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Objetivo: Valorar la utilidad de un control gravimétrico rutinario como control de calidad tras la elaboración de nutriciones parenterales (NP) con un error gravimétrico inferior al ± 5%. Material y métodos: Estudio prospectivo, en el que durante 2 meses se pesaron diariamente de 5 a 8 NP de gran volumen y durante 4 meses todas las NP de pequeño volumen, considerándose este valor el peso real. El peso teórico se calculó teniendo en cuenta las densidades, los volúmenes de todos los productos utilizados en la elaboración y el peso de las bolsas multicapas utilizadas. El error gravimétrico se calculó en porcentaje con respecto al peso teórico. Resultados: Se pesaron 168 NP de gran volumen y 42 de pequeño volumen, las medias de los errores gravimétricos fueron 1,42% (SD = 1,31) y 1,26% (SD = 0,64), con un error gravimétrico inferior al 5% en el 98,8% y 100% respectivamente. Conclusión: Establecer un control gravimétrico rutinario es una estrategia útil que puede ayudar a garantizar la calidad de la elaboración de NP.Objective: To assess the usefulness of establishing a routine gravimetric as quality assurance after the development of parenteral nutrition (PN) with a gravimetric error less than ± 5%. Material and methods: Prospective study in which 5 to 8 large volume PN were weighed daily during 2 months and for 4 months all small volume PN, considering this the real weight. The theoretical weight was calculated taking into account the densities, volumes of all products used in processing and the weight of the bags used. The gravimetric error was calculated as a percentage compared to the theoretical weight. Results: 168 large volume PN and 42 small volume were weighed, gravimetric errors measures were 1,42% (SD = 1,31) and 1,26% (SD = 0,64), with a gravimetric error less than 5% in 98,8% and 100% respectively. Conclusion: Establishing a routine gravimetric control is an useful strategy that can help to guarantee the quality of the PN development.

Objetivo: Valorar la utilidad de un control gravimétrico rutinario como control de calidad tras la elaboración de nutriciones parenterales (NP) con un error gravimétrico inferior al ± 5%. Material y métodos: Estudio prospectivo, en el que durante 2 meses se pesaron diariamente de 5 a 8 NP de gran volumen y durante 4 meses todas las NP de pequeño volumen, considerándose este valor el peso real. El peso teórico se calculó teniendo en cuenta las densidades, los volúmenes de todos los productos utilizados en la elaboración y el peso de las bolsas multicapas utilizadas. El error gravimétrico se calculó en porcentaje con respecto al peso teórico. Resultados: Se pesaron 168 NP de gran volumen y 42 de pequeño volumen, las medias de los errores gravimétricos fueron 1,42% (SD = 1,31) y 1,26% (SD = 0,64), con un error gravimétrico inferior al 5% en el 98,8% y 100% respectivamente. Conclusión: Establecer un control gravimétrico rutinario es una estrategia útil que puede ayudar a garantizar la calidad de la elaboración de NP.

Background: SARS-CoV-2 virus requires host proteases to cleave its spike protein to bind to its ACE2 target through a two-step furin-mediated entry mechanism. Aprotinin is a broad-spectrum protease inhibitor that has been employed as antiviral drug for other human respiratory viruses. Also, it has important anti-inflammatory properties for inhibiting the innate immunity contact system., Methods: This was a multicentre, double-blind, randomized trial performed in four Spanish hospitals comparing standard treatment versus standard treatment + aprotinin for patients with COVID-19 between 20 May 2020 and 20 October 2021. The primary efficacy outcomes were length of hospital stay and ICU admission. The secondary endpoints were each of the primary efficacy outcomes and a composite of oxygen therapy, analytical parameters and death. Safety outcomes included adverse reactions to treatment during a 30-day follow-up period. Treatment was given for 11 days or till discharge., Results: With almost identical analytical profiles, significant differences were observed in treatment time, which was 2 days lower in the aprotinin group (p = .002), and length of hospital admission, which was 5 days shorter in the aprotinin group (p = .003). The incidence of discharge was 2.19 times higher (HR: 2.188 [1.182-4.047]) in the aprotinin group than in the placebo group (p = .013). In addition, the aprotinin-treated group required less oxygen therapy and had no adverse reactions or side effects., Conclusion: Inhaled aprotinin may improve standard treatment and clinical outcomes in hospitalized patients with COVID-19, resulting in a shorter treatment time and hospitalization compared with the placebo group. The administration of aprotinin was safe., (© 2022 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.)

Objective: To evaluate incorporation of the hospital pharmacist to the routine activity of an Intensive Care Unit (ICU)., Design: A prospective observational study was carried out to evaluate the impact of pharmacist interventions, made by a pharmacist temporarily assigned to the ICU, upon medical prescriptions., Setting: A medical and surgical ICU with 21 beds., Patients: Patients with at least one ICU stay were included, while patients with admission and discharge in periods when the pharmacist was not present were excluded., Interventions: The interventions were made after daily review of the prescriptions, and were communicated verbally or in writing to the supervising physician., Main Variables: Number of interventions, therapeutic group of the drugs involved, type of intervention and degree of acceptance., Results: A total of 194 interventions were made in 62 patients. The majority were related to safety aspects (33%) and the optimization of therapy (32%). The most frequent interventions were the administration of drugs via the nasogastric tube (19%) and pharmacokinetic monitoring (14.4%). The most frequently involved groups of drugs were anti-infectious agents (33%) and digestive system medications (27%). A total of 56.2% of the interventions were made verbally, and 80% were accepted., Conclusions: Pharmacist adscription to an ICU and the implementation of interventions on prescriptions have allowed improvement of safety and the optimization of pharmacotherapy in more than 50% of the patients. The high rate of acceptance of these interventions would support the implementation of such programs in critical care units., (Copyright © 2018 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.)

Objectives: to describe the efficacy and safety of the off-label use of alendronate in the treatment of osteoporosis in children and adolescents., Method: a retrospective study (2008-2014) of all patients under 18 years who were dispensed alendronate for this indication. The criteria for initiating treatment were: bone mineral density with a Z-score ≤ -2.5 SD, a past history of bone fractures without a previous traumatism, and persistent pain. The variables collected were: demographic, treatment-related, clinical. and safety data. The treatment was considered to be effective when there was an increase in bone mineral density up to a Z-score > -2.5 SD., Results: a total of 12 patients, 8 of them male, with a mean age of 11 years (± 3 SD), were treated with alendronate. After a mean time of treatment of 2.15 years (± 1.2 SD), there was an increase in bone mineral density in all patients, 9 of which achieved a Z-score > -2.5 SD, so the drug was considered effective in 75% of cases. No patient had bone fractures or expressed adverse effects during treatment., Conclusions: alendronate increased bone mineral density and was well tolerated in all patients, therefore it could be considered as a therapeutic option in the treatment of osteoporosis in children., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)

Objective: To assess the usefulness of establishing a routine gravimetric as quality assurance after the development of parenteral nutrition (PN) with a gravimetric error less than ± 5%., Material and Methods: Prospective study in which 5 to 8 large volume PN were weighed daily during 2 months and for 4 months all small volume PN, considering this the real weight. The theoretical weight was calculated taking into account the densities, volumes of all products used in processing and the weight of the bags used. The gravimetric error was calculated as a percentage compared to the theoretical weight., Results: 168 large volume PN and 42 small volume were weighed, gravimetric errors measures were 1.42% (SD=1.31) and 1.26% (SD=0.64), with a gravimetric error less than 5% in 98,8% and 100% respectively., Conclusion: Establishing a routine gravimetric control is an useful strategy that can help to guarantee the quality of the PN development.