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ObjectiveTo systematically compare success, cure and complication rates of urethral sling surgeries in stress urinary incontinence patients with and without a history of pelvic radiotherapy (RT).Materials and methodsWe searched PUBMED, EMBASE, and Web of Science to identify relevant articles. The primary outcomes were the success and cure rates. The secondary outcomes included the rates of infection, urethral erosion, total complications, explantation, and satisfaction. Outcomes were analyzed using a random-effects model to calculate the unadjusted odds ratio (OR) in patients with a history of RT compared with those without prior RT.ResultsOn pooled analysis, we found significantly lower odds of success (OR 0.68; 95% confidence interval [CI] 0.53-0.87, P

Cultural integration of students and student population diversity play an important role in training college students, due to growing demand for diversity to solutions to human needs, the advancement of global economy and cultural understanding. This type of cultural integration has resulted in the new normal known as the multicultural classroom. However, studies have shown that multicultural classrooms are associated with low academic achievement due to cultural differences and trust problems within the new culture. As an HBCU, Tuskegee University is a multicultural environment and so is the Chemical Engineering Department. This study combines survey and focus group discussion to access the experiences of international students in the Chemical Engineering Department. The results suggest that while the issues of multicultural classrooms are experienced by internationals, such experiences are different for different students. Also, the students consider such experiences as part of the learning that makes them stronger upon graduation than when they enrolled.

Introduction: Effective consumer engagement practices can enhance patient safety. This is important for consumers from ethnic minority backgrounds who are exposed to increased risk of patient safety events. Using the Systems Engineering Initiative for Patient Safety model, this study explored staff experiences of creating opportunities for engagement with consumers from ethnic minority backgrounds to contribute to their cancer care safety. Method: A qualitative study was conducted using semistructured interviews with cancer service staff from four cancer services across two states in Australia. Purposive sampling was used to recruit healthcare staff from a diverse range of professions. Data were analysed using the Framework Analysis method. Results: Fifty‐four interviews were conducted with healthcare staff. Analysis of the qualitative interview data identified enablers and associated challenges that contributed to creating a shared understanding between consumers and staff of the information, processes, expectations and problems arising in care. Enablers and challenges are reported in relation to four themes: (1) co‐creating safety through shared understanding of care processes; (2) tools and technologies support planned communication; (3) organisational policy levers exist but lack implementation in direct care and (4) formal tasks incorporate consumer engagement more readily than informal interactions. Conclusion: The availability of infrastructure and resources to support communication with consumers from ethnic minority backgrounds was limited to specific tasks across the cancer care continuum. Strategies implemented by health services to foster effective communication during formal interactions now require expansion to support and create conditions for effective consumer engagement during informal and everyday care tasks. The use of innovative language support tools and cultural considerations are required at the service and system level to support consumer engagement in all types of care interactions. Public and Patient Involvement: The study was embedded within a larger project that included a consumer investigator and was guided by a consumer advisory group (CAG). These consumer team members have lived experience of cancer and are from diverse ethnic backgrounds. CAG members provided feedback on the draft interview guide and participant information for this study. [ABSTRACT FROM AUTHOR]

This article explores the integration of Artificial Intelligence (AI) in holiday decorations, focusing on Pumpkin Mike, an interactive AI-powered pumpkin that enhances the Halloween experience. The study discusses the use of facial recognition and machine learning technologies in Pumpkin Mike, as well as its market potential and financial projections. It also highlights the rise of smart holiday decor and the growing demand for tech-integrated solutions. The article concludes with a description of a social media campaign and financial projections for Pumpkin Mike. [Extracted from the article]

A study investigated the ability of 415 medical students at four North Carolina medical schools to ask risk-behavior questions and provide risk-reduction advice when interviewing a standardized patient concerned about human immunovirus (HIV) infection. A majority did not assess several important risk factors, and many would have provided incorrect information related to HIV testing and prevention of infection. (Author/MSE)

General purpose fissile package prototypes of two configurations, 16 in. and 18.5 in. diameter drum overpacks, were subjected to the free-drop, crush, puncture, and thermal hypothetical accident condition sequential tests for 10 CFR 71, Type B packagings. The tests demonstrated that the prototypes are very robust, easily withstanding the structural tests. The tests also confirmed that the urethane foam-filled overpack was able to withstand the thermal test. [DOI: 10.1115/1.3120264]

