21 results on '"Mina, Yair"'
Search Results
2. Atypical duration of epileptic and psychogenic nonepileptic events
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Anis, Saar, Fahoum, Firas, Korczyn, Amos D., Sverdlov, Diana, Abramovici, Sergiu, Mina, Yair, Neufeld, Miri Y., and Kipervasser, Svetlana
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- 2020
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3. Neurological manifestations of nontuberculous mycobacteria in adults: case series and review of the literature.
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Mina, Yair, Kline, Ahnika, Manion, Maura, Hammoud, Dima A., Tianxia Wu, Hogan, Julie, Sereti, Irini, Smith, Bryan R., Zerbe, Christa S., Holland, Steven M., and Nath, Avindra
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LITERATURE reviews ,MYCOBACTERIA ,IMMUNOLOGIC diseases ,MYCOBACTERIUM avium ,MYCOBACTERIUM avium paratuberculosis ,HIV infections ,EPILEPSY - Abstract
Introduction: Nontuberculous mycobacteria (NTM) mediated infections are important to consider in cases with neuroinflammatory presentations. We aimed to characterize cases of NTM with neurological manifestations at the National Institutes of Health (NIH) Clinical Center and review the relevant literature. Materials and methods: Between January 1995 and December 2020, six cases were identified. Records were reviewed for demographic, clinical, and radiological characteristics. A MEDLINE search found previously reported cases. Data were extracted, followed by statistical analysis to compare two groups [cases with slow-growing mycobacteria (SGM) vs. those with rapidly growing mycobacteria (RGM)] and evaluate for predictors of survival. NIH cases were evaluated for clinical and radiological characteristics. Cases from the literature were reviewed to determine the differences between SGM and RGM cases and to identify predictors of survival. Results: Six cases from NIH were identified (age 41 ± 13, 83% male). Five cases were caused by SGM [Mycobacterium avium complex (MAC) n = 4; Mycobacterium haemophilum n = 1] and one due to RGM (Mycobacterium abscessus). Underlying immune disorders were identified only in the SGM cases [genetic (n = 2), HIV (n = 1), sarcoidosis (n = 1), and anti-interferongamma antibodies (n = 1)]. All cases were diagnosed using tissue analysis. A literature review found 81 reports on 125 cases (SGM n = 85, RGM n = 38, nonidentified n = 2). No immune disorder was reported in 26 cases (21%). Within SGM cases, the most common underlying disease was HIV infection (n = 55, 65%), and seizures and focal lesions were more common. In RGM cases, the most common underlying condition was neurosurgical intervention or implants (55%), and headaches and meningeal signs were common. Tissue-based diagnosis was used more for SGM than RGM (39% vs. 13%, p = 0.04). Survival rates were similar in both groups (48% SGM and 55% in RGM). Factors associated with better survival were a solitary CNS lesion (OR 5.9, p = 0.01) and a diagnosis made by CSF sampling only (OR 9.9, p = 0.04). Discussion: NTM infections cause diverse neurological manifestations, with some distinctions between SGM and RGM infections. Tissue sampling may be necessary to establish the diagnosis, and an effort should be made to identify an underlying immune disorder. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Clinical benefits of FilmArray meningitis-encephalitis PCR assay in partially-treated bacterial meningitis in Israel
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Mina, Yair, Schechner, Vered, Savion, Michal, Yahav, Dafna, Bilavsky, Efraim, Sorek, Nadav, Ben-Zvi, Haim, and Adler, Amos
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- 2019
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5. Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases.
