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The study investigated the effects of attentional deficits on the relative preferences for associative, acoustic, and orthographic attributes in word recognition by 45 learning disabled children in grades 2, 4, and 6. (Author/PHR)

Describes a study designed to assess students' reading maturity, involving such factors as achievement, interests, attitudes, and leisure reading habits. (MKM)

Kindergarten children were administered a paired-associate learning task at the beginning and end of the school-year, under either regular (control) or self-generated visual imagery instructions. Age predicted performance in the imagery but not in the control condition. Results supported the developmental imagery hypothesis. (Author/RD)

The review examines issues and research relating to the involvement of the central nervous system in reading disorders. Questions regarding subtypes, pre- and perinatal influences, genetics, sex differences, and early identification are briefly surveyed along with a summary of major research findings in neuropsychology and neurology. (Author)

Integrates the concept of power with situational leadership by relating the perception of a leader's power bases with leadership styles. Sources of power are identified; situational leadership is reviewed; and the Power Perception Profile is discussed. Maturity levels and their relationships to power sources and leadership styles are discussed. (Author/BEF)

Sex education is important in the total educational process and the expressed needs of adolescents regarding essential topics should be included in such education. (JD)

The three articles in this collection discuss secular trends and changes in (1) human stature, weight, and maturation, (2) body proportions and composition, and (3) size and maturity. (CM)

This study examined differences between 232 middle- and lower-class pre- and postmenarcheal adolescents and differences across four developmental levels for the postmenarcheal group. Postmenarcheal adolescents had more problems, but were higher in self-concept, supporting the view that menarche onset is a positive event for most females. (Author/SJL)

Significant, though moderate, correlations between some of the verbal creativity measures and the selective attention variables were found, though this relationship changed as a function of age and the type of creativity measured. (DLS)

The article reviews the literature on possible growth-suppressing effects of stimulation medications in the long-term treatment of children with the hyperkinetic behavior syndrome. Journal available from Arthur Retlaw & Associates, Inc., Suite 2080, 1603 Orrington Avenue, Evanston, Illinois 60201 (Author/PHR)

Does not support Piaget's interpretations that mature moral judgment, dependent upon a decentered thought structure, develops around the ages of eight and nine. (RL)

The significance of menarche for girls' body image and sexual identification was investigated by assessing human figure drawings produced by 87 adolescent girls on two occasions, six months apart. (Author/MP)

Reports on a study to: (1) design, implement, and evaluate an undergraduate peer-helping program curriculum with the major objective of facilitating cognitive/affective maturity and (2) test the effectiveness and practicality of using formative research in designing and evaluating the program. Discusses findings and implications. (AYC)

Special certification for teachers of adolescent students is recommended both because of the uniqueness of these students and of the tasks their teachers perform. (JD)

Analyzes relationship between the availability of a comprehensive career education program and identity development in high school seniors by comparing students with a career education program to students with a counseling program. Analyzes students' individual alienation from social concerns. Suggests need for adult life preparation as well as career preparation. (SB)

Investigates the relationship between maturity of moral judgement and perception of maternal and peer attitudes in Brazilian sixth- and seventh-grade boys. (CM)

The Filter, Human-Capital, and Maturation hypotheses are discussed as the starting point for an analysis of the roles of a university. A student viewpoint is derived from the analysis of questionnaire responses of a first-year New Zealand university class (approximately 2,300 students). (Author/MLW)

The four stages of separation individuation--symbosis, differentiation, practice, and rapprochement--are examined and the early stages of childhood development are discussed in relation to the education of developmentally disabled children. (PHR)

Married couples rated their marital satisfaction and played interpersonal competitive games which revealed the success with which they interacted. Younger husbands who scored more maturely on the Stewart measure of psychosocial maturity belonged to more successful marriages, as did college-educated wives who showed less immaturity and more phallic adventurousness. (Author/BEF)

Historically rural society has been viewed as being characterized by a concensus on a set of values unique to rural life. Data gathered from random samples of 15 communities in the intermountain West suggests, in general, that rurality and social stratification need to be integrated into a theory of values. (BR)

The Missouri Children's Picture Series, a nonverbal objective personality test, was administered to 119 normal elementary children and 77 institutionalized aggressive adolescents. Several of the test scales, particularly the aggression and maturity scales, differentiated significantly between the groups. IQ related to test scores only for the institutionalized group. (Author/SJL)

The verbal interaction of 31 middle-class early adolescent boys and their parents was analyzed to provide information about the impact of the onset of puberty and formal operational thinking on relationships in the family system. (Author/MP)

