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Your search keyword '"Mckenna, Peter J."' showing total 293 results
Start Over Author "Mckenna, Peter J." Publication Type Academic Journals
293 results on '"Mckenna, Peter J."'

3. Cortical volume abnormalities in schizophrenia: Correlations with symptoms and cognitive impairment

Author

García-León, María Ángeles, Fuentes-Claramonte, Paola, Soler-Vidal, Joan, Ramiro-Sousa, Nuria, Salgado-Pineda, Pilar, Salavert, Josep, Torres, Llanos, Guerrero-Pedraza, Amalia, Tristany, Josep, Karuk, Andriana, Barbosa, Lucila, Del Olmo-Encabo, Pablo, Canut-Altemir, Pedro, Munuera, Josep, Sarró, Salvador, Salvador, Raymond, McKenna, Peter J., and Pomarol-Clotet, Edith

Published
2024
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5. Working memory deterioration as an early warning sign for relapse in remitted psychosis: A one-year naturalistic follow-up study

Author

Tao, Tiffany Junchen, Hui, Christy Lai Ming, Hui, Priscilla Wing Man, Ho, Elise Chun Ning, Lam, Bertha Sze Ting, Wong, Andreas Kar Hin, See, Sally Hiu Wah, Chan, Evie Wai Ting, Suen, Yi Nam, Lee, Edwin Ho Ming, Chan, Sherry Kit Wa, Chang, Wing Chung, Lo, William Tak Lam, Chong, Catherine Shiu Yin, Siu, Clara Man Wah, Choi, Yan Yin, Pomarol-Clotet, Edith, McKenna, Peter J, Honer, William G, and Chen, Eric Yu Hai

Published
2023
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6. Striatal dopamine synthesis capacity and its association with negative symptoms upon resolution of positive symptoms in first-episode schizophrenia and delusional disorder

Author

Wong, Stephanie M. Y., Suen, Y. N., Wong, Charlotte W. C., Chan, Sherry K. W., Hui, Christy L. M., Chang, W. C., Lee, Edwin H. M., Cheng, Calvin P. W., Ho, Garrett C. L., Lo, Gladys Goh, Leung, Eric Y. L., Yeung, Paul K. M. Au, Chen, Sirong, Honer, William G., Mak, Henry K. F., Sham, P. C., McKenna, Peter J., Pomarol-Clotet, Edith, Veronese, Mattia, Howes, Oliver D., and Chen, Eric Y. H.

Published
2022
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8. Psychometric properties of the Spanish version of the Health of Nation Outcome Scales for schizophrenia patients.

Author

Feria‐Raposo, Isabel, García‐León, María Ángeles, Rodríguez‐Cano, Elena, Blanco‐Blanco, Joan, Moreno‐Casbas, María Teresa, Gonzalez‐Castro, Ana Isabel, Gómez‐Lozano, María José, Guerrero‐Pedraza, Amalia, Sarri, Carmen, Portillo, Francisco, Sarró, Salvador, McKenna, Peter J., Salvador, Raymond, and Pomarol‐Clotet, Edith

Subjects
COGNITION disorders diagnosis, HEALTH status indicators, RESEARCH funding, CRONBACH'S alpha, DATA analysis, RESEARCH methodology evaluation, INTERVIEWING, RESEARCH evaluation, FUNCTIONAL assessment, KRUSKAL-Wallis Test, SCHIZOPHRENIA, SEVERITY of illness index, MANN Whitney U Test, PSYCHOMETRICS, STATISTICAL reliability, INTRACLASS correlation, STATISTICS, BARTHEL Index, INTER-observer reliability
Abstract

