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Abstract Background The aim of this study was to compare the cyclic fatigue resistance (CFR) of the newly developed pediatric nickel-titanium (NiTi) rotary file systems for root canal preparation of primary teeth. Methods Eighty pediatric NiTi rotary file systems files were used in this study, including 20 EasyInSmile X-Baby (25/0.04), 20 Scope miniScope (25/0.04), 20 EndoArt Pedo Gold (25/0.04), and 20 EndoArt Pedo Blue (25/0.04) files. Static CFR tests; performed on a custom-made stainless steel block with an inner diameter of 1.5 mm, an angle of curvature of 60° and a curved artificial canal with a radius of curvature of 5 mm. The test system was filled with distilled water and the temperature was kept constant at 35 ± 1 °C. The files were rotated in the simulated canal until fracture occurred. The number of cycles to failure (NCF) data was recorded, and all the fracture surfaces of the files were evaluated using scanning electron microscopy (SEM). One-way ANOVA and Tukey tests were used for statistical analysis of the data, and the significance level was set at p 0.05). Conclusion The EndoArt Pedo Blue file system showed the best CFR performance among the four file systems specifically designed for primary teeth.

Summary: Background: Adverse non-motor outcomes have a major impact on patients and caregivers after stroke, but knowledge of their prevalence, predictors and patterns across multiple health domains remains limited; we therefore aimed to obtain these data in a large observational prospective cohort study. Methods: We included data from the Stroke Investigation Group in North and Central London (SIGNAL) registry based at the University College London Hospitals (UCLH) Comprehensive Stroke Service which serves a multi-ethnic population of ∼1.6 million people. In adult patients diagnosed with acute stroke due to cerebral ischaemia or intracerebral haemorrhage (ICH) from January 2017 to January 2020 we evaluated non-motor outcomes (anxiety, depression, fatigue, sleep disturbance, social participation, pain, bowel dysfunction, bladder dysfunction, mood problems, communication problems, activities of daily living (ADL), memory and thinking problems) at 6-month follow-up. We evaluated baseline predictors in multivariable logistic regression, and correlations between domains using kappa statistics. Findings: Follow-up was complete for 3080 of 3338 (92.3%) eligible surviving patients (2534 ischaemic stroke, 547 with ICH; mean age 71.2 years, 1379 (44.8%) female, 1774 (59.3%) white). The most prevalent adverse non-motor outcomes were fatigue 1756 (57%), reduced social participation 1694 (55%), sleep disturbance 1663 (54%), and constipation 1355 (44%). The rates of adverse non-motor outcomes in ⩾ 1, ⩾ 2, ⩾ 3, ⩾ 4, and ⩾ 5 domains were 2310 (75%), 1571 (51%), 1519 (49%), 1232 (40%), and 801 (26%), respectively. Factors associated with adverse non-motor outcomes included stroke due to ICH, stroke severity, previous stroke, or history of cardiovascular disease. We identified moderate correlations between fatigue and sleep disturbance (kappa = 0.72); memory and thinking impairment and reduced ADL (kappa = 0.68); and communication problems and ADL (kappa = 0.70). Interpretation: Adverse non-motor outcomes are highly prevalent and often multiple at 6-months after stroke: 75% have at least one affected domain; fatigue, sleep disturbance, and reduced social participation each affect over 50% of survivors, and 26% of patients report ≥5 adverse outcomes. Our findings suggest an urgent need to better detect and mitigate these outcomes to improve quality of life after stroke. Funding: The National Institute for Health and Care Research (NIHR) UCLH Biomedical Research Centre.