BACKGROUND: Preterm birth is often associated with chorioamnionitis and leads to increased risk of neurodevelopmental disorders, such as autism. Preterm birth can lead to cerebellar underdevelopment, but the mechanisms of disrupted cerebellar development in preterm infants are not well understood. The cerebellum is consistently affected in people with autism spectrum disorders, showing reduction of Purkinje cells, decreased cerebellar grey matter, and altered connectivity. METHODS: Preterm rhesus macaque fetuses were exposed to intra-amniotic LPS (1 mg, E. coli O55:B5) at 127 days (80%) gestation and delivered by c-section 5 days after injections. Maternal and fetal plasma were sampled for cytokine measurements. Chorio-decidua was analyzed for immune cell populations by flow cytometry. Fetal cerebellum was sampled for histology and molecular analysis by single-nuclei RNA-sequencing (snRNA-seq) on a 10× chromium platform. snRNA-seq data were analyzed for differences in cell populations, cell-type specific gene expression, and inferred cellular communications. RESULTS: We leveraged snRNA-seq of the cerebellum in a clinically relevant rhesus macaque model of chorioamnionitis and preterm birth, to show that chorioamnionitis leads to Purkinje cell loss and disrupted maturation of granule cells and oligodendrocytes in the fetal cerebellum at late gestation. Purkinje cell loss is accompanied by decreased sonic hedgehog signaling from Purkinje cells to granule cells, which show an accelerated maturation, and to oligodendrocytes, which show accelerated maturation from pre-oligodendrocytes into myelinating oligodendrocytes. CONCLUSION: These findings suggest a role of chorioamnionitis on disrupted cerebellar maturation associated with preterm birth and on the pathogenesis of neurodevelopmental disorders among preterm infants.

Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced pluripotent stem cells (hiPSCs) offer the possibility of myocardial regeneration by differentiating into cardiomyocytes. However, hiPSC-derived cardiomyocytes (hiPSC-cardiomyocytes) exhibit fetal-like calcium flux and energy metabolism, which inhibits their engraftment. Several strategies have been explored to improve the therapeutic efficacy of hiPSC-cardiomyocytes, such as selectively enhancing energy substrate utilization and improving the transplantation environment. In this review, we have discussed the impact of altered mitochondrial biogenesis and metabolic switching on the maturation of hiPSC-cardiomyocytes. Additionally, we have discussed the limitations inherent in current methodologies for assessing metabolism in hiPSC-cardiomyocytes, and the challenges in achieving sufficient metabolic flexibility akin to that in the healthy adult heart. [ABSTRACT FROM AUTHOR]

Purpose: To explore the correlation between preoperative cephalic vein pathological types and the maturation of autogenous arteriovenous fistula (AVF) in patients with chronic kidney disease (CKD), providing new ideas and methods for clinical prediction of fistula maturation. Methods: A retrospective analysis was performed in 80 patients who underwent AVF creation surgery from June 2021 to June 2023 at our hospital. Patients were followed up for 6 months. Patients were classified into the mature group (n = 57) and the power loss group (n = 23) based on the AVF maturation status. Preoperative excised venous tissues were examined using Masson's trichrome staining to compare the intimal area (Ia), medial area (Ma), lumen diameter (Ld), average intimal thickness (Avg It), and average medial thickness (Avg Mt), along with the calculations and comparisons of Ia/Ma, Avg It/Avg Mt ratios. Factors influencing AVF power loss were identified using the multifactorial logistic regression analysis. Results: Ia, Ia/Ma, and Ld were lower in the power loss group compared to the mature group (P < 0.01). No significant difference was found in Avg Mt and Avg It/Avg Mt levels between the two groups (P > 0.05). The level of Avg It was higher in the power loss group (P < 0.05). Avg It was a risk factor (P < 0.001), while Ld was a protective factor for AVF power loss (P < 0.05). Conclusion: The levels of Avg It and Ld in preoperative cephalic vein tissue before AVF formation were correlated with AVF power loss. Early monitoring may improve therapeutic outcomes and prognosis of patients with stage 5 CKD. [ABSTRACT FROM AUTHOR]

