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3. Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study

Author

Nixdorf, Larissa, Hartl, Lukas, Ströhl, Stefanie, Felsenreich, Daniel Moritz, Mairinger, Magdalena, Jedamzik, Julia, Richwien, Paula, Mozayani, Behrang, Semmler, Georg, Balcar, Lorenz, Schwarz, Michael, Jachs, Mathias, Dominik, Nina, Bichler, Christoph, Trauner, Michael, Mandorfer, Mattias, Reiberger, Thomas, Langer, Felix B., Bauer, David Josef Maria, and Prager, Gerhard

Published
2024
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5. ELIMINATE: a PCR record-based macroelimination project for systematic recall of HCV-RNA-positive persons in Austria

Author

Schwarz, Caroline, Bauer, David, Dorn, Livia, Jachs, Mathias, Hartl, Lukas, Chromy, David, Weseslindtner, Lukas, Pfisterer, Nikolaus, Hennlich, Barbara, Stückler, Annika, Strassl, Robert, Voill-Glaninger, Astrid, Hübl, Wolfgang, Willheim, Martin, Köhrer, Karin, Jansen-Skoupy, Sonja, Tomez, Sabine, Krugluger, Walter, Madl, Christian, Schwarz, Michael, Balcar, Lorenz, Semmler, Georg, Brinkmann, Leonard, Burghart, Lukas, Antonitsch, Lukas, Weidinger, Gerhard, Riedl, Florian, Laferl, Hermann, Kurteva, Vesselina, Traugott, Marianna, Hind, Julian, Wenisch, Christoph, Aburaia, Abdelrahman, Sebesta, Christian, Schmid, Daniela, Rothweiler, Sonja, Remetic, Jelena, Gschwantler, Michael, Maieron, Andreas, and Reiberger, Thomas

Published
2024
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9. Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

Author

Paternostro, Rafael, Kwanten, Wilhelmus J., Hofer, Benedikt Silvester, Semmler, Georg, Bagdadi, Ali, Luzko, Irina, Hernández-Gea, Virginia, Graupera, Isabel, García-Pagán, Juan Carlos, Saltini, Dario, Indulti, Federica, Schepis, Filippo, Moga, Lucile, Rautou, Pierre-Emmanuel, Llop, Elba, Téllez, Luis, Albillos, Agustín, Fortea, Jose Ignacio, Puente, Angela, Tosetti, Giulia, Primignani, Massimo, Zipprich, Alexander, Vuille-Lessard, Elise, Berzigotti, Annalisa, Taru, Madalina-Gabriela, Taru, Vlad, Procopet, Bogdan, Jansen, Christian, Praktiknjo, Michael, Gu, Wenyi, Trebicka, Jonel, Ibanez-Samaniego, Luis, Bañares, Rafael, Rivera-Esteban, Jesús, Pericas, Juan M., Genesca, Joan, Alvarado, Edilmar, Villanueva, Candid, Larrue, Helene, Bureau, Christophe, Laleman, Wim, Ardevol, Alba, Masnou, Helena, Vanwolleghem, Thomas, Trauner, Michael, Mandorfer, Mattias, Francque, Sven, and Reiberger, Thomas

Published
2024
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10. Metabolomic profiles differentiate between porto-sinusoidal vascular disorder, cirrhosis, and healthy individuals

Author

Semmler, Georg, Petrenko, Oleksandr, Lozano, Juanjo Jose, Shalaby, Sarah, Sánchez-Avila, Juan I., Marella, Nara, Hannich, Thomas, Wöran, Katharina, Balcar, Lorenz, Simbrunner, Benedikt, Lampichler, Katharina, Mozayani, Behrang, Trauner, Michael, Mandorfer, Mattias, Reiberger, Thomas, García-Pagán, Juan-Carlos, and Scheiner, Bernhard

Published
2024
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12. Post-treatment LSM rather than change during treatment predicts decompensation in patients with cACLD after HCV cure

