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This paper summarized the nursing management for a case of hyperemesis gravidarum treated by acupoint pressing combined with acupoint Application of Traditional Chinese Medicine (TCM). Key issues of nursing mainly included acupoint selection, pressing technique, Chinese herbal medicine ointment making and precautions during treatment. In addition, life guidance, diet care, social support and psychological intervention were carried out jointly to reduce the frequency of vomiting and improve patient’s quality of life. (本文总结穴位按压联合中药穴位贴敷治疗1例妊娠剧吐患者的护理经验, 主要包括取穴、穴位按压、中药药膏调制以及注意事项等, 同时配合生活指导、饮食调护、社会支持、心理干预等护, 减少患者呕吐次数, 提升患者生活质量。)

Primary cutaneous aspergillosis (PCA) is a rare opportunistic infection caused by Aspergillus that can be life‐threatening. PCA is mainly reported in immunocompromised hosts such as patients with AIDS, those with hematologic malignancy, or infants with occlusive dressings. However, no study has previously reported PCA associated with toxic epidermal necrolysis (TEN). This study reports four cases of TEN complicated with PCA, presenting with discrete gray or black spots over newly formed epithelia. Risk factors of PCA in patients with TEN include host factors, iatrogenic factors, indoor environment, and wound care. Two of the four cases eventually died, highlighting the importance of further exploring PCA in patients with TEN. [ABSTRACT FROM AUTHOR]

Kimura's disease, also known as eosinophilic hyperplastic lymphogranuloma, is a benign chronic lymphoproliferative inflammatory disorder with unknown etiology. Due to its rare and high recurrence rate, there is currently no consensus on the optimal treatment approach. Currently, traditional treatment for this condition mainly including glucocorticoids, surgery and radiotherapy. In recent years, the rapid development of biologies and small molecule drugs has provided new options for this disease. This article reviews the treatment of Kimura' s disease and its recent advancements. [ABSTRACT FROM AUTHOR]

Background: Chromoblastomycosis is the World Health Organization (WHO)-recognized fungal implantation disease that eventually leads to severe mutilation. Cladophialophora carrionii (C. carrionii) is one of the agents. However, the pathogenesis of C. carrionii is not fully investigated yet. Methods: We investigated the pathogenic potential of the fungus in a Galleria mellonella (G. mellonella) larvae infection model. Six strains of C. carrionii, and three of its environmental relative C. yegresii were tested. The G. mellonella model was also applied to determine antifungal efficacy of amphotericin B, itraconazole, voriconazole, posaconazole, and terbinafine. Results: All strains were able to infect the larvae, but virulence potentials were strain-specific and showed no correlation with clinical background of the respective isolate. Survival of larvae also varied with infection dose, and with growth speed and melanization of the fungus. Posaconazole and voriconazole exhibited best activity against Cladophialophora, followed by itraconazole and terbinafine, while limited efficacy was seen for amphotericin B. Conclusion: Infection behavior deviates significantly between strains. In vitro antifungal susceptibility of tested strains only partly explained the limited treatment efficacy in vivo. [ABSTRACT FROM AUTHOR]

Steady-state interfacial waves under a one-dimensional (1-D) class-IV exact triad resonance are investigated in a two-layer fluid with a free surface upper boundary. Four groups (G1–G4) of convergent series solutions are obtained by the homotopy analysis method. Though the harmonic resonance conditions are contained in the class-IV resonance criteria, the influences of 1:2 harmonic resonances on the energy spectrum could be neglected. Unlike former steady-state resonant interfacial wave spectrum where all the components joining the resonance are significant, the energy of one primary component can be ignored for two groups (G2 and G4) of wave solutions obtained in this paper. It is found that a little energy induced from the external environment might greatly change the energy spectrum for G1. However, the energy introduced from the outside cannot vary the wave energy distribution for G2. The reason for the extremely high crests on the instantaneous profiles of free surfaces of G2 and G4 is that the peaks of the class-IV exactly resonant and some trivial components momentarily overlap at some special horizontal positions. The class-IV exact triad resonance curve could be divided into four pieces containing the existence ranges of G3 and G4 and two regions with no solution found. One of the regions without convergent solutions results from an infinite number of singularities or small divisors caused by infinite exact or near resonances. Our results indicate that steady-state interfacial waves with class-IV triad resonance interactions among one surface and two internal wave modes could exist. [ABSTRACT FROM AUTHOR]

