15 results on '"Takahiro Tokuda"'
Search Results
2. Predictors of recurrence based on intravascular ultrasound findings after Eluvia placement in symptomatic peripheral arterial disease: A retrospective study
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Takehiro Yamada, Takahiro Tokuda, Naoki Yoshioka, Akio Koyama, Ryusuke Nishikawa, Kiyotaka Shimamura, and Takuma Aoyama
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endovascular therapy ,lower extremity artery disease ,polymer‐coated paclitaxel‐eluting stent ,predictor ,Medicine - Abstract
Abstract Background and Aims Polymer‐coated drug‐eluting stents (Eluvia) have shown favorable clinical outcomes in real‐world registries. There are no reports on recurrent predictors after Eluvia placement based on intravascular ultrasound (IVUS) findings. Methods We analyzed clinical data from the ASIGARU PAD registry, a retrospective, multicenter, observational study that enrolled patients who underwent endovascular therapy for superficial femoral and proximal popliteal arteries lesions using Eluvia or drug‐coated balloon. The primary outcome was the identification of recurrent predictors, including IVUS parameters at 12 months. The rate of target lesion recurrence was also assessed. Results IVUS images were obtained in 54 of 65 cases. Seven recurrent cases (13.0%) were observed within 12 months. The random survival forest method presented eight predictive variables of recurrence: Clinical Frailty Scale (CFS), distal stent edge area, distal plaque burden, age, sex, distal external elastic membrane (EEM) area, minimum stent area (MSA), and distal lumen area. Furthermore, the partial dependence plot showed that frailty (CFS ≥ 6), smaller distal stent edge area, higher and lower distal plaque burden, older and younger age, female sex, smaller distal EEM area, smaller MSA, and smaller and larger distal lumen area predicted recurrence after Eluvia placement within 12 months. Conclusion CFS, distal stent edge area, distal plaque burden, age, sex, distal EEM area, MSA, and distal lumen area were significant recurrent predictors after Eluvia placement.
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- 2023
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3. External iliac artery pseudoaneurysm following treatment for arterio-ureteral fistula using a balloon-expandable stent-graft: A case report
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Naoki Yoshioka, MD, Kensuke Takagi, MD, Takahiro Tokuda, MD, Yasuhiro Morita, MD, and Itsuro Morishima, MD, PhD
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Pseudoaneurysm ,Stent-graft ,Arterio-ureteral fistula ,Infection ,Graft migration ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Sepsis and bleeding can lead to life-threatening complications, such as stent-graft infection and pseudoaneurysm, after stent-graft implantation. An 83 year-old woman was admitted to our hospital for sepsis 14 months after treatment with a balloon-expandable stent-graft for an arterio-ureteral fistula (AUF) between the right external iliac artery and the right ureter. Blood cultures were positive for methicillin-resistant Staphylococcus aureus and Candida tropicalis. A giant infectious pseudoaneurysm (44 × 70 mm) at the distal edge of the stent-graft was suspected of having caused the sepsis. Although endovascular therapy (EVT) was planned to correct the pseudoaneurysm, the right iliac artery spontaneously became occluded from the ostium of the right common iliac artery to the common femoral artery 5 days after diagnosing the pseudoaneurysm; hence, EVT was not performed. Antibiotic administration was continued, and blood culture results were negative. Although EVT using a stent graft for AUFs is effective, data on the chronic phase outcomes are limited. Therefore, patients with AUFs treated using stent-grafts should be carefully followed up.