Author

Maria Agostini, Sofia, Balcar, Lorenz, Battistella, Sara, Chromy, David, Cornberg, Markus, Deterding, Katja, Fernandez, Inmaculada, Fernandez-Rodriguez, Conrado, Gea, Francisco, Koeck, Fiona, Krawanja, Julia, Neumayer, Daniela, Riado, Daniel, Rincón, Diego, Schwabl, Philipp, Simbrunner, Benedikt, Trauner, Michael, Uson, Clara, Wedemeyer, Heiner, Semmler, Georg, Alonso López, Sonia, Pons, Monica, Lens, Sabela, Dajti, Elton, Griemsmann, Marie, Zanetto, Alberto, Burghart, Lukas, Hametner-Schreil, Stefanie, Hartl, Lukas, Manzano, Marisa, Rodriguez-Tajes, Sergio, Zanaga, Paola, Schwarz, Michael, Gutierrez, María Luisa, Jachs, Mathias, Pocurull, Anna, Polo, Benjamín, Ecker, Dominik, Mateos, Beatriz, Izquierdo, Sonia, Real, Yolanda, Ahumada, Adriana, Bauer, David Josef Maria, Mauz, Jim Benjamin, Casanova-Cabral, Michelle, Gschwantler, Michael, Russo, Francesco Paolo, Azzaroli, Francesco, Maasoumy, Benjamin, Reiberger, Thomas, Forns, Xavier, Genesca, Joan, Bañares, Rafael, and Mandorfer, Mattias

Published
2024
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13. Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease

Author

Thorhauge, Katrine Holtz, Semmler, Georg, Johansen, Stine, Lindvig, Katrine Prier, Kjærgaard, Maria, Hansen, Johanne Kragh, Torp, Nikolaj, Hansen, Camilla Dalby, Andersen, Peter, Hofer, Benedikt Silvester, Gu, Wenyi, Israelsen, Mads, Mandorfer, Mattias, Reiberger, Thomas, Trebicka, Jonel, Thiele, Maja, and Krag, Aleksander

Published
2024
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17. Austrian consensus on the diagnosis and management of portal hypertension in advanced chronic liver disease (Billroth IV)

Author

Mandorfer, Mattias, Aigner, Elmar, Cejna, Manfred, Ferlitsch, Arnulf, Datz, Christian, Gräter, Tilmann, Graziadei, Ivo, Gschwantler, Michael, Hametner-Schreil, Stephanie, Hofer, Harald, Jachs, Mathias, Loizides, Alexander, Maieron, Andreas, Peck-Radosavljevic, Markus, Rainer, Florian, Scheiner, Bernhard, Semmler, Georg, Reider, Lukas, Reiter, Silvia, Schoder, Maria, Schöfl, Rainer, Schwabl, Philipp, Stadlbauer, Vanessa, Stauber, Rudolf, Tatscher, Elisabeth, Trauner, Michael, Ziachehabi, Alexander, Zoller, Heinz, Fickert, Peter, and Reiberger, Thomas

Published
2023
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19. Porto-sinusoidal vascular liver disorder with portal hypertension: Natural history and long-term outcome

Author

Magaz, Marta, Giudicelli-Lett, Heloïse, Abraldes, Juan G., Nicoară-Farcău, Oana, Turon, Fanny, Rajoriya, Neil, Goel, Ashish, Raymenants, Karlien, Hillaire, Sophie, Téllez, Luis, Elkrief, Laure, Procopet, Bogdan, Orts, Lara, Nery, Filipe, Shukla, Akash, Larrue, Hélène, Degroote, Helena, Aguilera, Victoria, Llop, Elba, Turco, Laura, Indulti, Federica, Gioia, Stefania, Tosetti, Giulia, Bitto, Niccolò, Becchetti, Chiara, Alvarado, Edilmar, Roig, Cristina, Diaz, Raquel, Praktiknjo, Michael, Konicek, Anna-Lena, Olivas, Pol, Fortea, José Ignacio, Masnou, Helena, Puente, Ángela, Ardèvol, Alba, Navascués, Carmen A., Romero-Gutiérrez, Marta, Scheiner, Bernhard, Semmler, Georg, Mandorfer, Mattias, Damião, Filipe, Baiges, Anna, Ojeda, Asunción, Simón-Talero, Macarena, González-Alayón, Carlos, Díaz, Alba, García-Criado, Ángeles, De Gottardi, Andrea, Hernández-Guerra, Manuel, Genescà, Joan, Drilhon, Nicolas, Noronha Ferreira, Carlos, Reiberger, Thomas, Rodríguez, Manuel, Morillas, Rosa María, Crespo, Javier, Trebicka, Jonel, Bañares, Rafael, Villanueva, Càndid, Berzigotti, Annalisa, Primignani, Massimo, La Mura, Vincenzo, Riggio, Oliviero, Schepis, Filippo, Verhelst, Xavier, Calleja, José Luis, Bureau, Christophe, Albillos, Agustín, Nevens, Frederik, Hernández-Gea, Virginia, Tripathi, Dhiraj, Rautou, Pierre-Emmanuel, and García-Pagán, Juan Carlos