Accessible SummaryWhat is known on the subject?Functioning is one of the most affected areas in schizophrenia. Social, occupational and personal domains are affected, and these deficits are responsible for a major part of the disability associated with the disorder.There are several instruments to measure functioning, but the HoNOS provides a wide assessment of impairment in 12 areas of functioning.What does the paper add to existing knowledge?The Spanish version of the HoNOS shows good properties in terms of reliability and validity for use in schizophrenia patients.Although some authors divide the scale according to proposed underlying dimensions, in schizophrenia this division may not be appropriate.What are the implications for practice?A reliable and easy‐to‐use measure of impairment in different areas of functioning is useful for optimizing the treatment and rehabilitation of patients with schizophrenia. Introduction: The HoNOS scale was designed for the assessment of psychosocial impairment in various domains. While it is widely used in psychiatric settings, it has not been validated in Spanish for use in patients with schizophrenia. Aim: To examine the psychometric properties of the Spanish version of the HoNOS scale in a sample of schizophrenia patients. Method: A total of 194 individuals aged 18 to 65 with schizophrenia spectrum diagnoses were evaluated using the HoNOS. Illness severity and level of functioning were also assessed. Results: The HoNOS showed moderate internal consistency, good inter‐observer reliability and good test‐retest reliability. Factor analysis revealed an internal structure consisting of four factors, with item distribution differing from the theoretical dimensions proposed for the original scale. Discussion: The Spanish version of the HoNOS scale is a reliable and valid instrument for assessing psychosocial impairment in individuals diagnosed with schizophrenia spectrum disorders. However, further research is needed to determine its internal structure more accurately. Implications for Practice: The HoNOS scale provides researchers and clinicians with a valid measure of impairment in twelve different domains, which can facilitate and guide the treatment of schizophrenia patients. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect

Author

Fuentes-Claramonte, Paola, Ramiro, Núria, Torres, Llanos, Argila-Plaza, Isabel, Salgado-Pineda, Pilar, Soler-Vidal, Joan, García-León, María Ángeles, Albacete, Auria, Bosque, Clara, Panicalli, Francesco, Boix, Ester, Munuera, Josep, Tristany, Josep, Sarró, Salvador, Bernardo, Miquel, Salvador, Raymond, McKenna, Peter J., and Pomarol-Clotet, Edith

Published
2022
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12. Interindividual variability of functional connectome in schizophrenia

Author

Santo-Angles, Aniol, Salvador, Raymond, Gomar, Jesús J., Guerrero-Pedraza, Amalia, Ramiro, Núria, Tristany, Josep, Teixidó, Cristina, Ortiz-Gil, Jordi, Aguirre, Candibel, Bosque, Clara, López-Araquistain, Laura, Maristany, Teresa, Salgado-Pineda, Pilar, Sarró, Salvador, McKenna, Peter J., Bernardo, Miquel, Pomarol-Clotet, Edith, and Schwarzbach, Jens

Published
2021
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17. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Author

Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, van Erp, Theo G.M., Walton, Esther, Hibar, Derrek P., Schmaal, Lianne, Jiang, Wenhao, Glahn, David C., Pearlson, Godfrey D., Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Yamamori, Hidenaga, Bustillo, Juan R., Clark, Vincent P., Mueller, Bryon A., Cahn, Wiepke, de Zwarte, Sonja M.C., Hulshoff Pol, Hilleke E., Kahn, René S., Ophoff, Roel A., van Haren, Neeltje E.M., Andreassen, Ole A., Dale, Anders M., Doan, Nhat Trung, Gurholt, Tiril P., Hartberg, Cecilie B., Haukvik, Unn K., Jørgensen, Kjetil N., Lagerberg, Trine V., Melle, Ingrid, Westlye, Lars T., Gruber, Oliver, Kraemer, Bernd, Richter, Anja, Zilles, David, Calhoun, Vince D., Crespo-Facorro, Benedicto, Roiz-Santiañez, Roberto, Tordesillas-Gutiérrez, Diana, Loughland, Carmel, Carr, Vaughan J., Catts, Stanley, Cropley, Vanessa L., Fullerton, Janice M., Green, Melissa J., Henskens, Frans A., Jablensky, Assen, Lenroot, Rhoshel K., Mowry, Bryan J., Michie, Patricia T., Pantelis, Christos, Quidé, Yann, Schall, Ulrich, Scott, Rodney J., Cairns, Murray J., Seal, Marc, Tooney, Paul A., Rasser, Paul E., Cooper, Gavin, Shannon Weickert, Cynthia, Weickert, Thomas W., Morris, Derek W., Hong, Elliot, Kochunov, Peter, Beard, Lauren M., Gur, Raquel E., Gur, Ruben C., Satterthwaite, Theodore D., Wolf, Daniel H., Belger, Aysenil, Brown, Gregory G., Ford, Judith M., Macciardi, Fabio, Mathalon, Daniel H., O’Leary, Daniel S., Potkin, Steven G., Preda, Adrian, Voyvodic, James, Lim, Kelvin O., McEwen, Sarah, Yang, Fude, Tan, Yunlong, Tan, Shuping, Wang, Zhiren, Fan, Fengmei, Chen, Jingxu, Xiang, Hong, Tang, Shiyou, Guo, Hua, Wan, Ping, Wei, Dong, Bockholt, Henry J., Ehrlich, Stefan, Wolthusen, Rick P.F., King, Margaret D., Shoemaker, Jody M., Sponheim, Scott R., De Haan, Lieuwe, Koenders, Laura, Machielsen, Marise W., van Amelsvoort, Therese, Veltman, Dick J., Assogna, Francesca, Banaj, Nerisa, de Rossi, Pietro, Iorio, Mariangela, Piras, Fabrizio, Spalletta, Gianfranco, McKenna, Peter J., Pomarol-Clotet, Edith, Salvador, Raymond, Corvin, Aiden, Donohoe, Gary, Kelly, Sinead, Whelan, Christopher D., Dickie, Erin W., Rotenberg, David, Voineskos, Aristotle N., Ciufolini, Simone, Radua, Joaquim, Dazzan, Paola, Murray, Robin, Reis Marques, Tiago, Simmons, Andrew, Borgwardt, Stefan, Egloff, Laura, Harrisberger, Fabienne, Riecher-Rössler, Anita, Smieskova, Renata, Alpert, Kathryn I., Wang, Lei, Jönsson, Erik G., Koops, Sanne, Sommer, Iris E.C., Bertolino, Alessandro, Bonvino, Aurora, Di Giorgio, Annabella, Neilson, Emma, Mayer, Andrew R., Stephen, Julia M., Kwon, Jun Soo, Yun, Je-Yeon, Cannon, Dara M., McDonald, Colm, Lebedeva, Irina, Tomyshev, Alexander S., Akhadov, Tolibjohn, Kaleda, Vasily, Busatto, Geraldo F., Rosa, Pedro G.P., Serpa, Mauricio H., Zanetti, Marcus V., Hoschl, Cyril, Skoch, Antonin, Spaniel, Filip, Tomecek, David, Hagenaars, Saskia P., McIntosh, Andrew M., Whalley, Heather C., Lawrie, Stephen M., Knöchel, Christian, Oertel-Knöchel, Viola, Stäblein, Michael, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Uhlmann, Anne, Lopez-Jaramillo, Carlos, Dima, Danai, McMahon, Agnes, Faskowitz, Joshua I., Gutman, Boris A., Jahanshad, Neda, Thompson, Paul M., and Turner, Jessica A.

Published
2018
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23. Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task.

Author

Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Salgado-Pineda, Pilar, Ramiro, Núria, Soler-Vidal, Joan, Torres, Maria Llanos, Cano, Ramon, Argila-Plaza, Isabel, Panicali, Francesco, Sarri, Carmen, Jaurrieta, Núria, Sánchez, Manel, Boix-Quintana, Ester, Albacete, Auria, Maristany, Teresa, Sarró, Salvador, Raduà, Joaquim, McKenna, Peter J., Salvador, Raymond, and Pomarol-Clotet, Edith

Subjects
PREFRONTAL cortex, BRAIN, DIGITAL image processing, SCHIZOPHRENIA, PSYCHOSES, TASK performance, MAGNETIC resonance imaging, HEALTH outcome assessment, REGRESSION analysis, DOPAMINE, COMPARATIVE studies, REWARD (Psychology), DESCRIPTIVE statistics, RESEARCH funding, CLASSIFICATION of mental disorders, SOCIODEMOGRAPHIC factors
Abstract