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- 2021
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4. Impact of arm circumference on clinical outcomes in patients undergoing transcatheter aortic valve replacement
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Kenichi Shibata, Masanori Yamamoto, Masataka Kameshima, Hiroaki Fujiyama, Taisei Sano, Ai Kagase, Takahiro Tokuda, Yuya Adachi, Ryo Yamaguchi, Tetsuro Shimura, Naoki Iritani, Kazuma Murase, and Yutaka Koyama
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Arm circumference ,Transcatheter aortic valve replacement ,Clinical outcomes ,Japanese ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Although Arm circumference (AC) is considered to be a predictor of clinical outcomes of transcatheter aortic valve replacement (TAVR), limited data are available on the impact of this anthropometric measurement. This study aimed to investigate the clinical impact of AC on the outcomes of patients who underwent TAVR. Methods: AC was investigated in consecutive patients who underwent TAVR between March 2014 and May 2018. Patients were divided into low AC (n = 220) and high AC (n = 127) groups by a classification and regression tree (CART) survival model, and their baseline characteristics and mortality were compared. The correlations of AC with other frailty markers were also evaluated. Results: One-year clinical follow-up was completed in 100% of cases, and 89 patients (31 men, 58 women) died during the median follow-up period of 825 days. The low AC group was more fragile than the high AC group, and the AC value was significantly correlated with each frailty marker (all p
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- 2022
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5. Clinical Outcomes of Subcutaneous and Visceral Adipose Tissue Characteristics Assessed in Patients Underwent Transcatheter Aortic Valve Replacement
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Kenichi Shibata, PT, Masanori Yamamoto, MD, Sumio Yamada, PT, Toshihiro Kobayashi, RT, Satoshi Morita, RT, Ai Kagase, MD, Takahiro Tokuda, MD, Testuro Shimura, MD, Tatsuya Tsunaki, RT, Norio Tada, MD, Toru Naganuma, MD, Motoharu Araki, MD, Futoshi Yamanaka, MD, Shinichi Shirai, MD, Kazuki Mizutani, MD, Minoru Tabata, MD, Hiroshi Ueno, MD, Kensuke Takagi, MD, Akihiro Higashimori, MD, Yusuke Watanabe, MD, and Kentaro Hayashida, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Adipose tissue (AT) characteristics are considered to be a marker for predicting clinical outcomes. This study aimed to investigate the prognostic value of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) computed tomography (CT) assessment in patients who underwent transcatheter aortic valve replacement (TAVR). Methods: We used the Japanese multicentre registry data of 1372 patients (age: 84.5 ± 5.0 years, women: 70.6%) who underwent TAVR. The SAT and VAT were assessed according to the preprocedural CT area and density. Baseline characteristics and clinical outcomes were compared based on the differences in AT characteristics. The independent associations with all-cause mortality after TAVR were evaluated according to the CT area and density of AT. Results: Low-volume area of SAT and VAT was associated with worse clinical outcomes compared with high-volume area of SAT and VAT in patients who underwent TAVR (log-rank test P = 0.016 and P = 0.014). High CT density of SAT and VAT was associated with increasing mortality in comparison with low CT density of SAT and VAT (log-rank test P < 0.001 and P = 0.007). The Cox regression multivariate analysis demonstrated the independent association of increased all-cause mortality in the high SAT and VAT density (hazard ratio [HR]: 1.41, 95% confidence interval [CI]: 1.06-1.88, P = 0.019, and HR: 1.34, 95% CI: 1.03-1.76, P = 0.031, respectively), but not in the low SAT and VAT area (HR: 0.85, 95% CI: 0.74-1.29, P = 0.85, and HR: 0.78, 95% CI: 0.60-1.03, P = 0.085, respectively). Conclusions: CT-derived AT characteristics, particularly