Published
2024
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23. Dynamics in Liver Stiffness Measurements Predict Outcomes in Advanced Chronic Liver Disease

Author

Semmler, Georg, Yang, Zhenwei, Fritz, Laurenz, Köck, Fiona, Hofer, Benedikt Silvester, Balcar, Lorenz, Hartl, Lukas, Jachs, Mathias, Stopfer, Katharina, Schedlbauer, Anna, Neumayer, Daniela, Maurer, Jurij, Müllner-Bucsics, Theresa, Simbrunner, Benedikt, Scheiner, Bernhard, Trauner, Michael, Mandorfer, Mattias, Reiberger, Thomas, and Bauer, David Josef Maria

Published
2023
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24. Accuracy of spleen stiffness measurement for the diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a systematic review and individual patient data meta-analysis

Author

Alemanni, Luigina Vanessa, Vestito, Amanda, Renzulli, Matteo, Azzaroli, Francesco, Colecchia, Luigi, Castera, Laurent, Ronot, Maxime, Platon-Lupsor, Monica, Nicoara-Farcau, Oana, Ignat, Mina, Hias, Yoichi, Fichera, Anna, Ooi, Chin Chin, Borghi, Alberto, Bauer, David, Semmler, Georg, Mandorfer, Mattias, Calleja, José Luis, Elshaarawy, Omar, Romagnoli, Dante, Dajti, Elton, Ravaioli, Federico, Zykus, Romanas, Rautou, Pierre-Emmanuel, Elkrief, Laure, Grgurevic, Ivica, Stefanescu, Horia, Hirooka, Masashi, Fraquelli, Mirella, Rosselli, Matteo, Chang, Pik Eu Jason, Piscaglia, Fabio, Reiberger, Thomas, Llop, Elba, Mueller, Sebastian, Marasco, Giovanni, Berzigotti, Annalisa, Colli, Agostino, Festi, Davide, and Colecchia, Antonio

Published
2023
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31. Inter- and intra-reader agreement for gadoxetic acid–enhanced MRI parameter readings in patients with chronic liver diseases

Author

Beer, Lucian, Mandorfer, Mattias, Bastati, Nina, Poetter-Lang, Sarah, Tamandl, Dietmar, Stoyanova, Dilyana Plamenova, Elmer, Michael Christoph, Semmler, Georg, Simbrunner, Benedikt, Hodge, Jacqueline C, Sirlin, Claude B, Reiberger, Thomas, and Ba-Ssalamah, Ahmed

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Digestive Diseases, Hepatitis, Chronic Liver Disease and Cirrhosis, Biomedical Imaging, Liver Disease, Prevention, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Chronic Disease, Contrast Media, Female, Gadolinium DTPA, Humans, Liver Diseases, Magnetic Resonance Imaging, Male, Middle Aged, ROC Curve, Reproducibility of Results, Retrospective Studies, Young Adult, Liver, Magnetic resonance imaging, Liver diseases, Gadoxetic acid, Liver function tests, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

