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Start Over Author "Nakajima Toshiaki" Publication Type Academic Journals
593 results on '"Nakajima Toshiaki"'

2. Clinical usefulness of phase angle as an indicator of muscle wasting and malnutrition in inpatients with cardiovascular diseases

Author

Yokomachi, Jun, Fukuda, Taira, Mizushima, Yuta, Nozawa, Naohiro, Ishizaka, Hayato, Matsumoto, Kazuhisa, Kambe, Takahiro, Inoue, Shohta, Nishikawa, Kaori, Toyama, Yohei, Takahashi, Reiko, Arakawa, Tomoe, Yagi, Hiroshi, Yamaguchi, Suomi, Ugata, Yuusuke, Nakamura, Fumitaka, Sakuma, Masashi, Abe, Shichiro, Fujita, Hideo, Mizushima, Takashi, Toyoda, Shigeru, and Nakajima, Toshiaki

Published
2023

3. Utility of growth differentiation factor-15 as a predictor of cardiovascular surgery outcomes: Current research and future directions

Author

Shibasaki, Ikuko, Otani, Naoyuki, Ouchi, Motoshi, Fukuda, Taira, Matsuoka, Taiki, Hirota, Shotaro, Yokoyama, Shohei, Kanazawa, Yuta, Kato, Takashi, Shimizu, Riha, Tezuka, Masahiro, Takei, Yusuke, Tsuchiya, Go, Saito, Shunsuke, Konishi, Taisuke, Ogata, Koji, Toyoda, Shigeru, Fukuda, Hirotsugu, and Nakajima, Toshiaki

Published
2024
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6. Relationship between the serum GDF-15 concentration and muscle function in female patients receiving aortic valve replacement (TAVR, SAVR): Comparison with healthy elderly female subjects

Author

Fukuda, Taira, Nakajima, Toshiaki, Yazawa, Hiroko, Hirose, Suguru, Yokomachi, Jun, Kato, Takashi, Nishikawa, Riichi, Koshiji, Nobuo, Tokura, Michiaki, Nasuno, Takahisa, Nishino, Setsu, Obi, Syotaro, Shibasaki, Ikuko, Kanaya, Tomoaki, Nakamura, Fumitaka, Fukuda, Hirotsugu, Abe, Shichiro, Sakuma, Masashi, and Toyoda, Shigeru

Published
2022
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15. Left atrial reservoir strain is a marker of atrial fibrotic remodeling in patients undergoing cardiovascular surgery: Analysis of gene expression.

Author

Nakajima, Toshiaki, Haruyama, Akiko, Fukuda, Taira, Minami, Kentaro, Hirose, Suguru, Yazawa, Hiroko, Nakajima, Takafumi, Hasegawa, Takaaki, Kitagawa, Yoshiyuki, Obi, Syotaro, Inami, Shu, Oguri, Gaku, Shibasaki, Ikuko, Amano, Hirohisa, Arikawa, Takuo, Sakuma, Masashi, Abe, Shichiro, Fukuda, Hirotsugu, and Toyoda, Shigeru

Subjects
*ATRIAL flutter, *LEFT heart atrium, *GENE expression, *SPECKLE tracking echocardiography, *REVERSE transcriptase polymerase chain reaction, *CARDIOVASCULAR surgery
Abstract

Left atrial strain (LAS) measured by two-dimensional speckle tracking echocardiography (2DSTE) is considered to be a marker of LA structural remodeling, but it remains unsettled. We investigated the potential usefulness and clinical relevance of LAS to detect atrial remodeling including fibrosis by analyzing gene expression in cardiovascular surgery patients. Preoperative 2DSTE was performed in 131 patients (92 patients with sinus rhythm [SR] patients including paroxysmal AF [PAF], 39 atrial fibrillation [AF]) undergoing cardiovascular surgery. Atrial samples were obtained from the left atrial appendages, and mRNA expression level was analyzed by real-time reverse transcription polymerase chain reaction (RT-PCR) in 59 cases (24 PAF, 35 AF). Mean value of left atrial reservoir strain (mLASr) correlated with left atrial volume index (LAVI), and left atrial conduit strain (mLAScd). mLASr also correlated with left atrial contractile strain (mLASct) in SR patients including PAF. mLASr was significantly lower, and LAVI was higher, in the AF group, compared with SR patients including PAF. The expression of COL1A1 mRNA encoding collagen type I α1 significantly increased in AF patients (p = 0.031). mLASr negatively correlated with COL1A1 expression level, and multivariate regression analysis showed that mLASr was an independent predictor of atrial COL1A1 expression level, even after adjusting for age, sex, and BMI. But, neither mLAScd / mLASct nor LAVI (bp) correlated with COL1A1 gene expression. The expression level of COL1A1 mRNA strongly correlated with ECM-related genes (COL3A1, FN1). It also correlated ECM degradation-related genes (MMP2, TIMP1, and TIMP2), pro-fibrogenic cytokines (TGFB1 encoding TGFβ1, END1, PDGFD, CTGF), oxidant stress-related genes (NOX2, NOX4), ACE, inflammation-related genes (NLRP, IL1B, MCP-1), and apoptosis (BAX). Among the fibrosis-related genes examined, univariable regression analysis showed that log (COL1A1) was associated with log (TGFB1) (adjusted R2 = 0.685, p<0.001), log (NOX4) (adjusted R2 = 0.622, p<0.001), log (NOX2) (adjusted R2 = 0.611, p<0.001), suggesting that TGFB1 and NOX4 was the potent independent determinants of COL1A1 expression level. mLASr negatively correlated with the ECM-related genes, and fibrosis-related gene expression level including TGFB1, NOX2, and NLRP3 in PAF patients. PAF patients with low mLASr had higher expression of the fibrosis-related gene expression, compared with those with high mLASr. These results suggest that LASr correlates with atrial COL1A1 gene expression associated with fibrosis-related gene expression. Patients with low LASr exhibit increased atrial fibrosis-related gene expression, even those with PAF, highlighting the utility of LAS as a marker for LA fibrosis in cardiovascular surgery patients. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Rescue of Hereditary Form of Dilated Cardiomyopathy by rAAV-Mediated Somatic Gene Therapy: Amelioration of Morphological Findings, Sarcolemmal Permeability, Cardiac Performances, and the Prognosis of TO-2 Hamsters

