 and the Morris water maze test at P26-30. The expression of β-neurexin (β-NRX), N-methyl-d-aspartate receptor 2 subunit (NR2A and NR2B), neuroligin-1 (NLG-1), neuroligin-2 (NLG-2), postsynaptic density protein-95 (PSD-95), α1-subunit of the γ-aminobutyric acid A receptor (GABAAα1) and gephyrin in the hippocampus at P30 were measured by Western blot. The ultrastructure of synapses was examined under electron microscope.Results: Prolonged sevoflurane exposure at P7 resulted in cognitive deficiency in adolescence, as well as the downregulation of β-NRX, NR2A, NR2B, NLG-1, and PSD-95, and the upregulation of GABAAα1, NLG-2, and gephyrin in the hippocampal CA3 region. Sevoflurane anesthesia also increased the number of symmetric synapses in the hippocampus.Conclusions: Prolonged sevoflurane exposure during the brain development leads to cognitive deficiency and disproportion of excitatory/inhibitory synapses which may be caused by dysregulated expression of synaptic adhesion molecules of β-NRX and neuroligins. [ABSTRACT FROM AUTHOR]

The balance of excitatory and inhibitory neurons in the central nervous system is critical for maintaining brain function and sevoflurane, a general anesthetic and an GABA receptor modulator, may change the balance of excitatory and inhibitory neurons in the cortex during early brain development. Herein, we investigated whether prenatal sevoflurane exposure (PSE) disturbs cortical neuronal development and brain function. Pregnant rats at the gestational day 14.5 were subjected to sevoflurane exposure at 3.0% for 3 h and their offspring were studied thereafter. We found a significant increase of parvalbumin-positive neurons, vesicular GABA transporter (VGAT) and GAD67 expression, and GABA neurotransmitter, and a significant decrease of vesicular glutamate transporter 1 (VGLUT1) expression and glutamate in the medial prefrontal cortex (mPFC) of offspring. Pyramidal neurons showed atrophy with shorter dendrites, less branches and lower spine density visualized by Golgi stain and a decrease of excitability with the increased miniature inhibitory postsynaptic current (mIPSC) frequency and amplitude, the decreased miniature excitatory postsynaptic current (mEPSC) frequency and excitation/inhibition (E/I) ratio using whole-cell recording in offspring. There was a significant increase of inhibitory synapse in the mPFC detected by electron microscopy. Furthermore, PSE animals showed hypo-excitatory phenotype including depression-like behaviors and learning deficits. Thus, our studies provide novel evidence that PSE causes the persisted imbalance of excitatory and inhibitory neurons in the mPFC, and this is very likely the mechanisms of the sevoflurane-induced brain functional abnormalities. • Prenatal sevoflurane exposure (PSE) enhanced GABAergic neurotransmission. • PSE resulted in pyramidal neuron atrophy. • PSE changed the E/I balance in the prefrontal cortex. • PSE caused depression-like behaviors and learning deficits. [ABSTRACT FROM AUTHOR]

The development of the embryo sac is an important factor affecting seed setting in rice. Numerous genes associated with embryo sac (ES) development have been identified in plants. However, the function of the DEAD-box RNA helicase family genes on ES is poorly known in rice. Here, we characterized a rice DEAD-box protein, OsRH52A, which was localized in the nucleus and cytoplasm and highly expressed in the floral organs in rice. The knockout mutant, rh52a, displayed partial ES sterility, including degenerated ES (21.0%) and the presence of double-female-gametophyte (DFG) structure (11.8%). The DFG developed from two functional megaspores (FM) near the chalazal end in one ovule, and 3.4% of DFG could fertilize via the sac near the micropylar pole in rh52a. OsRH52A was found to interact with OsMFS1 and ZIP4, both of which play a role in homologous recombination in rice meiosis. RNA-seq identified 234 down-regulated differentially expressed genes (DEGs) associated with reproductive development, including the two genes, OsMSP1 and HSA1b, required for female germline cell specification. Taken together, our study demonstrated that OsRH52A is essential for the development of the embryo sac and provided cytological evidence regarding the formation of DFG., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Experimental Biology.)