Introduction: The emergence of resistance in Trichophyton rubrum to azoles and terbinafine has become increasingly evident in recent years, necessitating the development of novel antifungal drugs and the exploration of new indications for existing agents.Methods: In this study, we retrospectively evaluated the in vitro antifungal activity of 3 echinocandins (anidulafungin, caspofungin, and micafungin) against 73 clinical isolates of T. rubrum collected from a teaching hospital in Shanghai, China, using EUCAST E.DEF 9.3.1 with minor modification. We also reviewed the susceptibility of T. rubrum to echinocandins globally by literature searching.Results: Our findings revealed that micafungin exhibited the lowest modal minimum effective concentration (MEC) value (0.08 mg/L, n = 28) and the lowest geometric mean (GM) MEC value (0.014 mg/L) among the 73 isolates of T. rubrum tested, followed by anidulafungin with a modal MEC value of 0.016 mg/L (n = 67) and a GM of 0.018 mg/L. Caspofungin displayed a higher modal MEC value of 0.5 mg/L (n = 35) and a GM of 0.308 mg/L. Despite variations in methodologies, similar results were obtained from the review of five relevant studies included in our analysis.Discussion: Echinocandins exhibited excellent in vitro activity against T. rubrum isolates, with micafungin and anidulafungin demonstrating greater potency than caspofungin. These findings suggest that echinocandins could be considered as potential treatment options for managing recalcitrant dermatophytoses resulting from the emergence of resistance. However, it is important to note that the clinical efficacy of these in vitro findings has yet to be established and warrants further investigation. [ABSTRACT FROM AUTHOR]

Two new oleanane-type triterpene glycosides, phytolasides A (1) and B (2), and six known ones (3–8), were isolated from Phytolacca acinosa fruit fermentation broth. Their structures were elucidated by HR-ESI-MS and 1 D- and 2 D-NMR spectroscopic methods. Antiproliferation of compounds 1 and 2 against HepG2 cells was examined by using CCK8 assays. [ABSTRACT FROM AUTHOR]

Aim/Background: We investigated the composition and structure of intracellular polysaccharides in cucumber seeds (CSs) and their effect on Sprague-Dawley (SD) rats and potential activity for fracture healing. Materials and Methods: Polysaccharides are its main water-soluble active ingredient. The SD rat tibia fracture model was established by surgical method, and the healing effect of cucumber seed polysaccharides (CSPs) on SD rat tibia fracture was preliminarily explored. Through histopathological observation, determination of rat serum indicators alkaline phosphatase (AKP), acid phosphatase (ACP), BGP, X-ray imaging observation, and micro-Computed Tomography (CT) imaging observation at different periods. Results and Conclusion: The results showed that CSP enhanced the activity of osteoblasts, increased the metabolic rate of osteoclasts, increased the secretion of AKP, BGP, and ACP, shortened the fracture healing time of SD rats and effectively promoted the healing of tibial fractures in SD rats. [ABSTRACT FROM AUTHOR]

Because of the risks existing in supply chain finance, taking accounts receivable factoring business as the research object, this paper uses the evolutionary game method to analyzes the factors affecting the decision-making of the participants in supply chain finance, constructs an evolutionary game model between small and medium-sized enterprises and financial institutions, and analyzes the mechanism of blockchain to solve the financial risks of the supply chain by comparing the changes of evolutionary stability strategies before and after the introduction of blockchain technology. This paper aims to reduce financing risks by analyzing the mechanism of blockchain technology in supply chain finance. It is found that, firstly, blockchain technology can reduce the credit risk of financial institutions and solve financing problem. Credit risk plays a decisive role in whether financial institutions accept financing business decisions. Blockchain technology can reduce the operational risk of financial institutions and improve the business income of financial institutions. Secondly, the strict regulatory environment formed by blockchain technology makes the default behavior of small and medium-sized enterprises and core enterprises in a high-risk state at all times. No matter the profit distribution proportion that small and medium-sized enterprises can obtain through collusion, they will not choose to default, which effectively solves the paradox that small and medium-sized enterprises cannot obtain loans from financial institutions despite the increased probability of compliance. Then, the evolutionary game between financial institutions and small and medium-sized enterprises is balanced in that financial institutions accept business applications, small and medium-sized enterprises abide by the contract, and the convergence effect is better. Therefore, blockchain technology not only reduces the financing risk of financial institutions but also helps to solve the financing problems of small and medium-sized enterprises. [ABSTRACT FROM AUTHOR]