Author

Kawada, Tomie, Nakazawa, Mikio, Nakauchi, Sakura, Yamazaki, Ken, Shimamoto, Ryoichi, Urabe, Masashi, Nakata, Jumi, Hemmi, Chieko, Masui, Fujiko, Nakajima, Toshiaki, Suzuki, Jun-Ichi, Monahan, John, Sato, Hiroshi, Masaki, Tomoh, Ozawa, Keiya, and Toyo-oka, Teruhiko

Published
2002

26. Blood flow restriction reduces the increases in cardiorespiratory responses and subjective burden without inhibiting muscular activity during cycling at ventilatory threshold in healthy males.

Author

Uematsu, Azusa, Mizushima, Yuta, Ishizaka, Hayato, Hortobágyi, Tibor, Mizushima, Takashi, Toyoda, Shigeru, and Nakajima, Toshiaki

Subjects
ANAEROBIC threshold, BLOOD flow restriction training, BLOOD flow, OXYGEN consumption, CYCLING, AEROBIC exercises, HEART beat
Abstract

Low-intensity endurance exercise with blood flow restriction (KAATSU) is under consideration for use in cardiac rehabilitation. However, the physiological responses to such exercise have not yet been fully characterized. In an initial effort in healthy males (n = 11, age: 26.3±4.6 y), we compared the physiological responses to low-intensity endurance exercise with and without a thigh KAATSU. Participants performed maximal graded exercise testing using a cycle ergometer with or without KAATSU. We examined responses to cycling exercise at ventilatory threshold (VT) in heart rate (HR), oxygen consumption (VO2), dyspnea, ratings of perceived exertion (RPE), blood pressure (BP), and rectus femoris activation. Participants reached VT at a lower mechanical load, HR, VO2, dyspnea, and double product (HR×systolic BP) with KAATSU vs. no-KAATSU. At VT, RPE, and rectus femoris activity did not differ between the two conditions. These results suggest that KAATSU reduced exercise intensity to reach VT and the physiological responses to exercise at VT without changes in knee extensor muscle activation. Results from this pilot study in healthy males suggest that KAATSU aerobic exercise at VT intensity has the potential to be an effective and low-burden adjuvant to cycling in cardiac rehabilitation. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Provocation and Localization of Arrhythmogenic Triggers from Persistent Left Superior Vena Cava in Patients with Atrial Fibrillation.

Author

Minami, Kentaro, Nakamura, Kohki, Maeno, Eiko, Iida, Keitaro, Saito, Ikuta, Masuyama, Taiki, Kitagawa, Yoshiyuki, Nakajima, Toshiaki, Nakatani, Yosuke, Naito, Shigeto, Toyoda, Shigeru, Chovanec, Milan, Petrů, Jan, Škoda, Jan, Kumagai, Koji, and Neužil, Petr

Subjects
VENA cava superior, ATRIAL fibrillation, PROVOCATION tests (Medicine), PULMONARY veins, GALVANIC isolation
Abstract

Background: Although pulmonary vein isolation (PVI) is an established procedure for atrial fibrillation (AF), non-PV foci play a crucial role in AF recurrence. Persistent left superior vena cava (PLSVC) has been reported as critical non-PV foci. However, the effectiveness of provocation of AF triggers from PLSVC remains unclear. This study was designed to validate the usefulness of provoking AF triggers from PLSVC. Methods: This multicenter retrospective study included 37 patients with AF and PLSVC. To provoke triggers, AF was cardioverted, and re-initiation of AF was monitored under high-dose isoproterenol infusion. The patients were divided into two groups: those whose PLSVC had arrhythmogenic triggers initiating AF (Group A) and those whose PLSVC did not have triggers (Group B). Group A underwent isolation of PLSVC after PVI. Group B received PVI only. Results: Group A had 14 patients, whereas Group B had 23 patients. After a 3-year follow-up, no difference in the success rate for maintaining sinus rhythm was observed between the two groups. Group A was significantly younger and had lower CHADS2-VASc scores than Group B. Conclusions: The provocation of arrhythmogenic triggers from PLSVC was effective for the ablation strategy. PLSVC electrical isolation would not be necessary if arrhythmogenic triggers are not provoked. [ABSTRACT FROM AUTHOR]

Published
2023
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