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4,075 results on '"Moreno, Juan"'

3. Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight

Author

Tierney, Braden T., Kim, JangKeun, Overbey, Eliah G., Ryon, Krista A., Foox, Jonathan, Sierra, Maria A., Bhattacharya, Chandrima, Damle, Namita, Najjar, Deena, Park, Jiwoon, Garcia Medina, J. Sebastian, Houerbi, Nadia, Meydan, Cem, Wain Hirschberg, Jeremy, Qiu, Jake, Kleinman, Ashley S., Al-Ghalith, Gabriel A., MacKay, Matthew, Afshin, Evan E., Dhir, Raja, Borg, Joseph, Gatt, Christine, Brereton, Nicholas, Readhead, Benjamin P., Beyaz, Semir, Venkateswaran, Kasthuri J., Wiseman, Kelly, Moreno, Juan, Boddicker, Andrew M., Zhao, Junhua, Lajoie, Bryan R., Scott, Ryan T., Altomare, Andrew, Kruglyak, Semyon, Levy, Shawn, Church, George M., and Mason, Christopher E.

Published
2024
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5. SEOM-GEM clinical guidelines for cutaneous melanoma (2023)

Author

Márquez-Rodas, Iván, Muñoz Couselo, Eva, Rodríguez Moreno, Juan F., Arance Fernández, Ana Mª, Berciano Guerrero, Miguel Ángel, Campos Balea, Begoña, de la Cruz Merino, Luis, Espinosa Arranz, Enrique, García Castaño, Almudena, and Berrocal Jaime, Alfonso

Published
2024
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9. Case–control study assessing the impact of COVID19 in advanced kidney cancer patients treated with antiangiogenics or immunotherapy: the COVID-REN study

Author

García-Donas, Jesús, de Velasco, Guillermo, Madurga, Rodrigo, Chamorro, Jesús, Rosero, Diana, Etxaniz, Olatz, Pérez-Gracia, Jose Luis, Pinto, Álvaro, Cacho, Diego, Barba, María, Borrega, Pablo, Lázaro, Martín, Rodriguez, Laura, Villalobos, Laura, García, Lourdes, Cuellar, Andrés, Solís-Hernández, María Pilar, González, Amalia, Pernaut, Cristina, and Rodríguez-Moreno, Juan Francisco

Published
2024
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11. Yeast cell vacuum infusion into fungal pellets as a novel cell encapsulation methodology.

Author

Lúquez-Caravaca, Lara, Moreno, Juan, García-Martínez, Teresa, Mauricio, Juan, Jiménez-Uceda, Juan, Moreno-García, Jaime, Rai, Rewa, Nitin, Nitin, and Ogawa, Minami

Subjects
Cell immobilization, Cell retention, Vacuum infusion, Winemaking, Yeast biocapsules, Saccharomyces cerevisiae, Cell Encapsulation, Vacuum, Fermentation, Wine
Abstract

Immobilized yeast cells are used industrially in winemaking processes such as sparkling wine and Sherry wine production. Here, a novel approach has been explored for the infusion and immobilization of yeast cells into filamentous fungal pellets, which serve as a porous natural material. This was accomplished through vacuum application to force the yeast cells towards the core of the fungal pellets followed by culture in YPD medium to promote their growth from the interior. This method represents an improved variation of a previous approach for the assembly of yeast biocapsules, which entailed the co-culture of both fungal and yeast cells in the same medium. A comparison was made between both techniques in terms of biocapsule productivity, cell retention capacity, and cell biological activity through an alcoholic fermentation of a grape must. The results indicated a substantial increase in biocapsule productivity (37.40-fold), higher cell retention within the biocapsules (threefold), and reduction in cell leakage during fermentation (twofold). Although the majority of the chemical and sensory variables measured in the produced wine did not exhibit notable differences from those produced utilizing suspended yeast cells (conventional method), some differences (such as herbaceous and toasted smells, acidity, bitterness, and persistence) were perceived and wines positively evaluated by the sensory panel. As the immobilized cells remain functional and the encapsulation technique can be expanded to other microorganisms, it creates potential for additional industrial uses like biofuel, health applications, microbe encapsulation and delivery, bioremediation, and pharmacy. KEY POINTS: • New approach improves biocapsule productivity and cell retention. • Immobilized yeast remains functional in fermentation. • Wine made with immobilized yeast had positive sensory differences.