Background: Trichophyton rubrum, an important aetiological agent of superficial dermatophytosis, occasionally penetrates into deeper tissues, causing inflammation and a granulomatous response. Only few case reports of T. rubrum granuloma with molecular evidence for autoinoculation have been published. Objectives: To find the genetic basis of adaptation to a different microhabitat following autoinoculation of Trichophyton rubrum. Methods: A case of Majocchi's granuloma is reported, with isolation of T. rubrum strains from foot and chin, respectively. Whole‐genome sequencing of the two strains has been performed. Phylogenetic reconstruction and SIFT analysis were conducted. Results: A phenotypic difference has been observed between the two isolates. 20 and 19 indels, 8 and 15 SNVs were found in foot and chin strains, respectively. Foot and chin strains formed a monophyletic group. Two non‐synonymous mutations of chin strains were observed in the TERG_06754 gene encoding cytochrome c peroxidase (CCP). The G293C amino acid change in TERG_03373 was predicted to affect protein function significantly. The mutated amino acid (cysteine) was only found in the chin strain in all dermatophyte non‐redundant sequences. Conclusions: Non‐synonymous mutations located in TERG_06754 and TERG_03373 were predicted to affect protein functions, which may facilitate the adaption for invasion of the superficial cutaneous strain. As the different living environments of these two strains (oxygenous, lower‐temperature for the pedal strain; hypoxia, higher‐temperature for the chin strain), a stratum corneum‐to‐dermal adaption hypothesis of T. rubrum was proposed. [ABSTRACT FROM AUTHOR]

Daturataturin A (DTA), a withanolide compound in Datura metel L., exhibits excellent anti‐inflammatory and anti‐proliferative activities. Here, we report the study of DTA‐induced proliferation and inflammation in human immortalized keratinocytes (HaCaTs) and the associated molecular mechanisms. HaCaTs are a model of the epidermal proliferative state of cells. The pharmacodynamics and mechanism of DTA were studied by western blot, immunofluorescence, apoptosis and proliferation detection, and real‐time quantitative polymerase chain reaction. We confirmed that DTA induced HaCaT autophagy, which, in turn, induced HaCaT senescence and, ultimately, led to cell cycle arrest. DTA also negatively regulated inflammation through the activation of autophagy. This may be one of the mechanisms underlying the action of Datura metel L. preparation used for the treatment of psoriasis. [ABSTRACT FROM AUTHOR]

Abstract: Pressure ulcer formation depends on various factors among which repetitive ischaemia/reperfusion(I/R) injury plays a vital role. Molecular hydrogen (H2) was reported to have protective effects on I/R injuries of various internal organs. In this study, we investigated the effects of H2 inhalation on pressure ulcer and the underlying mechanisms. H2 inhalation significantly reduced wound area, 8‐oxo‐dG level (oxidative DNA damage) and cell apoptosis rates in skin lesions. H2 remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up‐regulating expression of Nrf2 and its downstream components in wound tissue and/or H2O2‐treated endothelia. Meanwhile, H2 inhibited the overexpression of MCP‐1, E‐selectin, P‐selectin and ICAM‐1 in oxidant‐induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF‐α, IL‐1, IL‐6 and IL‐8) production in the wound. Furthermore, H2 promoted the expression of pro‐healing factors (IL‐22, TGF‐β, VEGF and IGF1) and inhibited the production of MMP9 in wound tissue in parallel with acceleration of cutaneous collagen synthesis. Taken together, these data indicated that H2 inhalation suppressed the formation of pressure ulcer in a mouse model. Molecular hydrogen has potentials as a novel and alternative therapy for severe pressure ulcer. The therapeutic effects of molecular hydrogen might be related to its antioxidant, anti‐inflammatory, pro‐healing actions. [ABSTRACT FROM AUTHOR]

