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Your search keyword '"Park, Jinny"' showing total 342 results
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342 results on '"Park, Jinny"'

2. Ultra-deep sequencing mutation analysis of the BCR/ABL1 kinase domain in newly diagnosed chronic myeloid leukemia patients

Author

Park, Hyunkyung, Kim, Inho, Kim, Hyeong-Joon, Shin, Dong-Yeop, Lee, Sung-Yeoun, Kwon, Oh-Hyung, Kim, Dae-Young, Lee, Kyoo-Hyung, Ahn, Jae-Sook, Park, Jinny, Sohn, Sang-Kyun, Lee, Jeong-Ok, Cheong, June-Won, Kim, Kyoung Ha, Kim, Hoon-Gu, Kim, Hawk, Lee, Yoo Jin, Nam, Seung-Hyun, Do, Young Rok, Park, Sang-Gon, Park, Seong Kyu, Bae, Sung Hwa, Song, Hun Ho, Oh, Doyeun, Jung, Chul Won, and Park, Seonyang

Published
2021
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4. Clinical Outcomes of Decitabine Treatment for Patients With Lower-Risk Myelodysplastic Syndrome on the Basis of the International Prognostic Scoring System

Author

Jung, Ki Sun, Kim, Yoo-Jin, Kim, Yeo-Kyeoung, Park, Sung Kyu, Kim, Hoon Gu, Kim, Soo Jeong, Park, Jinny, Choi, Chul Won, Do, Young Rok, Kim, Inho, Park, Seonyang, Mun, Yeung-Chul, Jeong, Seong Hyun, Kim, Min-Kyoung, Yi, Hyeon Gyu, Chang, Myung Hee, Kim, Su Youn, Lee, Je-Hwan, and Jang, Jun Ho

Published
2019
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6. Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes.

Author

Jang, Hye-Yeon, Kim, Gi-Beum, Kim, Jeong-Mi, Kang, Sang Yull, Youn, Hyun-Jo, Park, Jinny, Ro, Su Yeon, Chung, Eun-Yong, Park, Kwang-Hyun, and Kim, Jong-Suk

Subjects
FIBROBLASTS, MITOGEN-activated protein kinases, NADPH oxidase, KERATINOCYTES, REACTIVE oxygen species
Abstract

Fisetin is a flavonoid found in plants and has been reported to be effective in various human diseases. However, the effective mechanisms of ultraviolet-A (UVA)-mediated skin damage are not yet clear. In this study, we investigated the protective mechanisms of fisetin regarding UVA-induced human dermal fibroblasts (HDFs) and human epidermal keratinocytes (HEKs) damages. Fisetin showed a cytoprotective effect against UVA irradiation and suppressed matrix metalloproteinases (MMPs), MMP-1, and MMP-3 expression. In addition, fisetin was rescued, which decreased mRNA levels of pro-inflammatory cytokines, reactive oxygen species production, and the downregulation of MAPK/AP-1 related protein and NADPH oxidase (NOX) mRNA levels. Furthermore, UVA-induced MMP-1 and MMP-3 were effectively inhibited by siRNAs to NOX 1 to 5 in HDFs and HEKs. These results indicate that fisetin suppresses UVA-induced damage through the NOX/ROS/MAPK pathway in HDFs and HEKs. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia

Author

Kim, Dae-Young, Joo, Young-Don, Lim, Sung-Nam, Kim, Sung-Doo, Lee, Jung-Hee, Lee, Je-Hwan, Kim, Dong Hwan (Dennis), Kim, Kihyun, Jung, Chul Won, Kim, Inho, Yoon, Sung-Soo, Park, Seonyang, Ahn, Jae-Sook, Yang, Deok-Hwan, Lee, Je-Jung, Lee, Ho-Sup, Kim, Yang Soo, Mun, Yeung-Chul, Kim, Hawk, Park, Jae Hoo, Moon, Joon Ho, Sohn, Sang Kyun, Lee, Sang Min, Lee, Won Sik, Kim, Kyoung Ha, Won, Jong-Ho, Hyun, Myung Soo, Park, Jinny, Lee, Jae Hoon, Shin, Ho-Jin, Chung, Joo-Seop, Lee, Hyewon, Eom, Hyeon-Seok, Lee, Gyeong Won, Cho, Young-Uk, Jang, Seongsoo, Park, Chan-Jeoung, Chi, Hyun-Sook, and Lee, Kyoo-Hyung

