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Background Inflammation and oxidative stress (OS) are important contributors to psoriasis pathogenesis. Proanthocyanidins (PCs) have anti-inflammatory and anti-oxidative activities. Previously, we discovered that PCs alleviated psoriasis-like mice symptoms, likely via mitigating inflammation and OS damage.Objective To elucidate the protective mechanism underlying PCs against the damage of TNF-ɑ-induced psoriasis-like cell models.Methods Psoriasis-like cell models were established with 7.5 ng/mL TNF-ɑ and then subjected to different-concentrations PCs treatment. Finally, inflammatory and oxidative parameters were determined. Besides, LY294002 (PI3K inhibitor) and ZnPP (HO-1 inhibitor) were employed to investigate the roles of PI3K/AKT and HO-1 in PCs against psoriasis-like cell models.Results After TNF-α treatment, cells organized tightly and proliferated greatly (P

Background Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out. Objectives To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders. Methods Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc. Results It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases. Conclusion Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.

Oil-use peony is a treasure with broad prospects. Heze City plans to develop oil-use peony as a local key industry. However, there are still many urgent problems that need to be solved for the sustained and healthy development of the oil-use peony industry. This paper delved into the comprehensive benefits of oiluse peony and its industrial development from the aspects of cultivating high-quality germplasm resources, technological innovation, policy support, developing leading enterprises, improving industrialization system, comprehensive promotion, and strengthening storage and transportation technology, aiming to provide some reference for further development of Heze oil-use peony industry. [ABSTRACT FROM AUTHOR]

The peony industry is a characteristic industry in Heze City, and oil-use peony is an emerging industry. Heze City has planned oil-use peony as a key support and development industry in the local area. The oil-use peony industry is full of treasures, but there are stiil many urgent problem to be solved for its sustained and healthy development: cultivation and planting, variety selection, product processing, and enterprise development, which have hindered the development of the oil-use peony industry. This paper delved into the comprehensive benefits of oil-use peony and its industrial development, providing some reference for the further development of the oil-use peony industry in Heze. [ABSTRACT FROM AUTHOR]

[Objectives] The effects of three exogenous phytohormones on the uptake and accumulation of Cd in the seedlings of Amaranthus mangostanus L. were investigated. [Methods] Three effective plant hormones, auxin (IAA), gibberellin (GA) and salicylic acid (SA) were selected and formulated into three concentrations, respectively, and were studied through pot experiments. [Results] The application of IAA, GA and SA increased the accumulation of Cd in each part of A. mangostanus. The absorption capacities of Cd in the roots, stems and leaves of A. mangostanus were related to the types and levels of hormones, and the overall trend was GA > SA > IAA. The leaves had significantly higher Cd translocation and bioaccumulation capacities than the stems. Under the treatment of 5ÛÛ mg/L low concentration of gibberellin, the translocation and bioaccumulation factors reached the highest. [Conclusions] The results indicated that the absorptive, accumulative and transferred capacities of Cd of the amaranth plants after using phytohormones were obviously higher than the control. [ABSTRACT FROM AUTHOR]

With Sunflower (Helianthus annuus L.) as an experimental material, phytohormones were externally applied, so as to screen phytohormones capable of alleviating environmental stress. Three kinds of phytohormones (auxin IAA, gibberellin GA and salicylic acid SA) were added through pot culture. The results showed that the three phytohormones aU improved the accumulation of 8 8Sr in sunflower plant, and increased the translocation and bioaccumulation factors of 8 8Sr; and under the 100 mg/LSA treatment, the adsorption capacity, TF and BCF of 8 8 Sr in sunflower plant reached the highest values. [ABSTRACT FROM AUTHOR]