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A signed graph (G, σ) is called a parity signed graph if there exists a bijective mapping f : V (G) → {1, . . ., |V (G)|} such that for each edge uv in G, f(u) and f(v) have same parity if σ(uv) = +1, and opposite parity if σ(uv) = −1. The rna number σ−(G) of G is the least number of negative edges among all possible parity signed graphs over G. Equivalently, σ−(G) is the least size of an edge-cut of G that has nearly equal sides. In this paper, we show that for the generalized Petersen graph Pn,k, σ−(Pn,k) lies between 3 and n. Moreover, we determine the exact value of σ−(Pn,k) for k ∈ {1, 2}. The rna numbers of some famous generalized Petersen graphs, namely, Petersen graph, Dürer graph, Möbius-Kantor graph, Dodecahedron, Desargues graph and Nauru graph are also computed. Recently, Acharya, Kureethara and Zaslavsky characterized the structure of those graphs whose rna number is 1. We use this characterization to show that the smallest order of a (4n + 1)-regular graph having rna number 1 is 8n + 6. We also prove the smallest order of (4n − 1)-regular graphs having rna number 1 is bounded above by 12n − 2. In particular, we show that the smallest order of a cubic graph having rna number 1 is 10. [ABSTRACT FROM AUTHOR]

Toxic shock syndrome (TSS) is a serious, potentially life-threatening condition resulting from an overwhelming immunological response to an exotoxin released by Staphylococcus aureus and group A streptococci. High index of suspicion, early diagnosis and aggressive therapeutic measures must be instituted in view of high mortality of the TSS. In recent years, new agents have been tested to reduce morbidity and mortality in patients with severe sepsis, in addition to standard supportive measures. Among them, recombinant human activated protein C (rhAPC) has been reported to significantly reduce mortality and morbidity in patients with severe sepsis and two or more acute organ failures. We describe our experience with this drug in the early reversal of septic shock from TSS. [ABSTRACT FROM AUTHOR]

A case of severe sodium valproate overdose is presented in which medicinal management failed to reverse coma of the patient. High-flux hemodialysis was then used to eliminate sodium valproate. This case demonstrated the effectiveness of hemodialysis in not only decreasing valproate levels very rapidly but also as an effective anti-coma management. [ABSTRACT FROM AUTHOR]