1. Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating.
- Author
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Zhu, Yang, Deng, Kaicheng, Zhou, Jianwei, Lai, Chong, Ma, Zuwei, Zhang, Hua, Pan, Jiazhen, Shen, Liyin, Bucknor, Matthew, Kim, Seungil, Chen, Guangjie, Ye, Sang-Ho, Zhang, Yue, Liu, Donghong, Gao, Changyou, Xu, Yonghua, Wang, Huanan, Wagner, William, and Ozhinsky, Eugene
- Abstract
Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.
- Published
- 2024