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Objectives: In recent years, biological precursor-based synthesis, particularly plant-based green synthesis, has piqued attention in the area of nanotechnology. The goal of this work is to look into the antibacterial, antifungal, antioxidant, and antiproliferation activity of silver nanoparticles (AgNPs) made from ethanolic extract of Salacia chinensis L. were investigated. Methods: This study can be broadly separated into three parts: the first extraction from Salacia chinensis L. roots, The second characterization of NPs by UV-Vis, DLS, FTIR and SEM, and the third analysis of its antimicrobial; antioxidant and antiproliferative properties. UV–Vis absorption indicated the synthesis of AgNPs, and the spectrum was seen at 401 and 447 nm. The existence of functional groups in the produced AgNPs was verified by FT-IR spectral peaks at 3423.83 cm−1. In three planes, XRD was calculated to investigate the crystallinity and consistent spherical size (peaks at 2θ values of at 28.78, 32.18, 38.04, 54.63, and 77.08°) of the particles. Results: The results of antibacterial, antifungal and antiproliferative effect of synthesized AgNPs with Salacia chinensis L. ethanolic root extract have admirable antimicrobial (19.5 mm), antioxidant (IC50 values 117.3, 59.61 g mL−1) and antiproliferative activity against HEK293 cell lines protect up to 90.3 % respectively. Conclusions: As a consequence, biosynthesized Salacia chinensis L. AgNPs shown outstanding effects and have the potential to be used as antibacterial, antioxidant, and antiproliferative agents.