Abstract Background Surface tension and contact angle properties, which play a crucial role in determining the effectiveness of irrigation solutions in penetrating dentin surfaces and dentin tubules, are highly important for the development of new irrigation solutions and their preferences. The aim of the current study was to compare the surface tension and contact angle properties of different irrigation solutions used in endodontics, both on the dentin surface and within dentin tubules. Methods In this study, the contact angles and surface tensions of 5.25% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 2% chlorhexidine (CHX), 5% boric acid (BA), 0.02% hypochlorous acid (HOCl), 0.2% chlorine dioxide (ClO2), Biopure MTAD, QMix solutions, and distilled water (control group) were measured. Measurements were conducted using a goniometer device (Attension Theta Lite Tensiometer, Biolin Scientific, USA), employing the sessile drop method for contact angle measurements on pre-prepared dentin surfaces, and the pendant drop method for surface tension. Results Contact angle measurements revealed no statistically significant differences between the contact angle values of MTAD, ClO2, and CHX or between NaOCl, QMix, BA, and HOCl (p > 0.05). However, EDTA exhibited a significantly greater contact angle than did MTAD, ClO2, CHX, NaOCl, QMix, BA, and HOCl (p 0.05). CHX exhibited lower surface tension than distilled water and HOCl (p

This study used skeletochronology to assess the relationships between age and body length among individuals in a population of the Tavas Frog (Rana tavasensis), located in the Çakıroluk plateau, Tavas district, Denizli province. The age varied from 3 to 12 years in both adult males and females. The age was 2 years in two subadult males, while it was 1 year in one juvenile specimen. The mean SVL and age of the adult individuals of the Çakıroluk population were 62.75 mm and 6.70 years in male specimens and 58.04 mm and 6.12 years in female specimens. A positive correlation was found between body size (SVL) and age in adult female and male individuals of the species. Because the number of individuals of the species is rapidly decreasing, species protection measures, based on knowledge related to the age structure and breeding features of these frogs, must be put into action urgently.

Objectives: To compare the cyclic fatigue resistances of MicroMega Remover, EndoArt, and ProTaper nickel-titanium retreatment files when used in curved artificial canals. Methods: A total of 45 new C-wire Remover, controlled-memory wire EndoArt D2, and nonheat-treated NiTi ProTaper D2 retreatment files, 15 per group, were tested in a stainless-steel block containing an 18-mm-long artificial canal with curvature in the apical third, an inner diameter of 1.5 mm, a curvature angle of 60°, and a radius of curvature of 5 mm. The experimental system was filled with distilled water, and the ambient temperature was kept constant at 35±1°C. The retreatment files were rotated until fracture to calculate the number of cycles to failure. The length of each fractured fragment was recorded. The number of cycles to failure and the fragment length values were analyzed using one-way analysis of variance (ANOVA) and Tukey post-hoc tests. The statistical significance level was set at p

Amaç: Bu çalışmanın amacı, yapay kanallar kullanılarak yeni ve kullanılmış Revo-S nikel titanyum döner eğe sisteminin döngüsel yorgunluk (DY) dirençlerinin karşılaştırılmasıdır. Gereç ve Yöntem: Her gruptan 12 adet olmak üzere toplam 72 adet yeni ve 2 defa klinikte kullanılmış Revo-S SC1 (25/.06), Revo-S SC2 (25/.04) ve Revo-S SU (25/.06) eğeler çalışmaya dahil edildi. DY direnci testleri için iç çapı 1.5 mm olan, 60° eğrilik açısı ve 5 mm eğrilik yarıçapına sahip olan kavisli bir yapay kanal içeren paslanmaz çelik blok kullanıldı. Deney sistemi distile su ile dolduruldu ve ortam sıcaklığı 35 ± 1 °C sıcaklıkta sabit tutuldu. Eğeler kırılma gerçekleşene kadar yapay kanal içinde çalıştırıldı. Her eğe için kırılma gerçekleşene kadar geçen süre kronometre ile kaydedildi ve eğelerin kırılıncaya kadar yaptıkları tur sayısı hesaplandı. Elde edilen veriler tek yönlü varyans analizi ve post-hoc Tukey testi kullanılarak değerlendirildi. Bulgular: Eğelerin kırılıncaya kadar yaptığı ortalama tur sayısı en yüksek yeni SC2 eğe grubunda (912.3 ± 76.8), en düşük ise kullanılmış SU eğe grubunda (204.2 ± 59.6) bulundu. SC1 ve SC2 eğeler için yeni ve kullanılmış eğeler arasında DY direnci açısından istatistiksel olarak anlamlı bir fark gözlenmez iken (p>0.05), SU eğe grubunda anlamlı bir fark bulundu (p

