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617 results on '"Schmutzhard, Erich"'

1. Ictal Electroencephalographic Characteristics of Nodding Syndrome: A Comparative Case‐Series from South Sudan, Tanzania, and Uganda

Author

Mazumder, Rajarshi, Lagoro, David Kitara, Nariai, Hiroki, Danieli, Alberto, Eliashiv, Dawn, Engel, Jerome, Bernardina, Bernardo Dalla, Kegele, Josua, Lerche, Holger, Sejvar, James, Matuja, William, Schmutzhard, Erich, Bonanni, Paolo, De Polo, Gianni, Wagner, Thomas, and Winkler, Andrea Sylvia

Subjects
Neurosciences, Mental Health, Brain Disorders, Pediatric, Clinical Research, Good Health and Well Being, Electroencephalography, Humans, Nodding Syndrome, South Sudan, Tanzania, Uganda, Clinical Sciences, Neurology & Neurosurgery
Abstract

Nodding syndrome (NS) is a poorly understood form of childhood-onset epilepsy that is characterized by the pathognomonic ictal phenomenon of repetitive vertical head drops. To evaluate the underlying ictal neurophysiology, ictal EEG features were evaluated in nine participants with confirmed NS from South Sudan, Tanzania, and Uganda and ictal presence of high frequency gamma oscillations on scalp EEG were assessed. Ictal EEG during the head nodding episode predominantly showed generalized slow waves or sharp-and-slow wave complexes followed by electrodecrement. Augmentation of gamma activity (30-70 Hz) was seen during the head nodding episode in all the participants. We confirm that head nodding episodes in persons with NS from the three geographically distinct regions in sub-Saharan Africa share the common features of slow waves with electrodecrement and superimposed gamma activity. ANN NEUROL 2022;92:75-80.

