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The aim of this work was to evaluate the hepatoprotective potential of fractions and phytosomal complexes of Telfairia occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomal complexes of ethanol extract fractions were prepared by the thin film hydration technique. Hepatoprotective activities were evaluated by biochemical assays and histopathological examination of liver sections. Intoxication of animals with pure ethanol significantly (p < 0.05) elevated their liver enzyme titers, whereas co-administration with various extracts and phytosomal complexes reversed the increases. Histopathological findings revealed liver tissue protective effects of the extracts with the phytosomal complexes exhibiting greater effects (p < 0.05). Significant differences at p ≤ 0.05 were observed in the liver indices of animals treated with co-administered ethanol and extract fractions or phytosomes complexes versus the positive control group. T. occidentalis leaf extract formulated as phytosomes, therefore, has good potential of enhancing the hepatoprotective activities of the extract. [ABSTRACT FROM AUTHOR]

Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media of different pH. Methods: Different formulations of slow-release matrix tablets of ciprofloxacin hydrochloride were prepared with polymers, namely, ethyl cellulose (Etc), hydroxyethyl cellulose (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using matrix embedding technique. The matrix tablets were characterized and studies of their dissolution profiles were studied in 0.1 N HCl (pH 1.2) and in simulated intestinal fluid (excluding enzymes) of pH 4.0, 6.0, and 7.4. Results: The tablets had the following characteristics: weight, 659.25 ± 7.96 to 661.65 ± 6.53 mg; hardness, 7.05 ± 0.21 to 9.60 ± 0.40 kgf; friability, 0.212 to 0.292 %; and drug content, 91.47 ± 0.53 to 112.50 ± 4.14 %. In batches prepared with ethyl cellulose, Eudragit L-100, and hydroxypropyl methylcellulose, drug release increased with a decrease in pH. However, matrix tablets prepared with hydroxyethyl cellulose displayed the highest drug release at pH 4.0 with Cmax of 108.75 % and T50% of 30.86 min; thereafter, drug release decreased with increase in pH. The pattern of drug release was Hec > Hpc > Eud > Etc in most media with more drug release in acidic than at alkaline pH. Conclusion: Release of ciprofloxacin from the formulated matrix tablets was pH-sensitive in vitro. This should be taken into consideration in designing sustained release oral form of ciprofloxacin. [ABSTRACT FROM AUTHOR]