Simple Summary: The main objective of this study was to provide the first information on the age structure of the critically endangered and endemic frog species, Rana tavasensis, in Türkiye. Age data are important in evaluating the dynamics of populations and effective conservation strategies should be addressed according to age-related parameters (e.g., longevity, mean age, growth rate, and age at maturity). Skeletochronology is an effective method for estimating the ages of amphibians, and using this method, we determined the mean age, longevity, and relationship between age and body size in both males and females of a R. tavasensis population in Çakıroluk, the terra-typica, located in Denizli province, Türkiye. The results of our study provides insights for taking feature measures to protect these frogs, whose number has progressively declined each year due to habitat loss and degradation. This study used skeletochronology to assess the relationships between age and body length among individuals in a population of the Tavas Frog (Rana tavasensis), located in the Çakıroluk plateau, Tavas district, Denizli province. The age varied from 3 to 12 years in both adult males and females. The age was 2 years in two subadult males, while it was 1 year in one juvenile specimen. The mean SVL and age of the adult individuals of the Çakıroluk population were 62.75 mm and 6.70 years in male specimens and 58.04 mm and 6.12 years in female specimens. A positive correlation was found between body size (SVL) and age in adult female and male individuals of the species. Because the number of individuals of the species is rapidly decreasing, species protection measures, based on knowledge related to the age structure and breeding features of these frogs, must be put into action urgently. [ABSTRACT FROM AUTHOR]

Age and body size in a lowland population of Lissotriton schmidtleri in the İstanbul Province of Türkiye were examined by applying the skeletochronology method. The age range varies between 5 to 11 years in males and 4 to 8 years in females. The mean age and SVL values were 8.1 years and 36.28 mm in males and 6.4 years and 37.72 mm in females. The mean SVL and age values showed a significant difference between the sexes. The present study showed sexual dimorphism and different life expectancy between sexes. The estimated potential reproductive lifespan was higher in males than females. [ABSTRACT FROM AUTHOR]

Objectives: This study assessed the antibacterial activity of both separate and combined uses of 5.25% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX), 17% ethylenediaminetetraacetic acid (EDTA), 3% hydrogen peroxide (H2O2), MTAD, SmearClear (SC) and 13.8% chlorine dioxide (ClO2) irrigation solutions against Enterococcus faecalis. Material and Methods: Two hundred eighty single rooted human premolars were randomly grouped into 26 test and 2 control (negative and positive) groups and were incubated for 24 h with E. faecalis, except for the negative control group. The tested solutions were as follow: NaOCl; CHX; ClO2; MTAD; SC; EDTA; H2O2; NaOCl + CHX; NaOCl + MTAD; SC + NaOCl; EDTA + NaOCl; H2O2 + NaOCl; ClO2 + CHX; CHX + MTAD; SC + CHX; EDTA + CHX; CHX + H2O2; ClO2 + MTAD; SC + ClO2; EDTA + ClO2; ClO2 + H2O2; SC+MTAD; EDTA+MTAD; MTAD + H2O2; SC + H2O2; and EDTA + H2O2. Optic density values were recorded at 0, 6, 12, 18, 24, 30, 36, 42 and 48 h and bac-terial growth curve created for each solution. Results: The CHX, MTAD and ClO2 showed a high poten-tial for the elimination of E. faecalis, both alone and in all combinations. The EDTA, H2O2, H2O2 + EDTA, H2O2 + NaOCl and SC + NaOCl groups showed less antibacterial activity than the other groups. The SC + CHX group showed the best antibacterial effect against E. faecalis. Conclusion: The SC + CHX com-bination can be recommended as the most effective irrigation regimen against E. faecalisin persis-tent endodontic infections.