the qualitative assessments, were useful for predicting the prognosis in patients after TAVR. Résumé: Introduction: Les caractéristiques du tissu adipeux (TA) sont considérées comme un marqueur de la prédiction des résultats cliniques. La présente étude avait pour objectif d’examiner la valeur pronostique de l’évaluation par tomodensitométrie (TDM) du tissu adipeux sous-cutané (TASC) et du tissu adipeux viscéral (TAV) des patients qui subissaient un remplacement valvulaire aortique par cathéter (RVAC). Méthodes: Nous avons utilisé les données du registre multicentrique japonais de 1 372 patients (âge : 84,5 ± 5,0 ans, femmes : 70,6 %) qui subissaient un RVAC. Nous avons évalué le TASC et le TAV selon la surface et la densité à la TDM préinterventionnelle. Nous avons comparé les caractéristiques initiales et les résultats cliniques en nous basant sur les différences dans les caractéristiques du TA. Nous avons évalué les associations indépendantes à la mortalité toutes causes confondues après le RVAC selon la surface et la densité du TA à la TDM. Résultats: La surface de faible volume du TASC et du TAV était associée à de plus mauvais résultats cliniques que la surface de grand volume du TASC et du TAV chez les patients qui subissaient le RVAC (test logarithmique par rangs P = 0,016 et P = 0,014). La densité du TASC et du TAV à la TDM était associée à l’augmentation de la mortalité en comparaison d’une faible densité du TASC et du TAV à la TDM (test logarithmique par rangs P < 0,001 et P = 0,007). L’analyse multivariée selon le modèle de régression de Cox démontrait l’association indépendante de l’augmentation de la mortalité toutes causes confondues lors de densité élevée du TASC et du TAV (rapport de risque [RR] 1,41, intervalle de confiance [IC] à 95 %, 1,06-1,88, P = 0,019, et RR 1,34, IC à 95 %, 1,03-1,76, P = 0,031, respectivement), mais non lors de faible surface du TASC et du TAV (RR 0,85, IC à 95 %, 0,74-1,29, P = 0,85, et RR 0,78, IC à 95 % : 0,60-1,03, P = 0,085, respectivement). Conclusions: Les caractéristiques du TA acquises par TDM, particulièrement les évaluations qualitatives, étaient utiles à la prédiction du pronostic des patients après le RVAC.
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- 2021
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6. Characteristics and Health Risks of Particulate Polycyclic Aromatic Hydrocarbons and Nitro-polycyclic Aromatic Hydrocarbons at Urban and Suburban Elementary Schools in Shanghai, China
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Lulu Zhang, Takahiro Tokuda, Lu Yang, Quanyu Zhou, Xuan Zhang, Wanli Xing, Qing Wu, Zhijun Zhou, Renjie Chen, Takayuki Kameda, Akira Toriba, Kazuichi Hayakawa, and Ning Tang
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children ,fine particles ,vehicle emission ,coal combustion ,toxicity equivalent factor ,exposure parameter ,inhalation cancer risk ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 - Abstract
PM2.1 was collected at urban and suburban elementary schools in Shanghai during two sampling periods in cold and warm seasons in 2007. Nine polycyclic aromatic hydrocarbons (PAHs) and ten nitro-polycyclic aromatic hydrocarbons (NPAHs) in PM2.1 were determined. During both seasons, the concentrations of PAHs and NPAHs at urban and suburban schools were not significantly different (p>0.05) and were higher in the cold period than in the warm period. According to the diagnostic ratios, PAHs and NPAHs at both schools were subject to the mixed effects of vehicle emission and coal combustion during both periods. Moreover, the results of the backward trajectory showed that PAHs and NPAHs were more susceptible to external polluted air masses in the cold period. At both urban and suburban schools, the inhalation cancer risk of PAHs and NPAHs in PM2.1 for children during elementary period was dozens of times of the acceptable risk level regulated by the U.S.EPA, highlighting the adverse impact of exposure to PAHs and NPAHs on the healthy development of children.