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Calvier, Laurent, Drelich, Aleksandra, Hsu, Jason, Tseng, Chien-Te, Mina, Yair, Nath, Avindra, Kounnas, Maria Z., and Herz, Joachim
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POST-acute COVID-19 syndrome ,COVID-19 pandemic ,COVID-19 ,ACUTE diseases ,TRANSGENIC mice - Abstract
Thromboembolic complications and excessive inflammation are frequent in severe COVID-19, potentially leading to long COVID. In non-COVID studies, we and others demonstrated that circulating Reelin promotes leukocyte infiltration and thrombosis. Thus, we hypothesized that Reelin participates in endothelial dysfunction and hyperinflammation during COVID-19. We showed that Reelin was increased in COVID-19 patients and correlated with the disease activity. In the severe COVID-19 group, we observed a hyperinflammatory state, as judged by increased concentration of cytokines (IL-1a, IL-4, IL-6, IL-10 and IL-17A), chemokines (IP-10 and MIP-1b), and adhesion markers (E-selectin and ICAM-1). Reelin level was correlated with IL-1a, IL-4, IP-10, MIP-1b, and ICAM-1, suggesting a specific role for Reelin in COVID-19 progression. Furthermore, Reelin and all of the inflammatory markers aforementioned returned to normal in a long COVID cohort, showing that the hyperinflammatory state was resolved. Finally, we tested Reelin inhibition with the anti-Reelin antibody CR-50 in hACE2 transgenic mice infected with SARS-CoV-2. CR-50 prophylactic treatment decreased mortality and disease severity in this model. These results demonstrate a direct proinflammatory function for Reelin in COVID-19 and identify it as a drug target. This work opens translational clinical applications in severe SARS-CoV-2 infection and beyond in auto-inflammatory diseases. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Deep Phenotyping of Neurologic Postacute Sequelae of SARS-CoV-2 Infection.
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Mina, Yair, Enose-Akahata, Yoshimi, Hammoud, Dima A., Videckis, Anthony J., Narpala, Sandeep R., O'Connell, Sarah E., Carroll, Robin, Lin, Bob C., McMahan, Cynthia Chen, Nair, Govind, Reoma, Lauren B., McDermott, Adrian B., Walitt, Brian, Jacobson, Steven, Goldstein, David S., Smith, Bryan R., and Nath, Avindra
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- 2023
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7. Clinical, Imaging, and Laboratory Findings in Patients With GATA2 Deficiency Presenting With Early-Onset Ischemic Stroke.
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Bierman-Chow, Shaia, Holland, Steven M., Hsu, Amy P., Palmer, Cindy, Lynch, John, Mina, Yair, Joo Cho, Hyun, and Joo Sophie Cho, Hyun
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- 2023
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8. Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis.
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Beck, Erin S, Maranzano, Josefina, Luciano, Nicholas J, Parvathaneni, Prasanna, Filippini, Stefano, Morrison, Mark, Suto, Daniel J, Wu, Tianxia, van Gelderen, Peter, de Zwart, Jacco A, Antel, Samson, Fetco, Dumitru, Ohayon, Joan, Andrada, Frances, Mina, Yair, Thomas, Chevaz, Jacobson, Steve, Duyn, Jeff, Cortese, Irene, and Narayanan, Sridar
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DISABILITIES ,MULTIPLE sclerosis ,WHITE matter (Nerve tissue) ,MAGNETIC resonance imaging ,SPINAL cord ,PEOPLE with disabilities - Abstract
Background: Dramatic improvements in visualization of cortical (especially subpial) multiple sclerosis (MS) lesions allow assessment of impact on clinical course. Objective: Characterize cortical lesions by 7 tesla (T) T
2 * -/T1 -weighted magnetic resonance imaging (MRI); determine relationship with other MS pathology and contribution to disability. Methods: Sixty-four adults with MS (45 relapsing–remitting/19 progressive) underwent 3 T brain/spine MRI, 7 T brain MRI, and clinical testing. Results: Cortical lesions were found in 94% (progressive: median 56/range 2–203; relapsing–remitting: 15/0–168; p = 0.004). Lesion distribution across 50 cortical regions was nonuniform (p = 0.006), with highest lesion burden in supplementary motor cortex and highest prevalence in superior frontal gyrus. Leukocortical and white matter lesion volumes were strongly correlated (r = 0.58, p < 0.0001), while subpial and white matter lesion volumes were moderately correlated (r = 0.30, p = 0.002). Leukocortical (p = 0.02) but not subpial lesions (p = 0.40) were correlated with paramagnetic rim lesions; both were correlated with spinal cord lesions (p = 0.01). Cortical lesion volumes (total and subtypes) were correlated with expanded disability status scale, 25-foot timed walk, nine-hole peg test, and symbol digit modality test scores. Conclusion: Cortical lesions are highly prevalent and are associated with disability and progressive disease. Subpial lesion burden is not strongly correlated with white matter lesions, suggesting differences in inflammation and repair mechanisms. [ABSTRACT FROM AUTHOR]- Published
- 2022
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9. Low cerebrospinal fluid volume and the risk for post-lumbar puncture headaches
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Droby, Amgad, Omer, Nurit, Gurevich, Tanya, Kestenbaum, Meir, Mina, Yair, Cedarbaum, Jesse M., Aizenstein, Orna, Giladi, Nir, Mirelman, Anat, and Thaler, Avner
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- 2020
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10. Logistic Regression-Based Model Is More Efficient Than U-Net Model for Reliable Whole Brain Magnetic Resonance Imaging Segmentation.
