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Objective: to evaluate urinary desoxypiridinoline (Dpd) levels in postmenopause patients, with osteoporosis or osteopenia after treatment with sodium alendronate. Methods: a quasiexperimental study was carried out in 118 patients, aged from 41 to 69 years. According to the densitometry results and treatment received, we formed five groups: group I, patients with osteoporosis, treated with 10 mg/day of alendronate; group IIA, patients with osteopenia treated with alendronate 5 mg/day; group IIB, patients with osteopenia treated with hormonal therapy replacement (HTR); group IIIA, patients with normal densitometry treated with change of life style habits; and group IIIB, patients with normal densitometry treated with HTR. Dpd urinary levels were measured in all patients at the beginning and 60 days after. The statistical analysis was t Student paired. Results: the group I diminished 7.8 nmol Dpd/mmol Cr with a p = 0.001. In the other groups the reduction of the urinary Dpd level was not significant. Conclusions: in osteoporosis the urinary Dpd excretion diminishes after 60 days of treatment with 10 mg/day of sodium alendronate. [ABSTRACT FROM AUTHOR] more...

A study based on the behaviour of hydroxyproline in 64 cases, 16 normal individuals, 10 with rheumatoid arthritis, 5 with systemic lupus erythematosus, 30 with osteoporois, 2 with vitamin D resistant rickets and 1 with osteomalacia, is presented, hydroxyproline is an amino acid derived from proline and is actually considered of great value in the study of collagen metabolism. The results obtained in each group of disease are presented and compared with those obtained in the normal individuals. We think that these late are very useful to establish in our medium, the average of normal free serum hydroxyproline and of total and free urine hydroxyproline, since we did not find related data in the consulted ational literature. more...