In this paper, ABAQUS is used to establish a 3D finite element analysis model and to analyze the fire performance of steel-concrete composite structures. A thermo-mechanical coupling constitutive model of steel considering high temperature creep, and a thermo-mechanical coupling constitutive model of concrete considering transient thermal strain and short-term high temperature creep were adopted. The temperature field and fire resistance of concrete-filled steel tubular (CFT) columns, steel-concrete composite beams, joints and single-story composite plane frames under fire were analyzed, and the calculated results were verified by experimental results. On this basis, a three-story an three-bay steel-concrete composite plane frame model was established and ABAQUS was used to investigate two failure modes of the plane frame under local fire. Fire resistance of the plane frame, deformation of beams and columns, and internal force at column base were studied to discuss the necessity of considering the influence on frame beam fire performance from the interaction between concrete slab and steel beam. Under beam failure mode, fire performance was compared among frame beam, simply supported beam and fixed beam. Under column failure mode, fire performance was compared between CFT frame columns and CFT single columns with fixed ends. The analytical results show that under beam failure mode, considering the interaction between steel beam and concrete slab can make full use of its fire performance for the steel-concrete composite beams; fire performance of frame beam is superior to that of simply supported beam and is slightly lower than that of fixed beam; under column failure mode, with two sides suffered from fire, the fire performance of CFT single side columns is superior to the rest of frame side columns, yet with both two and four sides suffering fire, the fire performance of CFT single columns is close to that of frame interior columns. [ABSTRACT FROM AUTHOR]

The flexible operation of thermal power plant has become a research hotspot for its safety and validity in eliminating power grid fluctuation from large-scale integration of renewable energy. Heat-power decoupling is effective technique to promote flexibility of combined heat and power plant. To address the insufficient dynamics investigation of combined heat and power plant under different heat-power decoupling strategies, an adaptive modeling approach is proposed. This method systematically fuses the mechanism analysis and data-driven fuzzy modeling to prepare for the controller design for rapid and deep load regulation in flexible operation. Firstly, the model structures with unknown parameters are determined by mechanism analyses to reflect the effects of various decoupling techniques on the characteristics of plant. Secondly, in view of the on-site data under wide load operation conditions, corresponding model structure is adaptively matched, and a new Takagi–Sugeno fuzzy modeling scheme depend on biquantum pigeon optimization algorithm is constructed for model parameters acquisition. The effectiveness of the proposed approach is illustrated based on a 350 MW supercritical combined heat and power unit. Simulation results illustrate that the adopted method can rapidly characterize dynamics of plant under different heat-power coupling conditions. All the model identification and verification errors in wide load operation conditions are less than 3.1% plant output, which reveals high modeling precision more than 97%. Thus, the established model provides solid foundation on highly matched controller for ensuring operational flexibility. • A modeling approach fusing mechanism analysis and T-S fuzzy modeling is constructed. • Various heat-power decoupling technics are considered in modeling of CHP plant. • Biquantum pigeon optimization algorithm is proposed for parameter identification. • Model effectiveness under two different heat-power coupling conditions is verified. [ABSTRACT FROM AUTHOR]

In China, Hordei Fructus Germinatus (HFG) is the germinated and dried fruit of Hordeum vulgare L , which is commonly used in clinical Chinese medicine. Traditional Chinese Medicine (TCM) theory holds that HFG can be both medicinal and edible, which means that it is derived from food medicine. Raw HFG and roasted HFG are used to treat hypogalactia, hyperprolactinemia and indigestion. In recent years, the lactogenic and galactophygous effects of HFG have attracted increasing attention. Nevertheless, there is much confusion over the use of raw and processed HFG, and the mechanism of its lactogenic effect seems remains poorly understood. This study aimed to explore the lactogenic effect of raw HFG and roasted HFG on rats with overloaded lactation and to reveal the underlying molecular mechanism. Raw and processed HFG water decoctions were given to overloaded lactation model rats at a dose of 1.7800 g kg−1·d−1, and the control group was given the same volume of water. The lactogenic effect of raw and processed HFG was evaluated by measuring daily lactation, body weight and pup body weight, serum PRL, E2, and GH contents after parturition, and the pathological characteristics of mammary tissue sections. cDNA microarrays can be used to screen diverse gene expression patterns and signaling pathways related to prolactin. The expression of relevant differentially expressed genes was verified by real-time PCR and western blotting. In vivo experiments demonstrated that the raw HFG water decoction stimulated mammogenesis, accelerated the transformation of the lobular acinar system, resulted in denser mammary epithelial cells and thicker glandular ducts that were full of milk and facilitated the secretion of milk. Moreover, HFG increased PRL, E2, and GH levels, pup body weight, daily lactation and the body weight of lactating rats. Following gene chip identification, KEGG pathway enrichment analysis revealed genes that were highly related to prolactin in the prolactin signaling pathway and JAK-STAT signaling pathway, and the main differentially expressed genes were Jak2 (down), Stat5α (up), cyclin D1 (up), SOCS1 (up), CISH (down) and PRLR (up). Compared with the control group, RT-PCR results indicated that Jak2 and CISH were downregulated and that Stat5α, cyclin D1, SOCS1 and PRLR were upregulated. Western blot assays showed that PRLR, STAT5α and cyclin D1 levels in the mammary glands of the raw HFG water decoction group were significantly increased, which was consistent with the results of cDNA microarray screening. The present study reveals that raw HFG effectively enhances lactation in rats, possibly by influencing the prolactin/JAK-STAT signaling pathway. Image 1 [ABSTRACT FROM AUTHOR]

