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Your search keyword '"Peters, Wilbert H.M."' showing total 125 results
Start Over Author "Peters, Wilbert H.M." Publication Type Academic Journals
125 results on '"Peters, Wilbert H.M."'

1. No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study

Author

Dong, Jing, Gharahkhani, Puya, Chow, Wong-Ho, Gammon, Marilie D., Liu, Geoffrey, Caldas, Carlos, Wu, Anna H., Ye, Weimin, Onstad, Lynn, Anderson, Lesley A., Bernstein, Leslie, Pharoah, Paul D., Risch, Harvey A., Corley, Douglas A., Fitzgerald, Rebecca C., Iyer, Prasad G., Reid, Brian J., Lagergren, Jesper, Shaheen, Nicholas J., Vaughan, Thomas L., MacGregor, Stuart, Love, Sharon, Palles, Claire, Tomlinson, Ian, Gockel, Ines, May, Andrea, Gerges, Christian, Anders, Mario, Böhmer, Anne C., Becker, Jessica, Kreuser, Nicole, Thieme, Rene, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Schmidt, Claudia, Izbicki, Jakob R., Hölscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Mayershofer, Rupert, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M., Moebus, Susanne, Knapp, Michael, Peters, Wilbert H.M., Neuhaus, Horst, Rösch, Thomas, Ell, Christian, Jankowski, Janusz, Schumacher, Johannes, Neale, Rachel E., Whiteman, David C., and Thrift, Aaron P.

Published
2019
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2. Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

Author

Masclee, A.A.M., Pierik, M., Mares, W., Hameeteman, W., Wahab, P.J., Seinen, H., Rijk, M.C.M., Harkema, I.M., de Bièvre, M., Oostenbrug, L., Bakker, C.M., Aquarius, M., van Deursen, C., van Nunen, A.B., Goedhard, J.G., Hamacher, M., Gisbertz, I.A.M., Brenninkmeijer, B.J., Tan, A.C.I.T.L., Aparicio-Pagés, M.N., Witteman, E.M., van Tuyl, S.A.C., Breumelhof, R., Stronkhorst, A., Gilissen, L.P.L., Schoon, E.J., Tjhie-Wensing, J.W.M., Temmerman, A., Nicolaï, J.J., van Bergeijk, J.D., Bac, D.J., Witteman, B.J.M., Mahmmod, N., Uil, J.J., Akol, H., Ouwendijk, R.J.T., van Munster, I.P., Pennings, M., De Schryver, A.M.P., van Ditzhuijsen, T.J.M., Scheffer, R.C.H., Römkens, T.E.H., Schipper, D.L., Bus, P.J., Straathof, J.W.A., Verhulst, M.L., Boekema, P.J., Kamphuis, J.T., van Wijk, H.J., Salemans, J.M.J.L., Vermeijden, J.R., van der Werf, S.D.J., Verburg, R.J., Spoelstra, P., de Vree, J.M.L., van der Linde, K., Jebbink, H.J.A., Jansen, M., Holwerda, H., van Bentem, N., Kolkman, J.J., Russel, M.G.V.M., van Olffen, G.H., Kerbert-Dreteler, M.J., Bargeman, M., Götz, J.M., Schröder, R., Jansen, J.M., Bos, L.P., Engels, L.G.J.B., Romberg-Camps, M.J.L., Keulen, E.T.P., van Esch, A.A.J., Drenth, J.P.H., van Kouwen, M.C.A., Wanten, G.J.A., Bisseling, T.J., van Vugt, M.W.J., van de Meeberg, P.C., van den Hazel, S.J., Stuifbergen, W.N.H.M., Grubben, M.J.A.L., de Wit, U., Dodemont, G.A.H., Eichhorn, R.F., van den Brande, J.M.H., Naber, A. H.J., van Soest, E.J., Kingma, P.J., Talstra, N.C., Bruin, K.F., Wolfhagen, F.H.J., Hommes, D.W., van der Veek, P.P.J., Hardwick, J.C.A., Stuyt, R.J., Fidder, H.H., Oldenburg, B., Tan, T.G., Coenen, Marieke J.H., de Jong, Dirk J., van Marrewijk, Corine J., Derijks, Luc J.J., Vermeulen, Sita H., Wong, Dennis R., Klungel, Olaf H., Verbeek, Andre L.M., Hooymans, Piet M., Peters, Wilbert H.M., te Morsche, Rene H.M., Newman, William G., Scheffer, Hans, Guchelaar, Henk-Jan, and Franke, Barbara

Published
2015
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10. Small increases in the urinary excretion of glutathione S-transferase A1 and P1 after cardiac surgery are not associated with clinically relevant renal injury

Author

Eijkenboom, Jos J.A., van Eijk, Lucas T.G.J., Pickkers, Peter, Peters, Wilbert H.M., Wetzels, Jack F.M., and van der Hoeven, Hans G.

Subjects
Complications and side effects, Risk factors, Health aspects, Cardiopulmonary bypass -- Health aspects, Heart surgery -- Complications and side effects -- Health aspects, Acute kidney failure -- Risk factors -- Complications and side effects, Heart -- Surgery, Acute renal failure -- Risk factors -- Complications and side effects
Abstract

Objective: Cardiac surgery is an important risk factor for the development of acute renal failure. Cytosolic enzymes glutathione Stransferase (GST) A1 and P1 are present selectively in proximal and distal [...]

Published
2005

45. Xanthine oxidase inhibition by allopurinol increases in vitro pyrazinamide-induced hepatotoxicity in HepG2 cells.

Author

Tostmann, Alma, Aarnoutse, Rob E., Peters, Wilbert H.M., Richard, P.N. Richard, and Boeree, Martin J.

