Search

This study introduces an approach to fabricating a stratified biphasic scaffold using vat photopolymerization. Two different printing materials were employed to prepare the construct, which was composed of polymer composite and hydrogel layers. Bioceramic‐loaded photosensitive resins, which were mainly formulated from poly(ɛ‐caprolactone‐co‐glycidyl methacrylate) (p(ɛ‐CL‐co‐GMA)) and hydroxyapatite (HAp), were introduced as the polymer composite layer. Besides, the water‐based photosensitive resin consisting of polyethylene glycol dimethacrylate (PEGDMA) was utilized to prepare the hydrogel layer. The effect of HAp content in the bioceramic‐loaded resins on the properties of 3D‐printed specimens (e.g., double bond conversion, printing fidelity, mechanical behavior, and morphology) was assessed. The biphasic scaffolds exhibited a compressive strength of approximately 90 MPa. An optical microscope and scanning electron microscope and energy dispersive x‐ray spectrometer (SEM/EDS) analysis were employed to confirm the printing fidelity and the distribution of bioceramics, respectively. Besides, the cytotoxicity result suggested that the biphasic scaffolds were noncytotoxic to articular chondrocytes. We have developed a straightforward strategy using light‐assisted 3D printing to fabricate the biphasic scaffold for further use in biomedical applications. [ABSTRACT FROM AUTHOR]

ABSTRACT The synthesis of two types of isocyanate side chain containing copolymers, poly(methyl methacrylate- co-isocyanatoethyl methacrylate) (P(MMA- co-IEM)) and poly(benzyl methacrylate- co-isocyanatoethyl methacrylate) (P(BnMA- co-IEM)), which were synthesized by Cu(0)-mediated radical polymerization, is reported. Polymerization proceeded to high conversion giving polymers of relatively narrow molar mass distributions. The incorporation of the bulky aromatic groups in the latter copolymer rendered it sufficiently stable toward hydrolysis and enabled the isolation of the product and its characterization by 1H and 13C NMR, and FTIR spectroscopy and SEC. Both P(MMA- co-IEM) and P(BnMA- co-IEM) were functionalized with dibutylamine, octylamine, and ( R)-(+)-α-methylbenzyl-amine, which further proved the successful incorporation of the isocyanate groups. Furthermore, P(BnMA- co-IEM) was used for the fabrication of liquid core microcapsules via oil-in-water interfacial polymerization with diethylenetriamine as crosslinker. The particles obtained were in the size range of 10-90 µm in diameter independent of the composition of copolymer. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 2698-2705 [ABSTRACT FROM AUTHOR]