Background: Adverse non-motor outcomes are common after acute stroke and likely to substantially affect quality of life, yet few studies have comprehensively assessed their prevalence, patterns, and predictors across multiple health domains. Aims: We aimed to identify the prevalence, patterns, and the factors associated with non-motor outcomes 30 days after stroke. Methods: This prospective observational hospital cohort study—Stroke Investigation in North and Central London (SIGNAL)—identified patients with acute ischemic stroke or intracerebral hemorrhage (ICH) admitted to the Hyperacute Stroke Unit (HASU) at University College Hospital (UCH), London, between August 1, 2018 and August 31, 2019. We assessed non-motor outcomes (anxiety, depression, fatigue, sleep, participation in social roles and activities, pain, bowel function, and bladder function) at 30-day follow-up using the Patient-Reported Outcome Measurement Information System-Version 29 (PROMIS-29) scale and Barthel Index scale. Results: We obtained follow-up data for 605/719 (84.1%) eligible patients (mean age 72.0 years; 48.3% female; 521 with ischemic stroke, 84 with ICH). Anxiety (57.0%), fatigue (52.7%), bladder dysfunction (50.2%), reduced social participation (49.2%), and pain (47.9%) were the commonest adverse non-motor outcomes. The rates of adverse non-motor outcomes in ⩾ 1, ⩾ 2 and ⩾ 3 domains were 89%, 66.3%, and 45.8%, respectively; in adjusted analyses, stroke due to ICH (compared to ischemic stroke) and admission stroke severity were the strongest and most consistent predictors. There were significant correlations between bowel dysfunction and bladder dysfunction (κ = 0.908); reduced social participation and bladder dysfunction (κ = 0.844); and anxiety and fatigue (κ = 0.613). We did not identify correlations for other pairs of non-motor domains. Conclusion: Adverse non-motor outcomes were very common at 30 days after stroke, affecting nearly 90% of evaluated patients in at least one health domain, about two-thirds in two or more domains, and almost 50% in three or more domains. Stroke due to ICH and admission stroke severity were the strongest and most consistent predictors. Adverse outcomes occurred in pairs of domains, such as with anxiety and fatigue. Our findings emphasize the importance of a multi-domain approach to effectively identify adverse non-motor outcomes after stroke to inform the development of more holistic patient care pathways after stroke. [ABSTRACT FROM AUTHOR]

Background: Pulmonary embolism (PE) is a common complication of deep vein thrombosis that causes high mortality and morbidity. This study aimed to determine the relationship between clinical risk scoring for early mortality and fractional exhaled nitric oxide (FeNO) in PE patients. Methods: The study included a total of 98 subjects, 68 patients diagnosed with PE in the emergency department, and 30 healthy controls. Patients with PE were grouped according to clinical scoring of early mortality risk as low (n = 20), moderate-low (n = 24), and moderate-high (n = 24) risk. FeNO levels were measured after diagnosis. Results: FeNO levels were significantly higher in patients with moderate-high risk PE compared to the other three groups and in those with moderate-low risk PE compared to the control group (p < 0.001 for all). Moderate to strong positive correlations were observed between FeNO level and mean pulmonary artery pressure (r = 0.818, p = 0.01), troponin-I (r = 0.67, p = 0.01), pro-BNP (r = 0.762, p = 0.01), and D-dimer levels (r = 0.652, p = 0.01). A FeNO cutoff value of 7.5 ppb had 84% sensitivity and 78% specificity in differentiating moderate-high risk PE from moderate-low risk PE. Conclusions: FeNO may be as reliable, noninvasive, and easily accessible as cardiac biomarkers in clinical risk scoring for early mortality in PE patients. [ABSTRACT FROM AUTHOR]

Throughout history, cities have offered a place for freedom and accommodated differences. Ideological and social developments have taken place in urban spaces where differences, different cultures and ideologies gathered together. Therefore, significant attention should be paid to public-oriented planning and design of urban spaces in the face of social segregation and disintegration experienced in cities. However, cities inTurkeyare mostly transformed under the pressure of international and national capital. The most recent legal instrument governing urban redevelopment, the Law no. 6306 on Transformation of Areas under Disaster Risk contains quite controversial provisions relating to many paradigms. Its uncertainty over public property and public spaces, and the Ministry of Environment and Urban Planning as the sole authority in this field leave all the public spaces at “risk”.GeziPark, a ‘saved’ public space in the backdrop of protests, is still exposed to risks of being stripped off its public nature. This study browses through the literature on public spaces and urban redevelopment, while evaluating the Law no. 6306 on Transformation of Areas under Disaster Risk. It goes on to evaluateGeziParkevents, from the perspective of these experiences and the interviews conducted thereafter. The study concludes how actually the aforementioned Law may itself pose risks for our public spaces.