Published
2023

12. Flor yeast immobilization in microbial biocapsules for Sherry wine production: microvinification approach.

Author

Pastor-Vega, Noelia, Carbonero-Pacheco, Juan, Mauricio, Juan, Moreno, Juan, García-Martínez, Teresa, Rai, Rewa, Moreno-García, Jaime, Nitin, Nitin, and Ogawa, Minami

Subjects
Flor biofilm, Flor yeast, Fortification, Glycerol consumption pre-acclimatization, Microbial biocapsules, Sherry wine, Saccharomyces cerevisiae, Wine, Glycerol, Acetaldehyde, Ethanol, Fermentation
Abstract

Sherry wine is a pale-yellowish dry wine produced in Southern-Spain which features are mainly due to biological aging when the metabolism of biofilm-forming yeasts (flor yeasts) consumes ethanol (and other non-fermentable carbon sources) from a previous alcoholic fermentation, and produces volatile compounds such as acetaldehyde. To start aging and maintain the wine stability, a high alcohol content is required, which is achieved by the previous fermentation or by adding ethanol (fortification). Here, an alternative method is proposed which aims to produce a more economic, distinctive Sherry wine without fortification. For this, a flor yeast has been pre-acclimatized to glycerol consumption against ethanol, and later confined in a fungal-based immobilization system known as microbial biocapsules, to facilitate its inoculum. Once aged, the wines produced using biocapsules and free yeasts (the conventional method) exhibited chemical differences in terms of acidity and volatile concentrations. These differences were evaluated positively by a sensory panel. Pre-acclimatization of flor yeasts to glycerol consumption was not successful but when cells were immobilized in fungal pellets, ethanol consumption was lower. We believe that immobilization of flor yeasts in microbial biocapsules is an economic technique that can be used to produce high quality differentiated Sherry wines.

Published
2023

14. Sequencing by avidity enables high accuracy with low reagent consumption

Author

Arslan, Sinan, Garcia, Francisco J., Guo, Minghao, Kellinger, Matthew W., Kruglyak, Semyon, LeVieux, Jake A., Mah, Adeline H., Wang, Haosen, Zhao, Junhua, Zhou, Chunhong, Altomare, Andrew, Bailey, John, Byrne, Matthew B., Chang, Chiting, Chen, Steve X., Cho, Byungrae, Dennler, Claudia N., Dien, Vivian T., Fuller, Derek, Kelley, Ryan, Khandan, Omid, Klein, Michael G., Kim, Michael, Lajoie, Bryan R., Lin, Bill, Liu, Yu, Lopez, Tyler, Mains, Peter T., Price, Andrew D., Robertson, Samantha R., Taylor-Weiner, Hermes, Tippana, Ramreddy, Tomaney, Austin B., Zhang, Su, Abtahi, Minna, Ambroso, Mark R., Bajari, Rosita, Bellizzi, Ava M., Benitez, Chris B., Berard, Daniel R., Berti, Lorenzo, Blease, Kelly N., Blum, Angela P., Boddicker, Andrew M., Bondar, Leo, Brown, Chris, Bui, Chris A., Calleja-Aguirre, Juan, Cappa, Kevin, Chan, Joshua, Chang, Victor W., Charov, Katherine, Chen, Xiyi, Constandse, Rodger M., Damron, Weston, Dawood, Mariam, DeBuono, Nicole, Dimalanta, John D., Edoli, Laure, Elango, Keerthana, Faustino, Nikka, Feng, Chao, Ferrari, Matthew, Frankie, Keith, Fries, Adam, Galloway, Anne, Gavrila, Vlad, Gemmen, Gregory J., Ghadiali, James, Ghorbani, Arash, Goddard, Logan A., Guetter, Adriana Roginski, Hendricks, Garren L., Hentschel, Jendrik, Honigfort, Daniel J., Hsieh, Yun-Ting, Hwang Fu, Yu-Hsien, Im, Scott K., Jin, Chaoyi, Kabu, Shradha, Kincade, Daniel E., Levy, Shawn, Li, Yu, Liang, Vincent K., Light, William H., Lipsher, Jonathan B., Liu, Tsung-li, Long, Grace, Ma, Rui, Mailloux, John M., Mandla, Kyle A., Martinez, Anyssa R., Mass, Max, McKean, Daniel T., Meron, Michael, Miller, Edmund A., Moh, Celyne S., Moore, Rachel K., Moreno, Juan, Neysmith, Jordan M., Niman, Cassandra S., Nunez, Jesus M., Ojeda, Micah T., Ortiz, Sara Espinosa, Owens, Jenna, Piland, Geoffrey, Proctor, Daniel J., Purba, Josua B., Ray, Michael, Rong, Daisong, Saade, Virginia M., Saha, Sanchari, Tomas, Gustav Santo, Scheidler, Nicholas, Sirajudeen, Luqmanal H., Snow, Samantha, Stengel, Gudrun, Stinson, Ryan, Stone, Michael J., Sundseth, Keoni J., Thai, Eileen, Thompson, Connor J., Tjioe, Marco, Trejo, Christy L., Trieger, Greg, Truong, Diane Ni, Tse, Ben, Voiles, Benjamin, Vuong, Henry, Wong, Jennifer C., Wu, Chiung-Ting, Yu, Hua, Yu, Yingxian, Yu, Ming, Zhang, Xi, Zhao, Da, Zheng, Genhua, He, Molly, and Previte, Michael