Background: Elderly patients have a high risk of developing postoperative cognitive dysfunction (POCD). Gastrointestinal disorders, such as constipation, in the elderly population may be involved in the pathogenesis of neurological disorders by promoting inflammatory responses due to a 'leaky gut'. General anesthetic sevoflurane may impair gastrointestinal function in elderly patients to trigger neurological complications following surgery. Therefore, we hypothesized that elderly individuals with gastrointestinal dysfunction may be more vulnerable to sevoflurane and consequently develop POCD., Methods: Aged mice were randomly divided into four groups: control (CTRL), CTRL+sevoflurane (Sev), slow transit constipation (STC), and STC + Sev. Mice in the STC and STC + Sev groups were intra-gastrically administrated loperamide (3 mg/kg, twice a day for 7 days) to induce a slow transit constipation (STC) model determined with fecal water content and the time of first white fecal pellet, whereas mice in the other groups received the similar volume of saline. One week later, mice in the CTRL+Sev group and STC + Sev group received 2% sevoflurane for 2 h. The gut permeability evaluated with 4-kDa fluorescein isothiocyanate (FITC)-dextran, serum cytokines, microglia density, TLR4/NF-κB signaling expression, and POCD-like behavioral changes were determined accordingly., Results: The loperamide-induced STC mice had decreased fecal water content and prolonged time of first white fecal pellet. Sevoflurane exposure caused significantly increased gut permeability and serum cytokines, as well as the activation of microglia and the TLR4/NF-κB signaling pathway in the prefrontal cortex of the aged STC mice. Sevoflurane also caused cognitive impairment and emotional phenotype abnormality in aged STC mice., Conclusion: Aged STC mice were more vulnerable to sevoflurane anesthesia and consequently developed POCD-like behavioral changes. Our data suggest that gastrointestinal disorders including constipation may contribute to the development of POCD., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Zhao, Lu, Qin, Chen, Shi, Wei, Xiong, Ma and Song.)

As a gamma-aminobutyric acid type A receptor agonist sevoflurane is a common general anesthetic used in anesthesia and affects the neural development in offspring. We hypothesized that sevoflurane could regulate interneurons via the neuregulin-1-epidermal growth factor receptor-4 (NRG1-ErbB4) pathway in the entorhinal cortex (ECT) of the middle pregnancy. Six female rats in middle pregnancy (14.5 days of pregnancy) were randomly and equally divided into sevoflurane (SeV) and control groups. The rats in the SeV group were exposed to 4% sevoflurane for 3 hours. The expression levels of NRG1 and ErbB4, parvalbumin (PV) and glutamic acid decarboxylase (GAD67), and N -methyl-D-aspartate receptor subunit 2A (NR2A) and subunit 2B (NR2B) in offspring were examined through immunohistochemistry. The pyramidal neurons in the ECT were examined via Golgi staining. The levels of NRG1 and ErbB4 were significantly decreased ( P < 0.01) and the levels of PV and GAD67 (interneurons) were found to be decreased in the SeV group ( P < 0.01). The level of NR2B was found to be increased while the level of NR2A being decreased in the SeV group ( P < 0.01). The development of pyramidal neurons was abnormal in the SeV group ( P < 0.05). Conclusively, prenatal sevoflurane exposure could lead to the disturbance of the interneurons by activating the NRG1-ErbB4 pathway and subsequently result in abnormal development of pyramidal neurons in middle pregnancy. Prenatal sevoflurane exposure in middle pregnancy could be potentially harmful to the neural development of rat offspring. This study may reveal a novel pathway in the influence mechanism of sevoflurane on rat offspring., Competing Interests: The authors declare no conflict of interest., (© 2021 The Author(s). Published by IMR Press.)

Although there is abundant evidence that an association between sensation seeking and adolescent Internet gaming addiction (IGA) exists, research has provided little insight into why adolescents with high sensation seeking are more likely to be focused on Internet and video games. Grounded in the social development model and ecological systems theory, this study investigated whether deviant peer affiliation mediated the relationship between sensation seeking and adolescent IGA, and whether this indirect link was moderated by parental knowledge. Participants were 1293 Chinese adolescents (49.65% male, M age = 12.89 ± 0.52 years) who completed questionnaires assessing sensation seeking, deviant peer affiliation, parental knowledge, and IGA. Structural equation models revealed that the positive association between sensation seeking and adolescent IGA was partially mediated by deviant peer affiliation. In addition, this indirect link was significantly moderated by parental knowledge. Specifically, the indirect path from sensation seeking to adolescent IGA was stronger for adolescents with low parental knowledge than for those with high parental knowledge. Identifying the role of peers and parents in the onset of adolescent IGA has key implications for prevention and intervention.

An amino-functionalized conjugated metallopolymer PFEN-Hg was developed as a cathode interlayer for inverted polymer solar cells. The resulting devices exhibited significantly improved performance with power conversion efficiencies exceeding 9%. Moreover, good device performance was achievable with the PFEN-Hg over a wider range of film thickness, likely due to the Hg-Hg interactions and improved π-π stacking.