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The main task of power communication sector during the 13 rd Five Year Plan is how to reasonably design the layout with UHV construction of electric power communication optical cable line resource and improve the overall power of the backbone communication network architecture.In this paper,the demand for power communication business is calculated at first.The forecast of demand of business is chosen as the important input parameter for the network topology planning optimization.Then,the adaptability of the business requirements of Hunan province’s electric power network architecture is analyzed by the network simulation.Finally,the paper gives the suggestions of capacity configuration,key sites and links in the backbone ring network.This research method can provide guidance on the planning of the electric power communication network during the13 rd Five Year Plan period.

Abstract: The plume of the Changjiang River in the East China Sea is the site of many interesting oceanographic and hydraulic processes. The improved COHERENS model is used to understand the dispersal and mixing processes, stratification, and circulation within the plume of the partially-mixed Changjiang River estuary during the spring tide under 6 m s−1 of prevailing south–southeasterly steady winds in the flood season. Modeled results show: (i) a part of the surface Changjiang River plume expands eastwardly and southeastwardly in the form of cloudy patchiness; (ii) the low salinity patch in the east offshore area, which is enhanced by winds; (iii) there is an increase in the thickness of the upper buoyant plume within the partially-mixed Changjiang River estuary; (iv) the stratification is enhanced by winds within the plume of the partially-mixed Changjiang River estuary; (v) modeled stratification parameter (ϕ) ranges from 50 to 450 J m−3; and (vi) the longitudinal landward and seaward estuarine circulations. [Copyright &y& Elsevier]

As a member of BRIC, Brazil arose out of a colony historically and the way of her economic development was different from that of China, though either of them is a newly-emerging developing country making much of what role the government should play in technological innovation to which the policy is of great significance to national rejuvenation. In Brazil there was an evolution process of the policy of technological innovation, i.e., starting from industrial policy to sci-tech policy and, finally, forming a systematic policy of technological innovation. The policies of technological innovation in different developmental periods in Brazil and what role the government played in the different periods of technological innovation are analyzed, which may be of far reaching importance to the transformation of Chinese governmental functions, by which our policy of technological innovation is possibly systematically perfected so as to cope with the financial crisis and revitalize China. [ABSTRACT FROM AUTHOR]

Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), which represents one of the most common cancers worldwide. Recent studies suggest that HBV's protein X (HBx) plays a crucial role in HCC development and progression. Earlier, genome-wide analysis identified that the receptor for hyaluronan-mediated motility (RHAMM) represents a putative oncogene and is overexpressed in many human cancers, including HCC. However, the mechanism underlying RHAMM upregulation and its role in tumorigenesis remain unclear. Here, we show that ectopic expression of HBx activates the PI3K/Akt/Oct-1 pathway and upregulates RHAMM expression in HCC cells. HBx overexpression leads to dissociation of C/EBPβ from the RHAMM gene promoter, thereby inducing RHAMM upregulation. RHAMM knockdown attenuates HBx-induced cell migration and invasion in vitro . In mice, HBx promotes cancer cell colonization via RHAMM upregulation, resulting in enhanced metastasis. Analysis of gene expression datasets reveals that RHAMM mRNA level is upregulated in patients with HCC with poor prognosis. IMPLICATIONS: These results indicate that RHAMM expression is upregulated by HBx, a process that depends on the inhibition of C/EBPβ activity and activation of the PI3K/Akt/Oct-1 pathway. These results have several implications for the treatment of HBV-positive HCC involving upregulation of RHAMM and cancer metastasis. VISUAL OVERVIEW: http://mcr.aacrjournals.org/content/molcanres/18/3/375/F1.large.jpg., (©2019 American Association for Cancer Research.)

Previous studies have shown that diallyl disulfide (DADS), a naturally occurring anticancer agent in garlic, arrested human gastric cancer cells (MGC803) in the G2/M phase of the cell cycle. Due to the importance of cell cycle redistribution in DADS-mediated anticarcinogenic effects, we investigated the role of checkpoint kinases (Chk1 and Chk2) during DADS-induced cell cycle arrest. In the present study, the northern blot analysis showed that mRNA expression of for Chkl and Chk2 was unchanged. Notably, DADS induced the accumulation of phosphorylated Chk1, but not of Chk2, activated phospho-ATR (ATM-RAD3-related gene), and dowregulated CDC25C and cyclin B1 expression. Furthermore, CDC25C was immunoprecipitated by anti-Chk1 but not anti-Chk2. Results of the overexpression and knockdown studies, showed that Chk1 but not Chk2 regulated the DADS-induced G2/M arrest of MGC803 cells. The overexpression of Chk1 resulted in significantly increased DADS-induced G2/M arrest, increased DADS-induced Chk1 phosphorylation and inhibited CDC25C expression. Knockdown of Chk1 reduced DADS‑induced G2/M arrest and blocked the DADS-induced inhibition of CDC25C and cyclin B1 expression. These results suggested that Chk1 is important in DADS‑induced cell cycle G2/M arrest in the human MGC803 gastric cancer cell line. Furthermore, the DADS-induced G2/M checkpoint response is mediated by Chk1 signaling through ATR/Chk1/CDC25C/cyclin B1.

Objective: To explore how to improve follow-up rate and follow-up quality in studies related to quality of life., Methods: A retrospective cross-sectional study was performed in patients with rectal cancer who underwent primary surgery at the Gastrointestinal Surgery Department, The First Affiliated Hospital, Sun Yat-sen University from August 2002 to February 2011 using the European Organization for Research and Treatment of Cancer QLQ-C30 and CR-38 questionnaires. The influence factors of follow-up rate and reasons for missing sex-related items were analyzed., Results: A total of 438 questionnaires were issued. Two hundred and eighty-five responses were received and the follow-up rate was 65.1%. Two hundred and sixty-two patients returned the questionnaires by mail. Responders and non-responders did not differ by sociodemographic and clinical characteristics including sex, age, postoperative time, complication, clinical stage and stoma. Significant differences were found when comparing the missing sex-related items grouped by sex, age, education and working status., Conclusions: Follow-up mode of mail supplemented by interview is suitable for current reality in China in studies on quality of life. Targeted methods should be adopted when investigating the different patient groups to improve follow-up rate of studies on quality of life and sexual function survey.