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Dieckhaus, Henry, Meijboom, Rozanna, Okar, Serhat, Wu, Tianxia, Parvathaneni, Prasanna, Mina, Yair, Chandran, Siddharthan, Waldman, Adam D., Reich, Daniel S., and Nair, Govind
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- 2022
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11. Mast Cell Inhibition Attenuates Myocardial Damage, Adverse Remodeling, and Dysfunction During Fulminant Myocarditis in the Rat
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Mina, Yair, Rinkevich-Shop, Shunit, Konen, Eli, Goitein, Orly, Kushnir, Tammar, Epstein, Frederick H., Feinberg, Micha S., Leor, Jonathan, and Landa-Rouben, Natalie
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- 2013
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12. Association of White Matter Hyperintensities With HIV Status and Vascular Risk Factors.
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Mina, Yair, Tianxia Wu, Hsing-Chuan Hsieh, Hammoud, Dima A., Shah, Swati, Chuen-Yen Lau, Ham, Lillian, Snow, Joseph, Horne, Elizabeth, Ganesan, Anuradha, Rapoport, Stanley I., Tramont, Edmund C., Reich, Daniel S., Agan, Brian K., Nath, Avindra, Smith, Bryan R., Wu, Tianxia, Hsieh, Hsing-Chuan, Lau, Chuen-Yen, and NIH-DOD NeuroHIV Consortium
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- 2021
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13. Clinical correlates and electroencephalographic features of FIRDA in a tertiary center.
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Mina, Yair, Fahoum, Firas, Abramovici, Sergiu, Anis, Saar, and Kipervasser, Svetlana
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FRONTOTEMPORAL lobar degeneration , *CENTRAL nervous system , *PEOPLE with epilepsy - Abstract
Objectives: We aimed to explore the diagnostic value, clinical correlates and electroencephalographic features of FIRDA (Frontal intermittent rhythmic delta activity). Materials and methods: We retrospectively reviewed reports from EEG studies done in adults at our tertiary center between January 2015 and May 2018. For cases demonstrating FIRDA, medical files were reviewed and each case was given a diagnostic category. EEG recordings were reviewed and electrophysiologic data were extracted including FIRDA characteristics (frequency, location, duration, and symmetry). Then, a statistical analysis was done to evaluate the relationship between the diagnostic categories and EEG variables. Results: Ninety‐four cases of FIRDA were found, with a frequency of 1.6% among inpatients. EEG recordings were available for review in 84 cases. FIRDA was asymmetric in 43 of these cases (49%), usually more prominent on the left (36/43, 84%). The diagnostic category groups included epilepsy (n = 39, 41%), other central nervous system (CNS) disease (n = 33, 35%), and systemic illness (n = 22, 23%). A significant difference in FIRDA location was found, as patients with epilepsy or other CNS disease, had a significantly higher probability for the delta activity to involve the temporal areas (frontotemporal location in 27/64 in these groups compared with 3/20 in the systemic illness group, P‐value = .033). Conclusions: This study provides insights to the diagnosis underlying FIRDA, especially the high rate of epilepsy patients, and calls for further neurologic investigation of cases in which FIRDA involves the temporal areas since most of these cases were due to epilepsy or other CNS disease and not a systemic illness. [ABSTRACT FROM AUTHOR]
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- 2019
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14. Neurosyphilis presenting as cranial nerve palsy, an entity which is easy to miss.