Copyright of Necmettin Erbakan University Dental Journal (NEU Dent J) is the property of Necmettin Erbakan University Dental Journal (NEU Dent J) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Textiles & Engineers / Tekstil ve Mühendis is the property of Union of Chambers of Turkish Engineers & Architects, Chamber of Textile Engineers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: This study aimed to investigate the effect of surface treatment and type of composite resin material on the color stability and surface roughness of different denture characterizing composites. Materials and methods: Two nanohybrids [Gradia Plus Gum, (GP) and SR Nexco Paste Gingiva, (SR)] and one microhybrid gingiva‐colored composite resin [Amaris Gingiva, (AG)] were investigated. A total of 120 disk‐shaped samples were prepared, 40 of each material. Samples were divided into two groups (n = 20) for each material according to the surface treatment applied: conventional polishing (control) and coated with a sealant in addition to the surface polishing. All groups were thermocycled. The surface roughness (Ra) was measured using a profilometer after thermal cycling. The samples were then divided into 2 subgroups (n = 10) and stored for 7 days in distilled water or coffee solution. Color differences (ΔE00) were calculated with a spectrophotometer. Results were evaluated with Kruskal‐Wallis and Mann‐Whitney U statistical analysis. Results: The type of denture characterizing composite material and surface treatment method revealed statistically significant differences for the ΔE00 (after immersion both in coffee and distilled water) and the Ra values of denture characterizing composite (p < 0.001 for both). All sealed groups showed significantly higher Ra than the all polished groups. Both in the polished groups and the sealant applied groups, the GP had the highest mean Ra values (0.29 ±0.05 μm and 0.47 ±0.09 μm, respectively). It was followed by SR (0.23 ±0.06 μm and 0.41 ±0.10 μm, respectively), and AG groups (0.20 ±0.06 μm and 0.39 ±0.09 μm, respectively). According to the mean ΔE00 results, all composite groups showed significantly higher ΔE00 values immersed in coffee solutions compared to distilled water. In coffee solutions, the highest ΔE00 was observed in the polished GP (1.90 ±0.40), and the lowest ΔE00 was observed in the polished SR (0.97 ±0.36). The sealed groups showed higher ΔE00 than the polished groups, except for GP. Conclusions: The surface roughness value of sealant applied groups were significantly higher than those of the polished groups. The surface sealant application significantly increased the staining of all composite groups compared to conventional polishing, except for GP. [ABSTRACT FROM AUTHOR]

The present study provides the first records (Birlik neighbourhood and Devrek District in Zonguldak Province) of the Bulgarian bent-toed gecko Mediodactylus danilewskii from the western Black Sea coastal region of Turkey. Morphological data of specimens from Edirne (Vakıf Village of Enez District) located in the Thrace part of Turkey are compared to those of specimens from the coast of the western Black Sea. The pholidolial and morphometric characters and colour-pattern features of the Zonguldak and Edirne specimens were found to be similar to those of M. danilewskii reported in the literature. [ABSTRACT FROM AUTHOR]