Chinese Herbal Medicine (CHM) is being more and more used in cancer treatment because of its ability to regulate the immune system. Chinese Herbal Medicine has several advantages over other treatment options, including being multi-component, multi-target, and having fewer side effects. Dendritic cells (DCs) are specialized antigen presenting cells that play a vital part in connecting the innate and adaptive immune systems. They are also important in immunotherapy. Recent evidence suggests that Chinese Herbal Medicine and its components can positively impact the immune response by targeting key functions of dendritic cells. In this review, we have summarized the influences of Chinese Herbal Medicine on the immunobiological feature of dendritic cells, emphasized an anti-tumor effect of CHM-treated DCs, and also pointed out deficiencies in the regulation of DC function by Chinese Herbal Medicine and outlined future research directions. [ABSTRACT FROM AUTHOR]

Macro- and microscopic studies of the state of the gonads of spawners of whitespotted char Salvelinus leucomaenis, Dolly Varden S. malma, and whitespotted char × Dolly Varden hybrids from the Utkholok River (northwestern Kamchatka) in the post-spawning period have revealed no anomalies in the structure of the gonads and their cytological state. The generative tissue of the testes and ovaries contained germ cells of subsequent generations, which indicates the capability of post-spawned individuals for repeated maturation and reproduction in the next year. The state of the gonads of hybrid individuals fully corresponds to that of polycyclic salmon fishes (Salmonidae) and does not differ from the parental species, whitespotted char and Dolly Varden; their gametogenesis has no visible deviations. This indicates the potential capacity of the hybrids from the Utkholok River for reproduction and maintaining their own population, in contrast to many other cases of interspecific hybridization in salmonids described in the literature. The resulting data on the state of the gonads and the results of the previous genetic analysis of hybrids indicate an important feature of the "Utkholok River" hybrid zone for chars of the genus Salvelinus, such as the transition of the entire system to the state of the so-called "hybrid swarm." This may lead to a scenario when hybrids can move to the next stage of microevolutionary processes, which will lead to their isolation from the parental species. [ABSTRACT FROM AUTHOR]

(1) Background: The kick of the ball in soccer is considered one of the most important technical gestures in soccer. Despite this, there is little evidence on ball-striking performance factors in base soccer. The main objectives of the present study were to identify the potential factors of long-ball kicking (LBK) performance and to determine the target training cut-off for LBK performance in young soccer players. (2) Methods: A cross-sectional observational study was conducted with 31 soccer players, with ages ranging from 12 to 18 years. Age, anthropometric data, sport experience, range of motion (ROM) and maximal isometric strength (MIS) of the lower limb were noted. Kick-of-the-ball performance was assessed by maximum ball displacement per kick. A k-mean cluster analysis determined two groups according to ball-kicking performance: low group (LPG-LBK) and high group (HPG-LBK). (3) Results: Differences were found between both groups in age, body mass, body mass index, leg length and knee flexion ROM (BF10 ≤ 6.33; δ ≥ 0.86 (moderate or higher)). Among the factors discussed above, age was the strongest predictor of ball-striking performance (odds ratio = 2.867; p = 0.003). The optimal cut-off for age predicting those players most likely to have a higher ball-striking performance was determined to be 13.5 years (p = 0.001; area under the curve = 85.3%). (4) Conclusions: Age over 13.5 increases the chances of a higher optimal ball-striking performance. The flexibility (knee flexion ROM) and strength (knee flexors) must be specifically trained in soccer players beginning at an early age. [ABSTRACT FROM AUTHOR]

Myocardial infarction leads to myocardial necrosis, and cardiomyocytes are non-renewable. Fatty acid-containing cardiomyocyte maturation medium promotes maturation of stem cell-derived cardiomyocytes.To study the effect palmitic acid on maturation of cardiomyocytes derived from human embryonic stem cells (hESCs) to optimize differentiation for potential treatment of myocardial infarction by hESCs.hESCs were differentiated into cardiomyocytes using standard chemically defined medium 3 (CDM3). Up to day 20 of differentiation, 200 Mm palmitic acid were added, and then the culture was continued for another 8 days to mimic the environment in which human cardiomyocytes mainly use fatty acids as the main energy source. Light microscopy, transmission electron microscopy, immunofluorescence, reverse transcription-polymerase chain reaction, and cellular ATP assays, were carried out to analyze the expression of relevant cardiomyocyte-related genes, cell morphology, metabolism levels, and other indicators cardiomyocyte maturity.Cardiomyocytes derived from hESCs under exogenous palmitic acid had an elongated pike shape and a more regular arrangement. Sarcomere stripes were clear, and the cells color was clearly visible. The cell perimeter and elongation rate were also increased. Myogenic fibers were abundant, myofibrillar z-lines were regularly, the numbers of mitochondria and mitochondrial cristae were higher, more myofilaments were observed, and the structure of round-like discs was occasionally seen. Expression of mature cardiomyocyte-associated genes TNNT2, MYL2 and MYH6, and cardiomyocyte-associated genes KCNJ4, RYR2,and PPARα, was upregulated (p < 0.05). Expression of MYH7, MYL7, KCND2, KCND3, GJA1 and TNNI1 genes was unaffected (p > 0.05). Expression of mature cardiomyocyte-associated sarcomere protein MYL2 was significantly increased (p < 0.05), MYH7 protein expression was unaffected (p > 0.05). hESC-derived cardiomyocytes exposed to exogenous palmitic acid produced more ATP per unit time (p < 0.05).Exogenous palmitic acid induced more mature hESC-CMs in terms of the cellular architecture, expression of cardiomyocyte maturation genes adnprotein, and metabolism. [ABSTRACT FROM AUTHOR]