Deficiency in several trace elements, including copper and selenium, is associated with increased levels of oxidative stress. Copper deficiency also has been shown to impair immune function. Previous work by others demonstrated that passage of an amyocarditic or myocarditic strain of coxsackievirus B3 (CVB3) through selenium- or vitamin E-deficient mice led to increased cardiac pathology. To determine whether a copper deficiency would similarly alter the pathogenesis of CVB3 infections, Swiss outbred dams and their litters were fed copper-deficient diets from birth and received either deionized water or water with 0.315 mmol/L copper as copper sulfate. At 4 wk of age, copper-adequate or -deficient male and female offspring were infected with an amyocarditic or myocarditic strain of CVB3. Heart titers were elevated at d 3 and 7 postinfection in copper-deficient mice infected with the myocarditic CVB3 strain (CVB3/20) but only at d 7 in deficient mice infected with the amyocarditic CVB3 strain (CVB3/0) compared with copper-adequate controls. Copper-deficient mice infected with either strain of CVB3 had increased cardiac pathology compared with copper-adequate controls. Genomic sequences of viruses isolated from copper-adequate and -deficient mice were identical. Heart cytokine expression was elevated in copper-deficient CVB3-infected mice compared with infected controls. Circulating CVB3specific IgG2a but not IgM levels were decreased in copper-deficient mice. Thus, copper deficiency is associated with an increased inflammatory response but decreased acquired immune response to CVB3 infection that results in increased cardiac pathology, presumably due to increased viral load.

Previous studies have shown that deficiencies in selenium (Se) and/or vitamin E (VE) can exacerbate the infectivity and pathogenesis of coxsackievirus B3 and influenza. Both Se and VE play a role in immune function and antioxidant defense. To determine whether these deficiencies would affect the normal course of infection with a metazoan parasite, mice were made deficient in Se and/or VE and inoculated with the gastrointestinal nematode parasite Heligmosomoides polygyrus. Both primary and secondary infections were assessed. Although the course of a primary infection with H. polygyrus was unaffected by diet, diets deficient in Se, VE, and both Se and VE (Se/VE double-deficiency) all caused delayed adult worm expulsion and increased fecundity during a secondary infection; suggesting an impaired intestinal response. H. polygyrus-induced IL-4 levels were diet-independent; but Se/VE double-deficiency blocked the H. polygyrus-induced IL-4 receptor-associated decrease in sodium-dependent glucose absorption in the jejunum that contributes to worm expulsion. In contrast, Se/VE double-deficiency had no effect on the infection-induced, IL-4R-associated increase in epithelial cell permeability that accompanies the infection. These results suggest that both Se and VE are required for specific IL-4-related changes in intestinal physiology that promote host protection against H. polygyrus. KEY WORDS: * selenium * vitamin E * parasite * immunity * gastrointestinal

Coming Out to Myself The paintings and photos found me: Greek gods, at first, then, in the pages of a play, an American one, Marlon Brando; next, as my sisters [...]

Carmine, a vivid crimson dye derived from the Mexican cochineal insect, is used to stain cell nuclei. chromosomes. or mucin by varying the mordant used. This study introduces antioxidants to the staining solution for cell nuclei to combat carmine's susceptibility to oxidation by air. Copper carmine is made by dissolving 0.8 g currie acetate monohydrate and 0.8 g carmine alum lake in 40 m! of water and adding 6 ml 28% ammonium hydroxide. 1 g glutathione and 500 mg vitamin C are added to prevent oxidation. The solution is stir]·ed 15 minutes and filtered through fast filter paper (Whatman #4). This solution keeps its staining efficacy undiminished for 3 weeks. Deparaffinized tissue sections are stained 10 min, differentiated 30 sec in 1% Hel in 70% ethanol, rinsed in water, dehydrated. cleared, and mounted. [ABSTRACT FROM AUTHOR]

Gold (I)-containing compounds, including aurothioglucose (ATG), are potent in vitro inhibitors of several selenocysteine-containing enzymes. Gold compounds have also been shown to potentiate the virulence of several viruses in mice, including coxsackievirus, implicated as a possible infectious agent in Keshan disease. One possible mechanism by which gold compounds may be increasing the virulence of viral infections in mice is by acting as a selenium antagonist in vivo and inducing oxidative stress. To investigate the possible role of gold compounds in inducing oxidative stress in mice, we assessed the ability of ATG administered in vivo to inhibit the activity of the selenocysteine-containing enzymes thioredoxin reductase (TR) and glutathione peroxidase (GPX1). Doses as low as 0.025 mg ATG/g body weight caused significant and prolonged inhibition of TR activity in all tissues examined. No such inhibition of GPX1 activity was seen, indicating differential in vivo sensitivity of the enzymes to inhibition by ATG. In liver and heart, some recovery of TR activity was observed after a 7-d period, but no recovery was observed in pancreas or kidney. Because TR is involved in several important cellular redox functions, its inhibition most likely will affect multiple cellular processes. These results indicate that in vivo administration of ATG results in significant and long-lasting inhibition of TR activity. Such inhibition of TR could lead to increased levels of oxidative stress in vivo, thereby increasing the virulence of several viruses including the coxsackievirus. KEY WORDS: thioredoxin reductase; glutathione peroxidase; aurothioglucose; selenium; mice