Search

Human tragedy could be summed up a single word—death. One first encounters it through the death of others, and then everyone faces it for themselves. The Christian faith confronts humanity’s final foe head on, delivering sustained hope amidst the sorrow and despair of impending death. This paper will first address the central role of the resurrection of the dead in First Corinthians. Second, the paper will present Paul’s retort to several challenges raised against the notion of the resurrection. Finally, the paper will attempt to systematize the means by which Paul proves the resurrection of the dead.

Introduction. Celiac disease (CD) is a chronic autoimmune disorder triggered by gluten ingestion in genetically predisposed individuals, presenting with a diverse range of symptoms that extend beyond the gastrointestinal tract. The condition’s systemic nature is evidenced by its extra-digestive manifestations, which can affect various organs including the skin, joints, liver, and nervous system. Methods. This descriptive, retrospective study was conducted at a tertiary care center, focusing on adult patients diagnosed with CD who exhibited extra-digestive symptoms. Data were extracted from medical records of patients admitted between January 1, 2010 and June 30, 2024. Variables included demographic information, primary diagnosis, and associated extra-digestive manifestations. Descriptive statistical methods were employed for data analysis. Results. The sample included 108 patients with CD, the mean age was 43.21 years, with a predominance of females (76.85%). Iron deficiency anemia was the most common extra-digestive manifestation, affecting 20.37% of patients, followed by hypoproteinemia (18.52%) and Hashimoto’s thyroiditis (14.81%). Cooccurrence analysis revealed frequent combinations of conditions, such as anemia with cardiovascular diseases and depressive disorders. Notable associations with neurological conditions like gluten ataxia and peripheral neuropathy were also observed. Conclusion. This study highlights the extensive extra-digestive manifestations of celiac disease, underscoring its systemic impact. The high prevalence of autoimmune conditions such as Hashimoto’s thyroiditis and rheumatoid polyarthritis among CD patients reflects the need for holistic management strategies. Discrepancies between our findings and existing literature, particularly regarding skin and neurological conditions, emphasize the need for further research to better understand these associations and the long-term effects of a gluten-free diet. [ABSTRACT FROM AUTHOR]

Currently, gold nanoparticles (GNPs) are considered an ideal delivery system due to their physiological stability, high bioactivity, and controlled release of biological component. Our primary objective was to comprehend the behavior of gold nanoparticles obtained with specific natural compounds in the gastrointestinal tract. We investigated the conduct of GNPs synthesized with natural compounds from Cornus mas L. (GNPsCM) or Sambucus nigra (GNPs-E) fruits, during the oral, gastric, and intestinal phases of the in vitro simulated gastrointestinal digestion. Additionally, we assessed their antioxidant capacity, phenolic content, and their potential to mitigate damages caused by nitro-oxidative stress after each phase of in vitro digestion. Results indicated that both GNPs-CM and GNPs-E maintained stability throughout simulated digestion, with some observed differences between them. Upon measuring antioxidant capacity, the GNPs-CM exhibited the lowest percentage of inhibition from hydrogen donor measurements (12.08%) after the simulated intestinal phase. Conversely, the GNPs-E displayed the highest inhibition percentage (65.3%) after the simulated oral phase. Concerning phenolic content, GNPs-CM showed a polyphenol content of 39.53 mg of gallic acid equivalents (GAE)/L, decreasing during gastrointestinal phases. GNPs-Eexhibited a polyphenol content of 100.99 mg GAE /l, also decreasing during gastrointestinal phases. [ABSTRACT FROM AUTHOR]

Introduction. Studies regarding antibiotics administration during pregnancy and atopic dermatitis (AD) in children are only few. In this context, the objective of our study was to investigate the potential association between the timing of intrauterine exposure to antibiotics or prenatal antibiotic administration in general and AD occurrence in children.