Background: Cerebral amyloid angiopathy (CAA), a common cause of intracerebral hemorrhage (ICH), is diagnosed using the Boston criteria including magnetic resonance imaging (MRI) biomarkers (cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS). The simplified Edinburgh criteria include computed tomography (CT) biomarkers (subarachnoid extension (SAE) and finger-like projections (FLPs)). The underlying mechanisms and diagnostic accuracy of CT compared to MRI biomarkers of CAA are unknown. Methods: We included 140 survivors of spontaneous lobar supratentorial ICH with both acute CT and MRI. We assessed associations between MRI and CT biomarkers and the diagnostic accuracy of CT- compared to MRI-based criteria. Results: FLPs were more common in patients with strictly lobar CMB (44.7% vs 23.5%; p = 0.014) and SAE was more common in patients with cSS (61.3% vs 31.2%; p = 0.002). The high probability of the CAA category of the simplified Edinburgh criteria showed 87.2% (95% confidence interval (CI): 78.3–93.4) specificity, 29.6% (95% CI: 18.0–43.6) sensitivity, 59.3% (95% CI: 38.8–77.6) positive predictive value, and 66.4% (95%: CI 56.9–75.0) negative predictive value, 2.3 (95% CI: 1.2–4.6) positive likelihood ratio and 0.8 (95% CI 0.7–1.0) negative likelihood ratio for probable CAA (vs non-probable CAA), defined by the modified Boston criteria; the area under the receiver operating characteristic curve (AUROC) was 0.62 (95% CI: 0.54–0.71). Conclusion: In lobar ICH survivors, we found associations between putative biomarkers of parenchymal CAA (FLP and strictly lobar CMBs) and putative biomarkers of leptomeningeal CAA (SAE and cSS). In a hospital population, CT biomarkers might help rule-in probable CAA (diagnosed using the Boston criteria), but their absence is probably not as useful to rule it out, suggesting an important continued role for MRI in ICH survivors with suspected CAA. [ABSTRACT FROM AUTHOR]

Copyright of Acta Odontologica Turcica is the property of Acta Odontologica Turcica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Some life-history traits (e.g. body size, SSD and age) of the Danford's lizard Anatololacerta danfordi were studied applying skeletochronology techniques to the phalangeal bones (n = 33). The mean of the snout-vent-length (SVL) was 59.02 ± 1.07 mm in females and 62.17 ± 1.38 mm in males. The mean SVL was not significantly different between sexes. Sexual size dimorphism was weakly expressed in the slightly bigger SVL of the males (SDI = -0.053). Sexual maturity was attained between the second and the fourth year of life in both sexes. The age ranged from 2 to 6 years in females and from 3 to 8 years in males. The means of age were 4.29 ± 0.31 LAGs in female specimens and 4.63 ± 0.37 LAGs in male specimens. The mean age was not significantly different between the sexes. [ABSTRACT FROM AUTHOR]

• PE is an important disease associated with considerable morbidity and mortality, especially in high-risk patients, and this risk increases with delayed thrombolytic treatment. • The decision for early thrombolytic therapy is made based on follow-up for patients at high-intermediate risk. Troponin-I, one of the cardiac biomarkers, may be a significant indicator for early mortality in clinical risk categorization, separating moderate-low-risk patients from intermediate-high-risk patients. • We discovered that YKL-40 could provide more valuable information in the initial period in differentiating between intermediate-high-risk patients and high-risk patients than troponin-I. Pulmonary embolism (PE) often occurs secondary to deep vein thrombosis and is an important cause of mortality and morbidity. This study aimed to evaluate the relationship between YKL-40 level and clinical risk score in patients with PE. The study included a total of 100 patients, 80 patients diagnosed with PE in the emergency department and 20 healthy controls. Patients with PE were divided into four groups: high-risk patients (n = 20), high-intermediate-risk patients (n = 20), low-intermediate-risk patients (n = 20), and low-risk patients (n = 20). Serum YKL-40 levels were measured by enzyme-linked immunosorbent assay. Pulmonary artery obstruction index (PAOI) was calculated from computed tomography angiography images. PAOI increased in correlation with PE risk and differed significantly between all patient groups (p < 0.001). Troponin-I levels were significantly higher in the high-risk and high-intermediate-risk groups compared to the other groups (p < 0.001), but did not differ significantly between high-risk and high-intermediate-risk patients (p = 0.09). YKL-40 level was significantly higher in the high-risk PE group than the high-intermediate-risk group (p < 0.001). In receiving operator characteristic curve analysis assessing the discriminatory value of YKL-40 for high-risk PE patients, a cut-off value of 227.2 ng/mL had sensitivity of 85 % and specificity of 70 %. YKL-40 may be an important biomarker in decisions regarding early thrombolytic treatment in patients with high-intermediate-risk PE. In addition, medical treatments targeting YKL-40 may also reduce thrombotic tendency in high-risk patient groups. [ABSTRACT FROM AUTHOR]

