7 results on '"Samuelson, Annika G."'
Search Results
2. Clinical Outcomes of Patients with Endophthalmitis after Dexamethasone Intravitreal Implant
- Author
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Samuelson, Annika G., Nahar, Ankur, Patel, Samir N., Mahmoudzadeh, Raziyeh, Salabati, Mirataollah, Yu-Chuan Kang, Eugene, Hinkle, John W., Soares, Rebecca R, Kuriyan, Ajay E., and Garg, Sunir J.
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- 2022
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3. Outcomes of Laser Retinopexy for Retinal Tears in Pseudophakic Eyes with Multifocal Versus Monofocal Intraocular Lenses: A Matched Cohort Study.
- Author
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Wakabayashi, Taku, Anderson, Hannah E., Samuelson, Annika G., Torjani, Ava, Shahlaee, Abtin, Mahmoudzadeh, Raziyeh, Salabati, Mirataollah, Klufas, Michael A., and Yonekawa, Yoshihiro
- Subjects
INTRAOCULAR lenses ,RETINAL surgery ,VITRECTOMY ,LASERS ,COHORT analysis ,RETINAL detachment - Abstract
Performing laser retinopexy through multifocal intraocular lenses may be challenging due to aberrations of the peripheral retinal view. This study investigated the influence of multifocal versus monofocal intraocular lenses on outcomes of laser retinopexy for retinal tears. Pseudophakic eyes (multifocal and monofocal intraocular lenses) that underwent in-office laser retinopexy for retinal tears, with a minimum follow-up of 3 months, were retrospectively analyzed. Eyes with multifocal intraocular lenses were matched to controls with monofocal intraocular lenses in a 1:2 ratio for age, gender, number, and location of retinal tears. The main outcome measure was the rate of complications. We included 168 eyes in the study. Fifty-six eyes (51 patients) with multifocal intraocular lenses were matched with 112 eyes (112 patients) with monofocal intraocular lenses. The mean follow-up was 26 months. Baseline characteristics were similar between two groups. No significant differences were noted in the rate of successful laser retinopexy without additional procedures (91% vs. 86% at 3 months and 79% vs. 74% during follow-up, in the multifocal intraocular lens and monofocal intraocular lens group, respectively). No significant differences were observed in the rate of subsequent rhegmatogenous retinal detachment (multifocal, 4% vs. monofocal, 6%, p=.716) or need for additional laser retinopexy for new tears (14% vs. 15%; p=.939). The surgery rates for vitreous hemorrhage (0% vs. 3%; p=.537), epiretinal membrane (2% vs. 2%; p=.553), and vitreous floaters (5% vs. 2%, p=.422) were not significantly different. Visual outcomes were also similar. Multifocal intraocular lenses did not appear to negatively impact the outcomes of in-office laser retinopexy for retinal tears. [ABSTRACT FROM AUTHOR]
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- 2023
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4. XMAP215 promotes microtubule-F-actin interactions to regulate growth cone microtubules during axon guidance in Xenopus laevis.
- Author
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Slater, Paula G., Cammarata, Garrett M., Samuelson, Annika G., Magee, Alexandra, Yuhan Hu, and Lowery, Laura Anne
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XENOPUS laevis ,MICROTUBULES ,CONES ,F-actin ,AXONS - Abstract
It has long been established that neuronal growth cone navigation depends on changes in microtubule (MT) and F-actin architecture downstream of guidance cues. However, the mechanisms by which MTs and F-actin are dually coordinated remain a fundamentally unresolved question. Here, we report that the well-characterized MT polymerase, XMAP215 (also known as CKAP5), plays an important role in mediating MT-F-actin interaction within the growth cone. We demonstrate that XMAP215 regulates MT-F-actin alignment through its N-terminal TOG 1-5 domains. Additionally, we show that XMAP215 directly binds to F-actin in vitro and co-localizes with F-actin in the growth cone periphery. We also find that XMAP215 is required for regulation of growth cone morphology and response to the guidance cue, Ephrin A5. Our findings provide the first strong evidence that XMAP215 coordinates MT and F-actin interaction in vivo. We suggest a model in which XMAP215 regulates MT extension along F-actin bundles into the growth cone periphery and that these interactions may be important to control cytoskeletal dynamics downstream of guidance cues. [ABSTRACT FROM AUTHOR]
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- 2019
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5. Conditional Metastasis of Uveal Melanoma in 8091 Patients over Half-Century (51 Years) by Age Group: Assessing the Entire Population and the Extremes of Age.