Background: Small bowel disorders present a diagnostic challenge due to the limited accessibility of the small intestine. Accurate diagnosis is made with the aid of specific procedures, like capsule endoscopy or double-ballon enteroscopy, but they are not usually solicited and not widely accessible. This study aims to assess and compare the diagnostic effectiveness of enteroscopy and video capsule endoscopy (VCE) when combined with artificial intelligence (AI) algorithms for the automatic detection of small bowel diseases. Materials and methods: We performed an extensive literature search for relevant studies about AI applications capable of identifying small bowel disorders using enteroscopy and VCE, published between 2012 and 2023, employing PubMed, Cochrane Library, Google Scholar, Embase, Scopus, and ClinicalTrials.gov databases. Results: Our investigation discovered a total of 27 publications, out of which 21 studies assessed the application of VCE, while the remaining 6 articles analyzed the enteroscopy procedure. The included studies portrayed that both investigations, enhanced by AI, exhibited a high level of diagnostic accuracy. Enteroscopy demonstrated superior diagnostic capability, providing precise identification of small bowel pathologies with the added advantage of enabling immediate therapeutic intervention. The choice between these modalities should be guided by clinical context, patient preference, and resource availability. Studies with larger sample sizes and prospective designs are warranted to validate these results and optimize the integration of AI in small bowel diagnostics. Conclusions: The current analysis demonstrates that both enteroscopy and VCE with AI augmentation exhibit comparable diagnostic performance for the automatic detection of small bowel disorders. [ABSTRACT FROM AUTHOR]

One of the most difficult issues that Jesus' contemporaries had to deal with was the question about his identity. In the context of a fierce monotheism, highlighted by the effects of the Babylonian exile, which definitely eliminated idolatry from Israel, a man's claim to possess divine nature would have been outrageous from the onset. However, one's response to the challenge of recognising Jesus' identity depends on whether he or she belongs to those who accept the Kingdom of Christ or those who reject it. In this paper we propose an analysis of Mark 8.27-30 in order to see just how Mark constructs the debate over Jesus' identity. From a methodological point of view, we will present some general aspects regarding the challenges raised by this text, therefore we will refer to the available Romanian translation, with its rendition of Mark's insights on said identity. The text's exegetical aspects, its key phrases, structural elements and the context of the events, together with the comparison between the affirmation of Jesus' identity in Mark and the other gospels, will underline the process that rounds up the identity debates in Mark's gospel. [ABSTRACT FROM AUTHOR]

The aim of this study was to compare transcaval and transaxillary artery access for transcatheter aortic valve replacement (TAVR) at experienced medical centers in contemporary practice. There are no systematic comparisons of transcaval and transaxillary TAVR access routes. Eight experienced centers contributed local data collected for the STS/ACC TVT Registry (Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry) between 2017 and 2020. Outcomes after transcaval and axillary/subclavian (transaxillary) access were adjusted for baseline imbalances using doubly robust (inverse propensity weighting plus regression) estimation and compared. Transcaval access was used in 238 procedures and transaxillary access in 106; for comparison, transfemoral access was used in 7,132 procedures. Risk profiles were higher among patients selected for nonfemoral access but similar among patients requiring transcaval and transaxillary access. Stroke and transient ischemic attack were 5-fold less common after transcaval than transaxillary access (2.5% vs 13.2%; OR: 0.20; 95% CI: 0.06-0.72; P = 0.014) compared with transfemoral access (1.7%). Major and life-threatening bleeding (Valve Academic Research Consortium 3 ≥ type 2) were comparable (10.0% vs 13.2%; OR: 0.66; 95% CI: 0.26-1.66; P = 0.38) compared with transfemoral access (3.5%), as was blood transfusion (19.3% vs 21.7%; OR: 1.07; 95% CI: 0.49-2.33; P = 0.87) compared with transfemoral access (7.1%). Vascular complications, intensive care unit and hospital length of stay, and survival were similar between transcaval and transaxillary access. More patients were discharged directly home and without stroke or transient ischemic attack after transcaval than transaxillary access (87.8% vs 62.3%; OR: 5.19; 95% CI: 2.45-11.0; P < 0.001) compared with transfemoral access (90.3%). Patients undergoing transcaval TAVR had lower rates of stroke and similar bleeding compared with transaxillary access in a contemporary experience from 8 US centers. Both approaches had more complications than transfemoral access. Transcaval TAVR access may offer an attractive option. [Display omitted] [ABSTRACT FROM AUTHOR]