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Piura, Yoav, Mina, Yair, Aizenstein, Orna, and Gadoth, Avi
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Neurosyphilis is a rare disease that until the 2000s was almost eradicated due to population awareness of HIV and efficient treatment. Since then, the prevalence of the entity is rising due to risk-associated behaviour such as unprotected intercourse. Neurosyphilis is still a difficult entity to diagnose especially when combined with acute HIV infection which can influence the usual clinical course of disease. In rare occasions, both acute HIV and early syphilis infection can present as mono or multiple cranial nerve palsies. This case demonstrates a rare manifestation of misdiagnosed early syphilis infection combined with acute HIV infection in a 34-year-old man with prior history of unprotected sex with men. [ABSTRACT FROM AUTHOR]
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- 2019
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15. Rituximab as a Second-Line Treatment for Lymphocytic Vasculitis of the Central Nervous System.
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Anis, Saar, Sharabi, Amir, Mina, Yair, Klein, Ainat, Cagnano, Emanuela, Elkayam, Ori, and Gurevich, Tanya
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- 2016
16. The repertoire of CSF antiviral antibodies in patients with neuroinflammatory diseases.
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Enose-Akahata, Yoshimi, Limin Wang, Almsned, Fahad, Johnson, Kory R., Mina, Yair, Ohayon, Joan, Xin Wei Wang, and Jacobson, Steven
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B cells , *CEREBROSPINAL fluid examination , *SARS-CoV-2 , *PLANT viruses , *NEUROPEPTIDE Y - Abstract
The article presents a study which hypothesized that if environmental factors including virus infections and immune reactivation against viruses play a role as triggers in multiple sclerosis (MS), then antibody signatures against such viral exposures may be defined that represent immunological signatures in patients with MS. Topics discussed include library preparation, viral exposure signature pipeline, and statistical pipeline.
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- 2023
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17. Persistent Autonomic and Immunologic Abnormalities in Neurologic Post-Acute Sequelae of SARS-CoV2 Infection.
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Goldstein DS, Mina Y, Walitt B, Sullivan P, Enose-Akahata Y, Jacobson S, Nguyen ML, Sidenko S, Wiebold A, Smith B, Gelsomino J, Isonaka R, Moore S, and Nath A
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- Humans, Female, Middle Aged, Male, Adult, SARS-CoV-2, Follow-Up Studies, COVID-19 complications, COVID-19 immunology, Post-Acute COVID-19 Syndrome, Autonomic Nervous System Diseases etiology, Autonomic Nervous System Diseases immunology
- Abstract
Objectives: After acute coronavirus disease-2019 (COVID-19), people often experience fatigue, "brain fog," or other central neurologic symptoms (neuro-post-acute SARS-CoV2, or "Neuro-PASC"). In this observational study we evaluated whether abnormalities noted on initial evaluation persist after at least another year., Methods: Neuro-PASC research participants who had undergone comprehensive inpatient testing at the NIH Clinical Center returned after at least 1 year for follow-up assessments including symptoms rating scales, MRI, lumbar puncture for tests of the CSF, physiologic recordings during the Valsalva maneuver and head-up tilting (with serial plasma catechols and cardiac Doppler ultrasound during the tilting), blood volume measurement, skin biopsies to examine sympathetic innervation, and blood sampling for neuroendocrine and immunologic measures., Results: 7 patients with Neuro-PASC (6 women, age range 42-63 years) underwent follow-up testing. 71% of initially abnormal test results remained abnormal at follow-up, including the pattern of CSF and serum oligoclonal bands, CSF indices of central catecholamine deficiency, baroreflex-cardiovagal dysfunction, the occurrence of tilt-evoked sudden hypotension, white matter hyperintensities on MRI, and adaptive responses in CSF., Discussion: In Neuro-PASC most of the autonomic and immunologic abnormalities found initially are still present after more than a year.
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- 2024
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18. Epidemiology of autoimmune encephalitis and comparison to infectious causes-Experience from a tertiary center.
