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Your search keyword '"Qi, Zhengjian"' showing total 164 results
Start Over Author "Qi, Zhengjian" Publication Type Academic Journals
164 results on '"Qi, Zhengjian"'

29. A Long‐Retention Cell Membrane‐Targeting AIEgen for Boosting Tumor Theranostics.

Author

Wang, Xing, Yang, Li, Li, Yuanhang, Wang, Xiaohan, and Qi, Zhengjian

Subjects
CELL membranes, COMPANION diagnostics, PHOTODYNAMIC therapy, DENSITY functional theory, COMBINED modality therapy, BOOSTING algorithms
Abstract

Designing and developing photosensitizers with cell membrane specificity is crucial for achieving effective multimodal therapy of tumors compared to other organelles. Here, we designed and screened a photosensitizer CM34 through donor/receptor regulation strategies, and it is able to achieve long‐retention cell membrane targeting. It is not only an extremely excellent cell membrane targeted tumor theranostic agent, but also found to be a promising potential immune activator. Specifically, CM34 with a larger intramolecular twist angle is more likely to form larger aggregates in aqueous solutions, and the introduction of cyanide group also enhances its interaction with cell membranes, which were key factors hindering molecular penetration of the cell membrane and prolonging its residence time on the cell membrane, providing conditions for further membrane targeted photodynamic therapy. Furthermore, the efflux of contents caused by cell necrosis directly activates the immune response. In summary, this study realizes to clarify and refine all potential mechanisms of action through density functional theory calculations, photophysical property measurements, and cellular level mechanism exploration, providing a new direction for the clinical development of cell membrane targeted anti‐tumor immune activators. [ABSTRACT FROM AUTHOR]

Published
2024
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42. The influences of different substituents on spectral properties of rhodamine B based chemosensors for mercury ion and application in EC109 cells

Author

Du, Wenqi, Cheng, Yu, Shu, Weixin, Wu, Baoying, Kong, Zhineng, and Qi, Zhengjian

Subjects
Chemical detectors -- Properties -- Evaluation, Chemistry
Abstract

Abstract: Six rhodamine-based 'turn-on' fluorescence chemosensors ([L.sub.1]-[L.sub.6]) with different substituents for mercury ([Hg.sup.x2+]) were readily synthesized and investigated; they displayed high selectivity and chelation enhanced ratiometric fluorescence change and colorimetric [...]

Published
2017

46. Nanospheres of Near-Infrared Aggregation-Induced Emission Probes to Target Mitochondria to Ablate Tumors with Reactive Oxygen Species Generation under Hypoxia.

Author

Xue, Ke, Wang, Xing, Zhang, Dongdong, Wang, Xiaohan, Zhao, Yongfei, Yang, Li, Deng, Jing, and Qi, Zhengjian

Abstract

Severe aggregation-caused quenching and the lack of special organelle targeting in conventional photosensitizers (PSs) have limited their advantages in terms of their accurate spatial–temporal control and noninvasive features. Furthermore, severe tumor hypoxia equally diminished the effectiveness of treatment. Herein, a series of aggregation-induced emission (AIE) PSs with precise targeting of organelles are synthesized by simply regulating the molecular structure. The rotation of the donor in the molecule was optimized by altering the tail chain of the triphenylamine derivative, which inhibited nonradiative internal conversion and promoted intersystem crossing to facilitate the free radical generation, and the production efficiency of the type I reactive oxygen species exceeds that of the commercial indicator rose bengal (3-fold). The optimal AIE PS named BETTP can specifically target mitochondria and recognize cancer cells. Simultaneously, live/dead cell costaining assays and flow cytometry validated that BETTP nanoparticles (NPs) have the ability to efficaciously ablate cancer cells in hypoxic conditions after encapsulating BETTP into carriers as nanoparticles. In addition, BETTP NPs also manifest superior performance during near-infrared imaging-guided type I photodynamic therapy in solid tumors. Such BETTP NPs demonstrate the critical feasibility of achieving precise delivery of drugs and targeting of organelles for precise therapy in hypoxic environments, providing a reliable reference for tumor hypoxia challenges. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Deep‐Red Perovskite Light‐Emitting Diodes with External Quantum Efficiency Exceeding 21% Enabled by Ligand‐Modulated Dimensionality Control.

Author

Liu, Zhe, Peng, Xiaomei, Xing, Shiyu, Qiu, Weidong, Li, Mengke, Shen, Chao, Sun, Guanwei, Zhou, Zhisheng, Gu, Qing, Pu, Junrong, Yang, Jiaji, Zhang, Jibin, Liu, Denghui, Shen, Chenyang, Qing, Jian, Xue, Qifan, Yip, Hin‐Lap, Di, Dawei, Hou, Lintao, and Qi, Zhengjian

Subjects
QUANTUM efficiency, LIGHT emitting diodes, PEROVSKITE, ENERGY dissipation, CRYSTAL defects
Abstract

Quasi‐2D perovskites show great promise for light‐emitting diodes owing to suppressed non‐radiative losses enabled by the energy funneling/cascading nanostructures. However, for red emission quasi‐2D perovskites, these ideal energy landscapes for efficient perovskite light‐emitting diodes (PeLEDs) can rarely be achieved due to detrimental aggregation of the low‐dimensional ligands in perovskite precursors, leading to poor device efficiency and stability. Here, a ligand‐modulated dimensionality control strategy is explored to achieve uniform phase distribution and reduce defect density for efficient light emission. In contrast to the model phenethylammonium iodide 2D ligand, the formation of small‐n phases can be inhibited by a structurally similar phenoxyethylammonium iodide ligand owing to the weakened aromatic stacking between ligands. Besides, the oxygen atoms can interact with the uncoordinated Pb2+ ions and promote the NI coordination in the perovskites, which greatly reduces the non‐radiative recombination defects in the ionic lattice. With this simple and effective approach, deep‐red quasi‐2D PeLEDs with record‐high external quantum efficiency of 21.6% and decent operational stability are achieved without the need for additional additives. These results highlight the potential of ligand‐modulated dimensionality control to achieve highly efficient and stable PeLEDs with a facile fabrication process. [ABSTRACT FROM AUTHOR]

Published
2022
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