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Background : Quarantine is one of the most effective strategies to control outbreaks of communicable diseases. Individuals under isolation or quarantine experience both physical and mental effects. Therefore, given its widespread implementation around the world, it is pertinent to analyze this effect on physical and mental health. The psychosocial impact model, which divides four dimensions into two main points, exposure or protection and positive or negative responses, was used to analyze the psychosocial impact of quarantine. Objectives : The present study aimed to investigate the psychosocial impact of people exposed to or protected from quarantine. Methods : We conducted a search for primary articles in the Web of Science and Scopus databases, and after applying the inclusion and exclusion criteria, we meta-analyzed five of them. Results : Quarantined individuals were more likely to experience anxiety ( K = 4; OR = 2.62) and depressive symptoms ( K = 6; OR = 1.61) compared to those who did not undergo quarantine. Researchers discuss a twofold increase in the probability of anxiety or depression among those in quarantine. As a result, advancing interventions that reduce this impact is critical for both health and the global economy. Conclusions : In terms of economic variables, the non-moderation of GDP per capita and the moderation of the GINI index stand out, demonstrating that countries must move toward policies that promote the reconstruction of more resilient and inclusive societies.