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Segal Y, Rotschild O, Mina Y, Maayan Eshed G, Levinson T, Paran Y, Dekel M, Cohen-Poradosu R, Ashkenazi A, Moreno I, Aizenstein O, Halutz O, Alcalay Y, and Gadoth A
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Objectives: The incidence of autoimmune encephalitis (AIE) has risen in the last decade, yet recent studies are lacking. We compared the epidemiology of autoimmune and infectious encephalitis cases in Tel-Aviv Sourasky Medical Center (TASMC) between 2010 and 2020., Methods: All encephalitis cases, aged 18 and above, admitted to TASMC between the years 2010 and 2020 were reviewed for demographic, clinical, laboratory, and imaging data and categorized based on etiology., Results: Two hundred and twenty-five patients with encephalitis were identified. The most common identifiable cause was viral (42%), followed by autoimmune encephalitis (35%), bacterial (18%), and fungal/parasitic (5%). The incidence of AIE cases out of the yearly admitted cases increased substantially, from 3.8/100 K in 2010 to 18.8/100 K in 2020. The incidence of viral cases also increased while those of bacterial and fungal/parasitic infections remained stable. Patients with AIE were younger compared to infectious patients (p-value <0.001) and had lower markers of systemic and cerebrospinal fluid inflammation (p-value for all <0.001). Seizures were more common among AIE patients (p-value <0.001), yet one-year mortality rates were higher among infectious patients (p-value <0.001)., Interpretation: AIE incidence has risen significantly in our institution during the past decade, with current rates comparable to those of all infectious causes combined. Based on this cohort, clinical clues for an autoimmune etiology include a non-inflammatory cerebrospinal fluid profile, the presence of seizures, and temporal lobe imaging abnormalities (also common in herpetic encephalitis). In light of its rising incidence and the importance of early treatment, AIE should be considered in the differential diagnosis of all encephalitis cases., (© 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
- Published
- 2024
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19. Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis.
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Beck ES, Maranzano J, Luciano NJ, Parvathaneni P, Filippini S, Morrison M, Suto DJ, Wu T, van Gelderen P, de Zwart JA, Antel S, Fetco D, Ohayon J, Andrada F, Mina Y, Thomas C, Jacobson S, Duyn J, Cortese I, Narayanan S, Nair G, Sati P, and Reich DS
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- Adult, Brain pathology, Humans, Magnetic Resonance Imaging methods, Disabled Persons, Multiple Sclerosis pathology, White Matter pathology
- Abstract
Background: Dramatic improvements in visualization of cortical (especially subpial) multiple sclerosis (MS) lesions allow assessment of impact on clinical course., Objective: Characterize cortical lesions by 7 tesla (T) T
2 * -/T1 -weighted magnetic resonance imaging (MRI); determine relationship with other MS pathology and contribution to disability., Methods: Sixty-four adults with MS (45 relapsing-remitting/19 progressive) underwent 3 T brain/spine MRI, 7 T brain MRI, and clinical testing., Results: Cortical lesions were found in 94% (progressive: median 56/range 2-203; relapsing-remitting: 15/0-168; p = 0.004). Lesion distribution across 50 cortical regions was nonuniform ( p = 0.006), with highest lesion burden in supplementary motor cortex and highest prevalence in superior frontal gyrus. Leukocortical and white matter lesion volumes were strongly correlated ( r = 0.58, p < 0.0001), while subpial and white matter lesion volumes were moderately correlated ( r = 0.30, p = 0.002). Leukocortical ( p = 0.02) but not subpial lesions ( p = 0.40) were correlated with paramagnetic rim lesions; both were correlated with spinal cord lesions ( p = 0.01). Cortical lesion volumes (total and subtypes) were correlated with expanded disability status scale, 25-foot timed walk, nine-hole peg test, and symbol digit modality test scores., Conclusion: Cortical lesions are highly prevalent and are associated with disability and progressive disease. Subpial lesion burden is not strongly correlated with white matter lesions, suggesting differences in inflammation and repair mechanisms.- Published