The aim of this study was to determine the safety and efficacy of same-day discharge (SDD) after transcatheter aortic valve replacement (TAVR) during the COVID-19 pandemic. The COVID-19 pandemic has placed significant stress on health care systems worldwide. SDD in highly selected TAVR patients can facilitate the provision of essential cardiovascular care while managing competing COVID-19 resource demands. Patient selection for SDD was at the discretion of the local multidisciplinary heart team, across 7 international sites. The primary outcome was a composite of cardiovascular death, stroke, myocardial infarction, all-cause readmission, major vascular complications, and new permanent pacemaker (PPM) implantation. From March 2020 to August 2021, 124 of 2,100 patients who underwent elective transfemoral TAVR were selected for SDD. The average age was 78.9 ± 7.8 years, the median Society of Thoracic Surgeons score was 2.4 (IQR: 1.4-4.2), and 32.3% (n = 40) had preexisting PPMs. There were no major vascular complications, strokes, or deaths during the index admission. One patient (0.8%) required PPM implantation for complete heart block and was discharged the same day. No patient required a PPM between discharge home and 30-day follow-up. The composite of cardiovascular death, stroke, myocardial infarction, all-cause readmission, major vascular complications, and new PPM at 30 days occurred in 5.7% patients (n = 6 of 106). SDD post-TAVR is safe and feasible in selected patients at low risk for adverse clinical events postdischarge. This strategy may have a potential role in highly selected patients even when the COVID-19 pandemic abates. [Display omitted] [ABSTRACT FROM AUTHOR]

This paper presents the work of Christ for the redemption of all creation, noticing how God made our salvation possible. In order to achieve this goal, we will look at the analogy between Adam (the old creation) and Christ (the new creation). This typological relationship outlines the principle of representation in Romans 5:12-21. From a methodological point of view, we propose to approach the Epistle to the Romans 5:12-21 and analyze the pattern it unfolds. Our working method involves three components. Firstly, we will deal with the framing and structure of this text studied in the broader context of the book; secondly, we will outline some exegetical aspects regarding the text; and finally, we will present the application of the theme highlighted by the text. [ABSTRACT FROM AUTHOR]

Since Gert Schiff's magisterial publication of 1973 on Henry Fuseli (1741–1825), a print identified as representing the enslaved prince Oroonoko has raised unsettling questions about the complex implication of even liberal, abolitionist eighteenth-century artists and intellectuals in the world system of enslaved labor. But problems of fit with Thomas Southerne's 1695 play Oroonoko, popular throughout the eighteenth century, and with Aphra Behn's 1688 eponymous novel demand a reattribution, placing the print in a debate about not only slavery in the Americas but also race, classicism, and the merits of Indigenous and European civilization in South Africa. [ABSTRACT FROM AUTHOR]

The first person represented as a subject's field of vision, as opposed to first-person language, has only been around for a century and a half. Yet the claims advanced by its philosophical inventor, Ernst Mach, are momentous: nothing less than the dissolution of the self into a world of sensations. A closer look at his images reveals less an elimination of the self than a reflection of the connection between subject, world, and others. [ABSTRACT FROM AUTHOR]

The article focuses on Joshua Reynolds's Portrait of a Black Man . Topics discussed include this essay will try to do so explicitly, drawing the consequences of treating an artifact not usually regarded in Enlightenment terms; and the portrait of a presently unidentified Black man, less as a product of than as itself productive of Enlightenment.