Published
2022

4. Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study

Author

Abbariao, Maritoni, Zaki, Shafiq Dexter Abou, Aleksic, Dejan, Aliling, Nicole, Rivas, Susana Arias, Artajos, Godard, Asukile, Melody, Atalar, Arife Çimen, Bae, Jong Seok, Banzrai, Chimeglkham, Bar, Michal, Barone, Valentina, Baykan, Betul, Beghi, Ettore, Berger, Thomas, Bilic, Ivica, Biller, Jose, Boskovic, Mateja, Cabreira, Verónica, Calado, Sofia, Canete, Maria Teresa, Celebisoy, Nese, Chen, Ike Leon, Chishimba, Lorraine, Chomba, Mashina, Constantino, Glenn Anthony, Cotelli, Maria Sofia, De Cauwer, Harald, Debroucker, Thomas, Orantes, Luis Del Carpio, Devaraj, Rashmi, D'Souza, Michelle, Ekizoglu, Esme, Elmali, Ayse Deniz, Fonseca, Ana Catarina, Furloni, Roberto, Gajre, Sunil, Azorin, David Garcia, Garfoot, Vanessa, Gasparic, Irena, Genç, Hamit, Glavica, Marinka, Guanaes, Luiz Gustavo, Gürsoy, Gizem, Hafiz, Nauman, Hasırcı, Buse, Helbok, Raimund, Hor, Chee Peng, Hughes, Stella, Hwang, Sungeun, Kaya, Irem Ilgezdi, Jakupi, Adi, Jamora, Roland Dominic, Kahwagi, Jamil, Kaprelyan, Ara, Kawatu, Nfwama, Kim, Manho, Kim, Hyunji, Kim, Hyun Kyung, Koffie, Desmond, Ladeira, Filipa, Lant, Suzannah, Lee, Woo-Jin, Lee, Sukyoon, Leonardo, Zerlyn, Lim, Christian Emmanuel, Lisak, Marijana, Loh, Hong Chuan, Loo, Lay Khoon, Huzjan, Arijana Lovrencic, Koh, Rosie Sue Luan Lu, Luabeya, Mesu'a Kabwa, Lugaresi, Alessandra, Macrohon, Bernadette, Majdak, Maja, Manalili, Sheryl, Manelli, Filippo, Mapoure, Yacouba Njankouo, Mascarella, Davide, Massano, João, Mataa, Mataa, Matibag, Jessica Leika, Matic-Gerodias, Alexandria, McMullen, Kate, Miranda, Miguel, Modequillo, Margaret, Shoab, Abul Kalam Mohammed, Motto, Cristina, Murphy, Sinead M., Mwendaweli, Naluca, Ng, Chen Fei, Ng, Rong Xiang, Ihsan, Mohd Khairul Nizam Nor, Nyein, Aye Myat, O'Connell, Karen, Oh, Seong-il, Ohnmar, Ohnmar, Özge, Aynur, Pajo, Azalea, Palavra, Filipe, Panteleienko, Larysa, Payne, Catherine, Pensato, Umberto, Peres, João, Peters, Steven, Polat, Burcu, Poljakovic, Zdravka, Punter, Martin Nicholas Michael, Quiles, Liz Edenberg, Ranieri, Angelo, Ratković, Marija, Renales, Maria Lina, Robles, Jose, Bedeković, Marina Roje, Rommer, Paulus, Šapina, Lidija, Sarac, Helena, Saylor, Deanna, Schmutzhard, Erich, Sharma, Anahita, Šimić, Aleksandra, Sipilä, Jussi O.T., Sokhi, Dilraj, Stagno, Mauro, Stancheva, Kristina, Stojsavljević, Marija, Subir, Ahamed, Surdhar, Sushee, Talabucon, Loreto, Jr, Tan, Hui Jan, Teoh, Sing Chiek, Vallejo, Dionis, Velioglu, Sibel K., Vukasović, Rafaela, Kit, Wong Wai, Welte, Tamara, Willekens, Barbara, Yesilot, Nilufer, Yu, Jeryl Ritzi T., Zaw, Moe Moe, Zhelyazkova, Sashka, Žitnik, Eva, Tamborska, A.A., Wood, G.K., Westenberg, E., Garcia-Azorin, D., Webb, G., Schiess, N., Netravathi, M., Baykan, B., Dervaj, R., Helbok, R., Lant, S., Özge, A., Padovani, A., Saylor, D., Schmutzhard, E., Easton, A., Lilleker, J.B., Jackson, T., Beghi, E., Ellul, M.A., Frontera, J.A., Pollak, T., Nicholson, T.R., Wood, N., Thakur, K.T., Solomon, T., Stark, R.J., Winkler, A.S., and Michael, B.D.

Published
2023
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10. Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions

Author

Thakur, Kiran T., Tamborska, Arina, Wood, Greta K., McNeill, Emily, Roh, David, Akpan, Imo J., Miller, Eliza C., Bautista, Alyssa, Claassen, Jan, Kim, Carla Y., Guekht, Alla, Pardo, Carlos A., Williams, Olajide, García-Azorín, David, Prasad, Kameshwar, Schmutzhard, Erich, Michael, Benedict D., Chou, Sherry H.-Y., Winkler, Andrea S., Solomon, Tom, and Elkind, Mitchell S.

Published
2021
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13. Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)

