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270 results on '"Pastorello E"'

4. Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta‐analysis

Author

Dhami, S., Nurmatov, U., Arasi, S., Khan, T., Asaria, M., Zaman, H., Agarwal, A., Netuveli, G., Roberts, G., Pfaar, O., Muraro, A., Ansotegui, I. J., Calderon, M., Cingi, C., Durham, S., van Wijk, R. Gerth, Halken, S., Hamelmann, E., Hellings, P., Jacobsen, L., Knol, E., Larenas‐Linnemann, D., Lin, S., Maggina, P., Mösges, R., Oude Elberink, H., Pajno, G., Panwankar, R., Pastorello, E., Penagos, M., Pitsios, C., Rotiroti, G., Timmermans, F., Tsilochristou, O., Varga, E.‐M., Schmidt‐Weber, C., Wilkinson, J., Williams, A., Worm, M., Zhang, L., and Sheikh, A.

Published
2017
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6. Clinical approach on challenge and desensitization procedures with aspirin in patients with ischemic heart disease and nonsteroidal anti‐inflammatory drug hypersensitivity

Author

Cortellini, G., Romano, A., Santucci, A., Barbaud, A., Bavbek, S., Bignardi, D., Blanca, M., Bonadonna, P., Costantino, M. T., Laguna, J. J., Lombardo, C., Losappio, L.M., Makowska, J., Nakonechna, A., Quercia, O., Pastorello, E. A., Patella, V., Terreehorst, I., Testi, S., Cernadas, J. R., Dionicio Elera, J., Lippolis, D., Voltolini, S., and Grosseto, D.

Published
2017
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29. New allergens in fruits and vegetables

Author

Pastorello, E. A., Incorvaia, C., Pravettoni, V., Farioli, L., Conti, A., Viganò, G., Rivolta, F., Ispano, M., Rotondo, F., and Ortolani, C.

Published
1998

43. NOTIZIE

Author

Camerani, V., Pastorello, E., and Ridolfi, Roberto

Published
1957

48. Characterization of the T-Cell Epitopes of the Major Peach Allergen Pru p 3.

Author

Pastorello, E. A., Monza, M., Pravettoni, V., Longhi, R., Bonara, P., Scibilia, J., Primavesi, L., and Scorza, R.

Subjects
*ALLERGENS, *PEACH, *IMMUNOTHERAPY, *EPITOPES, *T cells, *PHENOTYPES, *CYTOKINES
Abstract

Background: Pru p 3 is the major peach allergen recognized by more than 90% of peach-allergic individuals of the Mediterranean area. Identification of the dominant Pru p 3 T-cell epitopes can improve our understanding of the immune responses against this protein and could be helpful in the development of hypoallergenic immunotherapy. For this purpose, we examined the phenotypes, specificities and cytokine secretion profiles of proliferating T cells in response to Pru p 3 in peach-allergic individuals. Methods: Peripheral blood mononuclear cells from 15 peach-allergic patients were incubated with Pru p 3. The proliferation of antigen-specific T-cell lines (TCLs) was assessed by tritiated methylthymidine incorporation. T-cell epitopes were identified by analyzing the reactivity of TCLs against 8 overlapping peptides spanning the entire length of Pru p 3. We characterized the phenotype of Pru-p-3-specific TCLs by flow cytometry and analyzed their production of interleukin (IL) 4 and γ-interferon (IFN-γ) by ELISA. Results: Ninety-two Pru-p-3-specific TCLs were isolated (stimulation index ≥5). These TCLs proliferated mainly in response to Pru p 312–27 and Pru p 357–72. Pru-p-3-specific TCLs were mainly CD4+ (81%) and expressed cell surface CD30. In addition, TCLs produced high levels of IL-4 and low levels of IFN-γ, indicating a Th2 phenotype. Conclusions: Two immunodominant T-cell-reactive regions of Pru p 3 were identified: Pru p 312–27 and Pru p 357–72. These peptides showed a differential ability to elicit a Th2 response. Taken together, our results provide a better understanding of the immunological T-cell reactivity against Pru p 3. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2010
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49. Allergy and multiple sclerosis: a population-based case-control study.

Author

Pedotti, R., Farinotti, M., Falcone, C., Borgonovo, L., Confalonieri, P., Campanella, A., Mantegazza, R., Pastorello, E., and Filippini, G.

Subjects
MULTIPLE sclerosis, ALLERGIES, IMMUNOLOGIC diseases, IMMUNE response, SKIN inflammation, ATOPIC dermatitis, OBSTRUCTIVE lung diseases
Abstract

Background Epidemiological studies on the association between allergic disorders, T-helper type 2 (Th2) mediated, and multiple sclerosis (MS), a T-helper type 1 (Th1)/Th17-mediated disease, provided conflicting results. Objective The aim of this study was to further examine the association between allergic disorders and MS. Methods The association between MS and previous medical history of any type of allergy has been investigated in a population-based case-control study conducted in Northern Italy, based on telephone interviews to 423 cases and 643 population controls (refusal rates 3.7% and 9.4%, respectively). Controls were a random sample of the general population. Results A history of atopic allergies seems to confer protection against MS (odds ratio [OR], 0.58; 95% confidence interval [CI], 0.38-0.89; P = 0.012). In particular, the prevalence of allergic asthma was 4.9% in people with MS and 12% in control subjects (OR = 0.38; 95% CI 0.22-0.66, P < 0.01). No association was found between MS and nonatopic allergies. Conclusions Our findings are confirmatory of the putative protective effect of Th2-mediated disorders on Th1 immune responses associated with MS. A unifying theory on the mechanisms by which previous history of atopic allergies may modify the risk of MS is still lacking. [ABSTRACT FROM AUTHOR]

Published
2009
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50. Prevalence of Inherited Ataxias in the Province of Padua, Italy.

Author

Zortea, M., Armani, M., Pastorello, E., Nunez, G. F., Lombardi, S., Tonello, S., Rigoni, M. T., Zuliani, L., Mostacciuolo, M. L., Gellera, C., Di Donato, S., and Trevisan, C. P.

Subjects
ATAXIA, MOVEMENT disorders, EPIDEMIOLOGY
Abstract

Few population studies are available on epidemiological indexes of hereditary ataxias. An investigation on the prevalence rate of these movement disorders is in progress for the Veneto region, the main area of northeast Italy with a population of 4,490,586 inhabitants. The first results of this epidemiological survey concern the province of Padua, which numbers 845,203 residents (January 1, 2002). The prevalence rate of inherited ataxias has been estimated at 93.3 cases per million inhabitants. The most common types appeared to be the autosomal dominant forms, namely spinocerebellar ataxia type 1 and 2, with a prevalence of 24 per 1,000,000. In the same population, with a prevalence rate of 6 per 1,000,000, Friedreich's ataxia was defined as the prominent recessive autosomal form. There were very rare cases of ataxia telangiectasia, ataxia with vitamin E deficiency and cerebellar ataxia with congenital muscular dystrophy, a recently identified autosomal recessive disease. [ABSTRACT FROM AUTHOR]

Published
2004
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