HIV-1 virion maturation is an essential step in the viral replication cycle to produce infectious virus particles. Gag and Gag-Pol polyproteins are assembled at the plasma membrane of the virus-producer cells and bud from it to the extracellular compartment. The newly released progeny virions are initially immature and noninfectious. However, once the Gag polyprotein is cleaved by the viral protease in progeny virions, the mature capsid proteins assemble to form the fullerene core. This core, harboring two copies of viral genomic RNA, transforms the virion morphology into infectious virus particles. This morphological transformation is referred to as maturation. Virion maturation influences the distribution of the Env glycoprotein on the virion surface and induces conformational changes necessary for the subsequent interaction with the CD4 receptor. Several host factors, including proteins like cyclophilin A, metabolites such as IP6, and lipid rafts containing sphingomyelins, have been demonstrated to have an influence on virion maturation. This review article delves into the processes of virus maturation and Env glycoprotein recruitment, with an emphasis on the role of host cell factors and environmental conditions. Additionally, we discuss microscopic technologies for assessing virion maturation and the development of current antivirals specifically targeting this critical step in viral replication, offering long-acting therapeutic options. [ABSTRACT FROM AUTHOR]

This paper revisits core pieces of literature on EU foreign policy studies to gauge how far the endogenous institutional quality of EU foreign policy structures has matured by assessing its growth over time. In revisiting two foundational studies, it discusses whether the EU's foreign policy capabilities are still so unequivocally below the state level. First, it will return to the "capabilities-expectations gap" [Hill, C., 1993. The capability-expectations gap, or conceptualizing Europe's international role. Journal of Common Market Studies, 31 (3), 305–328] to investigate the quality of the institutional structure in foreign policy and in how far the EU's institutions fulfil general functions of foreign policy today. Second, it will explore whether "Who Speaks for Europe?" is still a pertinent question [Allen, D., 1998. Who speaks for Europe? The search for an effective and coherent external policy. In: J. Peterson, and H. Sjursen, eds. A common foreign policy for Europe? Competing visions of the CFSP. 41–58]. The results of this assessment allow a conceptualisation of foreign policy capabilities evolving in long-term, slow processes, yet resulting in differences in institutional quality that may otherwise be overlooked. The paper contributes to the overall assessment of the EU's maturation in foreign policy by providing assessments on institutional growth and developing a scale of foreign policy capabilities to capture these slow incremental developments. [ABSTRACT FROM AUTHOR]

This article examines the interplay of the maturation of the EU's identity as an international foreign and security actor with the institutionalisation of its foreign and security architecture. While the formal policy- and decision-making modes within the CFSP/CSDP have changed little during the past 25 years, the EU's international identity did still change over time, potentially indicating a "coming of age". How can we explain this maturation of the EU's foreign and security identity despite the critique of the EU's inefficiency and lack of adequateness in security policy? By means of re-interpreting existing scholarship, we argue that the relative maturation of the EU's foreign and security identity since the Lisbon Treaty is not so much linked to formal institutional change ("maturation by design"), but rather to changing informal institutional practice and the selection and use of respective instruments ("maturation by practice"). This dynamic, we argue, is due to an interplay of internal and external factors, accompanied by ongoing socialisation of member states in how they perceive the nature of the CFSP/CSDP and the EU as an international foreign and security actor. [ABSTRACT FROM AUTHOR]