Published
2015
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10. US and Dutch Perspectives on the Use of COVID-19 Clinical Prediction Models: Findings from a Qualitative Analysis.

Author

Basile, Melissa J., Helmrich, I. R. A. Retel, Park, Jinny G., Polo, Jennifer, Rietjens, Judith A.C., van Klaveren, David, Zanos, Theodoros P., Nelson, Jason, Lingsma, Hester F., Kent, David M., Alsma, Jelmer, Verdonschot, R. J. C. G., and Hajizadeh, Negin

Abstract

Introduction: Clinical prediction models (CPMs) for coronavirus disease 2019 (COVID-19) may support clinical decision making, treatment, and communication. However, attitudes about using CPMs for COVID-19 decision making are unknown. Methods: Online focus groups and interviews were conducted among health care providers, survivors of COVID-19, and surrogates (i.e., loved ones/surrogate decision makers) in the United States and the Netherlands. Semistructured questions explored experiences about clinical decision making in COVID-19 care and facilitators and barriers for implementing CPMs. Results: In the United States, we conducted 4 online focus groups with 1) providers and 2) surrogates and survivors of COVID-19 between January 2021 and July 2021. In the Netherlands, we conducted 3 focus groups and 4 individual interviews with 1) providers and 2) surrogates and survivors of COVID-19 between May 2021 and July 2021. Providers expressed concern about CPM validity and the belief that patients may interpret CPM predictions as absolute. They described CPMs as potentially useful for resource allocation, triaging, education, and research. Several surrogates and people who had COVID-19 were not given prognostic estimates but believed this information would have supported and influenced their decision making. A limited number of participants felt the data would not have applied to them and that they or their loved ones may not have survived, as poor prognosis may have suggested withdrawal of treatment. Conclusions: Many providers had reservations about using CPMs for people with COVID-19 due to concerns about CPM validity and patient-level interpretation of the outcome predictions. However, several people who survived COVID-19 and their surrogates indicated that they would have found this information useful for decision making. Therefore, information provision may be needed to improve provider-level comfort and patient and surrogate understanding of CPMs. Highlights: While clinical prediction models (CPMs) may provide an objective means of assessing COVID-19 prognosis, provider concerns about CPM validity and the interpretation of CPM predictions may limit their clinical use. Providers felt that CPMs may be most useful for resource allocation, triage, research, or educational purposes for COVID-19. Several survivors of COVID-19 and their surrogates felt that CPMs would have been informative and may have aided them in making COVID-19 treatment decisions, while others felt the data would not have applied to them. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study

Author

Byun, Ja Min, Kim, Young Jin, Yoon, Hwi-Joong, Kim, Si-Young, Kim, Hee-Je, Yoon, Jaeho, Min, Yoo Hong, Cheong, Jun-Won, Park, Jinny, Lee, Jae Hoon, Hong, Dae Sik, Park, Seong Kyu, Kim, Hyeoung-Joon, Ahn, Jae-Sook, Shin, Ho-Jin, Chung, Joo Seop, Lee, Won Sik, Lee, Sang Min, Park, Yong, Kim, Byung Soo, Lee, Je-Hwan, Lee, Kyoo-Hyung, Jung, Chul Won, Jang, Jun Ho, Min, Woo-Sung, Park, Tae Sung, and on behalf of the AML/MDS working party of Korean Society of Hematology

Published
2016
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14. Unsaturated Fatty Acids Complex Regulates Inflammatory Cytokine Production through the Hyaluronic Acid Pathway.