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- 2019
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7. Clinical performance of polymer-coated paclitaxel-eluting stent implanted for diffuse and calcified superficial femoral artery stenotic lesions: Insights from a patient on hemodialysis
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Naoki Yoshioka, Kensuke Takagi, Takahiro Tokuda, Yasuhiro Morita, and Itsuro Morishima
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Medicine (General) ,R5-920 - Abstract
In recent years, various devices have been approved for peripheral artery disease with femoropopliteal lesions. However, treatment of long, calcified, and diffused lesions is still challenging because these lesions are associated with restenosis. This report described the case of an 82-year-old man with bilateral severely calcified and diffused long lesions in the superficial femoral artery that was treated using polymer-coated paclitaxel-eluting stent and interwoven nitinol stent. After 6 months, in-stent restenosis was observed at the implantation site of the interwoven nitinol stents. Polymer-coated paclitaxel-eluting stents were deployed at the in-stent restenosis site. After another 6 months, angiography and intravascular ultrasound imaging revealed no restenosis at the polymer-coated paclitaxel-eluting stent site. Optical coherence tomography was also performed, revealing that the stent struts were well covered by neointima, which was very thin at approximately 0.1 mm. This representative case demonstrated substantial differences in the effects of devices; in other words, the superiority of polymer-coated paclitaxel-eluting stent in treating long, diffuse, and calcified lesions indicated that its implantation is a reasonable option when the initial gain was obtained following sufficient vessel preparation.
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- 2021
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8. Midterm Clinical Impacts of Biodegradable Polymer Everolimus-Eluting Stents Compared with Durable Polymer Everolimus-Eluting Stents: A 3-Year Propensity-Matched Study
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Hiroaki Matsuda, Ai Kagase, Takahiro Tokuda, Yusuke Ochiumi, Akira Murata, Yoriyasu Suzuki, and Tatsuya Ito
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objectives. Our aim was to evaluate the safety and efficacy of biodegradable polymer everolimus-eluting stents (BP-EES) compared with durable polymer everolimus-eluting stents (DP-EES) in midterm. Background. There are few data about midterm clinical outcomes of BP-EES compared with DP-EES. Methods and Results. Between January 2016 and December 2017, 395 consecutive patients were treated with BP-EES and 391 consecutive patients were treated with DP-EES in Nagoya Heart Center. The primary endpoint was a 3-year cumulative incidence of target lesion failure (TLF) defined as cardiac death, target vessel myocardial infarction (MI), and clinical indicated target lesion revascularization (TLR). Moreover, clinical indicated target vessel revascularization (TVR) and definite stent thrombosis (ST) were also evaluated as the secondary endpoints. After propensity score matching, 327 patients were selected in each group. At 3 years, the cumulative incidence of TLF was 4.5% in the BP-EES group versus 6.5% in DP-EES (adjusted HR 0.67 (95% CI 0.33–1.30), log-rank P=0.23). Regarding the individual components of the TLF at 3 years, the cumulative incidence of target vessel MI was significantly lower in BP-EES than in DP-EES (0% versus 1.9%: adjusted HR 0.83 (95% CI 0.71–0.97), log-rank P=0.01), but there was no difference between BP-EES and DP-EES in the incidence of cardiac death and clinically indicated TLR. The cumulative 3-year incidence of definite ST was significantly lower in BP-EES than in DP-EES (0% versus 1.6%, log-rank P=0.02). Conclusions. There were no significant differences of TLF between BP-EES and DP-EES within 3 years. In this study, BP-EES seems to prevent definite ST and be safer than DP-EES in midterm.
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- 2020
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9. Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining
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Takahiro Tokuda, Masahiro Yamawaki, Mitsuyohi Takahara, Shinsuke Mori, Kenji Makino, Yosuke Honda, Hiroya Takafuji, Takuro Takama, Masakazu Tsutsumi, Yasunari Sakamoto, Hideyuki Takimura, Norihiro Kobayashi, Motoharu Araki, Keisuke Hirano, and Yoshiaki Ito
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peri‐stent contrast staining ,segmental peri‐stent contrast staining ,stent thrombosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundPeri‐stent contrast staining (PSS) after metallic drug‐eluting stent deployment is associated with target lesion revascularization and very late stent thrombosis. However, the type of PSS that influences the clinical outcomes is unknown. Therefore, we aimed to reveal which PSS type was influencing clinical outcomes. Methods and ResultsThis study included 5580 de novo lesions of 4405 patients who were implanted with a first‐ or second‐generation drug‐eluting stent and who were evaluated using follow‐up angiography within 12 months after stent implantation. We compared the clinical outcomes of patients divided into focal PSS and segmental PSS groups for 6 years after stent implantation. Total PSS was observed in 97 lesions (2.2%), of which 42 and 55 lesions were focal and segmental PSS, respectively. Baseline characteristics were similar between groups, except for intraoperative chronic total occlusion (segmental PSS=47.3% versus focal PSS=11.9%, P=0.0001). The incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent (83.6% versus 16.4%, P=0.05). The cumulative incidence of stent thrombosis in the 6 years of segmental PSS group was significantly higher than that of the focal PSS group (13.9% versus 0%, P=0.04). The cumulative incidence of overall target lesion revascularization for restenosis, excluding target lesion revascularization procedures for stent thrombosis, was significantly higher in the segmental PSS group (38.0% versus 0%, P=0.01). ConclusionsThe incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent and appeared to be significantly associated with target lesion revascularization and stent thrombosis.
