1. Study of GABA in healthy volunteers: pharmacokinetics and pharmacodynamics
- Author
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Junfeng eLi, Zhaoyun eZhang, Xiaoxia eLiu, Yi eWang, Fei eMao, Junjun eMao, Xiaolan eLu, Dongdong eJiang, Yun eWan, Jia-Ying eLv, Guoying eCao, Qing eZhang, Naiqing eZhao, Mark eAtkinson, Dale L. Greiner, Gerald J. Prud'homme, Zheng eJiao, Yiming eLi, and Qinghua eWang
- Subjects
Glucagon ,Insulin ,GABA ,pharmacokinetics ,Glycated albumin ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Preclinical studies show that GABA exerts anti-diabetic effects in rodent models of type 1 diabetes. Because little is known about its absorption and effects in humans, we investigated the pharmacokinetics and pharmacodynamics of GABA in healthy volunteers. Twelve subjects were subjected to an open-labeled, three-period trial involving sequential oral administration of placebo, 2g GABA once, and 2g GABA three times/day for seven days, with a 7-day washout between each period. GABA was rapidly absorbed (Tmax: 0.5~1 h) with the half-life (t1/2) of 5 h. No accumulation was observed after repeated oral GABA administration for 7 days. Remarkably, GABA significantly increased circulating insulin levels in the subjects under either fasting (1.6-fold, single dose; 2.0-fold, repeated dose; p
- Published
- 2015
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