Background and aims. High fat diet (HFD) can lead to liver injury, through oxidative stress and inflammation. The use of natural compounds with antioxidant and antiinflammatory properties can have a protective potential. We aimed to investigate the effects of Cornus mas (CM) and gold nanoparticles phytoreduced with CM (GNPsCM) on hepatic alterations induced by HFD in rats. Methods. Female Sprague Dawley rats were randomly divided into four groups: control, HFD, HFD +CM and HFD + GNPsCM. The high fat diet was administered for 32 weeks and CM and GNPsCM were administered for 4 weeks after the HFD period. The high fat diet induced oxidative stress in liver, with lipid peroxidation and decreased antioxidant capacity, inflammation and minimal histological alterations. Results. The administration of CM and GNPsCM reduced lipid peroxidation produced by HFD and increased antioxidant potential in liver homogenates, while increasing inflammatory markers. Histological alterations were slightly improved by the intervention of compounds, and hyaluronic acid content of the liver without statistical significance as compared to HFD group. Conclusion. These findings support the potential of these treatments in addressing liver oxidative stress, mitigating liver damage induced by a high-fat diet. This investigation sheds light on the oxidative stress dynamics and histological alterations associated with high-fat diet-induced liver injury, contributing to our understanding of potential therapeutic interventions. [ABSTRACT FROM AUTHOR]

The article talks about a brief profile of art historian Alois Riegl, and his three Riegl translations united by his concept of mood (Stimmung). It mentions that three texts directly address his contemporaries' aesthetic sensibilities across a range of media from painting to masonry to magazine illustration. It mentions about philosopher Walter Benjamin's own sustained Rieglian engagements in the 1930s.

Professional health hazards are an important topic for healthcare providers, even in this period when emphasis is put on fighting pollution and mental diseases. In this context, a category of visual artists presents also their professional medical conditions. Although not severe in most cases, clinical conditions of visual artists are quite common, but scarcely reported. These pathological conditions may be considered as rare diseases, given their low prevalence in the general population, but are none less important. This paper reviews updated knowledge on health hazards affecting art photographers. Art photography is in continuous development and people at risk become more numerous. Diseases linked to professional activity of photographers involve several diseases: skin diseases caused by chemical or allergic interaction, visual disorders and psychological disorders. Preventive measures are suggested: photographers should avoid prolonged contact with offensive agents and if necessary use protection equipment; if necessary, they should follow recommendations to prevent health hazards of artistic photography; when needed, relaxation techniques should be learned and practiced. This is to our knowledge one of the very few reviews of this topic. [ABSTRACT FROM AUTHOR]

The functional gastrointestinal disorders recently received a better name, given by the Rome IV working committees. They are called now disorders of the gut-brain interaction. The new name reflects the progress in the knowledge of these disorders. They are no more perceived as idiopathic conditions, but rather as self-standing pathological entities. Therefore, they are no more diagnosed after ruling out any other pathology but benefit of criteria for positive diagnosis. The taxonomy remains however based on the topographic area to which symptoms are attributed. This paper reviews the disorders of the gut-brain interaction following the Rome IV taxonomy. The main clinical and pathogenetic features of each of them are presented [ABSTRACT FROM AUTHOR]

The major tragedy that humanity has to face is death. It is the enemy that every human being must face in at least two situations. On the one hand, death is the one that kidnaps loved ones in the family, causing the pain of separation. On the other hand, every human being must face his own death. Although this enemy often brings sorrow and despair into human life, it is the Christian faith that offers hope even in the face of death. This reason led me to address the theme of the resurrection of the dead in this paper. This theme is also presented by the apostle Paul, as an answer to one of the problems of the church in Corinth. In this paper we will present the role and place of the resurrection of the dead in 1 Corinthians, and then we will present the apostle's reasoned response to those who challenged the resurrection of the dead, and in the final part we will present the apostle Paul's perspective on how the dead will rise. [ABSTRACT FROM AUTHOR]