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- 2016
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10. Chronic Clinical Findings after Rheocarna® Therapy in a Chronic Limb-threatening Ischemia Patient with Inframalleolar Lesions.
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Akinori Satake, Takahiro Tokuda, Toru Niwa, Akihiro Suzuki, Yusuke Nakano, Hirohiko Ando, and Tetsuya Amano
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- 2024
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11. Development and Evaluation of a Low-Energy Consumption Wearable Wrist Warming Device.
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Guillaume Lopez, Takahiro Tokuda, Manami Oshima, Kizito Nkurikiyeyezu, Naoya Isoyama, and Kiyoshi Itao
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- 2018
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12. Development and Evaluation of a Low-Energy Consumption Wearable Wrist Warming Device.
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Lopez, Guillaume, Takahiro Tokuda, Manami Oshima, Kizito Nkurikiyeyezu, Naoya Isoyama, and Kiyoshi Itao
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WEARABLE technology ,ENERGY consumption ,BODY temperature regulation ,ENERGY conservation - Abstract
Today in Japan, comfortable lifestyle and environment realized by abundant electric power is being questioned by energy consumption reduction policies called"cool biz" in summer, and "warm biz" in winter. One reason of these policies is the bad energy consumption efficiency of current air-conditioning systems that cool or warm indirectly human body. Several researches have been investigating the effect of direct human body cooling and warming. However, most proposed solutions focus on direct head or neck cooling, using ice to cool a water circulating system, such temperature during use cannot be controlled accurately nor adapted to user and environment conditions. Recently, a Japanese research team developed a portable system using Peltier elements that can both cool and warm neck. Though cooling was demonstrated to affect positively both physiological and psychological state in summer heat environment, in cold climate it could be confirmed for only neck warming but not feet and hands. In our objective of developing effective energy saving technology for direct temperature-conditioning of human body, and in order to reduce the discomfort caused by body chillness, we have proposed and developed a Peltier element based wrist-mounted wearable device that directly warms human body. A first experimental study showed how wrist warming rhythm affects hyperthermic sensation. Then, we verified whether the thermal sensation of the body, including the extremities, is improved by changing the position where the wrist is warmed. [ABSTRACT FROM AUTHOR]
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- 2018
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13. The Impact of Decline in Activities of Daily Living (ADL) of Patients With Critical Limb Ischemia (CLI) After Endovascular Treatment.