Author

Kim, Gi-Beum, Seo, Kwansung, Youn, Jong-Ung, Kwon, Il Keun, Park, Jinny, Park, Kwang-Hyun, and Kim, Jong-Suk

Subjects
UNSATURATED fatty acids, HYALURONIC acid, CELL survival, CYTOKINES
Abstract

In this study, we aimed to develop natural and/or functional materials with antioxidant and anti-inflammatory effects. We obtained extracts from natural plants through an oil and hot-water extraction process and prepared an extract composite of an effective unsaturated fatty acid complex (EUFOC). Furthermore, the antioxidant effect of the extract complex was evaluated, and the anti-inflammatory effect was explored by assessing its inhibitory effect on nitric oxide production through its HA-promoting effect. We conducted a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay to evaluate the cell viability of the EUFOC, and the results showed that EUFOC was not cytotoxic at the test concentrations. In addition, it showed no endogenous cytotoxicity in HaCaT (human keratinocyte) cells. The EUFOC showed excellent 1,1-diphenyl-2-picrylhydrazyl- and superoxide-scavenging abilities. Moreover, it exerted an inhibitory effect on NO production at concentrations that did not inhibit cell viability. The secretion of all the cytokines was increased by lipopolysaccharide (LPS) treatment; however, this was inhibited by the EUFOC in a concentration-dependent manner. In addition, hyaluronic acid content was markedly increased by the EUFOC in a dose-dependent manner. These results suggest that the EUFOC has excellent anti-inflammatory and antioxidant properties, and hence, it can be used as a functional material in various fields. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone

Author

Kim, Seok Jin, Kang, Hye Jin, Kim, Jin Seok, Oh, Sung Yong, Choi, Chul Won, Lee, Soon Il, Won, Jong Ho, Kim, Min Kyoung, Kwon, Jung Hye, Mun, Yeung-Chul, Kwak, Jae-Yong, Kwon, Jung Mi, Hwang, In Gyu, Kim, Hyo Jung, Park, Jinny, Oh, Sukjoong, Huh, Jooryung, Ko, Young Hyeh, Suh, Cheolwon, and Kim, Won Seog

Published
2011
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19. Role of induction and consolidation chemotherapy in elderly acute myeloid leukemia patients

Author

Kim, Soo-Jeong, Cheong, June-Won, Kim, Dae-Young, Lee, Je-Hwan, Lee, Kyoo-Hyung, Kim, Yeo-Kyeoung, Kim, Hyeong-Joon, Song, Ik-Chan, Jo, Deog-Yeon, Lee, Jeong-Ok, Bang, Soo-Mee, Park, Jinny, Lee, Jae Hoon, Lee, Won-Sik, Joo, Young-Don, Maeng, Chi Hoon, Yoon, Hwi-Joong, Lee, Na-Ri, Kwak, Jae-Yong, Kim, Kyoung Ha, Won, Jong-Ho, Han, Bo Ram, Zang, Dae Young, Moon, Joon Ho, Sohn, Sang Kyun, Bae, Sung Hwa, Ryoo, Hun Mo, Kim, Sung-Yong, Lee, Mark Hong, Min, Yoo Hong, and The Korean Society of Hematology AML/MDS Working Party

Published
2014
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22. The relationship between the success rate of empirical antifungal therapy with intravenous itraconazole and clinical parameters, including plasma levels of itraconazole, in immunocompromised patients receiving itraconazole oral solution as prophylaxis: a multicenter, prospective, open-label, observational study in Korea

Author

Kim, Jin Seok, Cheong, June-Won, Kim, Yeo-Kyeoung, Park, Jinny, Mun, Yeung-Chul, Kang, Hye Jin, Yi, Hyeon Gyu, Lee, Je-Hwan, Kim, Yang Soo, Ryoo, Hun-Mo, Kim, Sung-Hyun, Kim, Ho Young, Kim, Jin Young, Lee, Dong-Gun, Kim, Hoon-Gu, Kim, Hawk, Joo, Young-Don, and Min, Yoo Hong

Published
2014
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26. Low-dose abdominopelvic computed tomography in patients with lymphoma: An image quality and radiation dose reduction study.