The war on Ukraine is the most severe security crisis that Europe, and the European Union (EU), has faced since World War II. Contrary to what many expected, the EU responded quickly and comprehensively to the Russian invasion. How, if in any way, does the EU's response to the war on Ukraine suggest that the EU is coming of age in the foreign and security domain? By exploring EU policies and actions across three key maturation processes, our analysis finds that the EU has become a more mature foreign policy actor, in a process that started well before the Russian full scale invasion but has escalated since then. With its broad response to the war on Ukraine, the EU has shown an increased ability to take quick decisions, provide resources and combine various instruments in response to a crisis (increased decision-making ability); it is taking on a clearer foreign policy role/identity as a principled pragmatist and crisis manager (more stable identity status); and this plays out in its relations with the US, in NATO and bilaterally (more salient and defined relations). [ABSTRACT FROM AUTHOR]

The EU has been confronted with novel global challenges ranging from economic, migration and security related crises, to an interstate war on its Eastern and Southern borders. Strategic partnerships have emerged as one of the key potential instruments to navigate these challenges, yet with contested debates over their impact on the EU's global standing as a foreign policy actor. This paper analyses how, if at all, EU strategic partnerships indicate a maturation of EU foreign policy in the global context. We argue that the utilisation of EU strategic partners emerges as an area with varied degrees of maturation. We identify three main indicators of these varied maturation degrees to assess the EU's use of strategic partnerships. First, we focus on the rationale behind the continuous tension between the EU's normative and strategic drivers for engaging in strategic partnerships. The second indicator of maturation is the EU's proactive role in adapting to its changing global environment, where a mature EU identifies other global players and presents them with cooperation opportunities. Finally, institutional maturity as a function of vertical coherence implies the proactive management of divisions among the EU institutions and member states over the modalities of these partnerships. [ABSTRACT FROM AUTHOR]

The Russian invasion of Ukraine has brought war back to the European continent and led to considerable change in EU member states' foreign policies. The consequential degree of EU foreign policy unity, as well as shifts in long-lasting national and collective security and defence taboos, has represented a significant departure from past practices. We use these processes of change as a starting point to set the scene for this special issue and to inform its main research question: in what manner, if at all, has the EU come of age as a foreign and security actor during Russia's war on Ukraine? This introduction situates the main question of the special issue into the wider scholarly debates on actorness and the EU's geopolitical ambitions. It conceptually develops the analogy of "coming of age" to examine a prospective maturation process of the EU as a foreign and security actor. In doing so, it not only interrogates what the EU as a mature foreign and security actor would look like, but it also develops the framework, identifies four maturation processes and reflects on necessary caveats for drawing inferences about the state of maturation of the EU as foreign and security actor. [ABSTRACT FROM AUTHOR]

Introduction: Although neuromuscular function varies significantly between strength and endurance-trained adult athletes, it has yet to be ascertained whether such differences manifest by early adolescence. The aim of the present study was to compare knee extensor neuromuscular characteristics between adolescent athletes who are representative of strength (wrestling) or endurance (triathlon) sports. Methods: Twenty-three triathletes (TRI), 12 wrestlers (WRE) and 12 untrained (CON) male adolescents aged 13 to 15 years participated in the present study. Maximal voluntary isometric contraction (MVIC) knee extensor (KE) torque was measured, and 100-Hz magnetic doublets were delivered to the femoral nerve during and after KE MVIC to quantify the voluntary activation level (%VA). The doublet peak torque (T100Hz) and normalized vastus lateralis (VL) and rectus femoris (RF) EMG (EMG/M-wave) activities were quantified. VL and RF muscle architecture was also assessed at rest using ultrasound. Results: Absolute and relative (to body mass) KE MVIC torques were significantly higher in WRE than TRI and CON (p < 0.05), but comparable between TRI and CON. No significant differences were observed between groups for %VA, T100Hz or either VL or RF muscle thickness. However, VL EMG/M-wave was higher, RF fascicle length longer, and pennation angle smaller in WRE than TRI and CON (all p < 0.05). Conclusion: The wrestlers were stronger than triathletes and controls, potentially as a result of muscle architectural differences and a greater neural activation. Neuromuscular differences can already be detected by early adolescence in males between predominantly endurance and strength sports, which may result from selection bias and/or physical training. [ABSTRACT FROM AUTHOR]