Published
2024
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16. Proteomic profiles of peritoneal fluid-derived small extracellular vesicles correlate with patient outcome in ovarian cancer

Author

Quiralte, Miguel, Barquin, Arantzazu, Yague-Fernandez, Monica, Navarro, Paloma, Grazioso, Tatiana P., Sevillano-Fernandez, Elena, Rodriguez-Moreno, Juan F., Balarezo-Saldivar, Alejandra, Peinado, Hector, Izquierdo, Elena, Millan, Carlos, Lopez-Carrasco, Irene, Prieto, Mario, Madurga, Rodrigo, Fernandez-Miranda, Ismael, Ruiz-Llorente, Sergio, and Garcia-Donas, Jesus

Subjects
Proteomics -- Analysis -- Health aspects, Ovarian cancer -- Diagnosis -- Patient outcomes -- Development and progression, Health care industry
Abstract

Cancer-derived small extracellular vesicles (sEVs) are capable of modifying the tumor microenvironment and promoting tumor progression. Ovarian cancer (OvCa) is a lethal malignancy that preferentially spreads through the abdominal cavity. Thus, the secretion of such vesicles into the peritoneal fluid could be a determinant factor in the dissemination and behavior of this disease. We designed a prospective observational study to assess the impact of peritoneal fluid-derived sEVs (PFD-sEVs) in OvCa clinical outcome. For this purpose, 2 patient cohorts were enrolled: patients with OvCa who underwent a diagnostic or cytoreductive surgery and nononcological patients, who underwent abdominal surgery for benign gynecological conditions and acted as the control group. Systematic extraction of PFD-sEVs from surgical samples enabled us to observe significant quantitative and qualitative differences associated with cancer diagnosis, disease stage, and platinum chemosensitivity. Proteomic profiling of PFD-sEVs led to the identification of molecular pathways and proteins of interest and to the biological validation of S100A4 and STX5. In addition, unsupervised analysis of PFD-sEV proteomic profiles in high-grade serous ovarian carcinomas (HGSOCs) revealed 2 clusters with different outcomes in terms of overall survival. In conclusion, comprehensive characterization of PFD-sEV content provided a prognostic value with potential implications in HGSOC clinical management., Introduction Ovarian cancer (OvCa) is the fifth leading cause of mortality among women and the foremost cause of death attributed to gynecological cancers in developed countries (1). Patients with OvCa [...]

Published
2024
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19. A 15-year consolidated overview of data in over 6000 patients from the Transthyretin Amyloidosis Outcomes Survey (THAOS)

Author

Gentile, Luca, Coelho, Teresa, Dispenzieri, Angela, Conceição, Isabel, Waddington-Cruz, Márcia, Kristen, Arnt, Wixner, Jonas, Diemberger, Igor, Gonzalez-Moreno, Juan, Cariou, Eve, Maurer, Mathew S., Planté-Bordeneuve, Violaine, Garcia-Pavia, Pablo, Tournev, Ivailo, Gonzalez-Costello, Jose, Duarte, Alejandra Gonzalez, Grogan, Martha, Mazzeo, Anna, Chapman, Doug, Gupta, Pritam, Glass, Oliver, and Amass, Leslie