Author

Yoon, Sungjin, Yoo, Kwai Han, Park, So Hyun, Kim, Hawk, Lee, Jae Hoon, Park, Jinny, Park, Seong Ho, and Kim, Hwa Jung

Subjects
HODGKIN'S disease, RADIATION doses, LYMPHOMAS, INTRACLASS correlation, LYMPH nodes
Abstract

This study aimed to evaluate image quality, the detection rate of enlarged lymph nodes, and radiation dose exposure of ultralow-dose and low-dose abdominopelvic computed tomography (CT) in patients with lymphoma. Patients with lymphoma who underwent abdominopelvic CT using dual-source scanner were retrospectively recruited from a single center. CT images were obtained at 90 kVp dual-source mode reformatted in three data sets using the advanced modelled iterative reconstruction algorithm: 100% (standard-dose CT), 66.7% (low-dose CT), and 33.3% (ultralow-dose CT). Two radiologists analyzed subjective image quality and detection of abdominal enlarged lymph nodes on ultralow-dose, low-dose, and standard-dose CT blindly and independently. The results were compared with reference standards. Three readers (two radiologists and one hematologist) reviewed overall image quality and spleen size. In total, 128 consecutive CT scans (77 complete response, 44 partial response, 6 progressive disease, and 1 initial evaluation) from 86 patients (64 B-cell lymphoma, 14 T/NK-cell lymphoma, and 8 Hodgkin's lymphoma cases) were assessed. The enlarged lymph node-based detection rates for two readers were 97.0% (96/99) and 94.0% (93/99) on standard-dose CT, 97.0% (96/99) and 94.0% (93/99) on low-dose CT, and 94.0% (93/99) and 89.9% (89/99) on ultralow-dose CT. Overall image quality was 3.8 ± 0.5, 3.9 ± 0.5, and 4.1 ± 0.5 on ultralow-dose CT; 4.7 ± 0.4, 4.6 ± 0.5, and 4.8 ± 0.3 on low-dose CT; and 4.8 ± 0.4, 4.7 ± 0.4, and 4.9 ± 0.2 on standard-dose CT, according to two radiologists and one hematologist, respectively. Intraclass correlation coefficients of spleen size were 0.90 (95% confidence interval [CI], 0.87–0.93), 0.91 (95% CI, 0.88–0.93), and 0.91 (95% CI, 0.88–0.93) on ultralow-dose, low-dose, and standard-dose CT, respectively. Mean effective radiation doses of standard-dose, low-dose, and ultralow-dose CT were 5.7 ±1.8 mSv, 3.8 ± 1.2 mSv, and 1.9 ± 0.6 mSv, respectively. Our findings suggest that ultralow-dose and low-dose CT, even with radiation doses reduced by 66.7% and 33.3%, respectively, maintained adequate image quality. These imaging modalities may be employed for follow-up lymphoma evaluation in consideration of the long surveillance periods. [ABSTRACT FROM AUTHOR]

Published
2022
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30. KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement

Author

Kim, Hee-Jin, Ahn, Hee Kyung, Jung, Chul Won, Moon, Joon Ho, Park, Chang-Hun, Lee, Ki-O, Kim, Sun-Hee, Kim, Yeo-Kyeoung, Kim, Hyeoung-Joon, Sohn, Sang Kyun, Kim, Sung Hyun, Lee, Won Sik, Kim, Kyoung Ha, Mun, Yeung-Chul, Kim, Hawk, Park, Jinny, Min, Woo-Sung, Kim, Hee-Je, Kim, Dong Hwan Dennis, and on behalf of AML/MDS working party, Korean Society of Hematology

