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Your search keyword '"Purcell, R."' showing total 886 results
Start Over Author "Purcell, R." Publication Type Academic Journals
886 results on '"Purcell, R."'

12. Transitions Study of predictors of illness progression in young people with mental ill health: study methodology

Author

Purcell, R., Jorm, A. F., Hickie, I. B., Yung, A. R., Pantelis, C., Amminger, G. P., Glozier, N., Killackey, E., Phillips, L., Wood, S. J., Mackinnon, A., Scott, E., Kenyon, A., Mundy, L., Nichles, A., Scaffidi, A., Spiliotacopoulos, D., Taylor, L., Tong, J. P.Y., Wiltink, S., Zmicerevska, N., Hermens, Daniel, Guastella, Adam, and McGorry, P. D.

Published
2015
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22. Comparative genomics of listeria species. (Reports)

Author

Glaser, P., Frangeul, L., Buchrieser, C., Rusniok, C., Amend, A., Baquero, F., Berche, P., Bloecker, H., Brandt, P., Chakraborty, T., Charbit, A., Chetouani, F., Couve, E., de Daruvar, A., Dehoux, P., Domann, E., Dominguez-Bernal, G., Duchaud, E., Durant, L., Dussurget, O., Entian, K.-D., Fsihi, H., Garcia-Del Portillo, F., Garrido, P., Gautier, L., Goebel, W., Gomez-Lopez, N., Hain, T., Hauf, J., Jackson, D., Jones, L.-M., Kaerst, U., Kreft, J., Kuhn, M., Kunst, F., Kurapkat, G., Madueno, E., Maitournam, A., Vicente, J. Mata, Ng, E., Nedjari, H., Nordsiek, G., Novella, S., de Pablos, B., Perez-Diaz, J.-C., Purcell, R., Remmel, B., Rose, M., Schlueter, T., Simoes, N., Tierrez, A., Vazquez-Boland, J.-A., Voss, H., Wehland, J., and Cossart, P.

Subjects
Listeriosis -- Causes of -- Research, Listeria monocytogenes -- Research, Science and technology, Research, Causes of
Abstract

Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic species, L. innocua (3,011,209 base pairs). We found a large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators, consistent with the ability of both species to adapt to diverse environments. The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events., Listeria monocytogenes is the etiologic agent of listeriosis, a severe food-borne disease. It survives in the extreme conditions encountered in the food chain, such as high salt concentrations and extremes [...]

Published
2001

30. Physical and mental health of older people while cocooning during the COVID-19 pandemic.

Author

Bailey, L, Ward, M, DiCosimo, A, Baunta, S, Cunningham, C, Romero-Ortuno, R, Kenny, R A, Purcell, R, Lannon, R, McCarroll, K, Nee, R, Robinson, D, Lavan, A, and Briggs, R

Subjects
COVID-19 pandemic, HEALTH of older people, MENTAL health, QUALITY of life, HEALTH services accessibility
Abstract

Background Cocooning or shielding, i.e. staying at home and reducing face-to-face interaction with other people, was an important part of the response to the COVID-19 pandemic for older people. However, concerns exist regarding the long-term adverse effects cocooning may have on their physical and mental health. Aim To examine health trajectories and healthcare utilization while cocooning in a cohort of community-dwelling people aged ≥70 years. Design Survey of 150 patients (55% female, mean age 80 years and mean Clinical Frailty Scale Score 4.8) attending ambulatory medical services in a large urban university hospital. Methods The survey covered four broad themes: access to healthcare services, mental health, physical health and attitudes to COVID-19 restrictions. Survey data were presented descriptively. Results Almost 40% (59/150) reported that their mental health was 'worse' or 'much worse' while cocooning, while over 40% (63/150) reported a decline in their physical health. Almost 70% (104/150) reported exercising less frequently or not exercising at all. Over 57% (86/150) of participants reported loneliness with 1 in 8 (19/150) reporting that they were lonely 'very often'. Half of participants (75/150) reported a decline in their quality of life. Over 60% (91/150) agreed with government advice for those ≥70 years but over 40% (61/150) reported that they disliked the term 'cocooning'. Conclusions Given the likelihood of further restrictions in coming months, clear policies and advice for older people around strategies to maintain social engagement, manage loneliness and continue physical activity and access timely medical care and rehabilitation services should be a priority. [ABSTRACT FROM AUTHOR]

Published
2021
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47. 183 Risk of Hypoglycaemia in Older Patients in Residential Care on Oral Hypoglycaemic Medication.

Author

Brennan, M, Crowe, A, Tiernan, C, Smith, M, Cogan, L, Purcell, R, Griffin, C, and Crowe, M

Subjects
HYPOGLYCEMIA, CONFERENCES & conventions, HYPOGLYCEMIC agents, ORAL drug administration, RESIDENTIAL care, OLD age, DISEASE risk factors
Abstract

Background Diabetes mellitus (DM) is common in older patients in residential care(RC) with prevalence ranging from 11-36%.Guidlines(1) on glucose targets to avoid the risk of hypoglycaemia or hyperglycaemia respectively in older people recommend avoiding a fasting glucose on treatment of 6mmol/L or a random glucose level higher than 11.0mmol/L. An HbA1c of 53to 59mmol/mol(7-7.5%) should be aimed for although this may need adjusting in RC and StoppFrail guidelines suggest a target of HbA1c of <8%(64mmol/mol). We assessed the prevalence, drug treatment and glycaemic control in 107 older patients in residential care at two sites in Dublin. Methods Patients with DM were identified from review of medical notes. Hypoglycaemic treatment whether oral hypoglycemic drugs(OHD) or insulin, capillary blood glucose measurements(CBGM) over the previous 28 day period, HbA1c values and weight change over the previous year respectively were tabulated from patient records. Results Sixteen patients (15%) aged 66-93 were documented with DM. Eight (50%) were on no hypoglycaemic treatment in whom OHD had been discontinued in 2 patients over the previous 6 months because of risk of hypoglycaemia.. Six patients (38%) were only on OHD, whilst 2 were on insulin. Of the 6 patients on OHD, CABGM were below 6mmol/L in 3 patients (50%) with no values above 11mmol/L. All 3 patients had lost weight (2.5-6.8Kg) over the previous year and HbA1c levels were below 53mmol/mol (7%) in all 3 patients. Conclusion Although our numbers are small, 50% of our patients in residential care on OHD are at risk of hypoglycemia possibly related to weight loss. Reducing or discontinuing their OHD may be appropriate. [ABSTRACT FROM AUTHOR]

Published
2019
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