Copyright of Folia Pharmaceutica Cassoviensia is the property of University of Veterinary Medicine & Pharmacy in Kosice and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Monitoring training load, recovery, and wellness in maturation ages is even more relevant than in adulthood, especially during congested schedules. The objective of this study was to quantify and describe the differences in external and internal load, recovery, and perceived wellness in elite under-16 female players during a period of three competitions in seven days based on their participation during matches. An observational design was used to quantify the external load (total distance, high-speed distance, and PlayerLoad) and internal load (differential sRPE), as well as the recovery and wellness of 18 international under-16 players during a development tournament. The external load pattern of the starting players was undulating, with matches showing the highest internal load values compared to training sessions and non-starters. Non-starter players (whether training or matches) showed similar external load and differential sRPE values throughout the tournament (p > 0.05). Starting players experienced higher internal load than non-starters during matches (p < 0.037), without differences between training sessions (p > 0.05). No changes were seen in wellness or recovery (all p-values > 0.05), except for non-starters in Session 3 compared to Session 7 (p = 0.024). Starting players had more weekly total minutes (p = 0.018), differential sRPE (breath: p = 0.002; leg: p = 0.002; cognitive: p = 0.003), total distance (p = 0.003), and PlayerLoad (p = 0.008) than non-starters. Our results indicate differing load patterns between starters and non-starters, which do not affect wellness and recovery differently. Starters accumulate more weekly total load. Coaches can use these findings to guide decisions and load compensations in high competition contexts for young female soccer players. [ABSTRACT FROM AUTHOR]

Effect of priming on the maturation and spawning were tested in two fish species using gonadotropin-releasing hormone (GnRH), carp pituitary homogenate (CPH) and clomiphene citrate (clomid). The fish were injected with a dose of GnRH, CPH and clomid, calibrated to contain 0.3ml/kg, 7 mg/kg and 70mg/kg respectively in three split doses (two priming doses and one final dose). Two priming doses enhanced the maturation and spawning in fish as evident from hormone assay, histology and gamete analysis. Among the inducing agents, two priming doses of GnRH showed 94% maturation and higher GSI (5.31♂;18.5♀) than CPH and clomid injected rohu. Subsequently, successful spawning recorded supported by elevated levels of FSH and LH in blood. Priming with CPH and clomid showed better maturation rate than GnRH injected Nile tilapia. The sperm count of tilapia administered with CPH and clomid was 3.7±0.72×109 and 4.1±0.86×109 respectively. The efficacy of hormonal priming in synchronising the gamete development in rohu and tilapia was further evident from the increased number of synchronised oocyte development. This study may help in developing strategies for broodstock and hatchery management of carps and tilapias. [ABSTRACT FROM AUTHOR]

The aging ability of dry white wines has been increasingly recognized. The present work aimed to identify which sensory features drive their quality assessment by experienced tasters. Individuals assessed several sensory attributes, using dark tasting glasses. Wines originated from the grape varieties Alvarinho, Arinto, Sauvignon Blanc and Pinot Bianco with a wide range of ages. Basic physical–chemical analysis, browning (Abs 420 nm), elemental composition and a partial volatile fraction were also determined. The overall quality scores were a function of complexity and balance and were negatively influenced by the perception of faultiness. The aging process could be associated with a continuous sensory space characterized by a declining perception of freshness and an intensification in the mellowed flavors. Despite their age, wines were characterized by an austere perception caused by their acidity, saltiness, bitterness, smoothness and dryness. Nevertheless, quality scores were similar from the youngest to the oldest tasted wines (17 years old). The exception was a Sauvignon Blanc wine from a recent vintage that was judged as faulty due to the perception of earthiness. Overall, the tasted wines displayed an unexpected aging ability as demonstrated by the difference between the predicted and real wine ages. To improve the recognition of old wines, the metaphor "mellowed by age" is proposed to describe flavors resulting from beneficial aging instead of "oxidized by age". [ABSTRACT FROM AUTHOR]

Copyright of Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi is the property of Ankara University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Menarche is a significant pubertal event influencing girls' participation in physical activity. As menarche is a sensitive matter, a non-invasive substitute is needed to help classify girls' maturity status and provide physical literacy to them in this regard. The objective of this exploratory study was to investigate the classification agreement between self-reported age of menarche and calculated maturity offset in adolescent girls from South Africa by making use of various statistical methods. Fifty-eight girls, n = 13 pre- and n = 45 post-menarche (Status Quo method) aged 13.51 ± 3.51 years at baseline, were analyzed (2010–2012). Independent t-testing, cross-tabulation, Roc Curve statistics and logistic regression were used to analyze the classification agreement between markers. All four statistical methods revealed the potential to categorize different maturity groups through the maturity offset equation, although the accuracy declined with increased age. A realized power of 0.92 was found for the group in the first year of the study, with a gradual and significant decline over time. Cross-tabs showed a significant moderate predictive effectiveness (Chi-square = 0.042) during T1, closer to PHV (13.51 years) although also declining significantly with increased age (T2, 14.51 years) beyond PHV (Chi-square = 0.459). Although positive results were found, caution must be used when using maturity offset equations in different homogenic populations due to their unique growth characteristics. [ABSTRACT FROM AUTHOR]