Background: A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction error (RPE). Nevertheless, few functional imaging studies have examined if patients with negative symptoms show reduced RPE-associated activations. Methods: Matched groups of DSM-5 schizophrenia patients with high negative symptom scores (HNS, N = 27) or absent negative symptoms (ANS, N = 27) and healthy controls (HC, N = 30) underwent fMRI scanning while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Results: In the HC, whole-brain analysis revealed that RPE was positively associated with activation in the ventral striatum, the putamen, and areas of the lateral prefrontal cortex and orbitofrontal cortex, among other regions. Group comparison revealed no activation differences between the healthy controls and the ANS patients. However, compared to the ANS patients, the HNS patients showed regions of significantly reduced activation in the left ventrolateral and dorsolateral prefrontal cortex, and in the right lingual and fusiform gyrus. HNS and ANS patients showed no activation differences in ventral striatal or midbrain regions-of-interest (ROIs), but the HNS patients showed reduced activation in a left orbitofrontal cortex ROI. Conclusions: The findings do not suggest that a generalized reduction of RPE signalling underlies negative symptoms. Instead, they point to a more circumscribed dysfunction in the lateral frontal and possibly the orbitofrontal cortex. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Neural correlates of referential/persecutory delusions in schizophrenia: examination using fMRI and a virtual reality underground travel paradigm.

Author

Fuentes-Claramonte, Paola, Salgado-Pineda, Pilar, Argila-Plaza, Isabel, García-León, María Ángeles, Ramiro, Núria, Soler-Vidal, Joan, Albacete, Auria, Delgado, Nicolas, Tavares, Paulo, Torres, María Llanos, Guerrero-Pedraza, Amalia, Portillo, Francisco, Boix, Ester, Munuera, Josep, Arévalo, Antonio, Sarró, Salvador, Salvador, Raymond, McKenna, Peter J., and Pomarol-Clotet, Edith

Subjects
RESEARCH, BRAIN, DELUSIONS, SCHIZOPHRENIA, VIRTUAL reality, MAGNETIC resonance imaging, RESEARCH funding, STATISTICAL correlation
Abstract

Background: The brain functional correlates of delusions have been relatively little studied. However, a virtual reality paradigm simulating travel on the London Underground has been found to evoke referential ideation in both healthy subjects and patients with schizophrenia, making brain activations in response to such experiences potentially identifiable. Method: Ninety patients with schizophrenia/schizoaffective disorder and 28 healthy controls underwent functional magnetic resonance imaging while they viewed virtual reality versions of full and empty Barcelona Metro carriages. Results: Compared to the empty condition, viewing the full carriage was associated with activations in the visual cortex, the cuneus and precuneus/posterior cingulate cortex, the inferior parietal cortex, the angular gyrus and parts of the middle and superior temporal cortex including the temporoparietal junction bilaterally. There were no significant differences in activation between groups. Nor were there activations associated with referentiality or presence of delusions generally in the patient group. However, patients with persecutory delusions showed a cluster of reduced activation compared to those without delusions in a region in the right temporal/occipital cortex. Conclusions: Performance of the metro task is associated with a widespread pattern of activations, which does not distinguish schizophrenic patients and controls, or show an association with referentiality or delusions in general. However, the finding of a cluster of reduced activation close to the right temporoparietal junction in patients with persecutory delusions specifically is of potential interest, as this region is believed to play a role in social cognition. [ABSTRACT FROM AUTHOR]

Published
2023
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33. A Multisite, Randomized Controlled Clinical Trial of Computerized Cognitive Remediation Therapy for Schizophrenia

Author

Gomar, Jesús J., Valls, Elia, Radua, Joaquim, Mareca, Celia, Tristany, Josep, del Olmo, Francisco, Rebolleda-Gil, Carlos, Jañez-Álvarez, María, de Álvaro, Francisco J., Ovejero, María R., Llorente, Ana, Teixidó, Cristina, Donaire, Ana M., García-Laredo, Eduardo, Lazcanoiturburu, Andrea, Granell, Luis, Mozo, Cristina de Pablo, Pérez-Hernández, Mónica, Moreno-Alcázar, Ana, Pomarol-Clotet, Edith, and McKenna, Peter J.