There are many project management methodologies which one can choose from when starting a new project. The purpose of this article is to analyze the most known methodologies, Agile and Waterfall, in order to determine which is the most suitable for a software project. We propose a practical study by analyzing the results of a survey designed to capture the experience of developers with the aforementioned methodologies. We will focus on the Scrum and Kanban Agile methods and Waterfall to analyze the findings of the study. Given the results of the study, we concluded that there is no silver bullet solution when it comes to choosing the methodology for a project, as numerous factors need to be accounted for. Waterfall will be a better solution for small projects that have well-defined requirements that will not change, while Agile is preferred when continuous delivery and feedback are important, requirements are not well defined and time to market is more important than releasing a full feature version. [ABSTRACT FROM AUTHOR]

Pipe damages and imperfections led to a start in researching ways of inspecting and maintaining the pipelines. An attractive solution is using mobile robots for this matter. This paper presents the development process of a wheeled in-pipe minirobot with adaptable structure called IPMR-3). IPMR-3has three articulated mechanisms placed at 120° angles around its central axis. The actuation is done with three DC motors. IPMR-3 can adapt its structure to pipe diameters ranged between 220 and 380 mm. The end of the paper presents the image capturing method, achieved with a C910 wireless video camera, and images from the testing process. [ABSTRACT FROM AUTHOR]

Background Insulin resistance ( IR) is present in type 1 diabetes mellitus ( T1 DM) and is suggested to be related to chronic diabetic complications. The primary aim of our study was to assess IR in T1 DM patients with and without chronic complications. A secondary aim was to evaluate the possible association between IR and chronic diabetic complications. Methods This cross-sectional study enrolled 272 patients with T1 DM. Insulin resistance was quantified using the estimated glucose disposal rate (e GDR). Associations between e GDR and each diabetes complication were first evaluated using binary logistic regression, then multiparametric logistic regression with stepwise selection of covariates. The discriminative value of e GDR was assessed by receiver operating characteristic ( ROC) curve analysis. Results Estimated GDR was lower in patients with chronic diabetic complications (6.1 vs 6.9 mg/kg per min [ P = 0.02] for retinopathy; 6.3 vs 7.3 mg/kg per min [ P < 0.01] for nephropathy; 6.5 vs 7.6 mg/kg per min [ P < 0.01] for neuropathy; and 5.2 vs 7.5 mg/kg per min [ P < 0.01] for cardiovascular complications). In univariate analysis e GDR was associated all diabetic complications. These associations remained significant after adjustment for different variables in the final regression models. In addition, e GDR was a good discriminator for each diabetic complication, with an area under the curve between 0.609 and 0.759. Conclusions Patients with chronic diabetic complications are more insulin resistant than those without complications. Moreover, IR was independently associated with the presence of each chronic diabetic complication, and seems to be a good discriminator for them all. [ABSTRACT FROM AUTHOR]

Copyright of Fibres & Textiles in Eastern Europe is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Henry Fuseli’s painting The Nightmare (1782), unusual in the artist’s oeuvre and in the painting of its time as the public visualization of a private mental state, can be made sense of in light of late eighteenth-century practices and theories of privacy and of the agency that minds can exert on the world and on each other. By comparison with another dream-like performance, Emma Hamilton’s Attitudes, and informed by David Hume’s theory of sympathy, which was designed to explain the social communicability of mental states, a reading of The Nightmare emerges which shows that it did not aim to make visible dream imagery, but to induce spectators to have or feel as if they had an analogous experience. The painting is thus typical of the formative stage of a modern understanding of public life as a contingent association of private lives. [ABSTRACT FROM AUTHOR]