- 2022
- Full Text
- View/download PDF
20. Neuropathic symptoms with SARS-CoV-2 vaccination.
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Safavi F, Gustafson L, Walitt B, Lehky T, Dehbashi S, Wiebold A, Mina Y, Shin S, Pan B, Polydefkis M, Oaklander AL, and Nath A
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Background and Objectives: Various peripheral neuropathies, particularly those with sensory and autonomic dysfunction may occur during or shortly after acute COVID-19 illnesses. These appear most likely to reflect immune dysregulation. If similar manifestations can occur with the vaccination remains unknown., Results: In an observational study, we studied 23 patients (92% female; median age 40years) reporting new neuropathic symptoms beginning within 1 month after SARS-CoV-2 vaccination. 100% reported sensory symptoms comprising severe face and/or limb paresthesias, and 61% had orthostasis, heat intolerance and palpitations. Autonomic testing in 12 identified seven with reduced distal sweat production and six with positional orthostatic tachycardia syndrome. Among 16 with lower-leg skin biopsies, 31% had diagnostic/subthreshold epidermal neurite densities (≤5%), 13% were borderline (5.01-10%) and 19% showed abnormal axonal swelling. Biopsies from randomly selected five patients that were evaluated for immune complexes showed deposition of complement C4d in endothelial cells. Electrodiagnostic test results were normal in 94% (16/17). Together, 52% (12/23) of patients had objective evidence of small-fiber peripheral neuropathy. 58% patients (7/12) treated with oral corticosteroids had complete or near-complete improvement after two weeks as compared to 9% (1/11) of patients who did not receive immunotherapy having full recovery at 12 weeks. At 5-9 months post-symptom onset, 3 non-recovering patients received intravenous immunoglobulin with symptom resolution within two weeks., Conclusions: This observational study suggests that a variety of neuropathic symptoms may manifest after SARS-CoV-2 vaccinations and in some patients might be an immune-mediated process., Competing Interests: Competing interests: The authors report no competing interests.
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- 2022
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21. Cervical and thoracic cord atrophy in multiple sclerosis phenotypes: Quantification and correlation with clinical disability.
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Mina Y, Azodi S, Dubuche T, Andrada F, Osuorah I, Ohayon J, Cortese I, Wu T, Johnson KR, Reich DS, Nair G, and Jacobson S
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- Adult, Atrophy pathology, Cross-Sectional Studies, Disability Evaluation, Disease Progression, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Phenotype, Spinal Cord pathology, Cervical Cord diagnostic imaging, Cervical Cord pathology, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis pathology, Multiple Sclerosis, Relapsing-Remitting diagnostic imaging, Multiple Sclerosis, Relapsing-Remitting pathology
- Abstract
Objective: We sought to characterize spinal cord atrophy along the entire spinal cord in the major multiple sclerosis (MS) phenotypes, and evaluate its correlation with clinical disability., Methods: Axial T
1 -weighted images were automatically reformatted at each point along the cord. Spinal cord cross-sectional area (SCCSA) were calculated from C1-T10 vertebral body levels and profile plots were compared across phenotypes. Average values from C2-3, C4-5, and T4-9 regions were compared across phenotypes and correlated with clinical scores, and then categorized as atrophic/normal based on z-scores derived from controls, to compare clinical scores between subgroups. In a subset of relapsing-remitting cases with longitudinal scans these regions were compared to change in clinical scores., Results: The cross-sectional study consisted of 149 adults diagnosed with relapsing-remitting MS (RRMS), 49 with secondary-progressive MS (SPMS), 58 with primary-progressive MS (PPMS) and 48 controls. The longitudinal study included 78 RRMS cases. Compared to controls, all MS groups had smaller average regions except RRMS in T4-9 region. In all MS groups, SCCSA from all regions, particularly the cervical cord, correlated with most clinical measures. In the RRMS cohort, 22% of cases had at least one atrophic region, whereas in progressive MS the rate was almost 70%. Longitudinal analysis showed correlation between clinical disability and cervical cord thinning., Conclusions: Spinal cord atrophy was prevalent across MS phenotypes, with regional measures from the RRMS cohort and the progressive cohort, including SPMS and PPMS, being correlated with disability. Longitudinal changes in the spinal cord were documented in RRMS cases, making it a potential marker for disease progression. While cervical SCCSA correlated with most disability and progression measures, inclusion of thoracic measurements improved this correlation and allowed for better subgrouping of spinal cord phenotypes. Cord atrophy is an important and easily obtainable imaging marker of clinical and sub-clinical progression in all MS phenotypes, and such measures can play a key role in patient selection for clinical trials., (Published by Elsevier Inc.)- Published
- 2021
- Full Text
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