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Background Most humerus shaft fractures can be treated successfully using the conservative methods. When choosing surgical fixation, there is a debate between the use of plate and screws and intramedullary nails. Aims The aim of this study was to compare the results of the dynamic compression plate and the antegrade interlocked humeral nail in the fixation of humerus shaft fractures. Patients and methods A total of 40 patients were selected by a randomized method to be treated by either method; there were 20 patients in each group and patients were followed up for at least 6 months until union. Result The results showed superiority of the plate in terms of the union rate and shoulder function and the use of the nail was better in terms of the infection rate and radial nerve palsy. Conclusion The plate is still the standard of treatment of the humerus shaft fracture and the nails better be used for more comminuted or open fractures. More future studies with large numbers required to overcome our relatively small number.