ObjectivesTo examine inter- and intra-observer agreement for four simple hepatobiliary phase (HBP)-based scores on gadoxetic acid (GA)-enhanced MRI and their correlation with liver function in patients with mixed chronic liver disease (CLD).MethodsThis single-center, retrospective study included 287 patients (62% male, 38% female, mean age 53.5 ± 13.7 years) with mixed CLD (20.9% hepatitis C, 19.2% alcoholic liver disease, 8% hepatitis B) who underwent GA-enhanced MRI of the liver for clinical care between 2010 and 2015. Relative liver enhancement (RLE), contrast uptake index (CUI), hepatic uptake index (HUI), and liver-to-spleen contrast index (LSI) were calculated by two radiologists independently using unenhanced and GA-enhanced HPB (obtained 20 min after GA administration) images; 50 patients selected at random were reviewed twice by one reader to assess intra-observer reliability. Agreement was assessed by intraclass correlation coefficient (ICC). The albumin-bilirubin (ALBI) score, the model of end-stage liver disease (MELD), and the Child-Turcotte-Pugh (CTP) score were calculated as standards of reference for hepatic function.ResultsIntra-observer ICCs ranged from 0.814 (0.668-0.896) for CUI to 0.969 (0.945-0.983) for RLE. Inter-observer ICCs ranged from 0.777 (0.605-0.874) for HUI to 0.979 (0.963-0.988) for RLE. All HBP-based scores correlated significantly (all p

Published
2019

33. Outcome of Budd-Chiari Syndrome Patients Treated With Direct Oral Anticoagulants: An Austrian Multicenter Study

Author

Semmler, Georg, Lindorfer, Alexander, Schäfer, Benedikt, Bartl, Stefan, Hametner-Schreil, Stephanie, Gensluckner, Sophie, Balcar, Lorenz, Pomej, Katharina, Lampichler, Katharina, Trauner, Michael, Aigner, Elmar, Datz, Christian, Zoller, Heinz, Hofer, Harald, Schöfl, Rainer, Mandorfer, Mattias, Reiberger, Thomas, and Scheiner, Bernhard

Published
2023
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36. Non-invasive tests for clinically significant portal hypertension after HCV cure

Author

Semmler, Georg, Lens, Sabela, Meyer, Elias L., Baiges, Anna, Alvardo-Tapias, Edilmar, Llop, Elba, Tellez, Luis, Schwabl, Philipp, Mauro, Ezequiel, Escudé, Laia, Díez, Cristina, Ibañez-Samaniego, Luis, Puente, Ángela, Fortea, José Ignacio, Abadía, Marta, Zanetto, Alberto, Conthe, Andrés, Hernandez-Évole, Helena, Luzko Scheid, Irina Sofia, Jia, Jidong, Yoshiji, Hitoshi, Francque, Sven M., Tsochatzis, Emmanuel A., Russo, Francesco Paolo, Crespo, Gonzalo, Forns, Xavier, Bañares, Rafael, Villanueva, Càndid, Hernández-Gea, Virginia, Reiberger, Thomas, Bosch, Jaume, García Pagán, Juan Carlos, and Mandorfer, Mattias

Published
2022
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37. Alpha-1 antitrypsin Pi∗Z allele is an independent risk factor for liver transplantation and death in patients with advanced chronic liver disease

Author

Balcar, Lorenz, Scheiner, Bernhard, Urheu, Markus, Weinberger, Patrick, Paternostro, Rafael, Simbrunner, Benedikt, Hartl, Lukas, Jachs, Mathias, Bauer, David, Semmler, Georg, Willheim, Claudia, Pinter, Matthias, Ferenci, Peter, Trauner, Michael, Reiberger, Thomas, Stättermayer, Albert Friedrich, and Mandorfer, Mattias

Published
2022
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38. Decompensation in Advanced Nonalcoholic Fatty Liver Disease May Occur at Lower Hepatic Venous Pressure Gradient Levels Than in Patients With Viral Disease