Author

Lyden, Patrick, Hemmen, Thomas, Grotta, James, Rapp, Karen, Ernstrom, Karin, Rzesiewicz, Teresa, Parker, Stephanie, Concha, Mauricio, Hussain, Syed, Agarwal, Sachin, Meyer, Brett, Jurf, Julie, Altafullah, Irfan, Raman, Rema, Hess, Mary Jane, Mullin, Anthony, Jane Hess, Mary, Muranevici, Gabriela, Piantadosi, Bonnie, Jimenez-Maggiora, Gustavo, So, Jia-Shing, Jain, Sonia, Diringer, Michael, Derdeyn, Colin, Stern, Barney, Hamilton, Scott, Dietrich, Dalton, Becker, Kyra, Yenari, Midori, Dirnagl, Ulrich, Wijman, Christine, Chamorro, Ángel, Janis, Scott, Moy, Claudia, Lin, Felice, Song, Shlee, Schlick, Konrad, Khanolkar, Pooja, Edwards, Nancy J, Roldan, Ana, Wilson, Jeanette, Little, Amy, Lewis, Pam, Neil, William, Bruce, Nhu, Guzik, Amy, Sohdi, Ajeet, Herial, Nabeel, Ovbiagele, Bruce, Meyer, Dawn, Modir, Royya, Chavez, Ronelyn, Velazquez, Angela, Mayer, Stephan, Claassen, Jan, Falo, Cristina, Tafreshi, Gilda, Kelly, Nancy, Shell, Erin, Dugan, Guy, Kim, Elizabeth, Tanner, Amy, Michel, Patrik, Eskandari, Ashraf, Oddo, Mauro, Suys, Tamarah, Remillard, Suzette, Cordier, Maria, Brown, Robert, Jasak, Sara, McCullough, Louise, Brautigam, Robert, Alexandrov, Andrei, Sisson, April, Albright, Karen, Broessner, Gregor, Schmutzhard, Erich, Escioglou, Elissanet, Jones, William, Poisson, Sharon, Simpson, Jennifer, Shah, Qaisar, Jonczak, Karin, Bussinger, Patricia, Lewandowski, Christopher, Berry, Shannen, Lundell, AnneMarie, Miller, Joseph B, Cruz-Flores, Salvador, Holzer, Eve, Torretta, Susan, Brown, David, Heim, Laura, and Smith, Carlos

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Stroke, Clinical Trials and Supportive Activities, Lung, Brain Disorders, Clinical Research, Neurosciences, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Hypothermia, Induced, Male, Middle Aged, Outcome Assessment, Health Care, Single-Blind Method, hypothermia, intention to treat analysis, ischemic stroke, neuroprotection, pneumonia, stroke, therapeutics, Collaborators, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposeTherapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. Therapeutic hypothermia for acute ischemic stroke is safe and feasible in pilot trials. We designed a study protocol to provide safer, faster therapeutic hypothermia in stroke patients.MethodsSafety procedures and 4°C saline infusions for faster cooling were added to the ICTuS trial (Intravascular Cooling in the Treatment of Stroke) protocol. A femoral venous intravascular cooling catheter after intravenous recombinant tissue-type plasminogen activator in eligible patients provided 24 hours cooling followed by a 12-hour rewarm. Serial safety assessments and imaging were performed. The primary end point was 3-month modified Rankin score 0,1.ResultsOf the intended 1600 subjects, 120 were enrolled before the study was stopped. Randomly, 63 were to receive hypothermia plus antishivering treatment and 57 normothermia. Compared with previous studies, cooling rates were improved with a cold saline bolus, without fluid overload. The intention-to-treat primary outcome of 90-day modified Rankin Score 0,1 occurred in 33% hypothermia and 38% normothermia subjects, odds ratio (95% confidence interval) of 0.81 (0.36-1.85). Serious adverse events occurred equally. Mortality was 15.9% hypothermia and 8.8% normothermia subjects, odds ratio (95% confidence interval) of 1.95 (0.56-7.79). Pneumonia occurred in 19% hypothermia versus 10.5% in normothermia subjects, odds ratio (95% confidence interval) of 1.99 (0.63-6.98).ConclusionsIntravascular therapeutic hypothermia was confirmed to be safe and feasible in recombinant tissue-type plasminogen activator-treated acute ischemic stroke patients. Protocol changes designed to reduce pneumonia risk appeared to fail, although the sample is small.Clinical trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01123161.

Published
2016

17. Frequency of Neurologic Manifestations in COVID-19: A Systematic Review and Meta-analysis

Author

Misra, Shubham, Kolappa, Kavitha, Prasad, Manya, Radhakrishnan, Divya, Thakur, Kiran T., Solomon, Tom, Michael, Benedict Daniel, Winkler, Andrea Sylvia, Beghi, Ettore, Guekht, Alla, Pardo, Carlos A., Wood, Greta Karen, Hsiang-Yi Chou, Sherry, Fink, Ericka L., Schmutzhard, Erich, Kheradmand, Amir, Hoo, Fan Kee, Kumar, Amit, Das, Animesh, Srivastava, Achal K., Agarwal, Ayush, Dua, Tarun, and Prasad, Kameshwar

Published
2021
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19. Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)]

Author

Hänggi, Daniel, Etminan, Nima, Mayer, Stephan A., Aldrich, E. Francois, Diringer, Michael N., Schmutzhard, Erich, Faleck, Herbert J., Ng, David, Saville, Benjamin R., Macdonald, R. Loch, and for the NEWTON Investigators

Published
2019
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26. Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns.

