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Your search keyword '"Sakakura, Teruyo"' showing total 99 results
Start Over Author "Sakakura, Teruyo" Publication Type Academic Journals
99 results on '"Sakakura, Teruyo"'

27. Effect on Physical and Mental Function of a Group Rhythm Exercise for Elderly Persons Certified under the Less Severe Grades of Long-Term Care Insurance.

Author

SUGIURA, YOSHITO, SAKURAI, HIROAKI, WADA, HIROSHI, SAKAKURA, TERUYO, and KANADA, YOSHIKIYO

Abstract

[Purpose] We examined the effect on physical and mental function of elderly persons of a group rhythm exercise designed with "safety, enjoyment, and length" as the primary considerations for elderly persons certified under the less severe grades of the long-term care insurance. [Subjects] The subjects were 20 persons (average age, 79.5 ± 7.2) certified between Need Support level 2 and Need Care level 2 who were attending a day-care service facility. [Method] The subjects were randomly allocated to an intervention and a control group. The intervention group performed an individual exercise program and the group rhythm exercise; the control group performed only the individual exercise program. To assess the effect, before the intervention and at 3 and 6 months afterwards, participants received a physical examination, performed strength tests and answered a questionnaire. [Results] In both groups a significant improvement in lower limb strength was seen. Furthermore, in the intervention group, significant improvements in mental function, walking ability and balance ability were also seen. [Conclusion] The results suggest that the group exercise could possibly become a beneficial exercise therapy for improving the mental and physical functions of elderly persons. [ABSTRACT FROM AUTHOR]

Published
2010
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28. Expression of matrix metalloproteinase-3 in mouse endometrial stromal cells during early pregnancy: Regulation by interleukin-1α and tenascin-C.

Author

Nishiura, Rika, Noda, Naomi, Minoura, Hiroyuki, Toyoda, Nagayasu, Imanaka-Yoshida, Kyoko, Sakakura, Teruyo, and Yoshida, Toshimichi

Subjects
METALLOPROTEINASES, PREGNANCY, INTERLEUKIN-1, TENASCIN, MESSENGER RNA, POLYMERASE chain reaction, IMMUNOHISTOCHEMISTRY
Abstract

During the peri-implantation period, the endometrium undergoes tissue remodeling and cellular rearrangement. To clarify the involvement of matrix metalloproteinases (MMPs) in endometrial remodeling, we isolated total RNAs from the endometrium of non-pregnant and pregnant mice on days 3 to 5 and evaluated mRNA expression of MMP-2, -3, -9, -11 and -13 using reverse transcription–polymerase chain reaction (PCR). Prompt increases in MMP-3 and -13 mRNA were found on day 4 of pregnancy. Quantitative real-time PCR showed that expression of MMP-3 and -13 increased significantly on day 4, up to 8.4 ± 2.7 times and 3.4 ± 1.5 times, respectively, the level in non-pregnant endometrium ( p < 0.05). On day 4, immunohistochemistry demonstrated MMP-3-positive endometrial stromal cells. At the same time, tenascin-C (TN-C) mRNA increased 11.1 ± 4.0 times from the level in non-pregnant endometrium ( p < 0.004). To clarify regulation of MMP-3 expression, we examined the effects of interleukin-1α (IL-1α) and TN-C on MMP-3 mRNA in cultured mouse endometrial stromal cells. Both substances resulted in a dose-dependent increase in MMP-3 mRNA (6.1 ± 1.8-fold at 1&ThickSpace;ng/ml of IL-1α and 3.9 ± 1.8-fold at 10&ThickSpace;μg/ml of TN-C). This study shows that MMP-3 expression is upregulated in endometrial stromal cells of the peri-implantation period and may be controlled by IL-1α and TN-C. [ABSTRACT FROM AUTHOR]

Published
2005
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47. Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes.

Author

Taguchi, O., Nishizuka, Y., Sakakura, Teruyo, and Kojima, A.

Subjects
BLOOD plasma, ETIOLOGY of diseases, IMMUNOGLOBULINS, IMMUNOCYTOCHEMISTRY, METALLOENZYMES, AUTOANTIBODIES
Abstract

Previous studies from our laboratory described a particular type of ovarian dysgenesis which develops in mice after neonatal thymectomy (Tx) at the critical age of 2-4 days after birth. The present experiment provides evidence which suggests an autoimmune aetiology for this phenomenon. By indirect immunofluorescence (IFL) and horse-radish peroxidase (HRPO) labelled antibody techniques, it was demonstrated that neonatally Tx mice of (C57BI/6Cr × A/JCr)F1 (B6A) and (C3H HeMs × 129/J)F1 (C31) hybrids produce circulating autoantibody(ies) against ooplasma of oocytes (AOA) in growing follicles, but not against oocytes in primordial follicles. Appearance of AOA was closely correlated with the development of oophoritis which was characterized by a rapid and complete loss of oocytes at early adulthood. In B6A and C31 mice, oophoritis occurred and AOA appeared in sera after Tx at day 3 (Tx-3) but not after Tx at days 0 or 7. Also, in athymic B6A and C31 nude mice neither oophoritis nor AOA were detectable. Complete absorption of AOA with homogenates of isogeneic normal adult ovaries, but not with homogenates of X-ray irradiated anovular ovaries or granulosa cell tumour may indicate the specificity of AOA. AOA was first demonstrated at day 30-40 in sera of Tx mice, whose ovaries showed a marked enhancement of follicular degeneration and the death of numerous oocytes with or without lymphocyte infiltration. High titres of AOA, detectable in sera of more than 2,000-fold dilutions, were assayed by the IFL technique at day 50-90; however, AOA gradually diminished in titre with age and disappeared at day 150-360 when no oocytes remained in the atrophic ovary. Mice thymectomized at day 3 occasionally produced autoantibodies against zona pellucida and with lesser frequency against steroid-producing cells of the ovary. These data indicate that in the mouse Tx at the critical age shortly after birth produces autoimmune oophoritis, subsequently resulting in early sterility. [ABSTRACT FROM AUTHOR]

Published
1980

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