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Abstract Background Social consensus in the nursing industry is that the job is accompanied by dirtiness. It is generally accepted that negative cognition about a career is an important determinant in reducing nursing students’ professional commitment. However, the impact of nursing students’ perceived work dirtiness on professional commitment and its mechanism remains unclear. This study aimed to analyze the association between perceived work dirtiness and professional commitment and to examine the mediating role of career adaptability and the moderating role of social support among nursing students in mainland China. Methods A cross-sectional online study was conducted among 341 nursing students from three medical universities in Henan, China. The participants’ perceived work dirtiness, career adaptability, professional commitment, and social support were obtained. SPSS 26.0 and Amos 23.0 software were used for the statistical analysis. Results Perceived work dirtiness was negatively related to career adaptability and professional commitment (P

The Ministry of Health Malaysia aims to fully replace liquid-based cytology (LBC) with Human Papillomavirus (HPV) tests and increase the screening coverage from a baseline of 25% to 40% by 2023, followed by a 10% yearly increment until 70% coverage. This transition requires proper planning, including the number of tests needed and budget allocation. This study aims to simulate different transition strategies involving the shift from LBC to HPV testing with expanded screening coverage to predict their impact on cervical cancer elimination in Malaysia. A system dynamics model was developed to simulate the transition from LBC to HPV testing and HPV vaccination coverage in Malaysia. The dynamic model utilised local epidemiological data, published research, and expert opinion when data was unavailable. The simulation showed that a combination of high HPV vaccination coverage and transitioning fully to five-yearly HPV testing by 2030, coupled with a 70% screening uptake by 2040, would accelerate cancer elimination in Malaysia by 18 years with an estimated screening cost of MYR1.81 billion equivalent to USD 411 millions compared to the baseline of using LBC as the primary screening method (MYR1.39 billion, USD 315 millions). Sustained, it would lead to averting 6,000 new cancer cases by 2070. Alternatively, conducting HPV screenings twice before age 50 would advance cervical cancer elimination by 14 years and prevent approximately 1000 new cases by 2070, with an estimated cost of MYR1.13 billion equivalent to USD 257 millions. A delay in achieving the full transition prolonged the elimination more than a delay in increasing the screening coverage. In all scenarios, yearly vaccination of 90% of girls age 13 is crucial to achieving elimination. In the Malaysian context, where HPV vaccination coverage has reached considerable levels, the evidence advocates for a full transition from LBC to HPV testing, ideally by 2030. While expanding screening coverage remains a critical factor in this endeavour, the findings unequivocally endorse prioritising the transition process. Trial registration: Trial registration number: NMRR ID-22-00187-DJU.

IntroductionOvarian cancer is one of the most common cancer among women in Malaysia. Patients with ovarian cancer are often diagnosed at an advanced stage. Despite initial response to surgery and chemotherapy, most patients will experience a relapse. Olaparib has been reported have promising effects among BRCA mutated ovarian cancer patients. This study aimed to evaluate the cost-effectiveness of olaparib as a maintenance therapy for BRCA ovarian cancer in Malaysia.MethodsWe developed a four-state partitioned survival model which compared treatment with olaparib versus routine surveillance (RS) from a Malaysian healthcare perspective. Mature overall survival (OS) data from the SOLO-1 study were used and extrapolated using parametric models. Medication costs and healthcare resource usage costs were derived from local inputs and publications. Deterministic and probabilistic sensitivity analyses (PSA) were performed to explore uncertainties.ResultsIn Malaysia, treating patients with olaparib was found to be more costly compared to RS, with an incremental cost of RM149,858 (USD 33,213). Patients treated with olaparib increased life years by 3.05 years and increased quality adjusted life years (QALY) by 2.76 (9.45 years vs 6.40 years; 7.62 vs 4.86 QALY). This translated to an incremental cost-effectiveness ratio (ICER) of RM 49,159 (USD10,895) per life year gained and RM54,357 (USD 12,047) per QALY gained, respectively. ICERs were most sensitive to time horizon of treatment, discount rate for outcomes, cost of treatment and health state costs, but was above the RM53,770/QALY threshold.ConclusionThe use of olaparib is currently not a cost-effective strategy compared to routine surveillance based upon the current price in Malaysia for people with ovarian cancer with BRCA mutation, despite the improvement in overall survival.