Author

Arndts, Kathrin, Kegele, Josua, Massarani, Alain S., Ritter, Manuel, Wagner, Thomas, Pfarr, Kenneth, Lämmer, Christine, Dörmann, Peter, Peisker, Helga, Menche, Dirk, Al-Bahra, Mazen, Prazeres da Costa, Clarissa, Schmutzhard, Erich, Matuja, William, Hoerauf, Achim, Layland-Heni, Laura E., and Winkler, Andrea S.

Subjects
ONCHOCERCA volvulus, EPILEPSY, NEUROLOGICAL disorders, BASIC proteins, FILARIASIS, SYNDROMES
Abstract

Previous studies have described the association of onchocerciasis (caused by Onchocerca volvulus) with epilepsy, including nodding syndrome, although a clear etiological link is still missing. Cases are found in different African countries (Tanzania, South Sudan, Uganda, Democratic Republic of the Congo, Central African Republic and Cameroon). In our study we investigated immunological parameters (cytokine, chemokine, immunoglobulin levels) in individuals from the Mahenge area, Tanzania, presenting with either epilepsy or nodding syndrome with or without O. volvulus infection and compared them to O. volvulus negative individuals from the same endemic area lacking neurological disorders. Additionally, cell differentiation was performed using blood smears and systemic levels of neurodegeneration markers, leiomodin-1 and N-acetyltyramine-O, β-glucuronide (NATOG) were determined. Our findings revealed that cytokines, most chemokines and neurodegeneration markers were comparable between both groups presenting with epilepsy or nodding syndrome. However, we observed elevated eosinophil percentages within the O. volvulus positive epilepsy/nodding syndrome patients accompanied with increased eosinophilic cationic protein (ECP) and antigen-specific IgG levels in comparison to those without an O. volvulus infection. Furthermore, highest levels of NATOG were found in O. volvulus positive nodding syndrome patients. These findings highlight that the detection of distinct biomarkers might be useful for a differential diagnosis of epilepsy and nodding syndrome in O. volvulus endemic areas. Trial-registration:NCT03653975. Author summary: A lot of epidemiological studies suggest that an infection with the filarial nematode Onchocerca volvulus is a risk factor for a certain form of epilepsy which includes the nodding syndrome. The seizures occur suddenly in previously healthy children between the ages of 3 and 18 years and the disease is an important public health problem in onchocerciasis-endemic regions with inadequate or lacking onchocerciasis elimination programmes. So far, no exact pathophysiological mechanisms were detected that shed light on how the parasite can trigger the seizures, although many factors have been investigated. However, most studies lack an accurate determination of an active/chronic O. volvulus infection; rather, they rely on the presence of circulating antibodies, which is only evidence of previous exposure to the parasite (and therefore positive in most people living in endemic areas. Within our study, we included participants from the Mahenge area, Tanzania, who were displaying epilepsy/nodding syndrome in absence or presence of a PCR-determined O. volvulus infection. We could show that the group of O. volvulus infected patients displayed higher levels of eosinophils, antigen-specific immunoglobulin levels as well as increased levels of a worm-related metabolic product (NATOG), which might be used as a potential diagnostic biomarker of the disease in future studies. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Neuropathological criteria of anti-IgLON5-related tauopathy

Author

Gelpi, Ellen, Höftberger, Romana, Graus, Francesc, Ling, Helen, Holton, Janice L., Dawson, Timothy, Popovic, Mara, Pretnar-Oblak, Janja, Högl, Birgit, Schmutzhard, Erich, Poewe, Werner, Ricken, Gerda, Santamaria, Joan, Dalmau, Josep, Budka, Herbert, Revesz, Tamas, and Kovacs, Gabor G.

Published
2016
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41. Reply to Jung

Author

Helbok, Raimund, Dietmann, Anelia, Lackner, Peter, Schmutzhard, Erich, and Kremsner, Peter G.