Subjects
TUBERCULOSIS treatment, HEPATOTOXICOLOGY, XANTHINE, OXIDASES, PYRAZINAMIDE, METABOLITES
Abstract

Despite the important role of pyrazinamide in tuberculosis treatment, little is known about the mechanism of pyrazinamide-induced hepatotoxicity. We inhibited xanthine oxidase in HepG2 cells by using a nontoxic concentration of allopurinol, a well-known xanthine-oxidase inhibitor. This increased in vitro pyrazinamide toxicity in HepG2 cells, which suggests that the hydroxy metabolites of pyrazinamide are probably not fully responsible for pyrazinamide-induced toxicity, and that pyrazinoic acid and pyrazinamide are involved in pyrazinamide toxicity. [ABSTRACT FROM AUTHOR]

Published
2010
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48. GENETIC POLYMORPHISMS IN ALCOHOL-METABOLIZING ENZYMES AND CHRONIC PANCREATITIS.

Author

Verlaan, Mariette, Te Morsche, René H.M., Roelofs, Hennie M.J., Laheij, Robert J.F., Jansen, Jan B.M.J., Peters, Wilbert H.M., and Drenth, Joost P.H.

Subjects
GENETIC polymorphisms, ALCOHOL dehydrogenase, CYTOCHROMES, PANCREATITIS, ENZYMES, GENES
Abstract

Aims: Alcohol misuse is now regarded as an important risk factor for development of chronic pancreatitis (CP). However, not every alcohol misuser develops CP and it therefore might be suggested that susceptibility could be further influenced by inter-individual variations in the activities of alcohol-metabolizing enzymes. Several genetic polymorphisms that may affect the activities of alcohol-metabolizing enzymes have been described. Therefore we determined whether polymorphisms in the genes for alcohol dehydrogenase 3 (ADH3) or cytochrome P450 2E1 (CYP2E1) predispose to the development of CP. Methods: DNA samples were obtained from 142 adult CP patients with hereditary (n = 21), alcoholic (n = 82) or idiopathic (n = 39) CP. DNA from 128 healthy controls and from 93 alcoholic controls was analysed for comparison. Patients and controls were all of Caucasian origin. Genetic polymorphisms in ADH3 and CYP2E1 were determined by PCR, followed by restriction-fragment-length-polymorphism analyses in all subjects. Results: The frequencies of ADH3 and CYP2E1 c1c2 genotypes did not differ between CP patients and alcoholic and healthy controls. However, a trend for a higher frequency of the CYP2E1 intron 6 D allele was demonstrated in patients with alcohol-induced CP, compared to that of healthy controls (OR = 3.03, 95%CI = 1.0-9.1) or alcoholic controls (OR = 2.76, 95%CI = 0.9-8.7). Conclusions: These data suggest that the presence of the CYP2E1 intron 6 DD genotype might confer a higher risk of alcoholic CP. [ABSTRACT FROM AUTHOR]

Published
2004
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49. Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome.

Author

Zusterzeel, Petra L.M., Visser, Willy, Bolm, Henk J., Peters, Wilbert H.M., Heil, Sandra G., Steegers, Eric A.P., Steegers, E. A.P., Zusterzeel, P L, Visser, W, Blom, H J, Peters, W H, Heil, S G, and Steegers, E A

Subjects
GENETIC polymorphisms, PREECLAMPSIA
Abstract

Objective: To investigate the prevalence of the 677 (C --> T) and 1298 (A --> C) polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene in our preeclamptic population. For a summary estimation of the risk of the 677 (C --> T) polymorphism for preeclampsia, we also performed a meta-analysis on four previously published case-control studies to which our results were added.Methods: Genotypes were analyzed by polymerase chain reaction followed by restriction enzyme analysis. The results of 176 nonpregnant women, previously hospitalized for preeclampsia in a tertiary care center, were compared with 403 Dutch population-based controls. Results were statistically analyzed with a chi-square test.Mean Outcome Measures: The incidence of the 677 (C --> T) and 1298 (A --> C) polymorphisms in the MTHFR gene.Results: The incidence of both MTHFR missense polymorphisms was not significantly different between cases and controls. We found an odds ratio (OR) of 1.5 [95% confidence interval (CI) 0.8-2.6, p = 0.17] and an OR of 1.0 (95% CI 0.6-1.9, p = 0.23) for the 677 (C --> T) and the 1298 (A --> C) polymorphism, respectively, in cases comparing the prevalence of the homozygous genotype versus the other two genotypes. The meta-analysis resulted in a significant OR of 2.0 (95% CI 1.4-2.9).Conclusions: In contrast to four previous studies, we were neither able to confirm an increased risk for preeclampsia to the 677 (C --> T) polymorphism nor did we find an increased risk for preeclampsia to the 1298 (A --> C) polymorphism. From the meta-analysis, however, we conclude that it cannot be ruled out that the homozygous 677TT genotype is a modest but significant risk factor for preeclampsia. [ABSTRACT FROM AUTHOR]

Published
2000
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50. Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss.

Author

Zusterzeel, Petra L.M., Nelen, Willianne L.D.M., Roelofs, Hennie M.J., Peters, Wilbert H.M., Blom, Henk J., and Steegers, Eric A.P.

Abstract

Examines occurrence of genetic polymorphisms in biotransformation enzymes in patients with recurrent early pregnant loss. Imbalance between phase I drug metabolizing enzymes and phase II detoxification enzymes; Development of pre-eclampsia; Glutathione S-transferase genes.

Published
2000
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