Author

Bassegoda, Octavi, Olivas, Pol, Turco, Laura, Mandorfer, Mattias, Serra-Burriel, Miquel, Tellez, Luis, Kwanten, Wilhelmus, Laroyenne, Alexia, Farcau, Oana, Alvarado, Edilmar, Moga, Lucile, Vuille-Lessard, Elise, Fortea, Jose Ignacio, Ibañez, Luis, Tosetti, Giulia, Vanwolleghem, Thomas, Larrue, Hélène, Burgos-Santamaría, Diego, Stefanescu, Horia, Paternostro, Rafael, Cippitelli, Annalisa, Lens, Sabela, Augustin, Salvador, Llop, Elba, Laleman, Wim, Trebicka, Jonel, Chang, Johannes, Masnou, Helena, Zipprich, Alexander, Miceli, Francesca, Semmler, Georg, Forns, Xavier, Primignani, Massimo, Bañares, Rafael, Puente, Angela, Berzigotti, Annalisa, Rautou, Pierre Emmanuel, Villanueva, Candid, Ginès, Pere, Garcia-Pagan, J.C., Procopet, Bogdan, Bureau, Cristophe, Albillos, Agustin, Francque, Sven, Reiberger, Thomas, Schepis, Filippo, Graupera, Isabel, and Hernandez-Gea, Virginia

Published
2022
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42. Liver Transplantation for Porto-Sinusoidal Vascular Liver Disorder: Long-term Outcome

Author

Magaz, Marta, Giudicelli-Lett, Heloïse, Nicoară-Farcău, Oana, Rajoriya, Neil, Goel, Ashish, Raymenants, Karlien, Hillaire, Sophie, Crespo, Gonzalo, Téllez, Luis, Elkrief, Laure, Fondevila, Constantino, Orts, Lara, Nery, Filipe, Shukla, Akash, Larrue, Hélène, Fundora, Yiliam, Degroote, Helena, Aguilera, Victoria, LLop, Elba, Turco, Laura, Indulti, Federica, Gioia, Stefania, Tosetti, Giulia, Bitto, Niccolò, Becchetti, Chiara, Alvarado, Edilmar, Roig, Cristina, Diaz, Raquel, Praktiknjo, Michael, Konicek, Anna-Lena, Soy, Guillem, Olivas, Pol, Fortea, José Ignacio, Masnou, Helena, Puente, Ángela, Ardèvol, Alba, Álvarez-Navascués, Carmen, Romero, Marta, Scheiner, Bernhard, Semmler, Georg, Mandorfer, Mattias, Damião, Filipe, Baiges, Anna, Turon, Fanny, Simón-Talero, Macarena, González-Alayón, Carlos, Díaz, Alba, García-Criado, Ángeles, de Gottardi, Andrea, Reverter, Enric, Blasi, Annabel, Genescà, Joan, Roux, Olivier, Francoz, Claire, Noronha Ferreira, Carlos, Reiberger, Thomas, Rodríguez, Manuel, Morillas, Rosa María, Crespo, Javier, Trebicka, Jonel, Bañares, Rafael, Villanueva, Càndid, Berzigotti, Annalisa, Primignani, Massimo, La Mura, Vincenzo, Riggio, Oliviero, Schepis, Filippo, Procopet, Bogdan, Verhelst, Xavier, Calleja, José Luis, Bureau, Christophe, Albillos, Agustín, Nevens, Frederik, Hernández-Gea, Virginia, Tripathi, Dhiraj, Rautou, Pierre-Emmanuel, Durand, François, and García-Pagán, Juan Carlos

Published
2022
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44. High histamine levels are associated with acute‐on‐chronic liver failure and liver‐related death in patients with advanced chronic liver disease.

Author

Schwarz, Michael, Simbrunner, Benedikt, Jachs, Mathias, Hartl, Lukas, Balcar, Lorenz, Bauer, David J. M., Semmler, Georg, Hofer, Benedikt S., Scheiner, Bernhard, Pinter, Matthias, Stättermayer, Albert F., Trauner, Michael, Reiberger, Thomas, and Mandorfer, Mattias

Subjects
VENOUS pressure, PORTAL hypertension, LIVER failure, SERUM albumin, HISTAMINE
Abstract