Published
2015
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37. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis

Author

Corlett, Philip R., Honey, Garry D., Aitken, Michael R.F., Dickinson, Anthony, Shanks, David R., Absalom, Anthony R., Lee, Michael, Pomarol-Clotet, Edith, Murray, Graham K., Mckenna, Peter J., Robbins, Trevor W., Bullmore, Edward T., and Fletcher, Paul C.

Subjects
Ketamine -- Physiological aspects, Frontal lobes -- Physiological aspects, Frontal lobes -- Research, Delusions -- Development and progression, Magnetic resonance imaging -- Usage, Health, Psychology and mental health
Published
2006

38. Clozapine alone versus clozapine and risperidone with refectory schizophrenia

Author

Honer, William G., Bergmann, Anderea, William, Richard, Thornton, Allen E., Falkai, Peter, Chen, Eric Y.H., MacEwan, William G., Pomoral-Clotet, Edith, Wasan, Kishor, Chan, Raymond C.K., McKenna, Peter J., Procyshyn, Ric, Wong, Jessica O.Y., and Stip, Emmanuel

Subjects
Clozapine -- Dosage and administration, Clozapine -- Comparative analysis, Risperidone -- Dosage and administration, Risperidone -- Comparative analysis, Drug therapy, Combination -- Comparative analysis, Schizophrenia -- Drug therapy
Abstract

A random study on patients with schizophrenia and a poor response to the treatment with clozapine was conducted. The treatment of schizophrenia with multiple antipsychotic drugs is common but the addition of risperidone to clozapine did not improve the symptoms in patients with severe schizophrenia.

Published
2006

44. Neural correlates of cognitive impairment in schizophrenia

Author

Ortiz-Gil, Jordi, Pomarol-Clotet, Edith, Salvador, Raymond, Canales-Rodríguez, Erick J., Sarró, Salvador, Gomar, Jesús J., Guerrero, Amalia, Sans-Sansa, Bibiana, Capdevila, Antoni, Junqué, Carme, and McKenna, Peter J.

Published
2011

45. CIBERSAM: Ten years of collaborative translational research in mental disorders

Author

Salagre, Estela, Arango, Celso, Artigas, Francesc, Ayuso-Mateos, José Luis, Bernardo, Miquel, Castro-Fornieles, Josefina, Bobes, Julio, Desco, Manuel, Fañanás, Lourdes, González-Pinto, Ana, Haro, Josep María, Leza, Juan Carlos, Mckenna, Peter J., Meana, José Javier, Menchón, José Manuel, Micó, Juan Antonio, Palomo, Tomás, Pazos, Ángel, Pérez, Víctor, Saiz-Ruiz, Jerónimo, Sanjuán, Julio, Tabarés-Seisdedos, Rafael, Crespo-Facorro, Benedicto, Casas, Miquel, Vilella, Elisabet, Palao, Diego, Olivares, Jose Manuel, Rodriguez-Jimenez, Roberto, and Vieta, Eduard

Published
2019
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46. Diez años de investigación traslacional colaborativa en enfermedades mentales: el CIBERSAM

Author

Salagre, Estela, Arango, Celso, Artigas, Francesc, Ayuso-Mateos, José Luis, Bernardo, Miquel, Castro-Fornieles, Josefina, Bobes, Julio, Desco, Manuel, Fañanás, Lourdes, González-Pinto, Ana, Haro, Josep María, Leza, Juan Carlos, Mckenna, Peter J., Meana, José Javier, Menchón, José Manuel, Micó, Juan Antonio, Palomo, Tomás, Pazos, Ángel, Pérez, Víctor, Saiz-Ruiz, Jerónimo, Sanjuán, Julio, Tabarés-Seisdedos, Rafael, Crespo-Facorro, Benedicto, Casas, Miquel, Vilella, Elisabet, Palao, Diego, Olivares, Jose Manuel, Rodriguez-Jimenez, Roberto, and Vieta, Eduard

Published
2019
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