Analysis of serum biomarkers for the assessment of atrophic gastritis (AG), considered as precursor of the intestinal type of gastric cancer, is of growing interest. The combination of pepsinogen (PG), gastrin-17 (G17) and anti-Helicobacter pylori (H. pylori) antibody serological assays (panel test) is a non-invasive tool for the diagnosis of atrophic gastritis. However, the diagnostic reliability of this test remains uncertain. The aim of our study was to assess the diagnostic performance of the serum panel test (GastroPanel) for the diagnosis of atrophic gastritis. From dyspeptic patients, endoscopic biopsy samples (two from the gastric corpus and two from the antrum) and blood samples were collected. The determination of sPGI, sPGII, sG17 and IgG antibodies to H. pylori (H.p IgG) was performed using an enzyme-linked immunosorbent assay (GastroPanel; Biohit Oyj). Histopathology results were compared with GastroPanel values. Sixty patients were included: 35 (58.3%) females and 25 (41.66%) males; mean age 67.63±9.36 years; 45% H. pylori-positive. A total of 65% of patients had atrophic gastritis. There were no significant differences between the levels of biomarkers and localization of atrophy. The ratio PG1/PG2 was lower in patients with multifocal atrophy; the difference being close to the threshold of statistical significance. In cases of intestinal metaplasia the values of G17, PG1, PG2, H.p IgG were not statistically altered compared to those without intestinal metaplasia; only the ratio PG1/PG2 was lower in intestinal metaplasia; the difference being almost of statistical significance. Our results revealed that, GastroPanel values did not differ depending on the severity of the atrophy. Biomarkers used by GastroPanel do not have enough accuracy for use in the diagnosis of atrophy in the population studied. A low accuracy only for the ratio PG1/PG2 in patients with multifocal atrophy was found. However, our data revealed a correlation in detecting intestinal metaplasia. [ABSTRACT FROM AUTHOR]

The stability and robustness of a complex network can be significantly improved by determining important nodes and by analyzing their tendency to group into clusters. Several centrality measures for evaluating the importance of a node in a complex network exist in the literature, each one focusing on a different perspective. Community detection algorithms can be used to determine clusters of nodes based on the network structure. This paper shows by empirical means that node importance can be evaluated by a dual perspective—by combining the traditional centrality measures regarding the whole network as one unit, and by analyzing the node clusters yielded by community detection. Not only do these approaches offer overlapping results but also complementary information regarding the top important nodes. To confirm this mechanism, we performed experiments for synthetic and real-world networks and the results indicate the interesting relation between important nodes on community and network level. [ABSTRACT FROM AUTHOR]

Background & Aims: The three manometric patterns of achalasia are considered by some authors as different stages in the evolution of the same disorder. The aims of our study were to characterize patients with achalasia, in order to find key differences supporting the idea of progression from one type to the other, and to assess the clinical evolution in time. Methods: From 280 high resolution esophageal manometry recordings we selected unique patients with achalasia. A standardized questionnaire used prior to each manometry recorded their symptoms. Manometric parameters (resting lower esophageal sphincter (LES) pressure, 4s-integrated relaxation pressure (IRP), length of the esophagus, etc.) were recorded. Patients were contacted to establish the clinical evolution. Results: We identified 108 new achalasia cases (mean age 48.2±16.2 years, 52.8% type I, 42.6% type II), 52 (48.1%) women. Dysphagia (98.1%), cough (64.8%), belching (60.2%) and reflux symptoms (53.7%) were frequently reported. Patients with type I achalasia reported more often that dysphagia worsened, compared to type II patients (χ²=7.3, p =0.007). Age, duration of dysphagia, body mass index (p=0.067) and esophageal length were similar in type I and type II achalasia. Resting LES pressure (64.7±22.6 mmHg vs. 54.3±21.6 mmHg, p=0.019) and 4s-IRP (45.3±17.6 mmHg vs. 38.4±15.5 mmHg, p=0.036) were higher in type II compared to type I achalasia. Overweight patients had a lower LES resting pressure and 4s-IRP compared to lean subjects. After a mean follow-up of 36.8±13.4 months, 49 (45.3%) patients responded to our follow-up, and 77.5% had an Eckardt score ≤ 3. Conclusions: Type I achalasia was the most common in our group. Type I patients had lower BMI but similar duration of dysphagia and mean age compared to type II. Type III is seldom and present in older patients. These findings suggest low probability of progression from type III and II to type I achalasia. Patients with type II achalasia had higher resting LES pressure and 4s-IRP than type I achalasia patients. [ABSTRACT FROM AUTHOR]