Background and Aims: The role of histamine in advanced chronic liver disease (ACLD) is poorly understood. We investigated plasma histamine levels across ACLD stages and their prognostic value. Methods: We included patients with evidence of ACLD, defined by portal hypertension (hepatic venous pressure gradient [HVPG] ≥6 mmHg) and/or a liver stiffness measurement by transient elastography ≥10 kPa, who underwent HVPG measurement between 2017 and 2020. Acute‐on‐chronic liver failure (ACLF) and/or liver‐related death were defined as composite endpoint. Results: Of 251 patients, 82.5% had clinically significant portal hypertension (median HVPG: 17 mmHg [interquartile range (IQR) 12–21]) and 135 patients (53.8%) were decompensated at baseline. Median plasma histamine was 8.5 nmol/L (IQR: 6.4–11.5), 37.1% of patients showed elevated values (>9.9 nmol/L). Histamine levels did not differ significantly across Child‐Turcotte‐Pugh (CTP) stages nor strata of model for end‐stage liver disease (MELD) or HVPG. Histamine levels correlated with markers of circulatory dysfunction (i.e. sodium, renin and aldosterone). During a median follow‐up of 29.2 months, 68 patients developed ACLF or liver‐related death. In univariate as well as in multivariate analysis (adjusting for age, sex, HVPG as well as either MELD, clinical stage, and serum albumin or CTP and serum sodium), elevated histamine levels remained associated with the composite endpoint. CTP‐based multivariate model adjusted sub‐distribution hazard ratio (asHR): 1.010 (95% CI: 1.004–1.021), p <.001; MELD‐based multivariate model asHR: 1.030 (95% CI: 1.017–1.040), p <.001. Conclusion: High levels of histamine were linked to circulatory dysfunction in ACLD patients and independently associated with increased risks of ACLF or liver‐related death. Further mechanistic studies on the link between histamine signalling and development of hyperdynamic circulation and ACLF are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Association between Diverticulosis and Colorectal Neoplasia: Analysis from a Large Austrian Database.

Author

Völkerer, Andreas, Wernly, Sarah, Semmler, Georg, Flamm, Maria, Ausserwinkler, Mathias, Datz, Leonora, Götz, Nikolaus, Hofer, Hannah, Aigner, Elmar, Datz, Christian, and Wernly, Bernhard

Subjects
COLON polyps, DIVERTICULOSIS, DIVERTICULITIS, COLORECTAL cancer, UNIVARIATE analysis, EARLY detection of cancer
Abstract

Background: Colorectal neoplasia and diverticulosis are common findings on colonoscopies. While adenomas are precursors to colorectal cancer, diverticulosis is usually asymptomatic but can lead to diverticulitis. Despite their prevalence and coexistence, the relationship between these conditions remains unclear. This study investigates whether diverticulosis is associated with adenomas, considering shared risk factors and potential inflammation-driven mechanisms. Methods: We examined 6154 asymptomatic individuals undergoing colorectal cancer screening in Austria. Diverticulosis and colorectal neoplasia were documented during screenings based on macroscopic definitions. Advanced neoplasia was defined as polyps >1 cm or high-grade dysplasia. Associations between diverticulosis and neoplastic findings were assessed using univariate and multivariable logistic regression models. Results: Although the overall incidence of any polypoid lesion was higher in the diverticulosis group (37% vs. 30%), statistical analysis revealed a comparable rate of advanced neoplasms in both groups. Importantly, no significant link between diverticulosis and advanced neoplasms was found (OR 1.125; 95% CI: 0.933 to 1.357, p = 0.218) even after adjusting for confounding factors. In a univariate analysis, a statistically significant association between diverticulosis and the presence of any colorectal polyps was identified (OR 1.388; 95% CI: 1.244–1.549, p < 0.0001). However, after adjusting for confounding factors in model 2 (OR 1.065, 95% CI: 0.942 to 1.204, p = 0.314) and model 3 (OR 1.071, 95% CI: 0.925 to 1.239, p = 0.360), this effect was also not statistically significant. Conclusions: Patients with diverticulosis share demographic and clinical features with those at risk of colorectal neoplasia, such as older age, male gender, and higher cardiometabolic risk. However, diverticulosis does not independently increase the risk of advanced colorectal neoplasia or unspecified polypoid lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Simple blood tests to diagnose compensated advanced chronic liver disease and stratify the risk of clinically significant portal hypertension.