Simple Summary: Mycoplasma capricolum subsp. capricolum (Mcc) is an important pathogen associated with diseases in goats, hindering the development of the livestock industry. We previously isolated the HN-B strain of Mcc from goats on Hainan Island, China. The genomic and biological characteristics of this strain were investigated. In this study, we infected mice and RAW264.7 cells with Mcc HN-B to explore its pathogenic mechanism in the host. Differentially expressed genes related to immune terms and pathways were identified using bioinformatic analyses. The expression of two inflammatory proteins, S100A8 and S100A9, was up-regulated in mouse lungs post Mcc HN-B infection. This study preliminarily elucidates the pathogenesis of Mcc in mice and paves the way for further research in goats. Mycoplasma capricolum subsp. capricolum (Mcc), a member of the Mycoplasma mycoides cluster, has a negative impact on the goat-breeding industry. However, little is known about the pathogenic mechanism of Mcc. This study infected mice using a previously isolated strain, Mcc HN-B. Hematoxylin and eosin staining, RNA sequencing, bioinformatic analyses, RT-qPCR, and immunohistochemistry were performed on mouse lung tissues. The results showed that 235 differentially expressed genes (DEGs) were identified. GO and KEGG enrichment analyses suggested that the DEGs were mainly associated with immune response, defensive response to bacteria, NF-kappa B signaling pathway, natural killer cell-mediated cytotoxicity, and T cell receptor signaling pathway. RT-qPCR verified the expression of Ccl5, Cd4, Cd28, Il2rb, Lck, Lat, Ptgs2, S100a8, S100a9, and Il-33. The up-regulation of S100A8 and S100A9 at the protein level was confirmed by immunohistochemistry. Moreover, RT-qPCR assays on Mcc HN-B-infected RAW264.7 cells also showed that the expression of S100a8 and S100a9 was elevated. S100A8 and S100A9 not only have diagnostic value in Mcc infection but also hold great significance in clarifying the pathogenic mechanism of Mcc. This study preliminarily elucidates the mechanism of Mcc HN-B-induced lung injury and provides a theoretical basis for further research on Mcc–host interactions. [ABSTRACT FROM AUTHOR]

The zirconium-based MOF/graphene oxide (UiO-66-N[H.sub.2]/GO) composites were prepared by ultrasonic dispersing different amounts of graphene oxide (GO) in a well-dissolved zirconium tetrachloride/[H.sub.2]BDC-N[H.sub.2] mixture, obtaining 2 wt% (UiO-66-N[H.sub.2]/GO-1), 5 wt% (UiO-66-N[H.sub.2]/GO-2), and 10 wt% (UiO-66-N[H.sub.2]/GO-3) GO composites. The products were characterized by XRD, FTIR, SEM, BET, Raman, UV, XPS, and Zeta potential. Adsorption experiments on simulated Eriochrome Black T (EBT) printing and dyeing wastewater were carried out using UiO-66-N[H.sub.2]/GO, and the optimal conditions for adsorption were obtained by exploring the effects of initial EBT concentration, time, pH, and salt ionic strength. Adsorption isotherms, kinetics, mechanism, and regeneration were also researched. The adsorption behavior was consistent with the Langmuir isotherm and fully compliant with pseudo secondary dynamics model. The adsorption capacity of UiO-66-N[H.sub.2]/GO-2 was found to be the highest of the three products, which was 263.158 mg/g. Therefore, the UiO-66-N[H.sub.2]/GO-2 composite was considered to be an excellent adsorbent for the adsorption of EBT from organic dye wastewater. Key words: metal-organic frameworks, graphene oxide, adsorption, Eriochrome Black T, wastewater. Nous avons fabrique des materiaux composites composes d'un reseau metallo-organique a base de zirconium et d'oxyde de graphene (UiO-66-N[H.sub.2]/GO) en dispersant a l'aide d'ultrasons differentes quantites d'oxyde de graphene dans un melange a dissolution complete de tetrachlorure de zirconium et de [H.sub.2]BDC-N[H.sub.2]. Cette methode a permis d'obtenir differents composites contentant 2% p/p (UiO-66-N[H.sub.2]/GO-1), 5% p/p (UiO-66-N[H.sub.2]/GO-2) et 10% p/p (UiO-66-N[H.sub.2]/GO) d'oxyde de graphene. Nous avons caracterise les produits obtenus par analyse DRX, spectroscopie FTIR, MEB, analyse BET, spectroscopie Raman, spectroscopie UV, analyse XPS et analyse du potentiel zêta. Nous avons utilise les composites UiO-66-N[H.sub.2]/GO pour realiser des experiences d'adsorption dans un modele d'eaux usees contaminees par des encres et des colorants a base de noir eriochrome T (NET). Nous avons etabli les conditions optimales d'adsorption en etudiant les effets de la concentration initiale de NET, du temps de contact, ainsi que du pH et de la force ionique de la solution. Nous avons egalement etudie les isothermes d'adsorption, la cinetique, la mecanistique, et la regeneration de ces composes. Le comportement d'adsorption correspondait a l'isotherme de Langmuir et concordait parfaitement avec le modele dynamique de pseudo-second ordre. Nous avons observe que le composite UiO-66-N[H.sub.2]/GO-2 presentait la capacite d'adsorption la plus importante des trois, soit 263,158 mg/g. Ces resultats montrent que le composite UiO-66-N[H.sub.2]/GO-2 constituerait un excellent adsorbant en contexte d'adsorption du NET dans les eaux usees contaminees par des colorants organiques. [Traduit par la Redaction] Mots-cles : reseaux metallo-organiques, oxyde de graphene, adsorption, noir eriochrome T, eaux usees., Introduction Water pollution has become a major environmental problem today, especially organic dye pollution, which has attracted widespread concern. Some industrial wastewater has been proved toxic or even carcinogenic. Therefore, [...]