119 results on '"Rejto, Paul A."'
Search Results
2. Comparative biomarker analysis of PALOMA-2/3 trials for palbociclib
3. Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy
4. Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer
5. Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome
6. Simulating Disorder-Order Transitions in Molecular Recognition of Unstructured Proteins: Where Folding Meets Binding
7. Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors
8. Pancreatic Cancer Action Network's SPARK: A Cloud-Based Patient Health Data and Analytics Platform for Pancreatic Cancer.
9. Unraveling Principles of Lead Discovery: From Unfrustrated Energy Landscapes to Novel Molecular Anchors
10. A Mean Field Model of Ligand-Protein Interactions: Implications for the Structural Assessment of Human Immunodeficiency Virus Type 1 Protease Complexes and Receptor-Specific Binding
11. P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer
12. Genomic Landscape of Copy Number Aberrations Enables the Identification of Oncogenic Drivers in Hepatocellular Carcinoma
13. Deciphering common failures in molecular docking of ligand-protein complexes
14. Examining ligand-protein interactions with binding-energy landscapes
15. Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy.
16. Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Vivo Limits Glucocorticoid Exposure to Human Adipose Tissue and Decreases Lipolysis
17. Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding
18. Statistical method on nonrandom clustering with application to somatic mutations in cancer
19. Visualization of fast energy flow and solvent caging in unimolecular dynamics
20. Chapter 8 Monte Carlo simulations of HIV-1 protease binding dynamics and thermodynamics with ensembles of protein conformations: Incorporating protein flexibility in deciphering mechanisms of molecular recognition
21. Interatomic potentials and the phase diagram of Xe/Pt(111).
22. A reactive-flux theory of chemical surface diffusion.
23. Reaction-path analysis of the tunneling splitting in fluxional molecules: Application to the degenerate rearrangement of hydrogen fluoride dimer.
24. N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites
25. TNER: a novel background error suppression method for mutation detection in circulating tumor DNA.
26. The development and SAR of pyrrolidine carboxamide 11β-HSD1 inhibitors
27. Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine.
28. Whole Exome Sequencing of Rapid Autopsy Tumors and Xenograft Models Reveals Possible Driver Mutations Underlying Tumor Progression.
29. Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
30. A Comprehensive Characterization of Genome-Wide Copy Number Aberrations in Colorectal Cancer Reveals Novel Oncogenes and Patterns of Alterations.
31. A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation.
32. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer.
33. Statistical method on nonrandom clustering with application to somatic mutations in cancer.
34. Crystal Structure of Human ABAD/HSD10 with a Bound Inhibitor: Implications for Design of Alzheimer's Disease Therapeutics
35. Monte Carlo simulations of the peptide recognition at the consensus binding site of the constant fragment of human immunoglobulin G: The energy landscape analysis of a hot spot at the intermolecular interface.
36. Hierarchy of simulation models in predicting molecular recognition mechanisms from the binding energy landscapes: Structural analysis of the peptide complexes with SH2 domains.
37. Monte Carlo study of ligand-protein binding energy landscapes with the weighted histogram analysis method.
38. Computer simulations of ligand-protein binding with ensembles of protein conformations: A Monte Carlo study of HIV-1 protease binding energy landscapes.
39. Towards understanding the mechanisms of molecular recognition by computer simulations of ligand-protein interactions.
40. Structural consensus in ligand-protein docking identifies recognition peptide motifs that bind streptavidin.
41. Mean field analysis of FKBP12 complexes with FK506 and rapamycin: Implications for a role of crystallographic water molecules in molecular recognition and specificity.
42. Exploring the energy landscapes of molecular recognition by a genetic algorithm: Analysis of the requirements for robust docking of HIV-1 protease and FKBP-12 complexes.
43. Identification and characterization of a novel and functional murine Pin1 isoform
44. Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing.
45. Decoding complex patterns of genomic rearrangement in hepatocellular carcinoma.
46. Antisense inhibition of 11βhydroxysteroid dehydrogenase type 1 improves diabetes in a novel cortisone-induced diabetic KK mouse model
47. Assay optimization and kinetic profile of the human and the rabbit isoforms of 11β-HSD1
48. Complexity and simplicity of ligand–macromolecule interactions: the energy landscape perspective
49. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcin.
50. TNER: a novel background error suppression method for mutation detection in circulating tumor DNA.
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