Author

Semmler, Georg, Hartl, Lukas, Mendoza, Yuly Paulin, Simbrunner, Benedikt, Jachs, Mathias, Balcar, Lorenz, Schwarz, Michael, Hofer, Benedikt Silvester, Fritz, Laurenz, Schedlbauer, Anna, Stopfer, Katharina, Neumayer, Daniela, Maurer, Jurij, Szymanski, Robin, Meyer, Elias Laurin, Scheiner, Bernhard, Quehenberger, Peter, Trauner, Michael, Aigner, Elmar, and Berzigotti, Annalisa

Published
2024
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47. Prevalence and prognostic value of zinc and selenium deficiency in advanced chronic liver disease.

Author

Dominik, Nina, Balcar, Lorenz, Semmler, Georg, Simbrunner, Benedikt, Schwarz, Michael, Hofer, Benedikt S., Hartl, Lukas, Jachs, Mathias, Scheiner, Bernhard, Pinter, Matthias, Trauner, Michael, Mandorfer, Mattias, Pilger, Alexander, and Reiberger, Thomas

Subjects
VENOUS pressure, TRACE elements, PROGNOSIS, INTERLEUKIN-6, LIVER diseases, ZINC, SELENIUM
Abstract

Summary: Background and Aims: Zinc and selenium are essential trace elements involved in important (patho)physiological processes. The prevalence and prognostic implications of zinc and selenium deficiency in patients with advanced chronic liver disease (ACLD) remain unknown. Methods: We determined serum zinc and selenium concentrations in 309 patients with ACLD undergoing hepatic venous pressure gradient (HVPG) measurement between 2019 and 2022. We evaluated the prevalence of zinc/selenium deficiency and assessed its association with severity of ACLD and liver‐related events (LRE, i.e. first/further hepatic decompensation/liver‐related death). Results: Among 309 ACLD patients (median: age: 57 [IQR: 50–64], MELD: 11 [IQR: 9–16], HVPG: 17 [IQR: 11–20]), 73% (227) and 63% (195) were deficient in zinc and selenium, respectively. Decompensated (dACLD) patients showed significantly lower serum zinc (median: 48 [IQR: 38–59] vs. compensated, cACLD: 65 [IQR: 54–78], p < 0.001) and selenium levels (median: 4.9 [IQR 4.0–6.2] vs. cACLD: 6.1 [IQR 5.1–7.3], p < 0.001). Significant correlations of zinc/selenium levels were found with MELD (zinc: ρ = −0.498, p < 0.001; selenium: ρ = −0.295, p < 0.001), HVPG (zinc: ρ = −0.400, p < 0.001; selenium: ρ = −0.157, p = 0.006) and liver disease‐driving mechanisms (IL6, bile‐acid homeostasis). On multivariable analysis, low zinc/selenium levels, age and MELD remained independently associated with LRE. Conclusion: Zinc and selenium deficiencies are common in ACLD patients especially with higher MELD and HVPG. Low zinc and selenium levels independently predicted hepatic decompensation and liver‐related death. The effect of zinc/selenium supplementation in ACLD should be investigated in future trials. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Clinical Course of Porto-Sinusoidal Vascular Disease Is Distinct From Idiopathic Noncirrhotic Portal Hypertension

Author

Wöran, Katharina, Semmler, Georg, Jachs, Mathias, Simbrunner, Benedikt, Bauer, David Josef Maria, Binter, Teresa, Pomej, Katharina, Stättermayer, Albert Friedrich, Schwabl, Philipp, Bucsics, Theresa, Paternostro, Rafael, Lampichler, Katharina, Pinter, Matthias, Trauner, Michael, Mandorfer, Mattias, Stift, Judith, Reiberger, Thomas, and Scheiner, Bernhard

Published
2022
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50. The differential activation of cardiovascular hormones across distinct stages of portal hypertension predicts clinical outcomes

Author

Hartl, Lukas, Jachs, Mathias, Desbalmes, Christopher, Schaufler, Dunja, Simbrunner, Benedikt, Paternostro, Rafael, Schwabl, Philipp, Bauer, David Josef Maria, Semmler, Georg, Scheiner, Bernhard, Bucsics, Theresa, Eigenbauer, Ernst, Marculescu, Rodrig, Szekeres, Thomas, Peck-Radosavljevic, Markus, Kastl, Stefan, Trauner, Michael, Mandorfer, Mattias, and Reiberger, Thomas

Published
2021
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