The aim of this study was to test a machine learning (ML) model to predict high-intensity actions and body impacts during youth football training. Sixty under-15, -17, and -19 sub-elite Portuguese football players were monitored over a 6-week period. External training load data were collected from the target variables of accelerations (ACCs), decelerations (DECs), and dynamic stress load (DSL) using an 18 Hz global positioning system (GPS). Additionally, we monitored the perceived exertion and biological characteristics using total quality recovery (TQR), rating of perceived exertion (RPE), session RPE (sRPE), chronological age, maturation offset (MO), and age at peak height velocity (APHV). The ML model was computed by a feature selection process with a linear regression forecast and bootstrap method. The predictive analysis revealed that the players' MO demonstrated varying degrees of effectiveness in predicting their DEC and ACC across different ranges of IQR. After predictive analysis, the following performance values were observed: DEC ( x ¯ predicted = 41, β = 3.24, intercept = 37.0), lower IQR (IQRpredicted = 36.6, β = 3.24, intercept = 37.0), and upper IQR (IQRpredicted = 46 decelerations, β = 3.24, intercept = 37.0). The player's MO also demonstrated the ability to predict their upper IQR (IQRpredicted = 51, β = 3.8, intercept = 40.62), lower IQR (IQRpredicted = 40, β = 3.8, intercept = 40.62), and ACC ( x ¯ predicted = 46 accelerations, β = 3.8, intercept = 40.62). The ML model showed poor performance in predicting the players' ACC and DEC using MO (MSE = 2.47–4.76; RMSE = 1.57–2.18: R2 = −0.78–0.02). Maturational concerns are prevalent in football performance and should be regularly checked, as the current ML model treated MO as the sole variable for ACC, DEC, and DSL. Applying ML models to assess automated tracking data can be an effective strategy, particularly in the context of forecasting peak ACC, DEC, and bodily effects in sub-elite youth football training. [ABSTRACT FROM AUTHOR]

To improve the folding and maturation efficiency of proteins that were first synthesized as precursors, the bacterial-derived SprD subtilisin was used as the research object and the folding and maturation of precursors were compared comprehensively by taking recombination expression of proteins, site-directed mutation of amino acids, purification of inclusion bodies, refolding of proteins in vitro and determination of enzyme catalytic abilities many other measures. The resluts showed that SprD precursors took about 230 min to complete the maturation under the mediation of wild-type pro-peptides. Mutations of E112A, S221A and S221C in sequences of mature peptide led to the prolongation or the failure of maturation. The tandem expression of pro-peptide and deletion of tyrosine at cleavage site between pro-peptide and mature peptide shortened the maturation time to 80~160 min and increased the maturation efficiency by 0.5~2.0 times, and the catalytic abilities of the corresponding mature enzymes were not affected. Although the single-site mutations in pro-peptide had little effects on maturation, they contributed the improvement of catalytic ability. Therefore, the maturation of proteins mediated by pro-peptides and the alternation of enzyme catalytic ability were 2 relatively independent processes and the expression modes of pro-peptide and the changes of cleavage site were suitable ways to promote protein maturation in vitro. Above results would provide a reference method for accelerating protein maturation and protein modification. [ABSTRACT FROM AUTHOR]