Rubella virus-associated granulomas commonly occur in immunocompromised individuals, exhibiting a diverse range of clinical presentations. These manifestations can vary from predominantly superficial cutaneous plaques or nonulcerative nodules to more severe deep ulcerative lesions, often accompanied by extensive necrosis and significant tissue destruction. TAP1 deficiency, an exceedingly rare primary immune-deficiency disorder, presents with severe chronic sino-pulmonary infection and cutaneous granulomas. This report highlights the occurrence of rubella virus-associated cutaneous granulomas in patients with TAP1 deficiency. Notably, the pathogenic mutation responsible for TAP1 deficiency stems from a novel genetic alteration that has not been previously reported. This novel observation holds potential significance for the field of diagnosis and investigative efforts in the context of immunodeficiency disorders., Competing Interests: Author JY was employed by the company Vision Medicals Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Su, Han, Yang and Lin.)

Background: Negative emotions are a major comorbidity of atopic dermatitis (AD). Evidence that supports the effectiveness of digital cognitive behavioral therapy (dCBT) as an adjuvant therapy for AD remains limited., Objective: To investigate the preliminary efficacy of additional dCBT and potential neurotransmitter biomarkers for AD accompanied by negative emotions., Methods: Thirty-two patients with AD were recruited and examined for clinical severity and negative emotions including insomnia, anxiety, and depression. Patients with mild-to-moderate negative emotions were divided into two groups that received standard care (N = 9) or mobile app-delivered CBT plus standard care (N = 11) for 12 weeks. Plasma levels of 40 neurotransmitters were determined using liquid chromatography tandem mass spectrometry pre- and post-treatment., Results: Skin lesions, itch, and insomnia were significantly improved in both treatment groups. Improvements of itch (P = 0.0449) and insomnia (P = 0.0089) were more robust in the combination treatment group than those in the standard treatment group. Neurotransmitters that involve tryptophan, dopamine, and histidine pathways were markedly altered in patients with AD compared with healthy controls. Taurine levels were selectively increased following dCBT plus standard care (P = 0.0259). Baseline levels of L-tyrosine were negatively correlated with the reduction of skin lesions (r = -0.9073, P = 0.0334) and itch intensity (r = -0.9322, P = 0.0210) in the combination therapy group., Conclusions: dCBT provides an efficacious supplementary approach for AD accompanied by negative emotions. Emotion-related neurotransmitters may contribute to AD and serve as indicators for treatment effects.

Triazole resistance in A. fumigatus is an increasing worldwide problem that causes major challenges in the management of aspergillosis. New antifungal drugs are needed with novel targets, that are effective in triazole-resistant infection. In this study, we retrospectively evaluated potency of the novel drug olorofim compared to contemporary antifungal agents against 111 clinical A. fumigatus isolates collected from Huashan Hospital, Shanghai, China, using EUCAST methodology, and reviewed the literature on triazole resistant A. fumigatus published between 1966 and 2020 in China. Olorofim was active in vitro against all tested A. fumigatus isolates with MIC 90 of 0.031mg/L (range 0.008-0.062 mg/L). For 4 triazole-resistant A. fumigatus (TRAF) isolates, the olorofim MIC ranged between 0.016-0.062mg/L. The reported rates of TRAF in China is 2.5% - 5.56% for clinical isolates, and 0-1.4% for environmental isolates.TR 34 /L98H/S297T/F495I is the predominant resistance mechanism, followed by TR 34 /L98H. Non TR-mediated TRAF isolates, mostly harboring a cyp51A single point mutation, showed greater genetic diversity than TR-mediated resistant isolates. Resistance due toTR 34 /L98H and TR 34 /L98H/S297T/F495I mutations among TRAF isolates might have evolved from separate local isolates in China. Continuous isolation of TRAF in China underscores the need for systematic resistance surveillance as well as the need for novel drug targets such as olorofim., (Copyright © 2021 Su et al.)