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Shields CL, Samuelson AG, Oh GJ, DeSimone JD, Sajjadi ZL, Bas Z, Kalafatis NE, Lally SE, Shields JA, and Dockery PW
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- Humans, Infant, Newborn, Infant, Child, Preschool, Child, Adolescent, Young Adult, Adult, Retrospective Studies, Survival Analysis, Survival Rate, Uveal Neoplasms pathology, Melanoma pathology
- Abstract
Purpose: To evaluate cumulative incidence of metastasis at specific timepoints after treatment of uveal melanoma in a large cohort of patients and to provide comparison of conditional outcomes in the youngest and oldest cohorts (extremes of age)., Methods: Retrospective analysis of 8091 consecutive patients with uveal melanoma at a single center over a 51-year period. The patients were categorized by age at presentation (0-29 years [n = 348, 4%], 30-59 years [n = 3859, 48%], 60-79 years [n = 3425, 42%], 80 to 99 years [n = 459, 6%]) and evaluated for nonconditional (from presentation date) and conditional (from specific timepoints after presentation) cumulative incidence of metastasis at five, 10, 20, and 30 years., Results: For the entire population of 8091 patients, five-year/10-year/20-year/30-year nonconditional cumulative incidence of metastasis was 15%/23%/32%/36%, and the conditional incidence improved to 6%/15%/25%/30% for patients who did not develop metastasis in the first three years. For the extremes of age (0-29 years and 80-99 years), the nonconditional cumulative incidence of metastasis revealed the younger cohort with superior outcomes at 8%/15%/19%/27% and 21%/29%/29%/29%, respectively (P < 0.001). The conditional incidence (at one-year and two-year timepoints with metastasis-free survival) showed persistent superior younger cohort survival (P < 0.001, P = 0.001), but no further benefit for patients with three-year metastasis-free survival at 4%/12%/16%/24% and 7%/18%/18%/18%, respectively (P = 0.09)., Conclusions: Non-conditional metastasis-free survival analysis for patients with uveal melanoma revealed the youngest cohort to have significantly better survival than the oldest cohort, and this persisted into one-year and two-year conditional metastasis-free survival but diminished at the three-year conditional timepoint.
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- 2023
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6. Multiple Internal Hernias: A Complication of Laparoscopic Roux-en-Y Gastric Bypass.
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Samuelson AG, Damron LF, Haddadin Z, Adnan SM, and Neff M
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- Female, Humans, Middle Aged, Anastomosis, Roux-en-Y adverse effects, Retrospective Studies, Internal Hernia complications, Abdominal Pain complications, Vomiting complications, Gastric Bypass adverse effects, Hernia, Abdominal diagnosis, Laparoscopy adverse effects
- Abstract
Introduction: Internal hernias are the most common cause of small bowel obstruction following laparoscopic Roux-en-Y gastric bypass surgery (LRYGBP) with four distinct types. Herein, we report the clinical course of a patient with two independent hernias at the Petersen's space and a rarer subtype at the jejunojejunal window. A high index of suspicion for less common subtypes of internal hernias and the possibility of multiple, simultaneous internal hernias is critical., Case Description: We describe the case of a 52-year-old female with a history of LRYGBP who presented with abdominal pain and emesis due to an internal hernia at Peterson's defect, requiring subsequent laparoscopic repair. On postoperative day three, the patient presented again with recurrent abdominal pain and emesis. Repeat exploratory laparoscopy found a separate internal hernia involving the jejunojejunal window with the previously repaired Petersen's defect intact., Discussion: This case illustrates a unique scenario of a patient post-LRYGBP with multiple internal hernias at the Peterson's space and the less common jejunojejunal window, which was missed during the index surgery. Failure to identify simultaneous hernias may result in additional invasive intervention and further morbidity., Conclusion: Multiple less-common variants of internal hernias may present simultaneously following LRYGBP., Competing Interests: Conflict of interests: none., (© 2023 by SLS, Society of Laparoscopic & Robotic Surgeons.)
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- 2023
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7. GEOGRAPHIC ACCESS DISPARITIES TO CLINICAL TRIALS IN RETINOPATHY OF PREMATURITY IN THE UNITED STATES.
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Soares RR, Cai LZ, Bowe T, Samuelson AG, Liu CK, Parikh D, Patel SN, Hinkle JW, and Yonekawa Y
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- Cross-Sectional Studies, Female, Humans, Infant, Newborn, Male, Morbidity trends, Retinopathy of Prematurity diagnosis, Retrospective Studies, United States epidemiology, Census Tract, Clinical Trials as Topic statistics & numerical data, Healthcare Disparities organization & administration, Retinopathy of Prematurity epidemiology
- Abstract
Background/purpose: To identify geographic and socioeconomic variables predictive of residential proximity to retinopathy of prematurity (ROP) clinical trial locations., Methods: This cross-sectional epidemiological study used census tract-level data from three national public data sets and trial-level data from ClinicalTrials.gov. Socioeconomic predictors of driving distance and time to the nearest ROP clinical trial location were identified. Primary outcomes were time >60 minutes and distance >60 miles traveled to the nearest ROP clinical trial site., Results: Multivariate analysis showed that residents were more likely to travel >60 minutes to the nearest ROP clinical trial site if they lived in census tracts that were rural (adjusted odds ratio 1.20, P = 0.0002), had higher percentages of the population living ≤ federal poverty level (fourth quartile vs. first quartile, adjusted odds ratio 1.19, P < 0.0001), or had less education (associate vs. bachelor's degree, adjusted odds ratio 1.01, P <0.007). By contrast, counties with higher percentages of births with birth weight <1500 g (adjusted odds ratio 0.88, P = 0.0062) were less likely to travel >60 minutes. Similar variables predicted travel distance., Conclusion: Although counties with higher incidences of very low-birth-weight infants were closer to ROP clinical trial sites, residents living in rural and low-income census tracts had significantly greater travel burdens.
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- 2021
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