Published
2013
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33. Waldeyer’s ring marginal zone B cell lymphoma: are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)

Author

Oh, Sung Yong, Kim, Won Seog, Kim, Jin Seok, Kim, Seok Jin, Lee, Suee, Lee, Dae Ho, Lee, Soon Il, Kang, Hye Jin, Choi, Chul Won, Park, Jinny, Song, Moo Kon, Kim, Hyo Jung, Kwon, Jung Hye, Kwak, Jae-Yong, Bae, Sung Hwa, Park, Byeong-Bae, Do, Young-Rok, Lee, Ho Sup, Jeong, Seong Hyun, Suh, Cheolwon, and Kim, Hyo-Jin

Published
2012
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36. Phase II trial of rituximab plus CVP combination chemotherapy for advanced stage marginal zone lymphoma as a first-line therapy: Consortium for Improving Survival of Lymphoma (CISL) study

Author

Kang, Hye Jin, Kim, Won Seog, Kim, Seok Jin, Lee, Je-Jung, Yang, Deok-Hwan, Kim, Jin Seok, Lee, Se-Ryeon, Lee, Gyeong-Won, Kim, Hyo Jung, Kim, Ho Young, Oh, Sung Yong, Kim, Hugh Chul, Eom, Hyeon-Seok, Chung, Jooseop, Park, Jinny, Suh, Cheolwon, and Ryoo, Baek-Yeol

Published
2012
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41. Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study

Author

Oh, Sung Yong, Kim, Won Seog, Kim, Jin Seok, Kim, Seok Jin, Lee, Suee, Lee, Dae Ho, Won, Jong-Ho, Hwang, In Gyu, Kim, Min Kyoung, Lee, Soon Il, Chae, Yee Soo, Yang, Deok-Hwan, Kang, Hye Jin, Choi, Chul Won, Park, Jinny, Kim, Hyo Jung, Kwon, Jung Hye, Lee, Ho Sup, Lee, Gyeong-Won, Eom, Hyeon Seok, Kwak, Jae-Yong, Lee, Won Sik, Suh, Cheolwon, and Kim, Hyo-Jin

Published
2010
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42. Bortezomib, doxorubicin, and dexamethasone combination therapy followed by thalidomide and dexamethasone consolidation as a salvage treatment for relapsed or refractory multiple myeloma: analysis of efficacy and safety

Author

Lee, Sung Sook, Suh, Cheolwon, Kim, Bong-Seog, Chung, Jooseop, Joo, Young-Don, Ryoo, Hun-Mo, Do, Young Rok, Jin, Jong-Youl, Kang, Hye Jin, Lee, Gyeong-Won, Lee, Moon Hee, Shim, Hyeok, Kim, Kihyun, Yoon, Sung-Soo, Bang, Soo Mee, Kim, Ho Young, Lee, Je-Jung, Park, Jinny, Lee, Dong Soon, Lee, Jae-Hoon, and the Korean Multiple Myeloma Working Party (KMMWP)

Published
2010
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43. Pulmonary marginal zone B-cell lymphoma of MALT type—What is a prognostic factor and which is the optimal treatment, operation, or chemotherapy?: Consortium for Improving Survival of Lymphoma (CISL) Study

Author

Oh, Sung Yong, Kim, Won Seog, Kim, Jin Seok, Kim, Seok Jin, Kwon, Hyuk-Chan, Lee, Dae Ho, Won, Jong Ho, Hwang, In Gyu, Kim, Min Kyoung, Lee, Soon Il, Chae, Yee Soo, Yang, Deok-Hwan, Lee, Gyeong-Won, Choi, Chul Won, Park, Jinny, Suh, Cheolwon, and Kim, Hyo-Jin

Published
2010
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