Published
2023
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23. A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Author

Ronk, Adam J., Lloyd, Nicole M., Zhang, Min, Atyeo, Caroline, Perrett, Hailee R., Mire, Chad E., Hastie, Kathryn M., Sanders, Rogier W., Brouwer, Philip J. M., Saphire, Erica Olmann, Ward, Andrew B., Ksiazek, Thomas G., Alvarez Moreno, Juan Carlos, Thaker, Harshwardhan M., Alter, Galit, Himansu, Sunny, Carfi, Andrea, and Bukreyev, Alexander

Published
2023
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26. Using TRIZ10 for Enhancing Creativity in Engineering Design Education

Author

Cano-Moreno, Juan David, Arenas Reina, José Manuel, Sánchez Martínez, Francisca Victoria, and Cabanellas Becerra, José María

Abstract

One of the popular creativity methods to solve technical problems is the Theory of Inventive Problem Solving, (TRIZ), however, requires a considerable investment of time. A teaching methodology for a simplified version of TRIZ (TRIZ10) has been developed for reducing learning time and improving the creative process in solving technical problems. This method has been applied in a small group of engineering design students as a proof of concept. The evaluation of the results obtained shows that students achieved adequate learning of this creative technique (75% overall efficiency). This method has led to the doubling of the number ideas developed by students compared to those generated before learning TRIZ10; further, it also improves a 10% the average degree of novelty for these ideas.

Published
2022
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28. eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis

Author

Addison, Jenni, Galley, Helen, Hall, Sally, Roughton, Sian, Taylor, Jane, Tennant, Heather, Webster, Nigel, Guleri, Achyut, Waddington, Natalia, Arawwawala, Dilshan, Durcan, John, Mitchell-Inwang, Christine, Short, Alasdair, Smolen, Susan, Swan, Karen, Williams, Sarah, Errington, Emily, Gordon, Tony, Templeton, Maie, McCauley, Marie, Venatesh, Pyda, Ward, Geraldine, Baudouin, Simon, Grier, Sally, Hall, Elaine, Higham, Charley, Soar, Jasmeet, Brett, Stephen, Kitson, David, Moreno, Juan, Mountford, Laura, Wilson, Robert, Hall, Peter, Hewlett, Jackie, McKechnie, Stuart, Faras-Arraya, Roser, Garrard, Christopher, Hutton, Paula, Millo, Julian, Parsons, Penny, Smiths, Alex, Young, Duncan, Raymode, Parizade, Andreou, Prem, Bowrey, Sarah, Hales, Dawn, Kazembe, Sandra, Rich, Natalie, Roberts, Emma, Thompson, Jonathan, Fletcher, Simon, Glister, Georgina, Rosbergen, Melissa, Cuesta, Jeronimo Moreno, Bion, Julian, Carrera, Ronald, Lees, Sarah, Millar, Joanne, Mitchell, Natalie, Nilson, Annette, Perry, Elsa Jane, Ruel, Sebastian, Wilde, Jude, Willis, Heather, Atkinson, Jane, Brown, Abby, Jacques, Nicola, Kapila, Atul, Prowse, Heather, Bland, Martin, Bullock, Lynne, Harrison, Donna, Krige, Anton, Mills, Gary, Humphreys, John, Armitage, Kelsey, Laha, Shond, Baldwin, Jacqueline, Walsh, Angela, Doherty, Nicola, Drage, Stephen, Ortiz-Ruiz de Gordoa, Laura, Lowes, Sarah, Walsh, Helen, Calder, Verity, Swan, Catherine, Payne, Heather, Higgins, David, Andrews, Sarah, Mappleback, Sarah, Hinds, Charles, Watson, D., McLees, Eleanor, Purdy, Alice, Stotz, Martin, Ochelli-Okpue, Adaeze, Bonner, Stephen, Whitehead, Iain, Hugil, Keith, Goodridge, Victoria, Cawthor, Louisa, Kuper, Martin, Pahary, Sheik, Bellingan, Geoffrey, Marshall, Richard, Montgomery, Hugh, Ryu, Jung Hyun, Bercades, Georgia, Boluda, Susan, Bentley, Andrew, Mccalman, Katie, Jefferies, Fiona, Allcock, Alice, Burnham, Katie, Davenport, Emma, Geoghegan, Cyndi, Knight, Julian, Maugeri, Narelle, Mi, Yuxin, Radhakrishnan, Jayachandran, Burnham, Katie L., Milind, Nikhil, Lee, Wanseon, Kwok, Andrew J., Cano-Gamez, Kiki, Geoghegan, Cyndi G., Zhang, Ping, Soranzo, Nicole, Hinds, Charles J., Knight, Julian C., and Davenport, Emma E.