Published
2008
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45. Characteristics of people with epilepsy and Neurocysticercosis in three eastern African countries–A pooled analysis.

Author

Stelzle, Dominik, Schmidt, Veronika, Keller, Luise, Ngowi, Bernard J., Matuja, William, Escheu, Gabrielle, Hauke, Peter, Richter, Vivien, Ovuga, Emilio, Pfausler, Bettina, Schmutzhard, Erich, Amos, Action, Harrison, Wendy, Kaducu, Joyce, and Winkler, Andrea S.

Subjects
NEUROCYSTICERCOSIS, PEOPLE with epilepsy, SEIZURES (Medicine), TAENIA solium, EPILEPSY, ZOONOSES
Abstract

Background: Neurocysticercosis (NCC), a zoonotic disease caused by the pork tapeworm T. solium, represents one of the most common causes of secondary epilepsy but remains often undiagnosed due to lack of awareness and diagnostic facilities. Methodology: We pooled data from four cross-sectional studies on epilepsy and NCC in eastern Africa. Study sites were in Uganda, Malawi and in Tanzania (Dar es Salaam and Haydom). The study in Uganda and Malawi were community-based, the two studies in Tanzania were hospital-based. The same questionnaire was used for assessment of clinical characteristics of patients with epilepsy. Computed tomography (CT) scans and serological testing were performed in order to diagnose NCC. Results: Overall, 1,179 people with epilepsy were included in our analysis. Of those, 941 PWE underwent CT scanning and were pooled for NCC analysis. Seventy patients were diagnosed with NCC, but NCC prevalence differed considerably between sites ranging from 2.0% (95%CI 0.4% to 3.6%) in Dar es Salaam to 17.5% (95%CI 12.4% to 22.6%) in Haydom. NCC prevalence did not show any association with sex but increased with age and was higher in rural than urban settings. In addition, being a farmer, non-Muslim, eating pork and living with pigs close by was associated with a higher NCC prevalence. PWE with NCC experienced their first epileptic seizure around 3 years later in life compared to PWE without NCC and their epileptic seizures seemed to be better controlled (p<0.001). There was no difference between focal onset seizures and focal signs on neurological examination in both groups (p = 0.49 and p = 0.92, respectively). The rT24H-EITB had a sensitivity for the detection of NCC of 70% (95% confidence interval [CI] 51 to 84%), the LLGP of 76% (95%CI 58 to 89%) and the antigen ELISA of 36% (95% CI 20 to 55%). Conclusions: NCC is prevalent among PWE in eastern Africa, although it may not be as common as previously stated. Demographic characteristics of PWE with NCC differed from those without NCC, but semiological characteristics and results on neurological examination did not differ compared to PWE without NCC. Interestingly, seizures seemed to be less frequent in PWE with NCC. Being aware of those differences and similarities may help triaging PWE for neuroimaging in order to establish a diagnosis of NCC. Author summary: Neurocysticercosis is a neglected zoonotic disease caused by the pork tapeworm Taenia solium. Patients with neurocysticercosis show a wide range of symptoms, from asymptomatic to severely affected by epileptic seizures, progressive headache or focal neurological deficits. Epileptic seizures are particularly common and up to 30% of people with epilepsy have neurocysticercosis in areas endemic for Taenia solium. The disease is often undiagnosed in Africa because of a lack of diagnostic opportunities (serological tests and neuroimaging). Furthermore, symptoms are too unspecific to diagnose patients solely based on clinical characteristics. Moreover, radiological features of neurocysticercosis differ between continents and have not been described yet for African populations. In this study, for the first time, we describe radiological but also clinical features of patients with epilepsy and neurocysticercosis in eastern Africa. We found that in Tanzania, Malawi and Uganda, neurocysticercosis is common in people with epilepsy although less common than previously reported. Also, most patients with neurocysticercosis have multiple parenchymal lesions and clinical features of people with epilepsy and neurocysticercosis do not differ substantially from people with epilepsy without neurocysticercosis. [ABSTRACT FROM AUTHOR]

Published
2022
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