Cerebral small vessel disease (CSVD) causes between 25% and 30% of all ischemic strokes. In acute lacunar ischemic stroke, despite often mild initial symptoms, early neurological deterioration (END) occurs in approximately 15–20% of patients and is associated with poor functional outcome, yet its mechanisms are not well understood.In this review, we systematically evaluated data on: (1) definitions and incidence of END, (2) mechanisms of small vessel occlusion, (3) predictors and mechanisms of END, and (4) prospects for the prevention or treatment of patients with END.We identified 67 reports (including 13,407 participants) describing the incidence of END in acute lacunar ischemic stroke. The specified timescale for END varied from <24 h to 3 weeks. The rate of END ranged between 2.3% and 47.5% with a pooled incidence of 23.54% (95% confidence interval (CI) = 21.02–26.05) but heterogeneity was high (I2 = 90.29%). The rates of END defined by National Institutes of Health Stroke Scale (NIHSS) decreases of ⩾1, ⩾2, ⩾3, and 4 points were as follows: 24.17 (21.19–27.16)%, 22.98 (20.48–25.30)%, 23.33 (16.23–30.42)%, and 10.79 (2.09–23.13)%, respectively, with lowest heterogeneity and greatest precision for a cutoff of ⩾2 points. Of the 20/67 studies (30%) reporting associations of END with clinical outcome, 19/20 (95%) reported worse outcomes (usually measured using the modified Rankin score at 90 days or at hospital discharge) in patients with END. In a meta-regression analysis, female sex, hypertension, diabetes, and smoking were associated with END.END occurs in more than 20% of patients with acute lacunar ischemic stroke and might provide a novel target for clinical trials. A definition of an NIHSS ⩾2 decrease is most used and provides the best between-study homogeneity. END is consistently associated with poor functional outcome. Further research is needed to better identify patients at risk of END, to understand the underlying mechanisms, and to carry out new trials to test potential interventions. [ABSTRACT FROM AUTHOR]

Life-history traits (e.g. body size, sexual size dimorphism and age) of a Turkish population of the Lebanon lizard Phoenicolacerta laevis were studied using skeletochronology techniques. We measured phalangeal bones (n = 30). The mean snout-vent length (SVL) was slightly different between the sexes. We recorded weakly expressed sexual size dimorphism: the snout-vent-length of the males was slightly bigger (SDI = -0.01). Sexual maturity was attained between the second and the fourth year of life in both sexes. The age ranged from 3 to 11 years in females and from 3 to 12 years in males. The mean SVL was 65.33 ± 3.06 mm in females and 66.59± 3.76 mm in males. The mean age was 6.67 ± 2.63 years in females and 6.47 ± 2.75 years in males. There was no statistically significant difference in mean age between the sexes. [ABSTRACT FROM AUTHOR]

A winter activity of the Danford’s lizard, Anatololacerta danfordi (Günther, 1876) has been observed during two winter seasons in Sütçüler and Aksu districts of Isparta province of Turkey. There is no information in the literature about the active season of this species. Our data showed that this lizard species may be active in winter. Activations of the adult individuals of the species mainly consisted of sunbathing on the rocks and preying. [ABSTRACT FROM AUTHOR]

Copyright of Acta Stomatologica Croatica is the property of Acta Stomatologica Croatica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The aim of this in vitro study was to investigate the possible interactions between photon-induced photoacoustic streaming (PIPS)-activated oxidizing agents and 2% chlorhexidine digluconate. Background data: There is no information about the safety of laser-activated oxidizing agents in combination usage with chlorhexidine gluconate. Materials and methods: Groups were designed as follows G1: 98% para-chloroaniline (PCA); G2: 2% chlorhexidine (CHX); G3: 5.25% sodium hypochlorite (NaOCl) +2% CHX; G4: 5.25% NaOCl (30 sec PIPS activated) +2% CHX; G5: 5.25% NaOCl (60 sec PIPS activated) +2% CHX; G6: 3.5% chlorine dioxide (ClO2) + 2% CHX; G7: 3.5% (ClO2) (30 sec PIPS activated) +2% CHX; G8: 3.5% (ClO2) (60 sec PIPS activated) +2% CHX. The laser-irrigation protocol was performed with an erbium:yttrium-aluminum-garnet laser with a wavelength of 2940nm equipped with a 140mm long endodontic fiber tip (PIPS) using 10mJ at 15Hz (0.15 W),per pulse operating outputs. Groups were analyzed with proton nuclear magnetic resonance spectroscopy, using PCA as an internal standard. Results: No free PCA was formed in any groups of mixtures or after PIPS activation. Conclusions: Mixing of 3.5% ClO2 and 2% CHX does not form bulky precipitates, unlike the mixture NaOCl + CHX. PIPS activation does not cause changes in reactions of oxidizing agents. [ABSTRACT FROM AUTHOR]