Introduction: Crohn's disease is a chronic inflammatory bowel disease which might result from a complex interaction between the following: genetic susceptibility, impaired immune response and environmental triggers. It is delineated by a transmural, granulomatous inflammation that can affect the entire gastrointestinal tract, illustrating a discontinuous pattern. It involves periods of activity and remission, with the presenting symptoms: colicky pain, low-grade fever and weight loss due to diarrhea, anorexia and fear of eating. Case Report: We report a case of a 41-year-old male with a history of ileocaecal Crohn's disease who is non-responsive at both immunosuppressive drugs (Azathioprine) and anti-inflammatory drugs (Mesalazine). The patient had undergone ileocolonic anastomosis after right hemicolectomy due to an acute episode in 2010 and has been under immunosuppressive and anti-inflammatory therapy since. He is also known with erosive antral gastritis as well as with an old myocardial infarction for which he follows a therapy with Clopidogrelum and Bisoprololum. Total colonoscopy performed in 2010 illustrated the hemicolectomy as well as grade 1 internal hemorrhoids with small lesions. However, the one performed in 2022 showed an upper rectal sessile polyp, which has been endoscopically excised. An upper GI endoscopy performed in 2022 confirmed the erosive antral gastritis. Discussions : Since the classical treatment was non-effective for this patient, the biological therapy was implemented. It has to be taken into consideration the fact that the most common indications for surgery are represented by fistula, abscess, obstruction and in this particular case, surgical management was necessary due to the unfavorable evolution. Moreover, patients with elderly onset are associated with a less progressive course of the disease and a better outcome. Conclusions: To conclude, the presented case displays the situation of a patient that suffered a major complication during the standard therapy, so that the surgical intervention was necessary. The alternative treatment established in this case was the biological one. Currently, the patient has been recommended the new implemented treatment and he is expected for a follow up in order to initiate the proper therapy with Adalimumab. [ABSTRACT FROM AUTHOR]

Aortic stenosis (AS), the most common valvular disease in the western world has been traditionally treated with surgical aortic valve replacement (SAVR) but is increasingly treated by transcatheter aortic valve replacement (TAVR). While patients over age 65 are preferably treated with bioprosthetic tissue valves, there is considerable uncertainty in the choice between TAVR and SAVR. We present various considerations for optimizing the life-long management of patients receiving bioprosthetic valves (SAVR or TAVR). To maximize life expectancy and minimize cumulative lifetime risk, we suggest decision making individualized for patient anatomy and overall (current and future) risk., (Copyright © 2024. Published by Elsevier Inc.)

Background and Aims: The nonpharmacological therapy in irritable bowel syndrome (IBS) is expanding rapidly. Practitioners and medical educators need to be aware of progress and changes in knowledge of this topic. The Romanian Society of Neurogastroenterology aimed to create guidelines based on best evidence on the use of nonpharmacological therapy in IBS., Methods: A group of experts was constituted. This was divided in eleven subgroups dedicated to eleven categories of nonpharmacological therapy. The subgroups searched the literature and formulated statements and recommendations. These were submitted to vote in order to obtain consensus., Results: The outcome of this activity is represented by the guidelines of the Romanian Society of Neurogastroenterology, presented in this paper. The recommendations are seen as complementary to the pharmacological therapy and are not intended to recommend avoiding pharmacological drugs., Conclusions: These guidelines were elaborated by a Delphi process and represent a useful tool for physicians managing patients with IBS.