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Your search keyword '"Reggie Edgerton V"' showing total 26 results
Start Over Author "Reggie Edgerton V" Publication Type Academic Journals
26 results on '"Reggie Edgerton V"'

1. Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Author

Nielson, Jessica L., Haefeli, Jenny, Salegio, Ernesto A., Liu, Aiwen W., Guandique, Cristian F., Stück, Ellen D., Hawbecker, Stephanie, Moseanko, Rod, Strand, Sarah C., Zdunowski, Sharon, Brock, John H., Roy, Roland R., Rosenzweig, Ephron S., Nout-Lomas, Yvette S., Courtine, Gregoire, Havton, Leif A, Steward, Oswald, Reggie Edgerton, V., Tuszynski, Mark H., Beattie, Michael S., Bresnahan, Jacqueline C., and Ferguson, Adam R.

Published
2015
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10. Weight Bearing Over-ground Stepping in an Exoskeleton with Non-invasive Spinal Cord Neuromodulation after Motor Complete Paraplegia.

Author

Gad, Parag, Gerasimenko, Yury, Zdunowski, Sharon, Turner, Amanda, Sayenko, Dimitry, Lu, Daniel C., and Reggie Edgerton, V.

Subjects
PARAPLEGIA, ELECTRIC stimulation, BODY temperature regulation, THERAPEUTICS
Abstract

We asked whether coordinated voluntarymovement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacological neuromodulation by buspirone. We also asked whether these neuromodulatory strategies could facilitate stepping assisted by an exoskeleton (EKSO, EKSO Bionics, CA) that is designed so that the subject can voluntarily complement the work being performed by the exoskeleton.We found that spinal cord stimulation and drug enhanced the level of effort that the subject could generate while stepping in the exoskeleton. In addition, stimulation improved the coordination patterns of the lower limb muscles resulting in a more continuous, smooth stepping motion in the exoskeleton along with changes in autonomic functions including cardiovascular and thermoregulation. Based on these data from this case study it appears that there is considerable potential for positive synergistic effects after complete paralysis by combining the over-ground step training in an exoskeleton, combined with transcutaneous electrical spinal cord stimulation either without or with pharmacological modulation. [ABSTRACT FROM AUTHOR]

Published
2017
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17. Mammalian Muscle Fiber Types and Their Adaptability.

Author

REGGIE EDGERTON, V.

Abstract

The neuromuscular system can adapt to a variety of different kinds of chronic workloads. The specificity of these adaptations is reflected in the specific components of the neuromuscular system that are overloaded. An examination of changes that occur during normal development can serve as a basis for efforts to understand the mechanisms which are responsible for the maintenance of a given histochemical, biochemical and physiological profile of a motor unit. The normal process of muscle development can be retarded by spinal transection or immobilizing a neonatal muscle and some of the neonatal features can be reintroduced in adult animals by these same procedures. In general the speed related properties of fast skeletal muscle are not altered markedly by any type of physiological overload. There is some evidence that immobilization or intense endurance trained slow muscle is faster than the normal muscle. The metabolic properties related to maintenance of tension during prolonged work are readily adaptable to chronic low resistance-highly repetitive contractions. Factors that determine the specificity of the response to neuromuscular overload seem to be motor unit recruitment frequency, the tension produced within the musculature and the duration of the tensions. [ABSTRACT FROM PUBLISHER]

Published
1978
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26. Reply

Author

Hutton, Robert S., Roy, Roland R., and Reggie Edgerton, V.

Published
1989
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