Aims: HIF1-α is an important transcription factor in the regulation of the immune response. The protective function of HIF1-α in the host epithelial immune response to Aspergillus fumigatus requires further clarification. Methods: In this study we demonstrated the effect of upregulation of HIF1-α expression in A549 cells and mouse airway cells exposed to A. fumigatus in vivo . Results: The killing capacity was enhanced by boosting proinflammatory factors both in vitro and in vivo . Moreover, airway inflammation was reduced in the HIF1-α-upregulated mice. Conclusion: We identified a protective role for HIF1-α in anti- A. fumigatus immunity. Modulation of HIF1-α might be a target for the development of aspergillosis therapy.

The Trichophyton rubrum species complex comprises commonly encountered dermatophytic fungi with a worldwide distribution. The members of the complex usually have distinct phenotypes in culture and cause different clinical symptoms, despite high genome similarity. In order to better delimit the species within the complex, molecular, phenotypic, and physiological characteristics were combined to reestablish a natural species concept. Three groups, T. rubrum , T. soudanense , and T. violaceum , could be distinguished based on the sequence of the internal transcribed spacer (ITS) ribosomal DNA barcode gene. On average, strains within each group were similar by colony appearance, microscopy, and physiology, but strains between groups showed significant differences. Trichophyton rubrum strains had higher keratinase activity, whereas T. violaceum strains tended to be more lipophilic; however, none of the phenotypic features were diagnostic. The results of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and amplified fragment length polymorphism (AFLP) were partially consistent with the ITS data but failed to distinguish the species unambiguously. Despite their close similarity, T. violaceum , T. soudanense , and T. rubrum can be regarded as independent species with distinct geographical distributions and clinical predilections. Trichophyton soudanense is pheno- and genotypically intermediate between T. rubrum and T. violaceum For routine diagnostics, ITS sequencing is recommended., (Copyright © 2019 Su et al.)

Aim: Aspergillus fumigatus is one of the most common opportunistic fungi that can cause invasive infection. To profile the kinetic variation of immune cells and cytokines after exposure to A. fumigatus thoroughly, we established a pulmonary A. fumigatus infection model in temporarily immunosuppressed mice. Materials & methods: Systematic and kinetic studies of different immune cells and cytokines were performed. Results: We observed that the granulocytes and macrophages recruited to the site of infection played an important role in the infectious phase. There was a significant increase in the cytokines IFN-γ, IL-6, TNF-α as well as the chemokines CXCL1, MIP-1α, MIP-2 and CCL5 after infection. IL-10 was found to participate in balancing the anti-inflammatory response in the recovery phases. The immune response mediated by T cells was mainly presented by the Th1-type on day 7 after exposure with a high proportion of IFN-γ + CD4 + T cells and CD4 + CD44 high CD62L low effector T cells. Conclusion: These kinetic parameters of the immune response might provide diagnostic clues for A. fumigatus infection.

Polydopamine capsule has aroused wide attention since its emergence, because of its biocompatibility and the great potential as drug delivery carrier. However, preparing the nanometer PDA capsule (PDAC) is still remained a challenge, especially with the size below 300 nm. Moreover, there is little research about its photoacoustic imaging (PAI) and photothermal therapy (PTT) effect. In this paper, we reported an improved DMDES emulsion template method to obtain 200 nm PDAC, and act as highly efficient theranostic agent for photoacoustic imaging (PAI) and chemo-photothermal synergistic therapy. Due to its hollow structure and the higher photothermal conversion efficiency (η), the PDAC showed excellent PAI ability as its PA intensity was far outweigh the PBS and over two folders than the same size polydopamine particles (PDAP) at the same concentration in vitro. The animal experiment also verified this conclusion. Then the anticancer drug-doxorubicin (DOX) was loaded on PDAC via electrostatic interaction and π-π stacking. Moreover, the drug release was pH responsive and NIR laser responsive to minimize the side effect, and this system was proved to efficiently ablate the tumor in vitro and in vivo experiments. This research highlights the great potential of PDA capsule as a new theranostic agent.