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Introduction: Breast cancer is one of the most common malignancies in the world that leads to women's death. Proteasomes are large protein molecules that remove damaged or redundant proteins from the body through an enzyme called proteolysis. The 26S proteasome complex participates in the destruction of various proteins, regulates cellular mechanisms, and abnormalities in the regulation are linked to the development of cancer. Proteasome inhibitors block the activity of proteasomes, which are responsible for breaking down proteins and regulating gene expression through various signaling pathways. Many proteasome inhibitors have been developed by targeting the 26S proteasome complex for antitumor effects. These proteasome inhibitors have shown anticancer action by activating apoptosis in different tumor types. This study aimed to investigate the anticancer activity of a unique molecule with proteasome inhibitory properties that contains a tetrazole and oxadiazole ring on breast cancer cells. Method: In this study, ER+ breast cancer cells (MCF-7) were used. Cell viability was analyzed by MTT assay, and the half-maximal inhibitory concentration (IC50) value with the most effective time was determined. The apoptosis was detected by flow cytometry using Annexin V/PI in addition to Acridine Orange/Ethidium Bromide (AO/EB) double staining. Results: Cell viability results revealed that a new designed proteasome inhibitor induced cytotoxicity in ER+ breast cancers best at 72 hrs. However, the results showed that inhibitor containing tetrazole and oxadiazole rings has a lower IC50 value (200 µM) compared to inhibitor with only tetrazole. Flow cytometry analysis and AO/EB staining results also supported the viability data. Conclusion: The results of this study showed that proteasome inhibitor containing a tetrazole ring has some anti-cancer effect, but the addition of an oxadiazole ring to the molecule increases cell death caused by the inhibitor. [ABSTRACT FROM AUTHOR]

We examine three key issues related to flexibility in planning: the first is to understand how flexibility in planning emerges and to define its content; the second relates to how flexibility is formed in planning practices; and the third is to examine the outcomes of flexibility in planning practices. While focusing on the production of large-scale housing projects in Turkey, we examine the emergence of flexibility in planning in Turkey, the extent of this flexibility, how flexibility in Turkey is defined in its planning practices and the outcomes of such planning practices. We base our examination on two projects in Istanbul, one in a newly developing area and the other in an urban renewal area. Some lessons from our research will be relevant to other developing countries that have similar dynamics. [ABSTRACT FROM AUTHOR]

In this paper we introduce the class of m-valent Janowski close to convex harmonic functions. Growth and distortion theorems are obtained for this class. Our study is based on the harmonic shear methods for harmonic functions. [ABSTRACT FROM AUTHOR]

Let f(z) = a1z + a1z2 + … , a1 ≠= 0, be regular in ιzι < 1 and have there no zeros except at the origin. Reade ([3]) and the Sakaguchi ([2]) showed that a necessary and sufficient condition for f(z) to be a member of the class C(k) is that f(z) has a representation of the form f(z) = s(z)(p(z))k where s(z) is a regular function starlike with respect to the origin for ιzι < 1, k is a positive constant, and p(z) is a regular function with positive real part in ιzι < 1. The class of close-to-star functions introduced by Reade ([4]) is equivalent to C(1). In this paper we define the class C(k, A,B) (-1 ≤ B < A ≤ 1, k is positive constant) which contains the functions of the form f(z) = s(z)(p(z))k where s(z) is a regular Janowski starlike function, and p(z) is a regular function with positive real part in ιzι < 1. The aim of this paper is to give some properties and distortion theorems for this class. [ABSTRACT FROM AUTHOR]