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Takahiro Tokuda, Keisuke Hirano, Masahiro Yamawaki, Motoharu Araki, Norihiro Kobayashi, Yasunari Sakamoto, Shisuke Mori, Masakazu Tsutsumi, Yosuke Honda, and Yoshiaki Ito
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AMPUTATION , *CONFIDENCE intervals , *FOOT , *INFECTION , *ISCHEMIA , *LEG , *LIFE skills , *MULTIVARIATE analysis , *SURVIVAL , *WOUND healing , *ACTIVITIES of daily living , *DISCHARGE planning , *TREATMENT effectiveness , *DISEASE incidence , *DISEASE prevalence , *RETROSPECTIVE studies , *ODDS ratio , *BARTHEL Index , *PROGNOSIS - Abstract
Background: Certain patients with critical limb ischemia (CLI) experience significant decline in activities of daily living (ADL) during hospitalization. The prognosis of decline in ADL during hospitalization remains unknown. Methods: A retrospective analysis was performed on collected data of patients with CLI treated by endovascular treatment between April 2007 and December 2015. We evaluated CLI in patients ADL at the time of hospitalization and after discharge using the Barthel index. We classified all patients into patients with decline in ADL and stable in ADL and compared clinical outcomes (cumulative incidence of wound healing, amputation-free survival at 1 year) between the 2 groups. Results: Two hundred and fifty-five consecutive patients with CLI (221 limbs), who underwent successful endovascular intervention, were enrolled in this study. Of all patients, 22 patients were classified into the decline group. The prevalence of wound, Ischemia, foot infection (WIfI) classification high grade was higher in the decline group (30.7% vs 63.6%; P < .01). The wound healing rates were worse in the decline group than in the stable group (40% vs 78% at 1 year; P < .01). The same trends were observed in the amputation-free survival (37% vs 78%; P < .01). After multivariate analysis, decline in ADL was an independent predictor of wound healing and amputation-free survival (odds ratio [OR]: 2.85, 95% confidence interval [CI]: 1.61-3.35, P < .01; OR: 2.46, 95% CI: 1.26-4.53, P = .01). Conclusions: Patients with CLI with decline in ADL during hospitalization were found to have a poor prognosis suggesting that a decline in ADL may affect the clinical outcomes. [ABSTRACT FROM AUTHOR]
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- 2018
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14. A Sheathless Retrograde Approach Via the Popliteal Artery Is Useful and Safe for Treating Chronic Total Occlusions in the Superficial Femoral Artery.
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Takahiro Tokuda, Keisuke Hirano, Toshiya Muramatsu, Reiko Tsukahara, and Masatsugu Nakano
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Purpose: To compare the safety and success of a retrograde approach using a microcatheter vs. a sheath in the treatment of superficial femoral artery (SFA) chronic total occlusions (CTOs). Methods: From April 2007 to December 2012, 188 consecutive patients underwent EVT for 229 de novo SFA CTOs using the retrograde approach in 68 patients (35 men; mean age 72 years). This cohort was divided into cases performed with a 4-F or 6-F sheath (n=28, 36 limbs) and those with a 2.1-F microcatheter (n=35, 49 limbs). The primary outcomes were mean time to hemostasis and number of intra- and postoperative puncture site complications, as well as the success of popliteal artery puncture, lesion crossing, and reperfusion. Results: There were no significant differences between two groups in baseline characteristics. PA puncture was successful in all limbs, and the success in crossing the lesion with the wire was not significantly different (91.9% in the sheath group vs. 89.8% in the microcatheter group). Mean time to hemostasis was 8.9±8.8 minutes in the microcatheter group vs. 47.7±13 minutes in the sheath group (p<0.0001). There was a significant difference in intraoperative and postoperative complications (22.2% in the sheath group vs. 2.0% in the microcatheter group, p=0.002). Conclusion: Based on this retrospective analysis, the use of a microcatheter for SFA CTO retrograde access appears to be superior to 4-F or 6-F sheaths in terms of shorter time to hemostasis and fewer complications. [ABSTRACT FROM AUTHOR]
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- 2014
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15. Novel Ultrasonography
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Takimura, Hideyuki, Muramatsu, Toshiya, Tsukahara, Reiko, Ito, Yoshiaki, Sakai, Tsuyoshi, Ishimori, Hiroshi, Hirano, Keisuke, Nakano, Masatsugu, Araki, Motoharu, Kato, Tamon, Kobayashi, Norihiro, Sakamoto, Yasunari, Ishii, Ai, Takama, Takuro, and Takahiro, Tokuda
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- 2013
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