Published
2024
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31. Real life experience of tafamidis for the treatment of Spanish patients with Val30Met transthyretin amyloidosis with polyneuropathy

Author

Sanso, Maria Antonia Ribot, Rodriguez, Adrián Rodriguez, Vicente, Laura Martínez, Sevilla, Teresa, Garro, Cristina Borrachero, Martín, Julian Fernández, Vicente, Adrián Antón, de la Prida, Moises Morales, Dávila, Lucía Galán, Vázquez, Laura González, Valle, Ferran Martínez, Pons, Carlos Casasnovas, Bau, Arturo Fraga, Barroso, Eugenia Cisneros, López, Inés Losada, and González-Moreno, Juan

Published
2024
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37. Principios implícitos y relaciones sistemáticas

Author

Moreno, Juan Luis

Subjects
Law in general. Comparative and uniform law. Jurisprudence, K1-7720, Jurisprudence. Philosophy and theory of law, K201-487
Abstract

Este artículo hace un examen formal del razonamiento jurídico con principios implícitos desde el positivismo lógico y partiendo de los trabajos de Alonso en la materia. A la vista de las tesis de la separación fuerte y débil entre principios y reglas y de las diferencias entre norma y proposición normativa, se presentan problemas para considerar que las consecuencias lógicas que Alonso denomina principios implícitos son principios. Como correlación caso-solución carecen de la nota de generalidad y como relaciones de preferencia son sólo proposiciones normativas que derivan de aplicar un criterio de preferencia al sistema normativo. En su caso, el criterio de preferencia podría considerarse un principio implícito, pero al ser una proposición normativa surgen problemas de juridicidad, justificación y coherencia del principio.

Published
2015
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42. Magnetospheric Venus Space Explorers (MVSE) mission: A proposal for understanding the dynamics of induced magnetospheres

Author

Albers, Roland, Andrews, Henrik, Boccacci, Gabriele, Pires, Vasco D.C., Laddha, Sunny, Lundén, Ville, Maraqten, Nadim, Matias, João, Krämer, Eva, Schulz, Leonard, Palanca, Ines Terraza, Teubenbacher, Daniel, Baskevitch, Claire, Covella, Francesca, Cressa, Luca, Moreno, Juan Garrido, Gillmayr, Jana, Hollowood, Joshua, Huber, Kilian, Kutnohorsky, Viktoria, Lennerstrand, Sofia, Malatinszky, Adel, Manzini, Davide, Maurer, Manuel, Nidelea, Daiana Maria Alessandra, Rigon, Luca, Sinjan, Jonas, Suarez, Crisel, Viviano, Mirko, and Knutsen, Elise Wright

Published
2024
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49. SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

Author

Gonzalez-Cao, Maria, Puertolas, Teresa, Martinez-Vila, Clara, Carrera, Cristina, Maldonado Seral, Cayetana, Rodríguez-Jiménez, Pedro, Sequero, Silvia, Cerezuela-Fuentes, Pablo, Feltes Ochoa, Rosa, Muñoz, Eva, Antoñanzas Basa, Mónica, Martín-Liberal, Juan, Soria, Ainara, Francisco Rodriguez Moreno, Juan, Marquez-Rodas, Ivan, Lopez Criado, Pilar, Luis Manzano, José, Lopez-Castro, Rafael, Ayala de Miguel, Pablo, Villalobos, Laura, Martin Algarra, Salvador, Gonzalez-Barrallo, Ines, Boada, Aram, García Castaño, Almudena, Puig, Susana, Crespo, Guillermo, Luna Fra, Pablo, Aguayo Zamora, Cristina, Feito Rodríguez, Marta, Valles, Lara, Drozdowskyj, Ana, Gardeazabal, Jesús, Antonio Fernandez-Morales, Luis, Rodrigo, Alberto, Cruz, Raquel, Yelamos, Oriol, Rubio, Belen, Mujica, Karmele, Provencio, Mariano, and Berrocal, Alfonso

Published
2023
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