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Mothers' emotion talk, children's emotion talk, and children's understanding of emotion were examined in 50 mother-child dyads at 41 months. Language measures included total emotion words, unique emotion words, labels, explanations, and different types of explanations. Children's emotion understanding was assessed for labeling, situation, and role-taking knowledge, as well as an overall score. There were different patterns of relations between mothers' emotion talk and boys' and girls' emotion talk, with mothers' emotion talk related more strongly to boys' emotion talk. Mothers' emotion talk for boys and girls was differentially related to the subparts of the emotion understanding test. Specifically, mothers' total emotion talk predicted boys' performance on the situation knowledge test and their use of causal emotion explanations predicted boys' overall score, but none of the maternal variables predicted girls' performance. This finding may result from differences in variability of maternal speech to boys' and girls', and it may be due to differences in maternal speech in earlier years.

Mothers’ emotion talk, children's emotion talk, and children's understanding of emotion were examined in 50 mother–child dyads at 41 months. Language measures included total emotion words, unique emotion words, labels, explanations, and different types of explanations. Children's emotion understanding was assessed for labeling, situation, and role-taking knowledge, as well as an overall score. There were different patterns of relations between mothers’ emotion talk and boys’ and girls’ emotion talk, with mothers’ emotion talk related more strongly to boys’ emotion talk. Mothers’ emotion talk for boys and girls was differentially related to the subparts of the emotion understanding test. Specifically, mothers’ total emotion talk predicted boys’ performance on the situation knowledge test and their use of causal emotion explanations predicted boys’ overall score, but none of the maternal variables predicted girls’ performance. This finding may result from differences in variability of maternal speech to boys’ and girls’, and it may be due to differences in maternal speech in earlier years. [ABSTRACT FROM AUTHOR]

Predictive assays are needed to help optimise treatment in muscle-invasive bladder cancer, where patients can be treated by either cystectomy or radical radiotherapy. Our finding that low tumour MRE11 expression is predictive of poor response to radiotherapy but not cystectomy was recently independently validated. Here we investigated further the mechanism underlying low MRE11 expression seen in poorly-responding patients. MRE11 RNA and protein levels were measured in 88 bladder tumour patient samples, by real-time PCR and immunohistochemistry respectively, and a panel of eight bladder cancer cell lines was screened for MRE11, RAD50 and NBS1 mRNA and protein expression. There was no correlation between bladder tumour MRE11 protein and RNA scores (Spearman's rho 0.064, p=0.65), suggesting MRE11 is controlled post-transcriptionally, a pattern confirmed in eight bladder cancer cell lines. In contrast, NBS1 and RAD50 mRNA and protein levels were correlated (p=0.01 and p=0.03, respectively), suggesting primary regulation at the level of transcription. MRE11 protein levels were correlated with NBS1 and RAD50 mRNA and protein levels, implicating MRN complex formation as an important determinant of MRE11 expression, driven by RAD50 and NBS1 expression. Our findings of the post-transcriptional nature of the control of MRE11 imply that any predictive assays used in patients need to be performed at the protein level rather than the mRNA level.

Objectives: To compare the measles vaccine coverage achieved through the routine vaccination program with that achieved during the 2002 supplemental immunization activity (SIA) at the national and provincial level, the percentage of previously unvaccinated children (zero-dose children) reached during the SIA, and the equity of measles vaccine coverage among children aged 9-23 months in Kenya., Methods: Using data from a post-SIA coverage survey conducted in Kenya, we compute routine and SIA measles vaccine coverage and the percent of zero-dose children vaccinated during the SIA at the national and provincial level. Nationwide and for each province, we use the concentration index (CI) to measure equity of measles vaccine coverage., Results: The SIA improved both coverage and equity, achieving significantly higher coverage in all provinces with routine measles vaccination coverage less than 80%, reached a large percentage of zero-dose children in these provinces, and reached more children belonging to the poorest households., Conclusion: Overall, by improving both measles vaccine coverage and equity in Kenya, the 2002 SIA reduced the gap in immunity between rich and poor households. Measles SIAs provide an ideal platform for delivering other life-saving child health interventions.