Background: Within the follicular fluid, extracellular vesicles (EVs) guide oocyte growth through their cargo microRNAs (miRNAs). Here, we investigated the role of EVs and their cargo miRNAs by linking the miRNAs found in EVs, derived from the fluid of an individual follicle, to the ability of its oocyte to become a blastocyst (competent) or not (non-competent). Methods: Bovine antral follicles were dissected, categorized as small (2–4 mm) or large (5–8 mm) and the corresponding oocytes were subjected to individual maturation, fertilization and embryo culture to the blastocyst stage. Follicular fluid was pooled in 4 groups (4 replicates) based on follicle size and competence of the corresponding oocyte to produce a blastocyst. Follicular fluid-derived EVs were isolated, characterized, and subjected to miRNA-sequencing (Illumina Miseq) to assess differential expression (DE) in the 4 groups. Functional validation of the effect of miR-34c on embryo development was performed by supplementation of mimics and inhibitors during in vitro maturation (IVM). Results: We identified 16 DE miRNAs linked to oocyte competence when follicular size was not considered. Within the large and small follicles, 46 DE miRNAs were driving blastocyst formation in each group. Comparison of EVs from competent small and large follicles revealed 90 DE miRNAs. Cell regulation, cell differentiation, cell cycle, and metabolic process regulation were the most enriched pathways targeted by the DE miRNAs from competent oocytes. We identified bta-miR-34c as the most abundant in follicular fluid containing competent oocytes. Supplementation of miR-34c mimic and inhibitor during IVM did not affect embryo development. However, blastocyst quality, as evidenced by higher cell numbers, was significantly improved following oocyte IVM in the presence of miR-34c mimics, while miR-34c inhibitors resulted in the opposite effect. Conclusion: This study demonstrates the regulatory effect of miRNAs from follicular fluid-derived EVs on oocyte competence acquisition, providing a further basis for understanding the significance of miRNAs in oocyte maturation and embryonic development. Up-regulation of miR-34c in EVs from follicular fluid containing competent oocytes and the positive impact of miR-34c mimics added during IVM on the resulting blastocysts indicate its pivotal role in oocyte competence. [ABSTRACT FROM AUTHOR]

Background and Aim: The antioxidant effects of ergothioneine (EGT) on in vitro culture of porcine zygote are not well established. The study investigated the impact of EGT supplementation on meiotic competence and development of porcine oocytes. Materials and Methods: The impact of EGT concentrations (0, 5, 10, 25, 50, and 100 µM) during in vitro maturation (IVM) on the progression of meiotic maturation, fertilization, and blastocyst formation in porcine oocytes was assessed. The DNA fragmentation level was evaluated to determine oocyte and blastocyst quality. Results: The proportion of metaphase II oocytes was significantly greater (p < 0.05) in EGT-cultured oocytes than in control oocytes, regardless of the EGT concentration, and those oocytes with 10 µM or more EGT had fewer DNA-fragmented nuclei (p < 0.05). Blastocysts derived from oocytes cultured with 10 µM EGT had the highest proportion (p < 0.05), while those from control oocytes or oocytes cultured with 50 µM or less EGT had significantly higher proportions. Despite EGT supplementation, there were no noticeable differences in total cell numbers and DNA fragmentation indices in the derived blastocysts. Conclusion: Supplementing with EGT during IVM leads to better oocyte maturation, quality, and embryonic development due to decreased DNA fragmentation. The present study failed to elucidate the mechanism of DNA fragmentation reduction by EGT. More research needs to be conducted to explore the antioxidant mechanism of EGT. [ABSTRACT FROM AUTHOR]

Purpose: To understand athletic performance before and after puberty, this study determined 1) the age at which the sex difference increases among elite youth track and field athletes for running and jumping events, and 2) whether there is a sex difference in performance before ages associated with puberty among elite youth athletes. Methods: Track and field records of elite USmale and female youth (7-18 yr) across 3 yr (2019, 2021, and 2022) were collected from an online database (athletic.net). The top 50 performances were recorded for 100-, 200-, 400-, and 800-m track running, long jump, and high jump. Results:Males ran faster than females at every age in the 100, 200, 400 and 800 m (P < 0.001). When combining all running events, the sex difference (%) was 4.0% ± 1.7% between 7 and 12 yr and increased to 6.3% ± 1.1% at 13 yr and 12.6% ± 1.8% at 18 yr (P < 0.001). Similarly, males jumped higher and farther than females at every age (P < 0.001). For long jump, the sex differencewas 6.8%± 2.8% between 7 and 12 yr, increasing to 8.5% ± 1.7% at 13 yr and 22.7% ± 1.4% at 18 yr (P < 0.001). For high jump, the sex difference was 5.3% ± 5.2% between 7 and 12 yr, increasing to 12.4% ± 2.9% at 15 yr and 18.4% ± 2.04% at 18 yr (P < 0.001). Conclusions: Before 12 yr of age in elite youth track and field athletes, there was a consistent and significant sex difference of ~5%, such that males ran faster and jumped higher and farther than females. The magnitude of the sex difference in performance increased markedly at 12-13 yr for running and long jump and 14 yr for high jump and thus was more pronounced after ages associated with puberty. [ABSTRACT FROM AUTHOR]